dupuytrens-contracture.xiaflex.com Open in urlscan Pro
23.36.162.216  Public Scan

Form analysis
3 forms found in the DOM

<form class="navbar-item zip-form flex-wrap orange-bg" data-v-57523a1e=""><a href="/patient/specialist-locator" data-v-57523a1e=""><label for="" class="is-uppercase bold" data-v-57523a1e="">Locate a Specialist</label></a>
  <div class="is-flex white-bg" data-v-57523a1e=""><input id="navbar-zip" placeholder="Enter ZIP code" data-v-57523a1e=""> <button type="submit" aria-label="Search your zip code" class="icon-locate" data-v-57523a1e=""><svg data-v-57523a1e="">
        <use xlink:href="#icon-locate" data-v-57523a1e=""></use>
      </svg></button></div>
</form>

<form class="zip-form flex-wrap orange-bg" data-v-76645db2="">
  <a href="/patient/specialist-locator" style="text-decoration:none" data-v-76645db2=""><label for="" class="is-uppercase is-hidden-mobile bold" data-v-76645db2="">Locate a Specialist</label></a>
  <div class="is-flex white-bg" data-v-76645db2=""><input id="locator-zip" placeholder="Enter ZIP code" data-v-76645db2=""> <button type="submit" aria-label="Search your zip code" class="icon-locate" data-v-76645db2=""><svg data-v-76645db2="">
        <use xlink:href="#icon-locate" data-v-76645db2=""></use>
      </svg></button></div>
</form>

<form class="zip-form flex-wrap orange-bg is-hidden-tablet"><a href="/specialist-locator" class="no-underline"><label for="" class="is-uppercase bold">Locate a Specialist</label></a>
  <div class="is-flex white-bg"><input id="isi-zip" placeholder="Enter ZIP code"> <button type="submit" aria-label="Search your zip code" class="icon-locate"><svg>
        <use xlink:href="#icon-locate"></use>
      </svg></button></div>
</form>

Text Content

 * Visit Healthcare Professional Website
 * Medication Guide
 * Important Safety Information
 * Full Prescribing Information

Home Dupuytren’s Contracture XIAFLEX Videos Resources
Locate a Specialist

 * Full Prescribing Information
 * Medication Guide
 * Visit Healthcare Professional Website
 * Important Safety Information

Hand Specialist


EXPLORE NONSURGICAL XIAFLEX® FOR DUPUYTREN’S CONTRACTURE

Actual patients
compensated for their time

What is XIAFLEX?

How is XIAFLEX thought to work?

How is XIAFLEX administered?

How can XIAFLEX help?

Is XIAFLEX effective for treating a contracture?

What can I expect at my XIAFLEX procedure?

Is XIAFLEX safe?

What are the side effects of XIAFLEX?

How much does XIAFLEX cost?

How do I get XIAFLEX?

 * Q 01
   
   
   WHAT IS XIAFLEX?
   
   XIAFLEX is an FDA-approved nonsurgical injectable treatment for adults with
   Dupuytren’s contracture when a “cord” can be felt. XIAFLEX should be injected
   by a healthcare provider experienced in injection procedures of the hand and
   in treating people with Dupuytren’s contracture.
   
   Please see below for the most common side effects.

 * Q 02
   
   
   HOW IS XIAFLEX THOUGHT TO WORK?
   
   XIAFLEX is injected into the collagen “cord” that is causing the contracture.
   After injection, the XIAFLEX enzymes are thought to attach to the collagen
   that makes up the rope-like cord in the palm, unwinding the collagen and
   eventually, breaking it down.
   
   The mechanism of action of XIAFLEX in Dupuytren’s contracture is not fully
   understood.
   
   Watch the video to see how XIAFLEX is thought to work.
   
   Watch Now
   
   

 * Q 03
   
   
   HOW IS XIAFLEX ADMINISTERED?
   
   XIAFLEX is an injection given in a doctor’s office by a Hand Specialist with
   XIAFLEX training. Treatment doesn’t require general anesthesia, and up to 2
   cords in 1 hand may be treated during 1 office visit.
   
   Dupuytren’s contracture may come back—no matter what treatment option you
   use. If your contracture returns after treatment, your Hand Specialist will
   let you know if XIAFLEX may be used again.

 * Q 04
   
   
   HOW CAN XIAFLEX HELP?
   
   Studies show that prescription XIAFLEX, along with a finger extension
   procedure, may help straighten or nearly straighten finger(s) affected by
   Dupuytren’s contracture and may improve range of motion after up to 3
   injections.
   
