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Effective URL: https://www.indivumed-therapeutics.com/
Submission: On November 08 via api from US — Scanned from DE
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SCREENING-READY NOVEL TARGET PACKAGES FOR PRECISION ONCOLOGY
THE WORLD NEEDS BETTER DRUGS
AGAINST CANCER
Striving for a future in which every cancer patient can benefit from precise
therapeutic treatments, we are committed to advancing the discovery
and development of novel drugs.
We create screening-ready packages of novel targets set up for reproducibility
to partner with the pharmaceutical industry. Our disease-relevant targets offer
a high probability of successful therapeutic development further along our
partners’ R&D pipeline.
Equipped with more than 20 years of experience and a truly unique resource, we
are helping to shape the future of precision cancer therapeutics.
THE EXCELLENT-DATA APPROACH
TO NOVEL TARGET ID
Through our unique approach, we generate reliable and reproducible data that
reflects the molecular reality of cancer at an unparalleled level.
This is key to discovering truly novel targets - find out how.
OUR GLOBAL
CLINICAL NETWORK
Through our global clinical network, we have direct access to high-quality
biospecimens and data that are crucial to making all relevant details of a
cancer disease transparent. They cover a wide variety of biological backgrounds
and regional variances from all over the world.
Read more
STANDARDIZED COLLECTION
AND PROCESSING
Special procedures, including keeping cold ischemia times to under ten minutes,
ensure pre-analytically controlled specimen with a very high sample integrity.
This preserves the expression of otherwise undetectable therapeutic targets.
Samples are paired with 300 different clinical data points and up to ten years
of follow-up data.
MULTI-OMICS
DATA GENERATION
The excellent quality of our samples enables an in-depth multi-omics approach
for matched tumor and normal tissue. Using next-generation sequencing and mass
spectrometry technologies, we extract proteomics, phosphoproteomics,
transcriptomics, genomics, and miRNA from tissue samples.
THE KEY TO PRECISION
ONCOLOGY
Through our unique approach, we generate reliable and reproducible data that
reflects the molecular reality of cancer at an unparalleled level. This is key
to discovering and identifying truly novel targets and provides a valuable
resource for successful drug development.
BOOSTING THE PHARMACEUTICAL INDUSTRY’S R&D PIPELINES
To maximize the value of our data for pharmaceutical development, we have
established a holistic target identification process. Each step in this process
is designed to increase the probability of successful therapeutic development
further down the pipeline and the chances of a novel drug reaching the market.
TARGET DISCOVERY –
UNRAVELLING TRILLIONS OF DATA POINTS
To explore the entirety of our database for hidden patterns, we have established
nRavel® – a proprietary platform for multivariate data analytics that integrates
advanced biomathematical and bioinformatics tools. By combining multi-omic
expression signatures and prognostic data in selected cohorts, we identify novel
and disease-relevant targets – in the correct tissue and for the correct cohort.
TARGET VALIDATION –
WHERE SAMPLE QUALITY PAYS OFF AGAIN
Once we have identified a target using nRavel®, we validate it in proprietary 2D
and 3D cellular models based on immortalized cells or primary cells derived from
the original patient cohort used in discovery. These models provide a very
accurate recapitulation of the patient’s physiological processes while
representing the characteristic features of the disease.
TARGET REFINEMENT –
PREPARING THE PACKAGE FOR R&D PARTNERSHIPS
Our IP-protected packages consist of screening-ready targets that are set up for
reproducibility within our partners’ R&D pipelines. The protein type and
biochemical characteristics, cellular location, and biological function are
biochemically characterized. Proof-of-concept drug screening assays are
established for cell-free and cell-based compound screening.
LET’S MOVE PRECISION ONCOLOGY FORWARD
We collaborate with pharmaceutical partners, providing novel screening-ready
target packages for the development of innovative cancer therapeutics. Beyond
this, we work with biotech companies and academic institutions and participate
in R&D partnerships, providing expertise, skills, and knowledge in various
capacities.
GET IN TOUCH
If you would like to discuss a collaboration or learn more about our target
identification process, please do not hesitate to get in touch. We look forward
to hearing from you.
Call us now at:
+49 40 4133 83 0
Send an E-mail at:
info@indivumed.com
10 minutes can make all the difference!
Click here to check out our latest study about significant molecular changes in
tumor samples within minutes of collection.
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