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No copayment, deductible needed for preventive benefit * 8 Medicine Cabinet Essentials for Cold and Flu Season Keep these items on hand to identify and treat troubling symptoms Health COMMON DECONGESTANTS THAT DON’T ACTUALLY WORK AN INGREDIENT FOUND IN MANY COLD AND FLU PRODUCTS WON’T RELIEVE YOUR STUFFY NOSE -------------------------------------------------------------------------------- By Rachel Nania, AARP 83 Comments En español Published September 18, 2023 / Updated November 07, 2024 Tim Boyle / Getty Images * Facebook * Twitter * LinkedIn With cold and flu season upon us, it’s time to take stock of what’s in the medicine cabinet. This year, that process may involve not only getting rid of any expired boxes and bottles but also rethinking certain remedies that never worked in the first place. The U.S. Food and Drug Administration (FDA) is proposing that phenylephrine, a common decongestant found in many over-the-counter cold medications, be removed from these products. The proposal, issued Nov. 7, comes roughly a year after an advisory panel of experts concluded the ingredient is ineffective at relieving nasal congestion when taken by mouth. Members only Entertainment Subscribe to AARP's Lifestyle Newsletter Every month, get the top entertainment stories, relationship advice, movie reviews and online games Members only “It is the FDA’s role to ensure that drugs are safe and effective,” Patrizia Cavazzoni, M.D., director of the FDA’s Center for Drug Evaluation and Research, said in a statement. “Based on our review of available data, and consistent with the advice of the advisory committee, we are taking this next step in the process to propose removing oral phenylephrine because it is not effective as a nasal decongestant.” Phenylephrine is supposed to work by reducing swelling of the blood vessels in the nasal passages, making it easier to breathe. But when taken orally, “it basically becomes deactivated before it enters your bloodstream,” says Stefanie Ferreri, a professor of pharmacy at the University of North Carolina Eshelman School of Pharmacy. “It’s almost like a placebo, a sugar pill, when it’s taken orally.” Experts stress that phenylephrine, which has been sold for decades, isn’t dangerous, and it is still effective when used as a nasal spray or as drops to dilate the eyes. But it can be harmful to your wallet if you’re buying a pill that’s ineffective to relieve congestion, Ferreri says. Products containing phenylephrine — including those sold by big brands such as Tylenol, Advil, Sudafed and Mucinex — generated nearly $1.8 billion in sales in 2022, according to data presented by the advisory panel in 2023. COMMON DECONGESTANTS THAT WON’T WORK Here are examples of oral medications that may help your headache or sore throat, but they won’t relieve your stuffy nose. 1. Advil Sinus Congestion & Pain 2. Tylenol Cold + Head Congestion Severe 3. Mucinex Sinus-Max Severe Congestion & Pain Relief 4. Benadryl Allergy Plus Congestion 5. DayQuil Cold + Flu 6. Sudafed PE 7. Theraflu Severe Cold Relief Daytime 8. Vicks Sinex Severe This list is not exhaustive. Phenylephrine is found in a number of oral over-the-counter products. WHAT WORKS AND WHAT DOESN’T FOR A STUFFY NOSE Phenylephrine, sometimes labeled PE on packaging, is sold on its own but is often found in combination products that contain ingredients meant to knock out a range of symptoms that can accompany congestion — sore throat, fever, body aches and so on. Because of this, you may not want to toss out everything containing phenylephrine, says Sarah Westberg, a professor at the University of Minnesota College of Pharmacy. That box of cold and flu medication could help with your other symptoms, it just won’t unclog your nose. LAST CHANCE! JOIN AT 2024 RATES! Membership rates going up in 2025 Join Renew ARTICLE CONTINUES AFTER ADVERTISEMENT If you’re looking for a decongestant that will work, there are options — just be sure to talk to your doctor or pharmacist before taking one, especially if you take other medications, experts stress. Nearly half of older adults take at least five drugs daily. Pseudoephedrine is an effective oral alternative, Westberg says. It’s available without a prescription, but it’s not as easy to buy as phenylephrine since pseudoephedrine can be used to illegally make methamphetamine, a stimulant that can be highly addictive. It’s technically behind the counter, so you’ll need to ask the pharmacist for a product containing pseudoephedrine and will only be able to purchase a limited amount at one time. “You can still get enough to treat your cough and cold,” Ferreri says. Members only Entertainment AARP Streams App Watch Movies for Grownups and AARP Theater for free on the app Members only Just know that pseudoephedrine can cause an increase in blood pressure, so it’s important to talk to your doctor before taking it if you have high blood pressure or heart disease. About 70 percent of adults 65 and older have high blood pressure. Another option: “Go straight to the source” and consider a nasal spray, Ferreri says. A spray product containing phenylephrine will work fine when it comes to relieving congestion, though this can similarly affect your blood pressure. Saline nasal sprays that don’t contain medication can also provide relief. “Consumers should know that a range of safe and effective drugs and other treatments is available to temporarily relieve congestion symptoms due to allergies or a common cold,” Theresa Michele, M.D., director of the FDA’s Office of Nonprescription Drug Products, said in a statement. “Consumers can also talk to their doctor or pharmacist about ways to treat these symptoms.” THE DECONGESTANT AISLE COULD SHRINK The FDA's order is just a proposal; only a final order will affect what products can be marketed, the agency says. If the FDA removes phenylephrine from over-the-counter medications, it could “have a big impact on the market,” Westberg says. “There are a lot of products that will need to be reformulated.” (The FDA said it will give companies “appropriate time” to do this.) That’s not a bad thing, though, Ferreri says. “Right now, I think we have way too many [options] on the market, and it’s almost confusing. You want to have things on the market that are safe and effective, and [we need to] narrow it down so you know what you’re buying is going to work,” she says. Editor's note: This story, first published Sept. 18, 2023, has been updated with new information. %{postComment}% Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments. Discover AARP Members Only Access Renew your membership AARP NEWSLETTERS Get the Your Health newsletter from AARP Sign up for the latest health news, fitness and nutrition updates and more! Subscribe See All Newsletters Privacy Policy AARP NEWSLETTERS Get the Your Health newsletter from AARP Sign up for the latest health news, fitness and nutrition updates and more! 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