   XIAFLEX may help contractures ranging from less severe to more severe,
   multiple contractures (up to 2 cords), or contractures that have come back.

 * Q 05
   
   
   IS XIAFLEX EFFECTIVE FOR TREATING A CONTRACTURE?
   
   Explore the images to see a few results from people with Dupuytren’s
   contracture who received XIAFLEX.
   
   Treatment of 1 contracture
   
   TREATMENT OF 1 CONTRACTURE
   
   MP joint of the left ring finger
   
   For all patients shown, XIAFLEX was injected into the “cord” (MP joint, PIP
   joint, or both) and a finger extension procedure was performed for each joint
   48 hours later.
   
   See after photo
   See before photo
   Treatment of 1 contracture
   
   TREATMENT OF 1 CONTRACTURE
   
   PIP joint of the right pinky
   
   For all patients shown, XIAFLEX was injected into the “cord” (MP joint, PIP
   joint, or both) and a finger extension procedure was performed for each joint
   48 hours later.
   
   See after photo
   See before photo
   Treatment of 2 contractures on the same hand
   
   TREATMENT OF 2 CONTRACTURES ON THE SAME HAND
   
   MP and PIP joints of the left pinky
   
   For all patients shown, XIAFLEX was injected into the “cord” (MP joint, PIP
   joint, or both) and a finger extension procedure was performed for each joint
   48 hours later.
   
   See after photo
   See before photo

 * Q 06
   
   
   WHAT CAN I EXPECT AT MY XIAFLEX PROCEDURE?
   
   Step 01
   
   THE DAY OF YOUR INJECTION—THE PROCEDURE
   
    * The Hand Specialist will inject XIAFLEX directly into the cord causing
      your finger(s) to bend. If you have 2 contractures on the same hand, your
      Hand Specialist may give you 2 injections during the same visit
    * Then, your hand will be bandaged, and you will be advised to keep your
      hand elevated until bedtime
    * Limit the movement of your treated finger(s) and do not manually bend or
      straighten the treated finger(s) yourself. You may see swelling or
      bruising after the injection
    * Plan to have someone drive you home from the procedure
   
   Call your Hand Specialist right away if you have any serious side effects.
   
   
   
   
   Step 02
   
   YOUR FOLLOW-UP APPOINTMENT— EXTENDING YOUR FINGER(S)
   
    * At your follow-up appointment approximately 1 to 3 days after the
      injection procedure, if you still have a cord, a Hand Specialist may try
      to extend the treated finger(s) and “break” the cord to help straighten
      your finger(s). Your doctor may use local anesthetic for this procedure
    * After the injection and finger extension procedures, and leading up to
      your 30-day follow-up appointment, it’s important to wear the splint
      provided by your Hand Specialist at bedtime nightly for up to 4 months and
      do finger exercises several times a day for several months
   
   Follow the Hand Specialist’s instructions on when you can start doing normal
   activities with your injected hand.
   
   Step 03
   
   30 DAYS AFTER THE INJECTION— CHECKING YOUR PROGRESS
   
    * At the second follow-up appointment, the Hand Specialist will examine your
      progress. Depending on the results or if the cord(s) is still present,
      they may suggest additional injections and finger extension procedures (up
      to 3 times per cord, approximately 4 weeks apart)
   
   

 * Q 07
   
   
   IS XIAFLEX SAFE?
   
   XIAFLEX is considered safe for the treatment of Dupuytren’s contracture in
   adults over 18 with a “cord” that can be felt.
   
    * It was approved by the FDA in 2010, after clinical trials showed its
      effectiveness in reducing the degree of contracture and improving range of
      motion when compared with patients who were treated with no medication
      (placebo)
    * Additionally, in a long-term, 5-year observational study of patients who
      had participated in the clinical trials of XIAFLEX for Dupuytren’s
      contracture, a subset of patients who had recurrence were re-treated with
      XIAFLEX in a subsequent study. No new adverse events were reported

 * Q 08
   
   
   WHAT ARE THE SIDE EFFECTS OF XIAFLEX?
   
   XIAFLEX can cause serious side effects such as tendon rupture, ligament
   damage, and/or nerve injury or other serious injury of the hand;
   hypersensitivity reactions, including anaphylaxis; fainting, and increased
   chance of bleeding in certain cases.
   
