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This undated electron microscope image shows SARS-CoV-2, yellow, emerging from
the surface of cells, blue/pink, cultured in a laboratory. (Courtesy of
NIAID-RML)
News & Discoveries


NATURAL IMMUNITY TO COVID-19 DETECTED AT 20 MONTHS AFTER INFECTION: STUDY

By Zachary Stieber
Zachary Stieber
Reporter
Zachary Stieber covers U.S. news and stories relating to the COVID-19 pandemic.
He is based in Maryland.
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February 4, 2022 Updated: February 4, 2022
biggersmaller
Print

Protection against the virus that causes COVID-19 among the recovered was
detected by researchers at 20 months post-infection, adding to the body of
evidence that such protection, known as natural immunity, is long-lasting.

Researchers found antibodies against the SARS-CoV-2 spike protein
receptor-binding domain (RBD) in 99 percent of study participants who tested
positive for COVID-19, with some having had the illness as long as 20 months
prior.

SARS-CoV-2 is another name for the CCP (Chinese Communist Party) virus, which
causes COVID-19. Antibodies are a form of protection against the virus.

The researchers, led by Dr. Dorry Segev, the director of the Epidemiology
Research Group in Organ Transplantation at Johns Hopkins University, put out a
call for unvaccinated, healthy adults in the fall of 2021 and divided them into
three groups. The first group consisted of 295 participants who had
test-confirmed COVID-19 infections in the past; the second consisted of 275
participants who believed they recovered from COVID-19 but did not get a test;
the third consisted of 246 people who did not think they ever had COVID-19 and
had never tested positive.

In the first group, all but 2 of the participants tested positive for the
antibodies, and there was no indication that the level of protection waned over
time.

About 55 percent of the second group tested positive for anti-RBD antibodies,
and the median level among those who did was lower.

The third group had the lowest percentage, 11 percent, of participants who had
the antibodies and the level among those who did was the lowest.

“The major takeaway is that natural immunity … is strong and durable,” Segev
told The Epoch Times in an email.

The peer-reviewed study, which was funded by charitable donations from the
Ben-Dov family, was published by the Journal of the American Medical
Association.

Dr. Nasia Safdar, a professor in the Division of Infectious Disease at the
University of Wisconsin’s School of Medicine and Public Health, said the results
were encouraging, “but likely applicable only to a healthy adult population,
with the ability and resources to go get a blood draw.”

“We are probably missing the immunocompromised, older, frail group of people
where immune response may be very different than other groups,” Safdar, who was
not involved in the study, told The Epoch Times via email.

Researchers noted that it antibodies are just one measure of immunity and that
it remains unclear whether the anti-RBD antibodies will protect people against
emerging virus variants.

The Omicron variant became dominant in the United States in December 2021 and
research suggests it can evade protection from vaccines and prior infection
better than Delta, the strain it displaced.

Most previous studies have found that natural immunity is superior to
vaccination, including while Delta was dominant. One study was backed by the
U.S. Centers for Disease Control and Prevention.

A key question about the protection, though, is how long it will last. Some
experts recommend people get at least one shot of a COVID-19 vaccine even if
they’ve recovered from the disease due to the uncertainty, though others point
to research indicating the vaccines would only give a small boost in protection
to the naturally immune.

The new study was published several weeks after a different, non-peer reviewed
paper found evidence of natural immunity at 18 months past infection in a
collection of vaccinated and unvaccinated people.

Segev said he and other scientists are studying how Omicron affects the
naturally immune, with plans to publish results on a preprint server soon.




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