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> HOME PAGE
> 
> PanDaTox version: 1.0
> 
> The PanDaTox database aims at identifying genes and intergenic regions that
> are unclonable in E. coli, to aid in the discovery of new antibiotics and
> biotechnologically beneficial functional genes. It is also designed to improve
> the efficiency of metabolic engineering, by systematically identifying enzymes
> whose products are toxic to E. coli.
> 
> PanDaTox is a database of genes that are potentially toxic to bacteria. The
> construction of this database is based on computational methods that scan a
> microbial genome and detect specific genes that kill E. coli if cloned into
> it. These methods identify genes and intergenic regions that fail to propagate
> in E. coli in the process of whole genome shotgun sequencing, thus creating
> sequencing gaps. It has been shown that these sequencing gaps are frequently
> caused by toxic genes, which may have antimicrobial properties.
> 
> PanDaTox holds and presents a set of >40,000 genes that may be toxic to
> bacteria. These genes are the result of a computational analysis performed on
> ~400 microbial genomes. Users can search for toxic genes in their genome of
> interest; check who are the homologs of these toxic genes and whether these
> homologs are toxic as well; query the database using a keyword-based search
> for genes answering to specific user-supplied criteria; and perform a
> sequence-based search (blast) for genes in the database that are similar to a
> query gene of their choice. The toxicity information for each gene is
> presented in both numerical and graphical manners, and details on each gene,
> including its DNA sequence, protein sequence, and various links to external
> web sources are presented.
> 
>     

Comments and Suggestions: rotem.sorek@weizmann.ac.il