   Call the Hand Specialist right away if you have:
   
    * •Signs of infection after your injection such as fever, chills, increased
      redness, or severe swelling
    * •Numbness or tingling in the treated finger(s)
    * •Trouble bending the injected finger(s) after the swelling goes down or
      you have problems using your treated hand after your follow-up visit
    * •Increased pain in the injected finger(s) or hand after your injection or
      after your follow-up visit
    * •Tears in the skin of your treated finger(s) or hand after your injection
      or after your follow-up visit
    * •Signs of an allergic reaction such as hives, chest pain, swollen face,
      low blood pressure, breathing trouble, or dizziness or fainting
   
   If you have dizziness or feel faint after receiving XIAFLEX, lie down until
   the symptoms go away.
   
   The most common side effects with XIAFLEX for the treatment of Dupuytren’s
   contracture include: swelling of the injection site or the hand; bruising or
   bleeding at the injection site; pain or tenderness of the injection site or
   the hand; swelling of the lymph nodes (glands) in the elbow or armpit;
   itching; breaks in the skin; redness or warmth of the skin; and pain in the
   armpit.
   
   Tell your healthcare provider if you have any side effect that bothers you or
   does not go away. These are not all of the possible XIAFLEX side effects.
   For more information, ask your healthcare provider or pharmacist.

 * Q 09
   
   
   HOW MUCH DOES XIAFLEX COST?
   
   For most eligible patients with commercial insurance plans, there is a $0
   copay for XIAFLEX injections when you use the XIAFLEX Copay Assistance
   Program.*
   
   How much you pay for XIAFLEX will depend on your health benefits or insurance
   coverage. The XIAFLEX Copay Assistance Program can cover up to $1,200 of your
   out-of-pocket costs for each vial.
   
   Learn more about savings with XIAFLEX and how to qualify for the XIAFLEX
   Copay Assistance Program on our Resources page.

 * Q 10
   
   
   HOW DO I GET XIAFLEX?
   
   XIAFLEX is only available by prescription. Visit a XIAFLEX-trained Hand
   Specialist and ask about XIAFLEX for your Dupuytren’s contracture.
   
   If you need to find a Hand Specialist, you can use our Hand Specialist
   Locator below.

Get started by entering your ZIP code
to find a XIAFLEX-trained Hand Specialist now.

Locate a Specialist


or use my location



--------------------------------------------------------------------------------

Watch a genuine conversation about nonsurgical XIAFLEX treatment



Locate a Specialist

Click for more Less

WHAT IS XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s
contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and
effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION FOR XIAFLEX

Do not receive XIAFLEX if you have had an allergic reaction to collagenase
clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other
collagenase product. See the end of the Medication Guide for a complete list of
ingredients in XIAFLEX.

XIAFLEX CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

 * Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may
   cause damage to a tendon or ligament in your hand and cause it to break or
   weaken. This could require surgery to fix the damaged tendon or ligament.
   Call your healthcare provider right away if you have trouble bending your
   injected finger (towards the wrist) after the swelling goes down or you have
   problems using your treated hand after your follow-up visit
 * Nerve injury or other serious injury of the hand. After finger procedures,
   some people developed tears in the skin (lacerations), and local skin and
   soft-tissue necrosis (death of skin cells). Some lacerations and necrosis
   required skin grafting, or other surgery including amputation. Call your
   healthcare provider right away if you get numbness, tingling, increased pain,
   or tears in the skin (laceration) in your treated finger or hand after your
   injection or after your follow-up visit
 * Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions
   can happen in people who receive XIAFLEX because it contains foreign
   proteins. Call your healthcare provider right away if you have any of these
   symptoms of an allergic reaction after an injection of XIAFLEX:
   * hives
   * swollen face
   * breathing trouble
   * chest pain
   * low blood pressure
   * dizziness or fainting
 * Fainting. Fainting (passing out) or near fainting can happen in people who
   receive XIAFLEX, especially following finger procedures
   If you have dizziness or feel faint after receiving XIAFLEX, lie down until
   the symptoms go away.
 * Increased chance of bleeding. Bleeding or bruising at the injection site can
   happen in people who receive XIAFLEX. Talk to your healthcare provider if you
   have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an
allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or
any other medical conditions. Tell your healthcare provider about all the
medicines you take, including prescription and non-prescription medicines,
vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can
cause serious side effects. Especially tell your healthcare provider if you take
medicines to thin your blood (anticoagulants). If you are told to stop taking a
blood thinner before your XIAFLEX injection, your healthcare provider should
tell you when to restart the blood thinner. Ask your healthcare provider or
pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s
contracture include:

 * swelling of the injection site or the hand
 * bruising or bleeding at the injection site
 * pain or tenderness of the injection site or the hand
 * swelling of the lymph nodes (glands) in the elbow or armpit
 * itching
 * breaks in the skin
 * redness or warmth of the skin
 * pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or
does not go away. These are not all of the possible side effects with XIAFLEX.
For more information, ask your healthcare provider or pharmacist.

Click for full Prescribing Information, including Medication Guide.

*Based on analysis of claims filed September 2011 through March 2018.

Intended for U.S. Residents Only

--------------------------------------------------------------------------------

 * Home
 * Prescribing Information
 * Contact Us
 * Site Map
 * Corporate Home

Rx Only XIAFLEX® is a registered trademark of Endo International plc or one of
its affiliates. © 2023 Endo International plc or one of its affiliates. All
rights reserved. Privacy/Legal XD-06823/February 2023 www.xiaflex.com
1-800-462-ENDO (3636)
 * 
 * 
 * 

Quick Links

Have you taken the Tabletop Test?

Why choose XIAFLEX?

Sign up for updates
 * 
 * 
 * 

YOU ARE ABOUT TO LEAVE THE XIAFLEX® (COLLAGENASE CLOSTRIDIUM HISTOLYTICUM)
WEBSITE.

The information contained in this section of the site is intended for US
healthcare professionals only.

Click CONTINUE if you are a healthcare professional.

Continue Cancel



YOUR PRIVACY IS IMPORTANT TO US!

This website uses cookies and other tracking technologies to enhance site
navigation, analyze site usage, and assist in our marketing efforts. By clicking
“I Agree” you consent to our use of cookies and other tracking technologies on
our website, and the disclosure of the tracking data to our
third-party/advertising and analytics partners for the purposes listed above. To
change your cookie preferences, please click “Cookie Settings.” If you click on
“I Disagree” only cookies required for this site to function will remain active.
For more information, see our Privacy/Legal policies.

Cookies Settings I Disagree I Agree



PRIVACY PREFERENCE CENTER




 * YOUR PRIVACY


 * STRICTLY NECESSARY COOKIES


 * FUNCTIONAL COOKIES


 * PERFORMANCE COOKIES


 * TARGETING COOKIES

YOUR PRIVACY

When you visit our website, we store cookies on your browser to collect
information. The information collected might relate to you, your preferences or
your device, and is mostly used to make the website work as you expect it to and
to provide a more personalized web experience. However, you can choose not to
allow certain types of cookies, which may impact your experience of the website
and the services we are able to offer. Click on the different category headings
within the Privacy Preference Center for more information or to update the
default settings. You cannot opt out of our first-party “Strictly Necessary
Cookies” as they are deployed to ensure the proper functioning of our website
(such as prompting the cookie banner and remembering your settings, logging in
to your account, redirecting you when you log out, etc.). For more information
about cookies, see our
Privacy/Legal Policies.

STRICTLY NECESSARY COOKIES

Always Active

These cookies are necessary for the website to function and cannot be turned off
in our systems. These cookies are usually only set in response to actions made
by you which amount to a request for services, such as setting your privacy
preferences, logging in or filling in forms. You can set your browser to block
or alert you about these cookies, however, blocking these cookies may cause some
parts of the website not to function properly. These cookies do not store any
personally identifiable information.

FUNCTIONAL COOKIES

Functional Cookies Inactive


These cookies enable the website to provide enhanced functionality and
personalization. They may be set by us or by third-party providers whose
services we have added to our pages. If you deactivate these cookies, some or
all of these services may not function properly.

PERFORMANCE COOKIES

Performance Cookies Inactive


These cookies allow us to count visits and traffic sources so we can measure and
improve the performance of our website. They provide information that helps us
determine which pages are the most and least popular and see how visitors move
around the website. All information these cookies collect is aggregated and
therefore anonymous. If you deactivate these cookies, we will not know when you
have visited our website and will not be able to monitor its performance.

TARGETING COOKIES

Targeting Cookies Inactive


These cookies may be set on our website by our advertising partners. They may be
used by those partner companies to build a profile of your interests and show
you relevant advertisements on other websites. These cookies do not store
personal information but are based on uniquely identifying your browser and
internet device. If you deactivate these cookies, you will experience less
targeted advertising.

Back Button


COOKIE LIST

Filter Button
Consent Leg.Interest
checkbox label label
checkbox label label
checkbox label label

Clear
checkbox label label
Apply Cancel
Confirm My Choices
Reject All Cookies Allow All Cookies