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Behrends Lab Membrane Physiology and Technology



MEMBRANE PHYSIOLOGY AND TECHNOLOGY RESEARCH



Biological membranes are at once barriers and interfaces. They separate spaces
and at the same time allow controlled transport and communication between them,
the former being largely a function of the membrane lipids while the latter is
the job of the membrane proteins.

Fig. 1: My first electrophysiological recording (Munich ca. 1982).
Electrooculogram from a fellow medical student. She was reading “A la recherche
du temps perdu”.

Fig. 2: My first action potential (Munich 1985). Intracellular recording from a
rat sympathetic ganglion cell with a sharp electrode (a.k.a “glass nanopore”),
filled with 3M KCl. Resistance approx. 50 MOhms.

Moreover, membranes generate all bioelectric signals and serve as the medium for
cellular electrical signaling from graded, local potential changes to propagated
action potentials by regulated flux of charged particles (ions). Finally, fusion
and fission of membranes underlie transport of matter between cellular
organelles and between them and the extracellular space (exo- and endocytosis)
and a combination of exocytosis with regulated ion flux underlies synaptic
communication between cells.



Electrophysiology is arguably still the most powerful, versatile, and
quantitative method to study membrane function. It covers the entire spectrum
from whole organismic systems (Fig. 1) to single cells (Fig. 2) and even single
molecules (Fig. 3). As a real-time technique, electrophysiology lets you
actually “feel the pulse” of single cells or even single molecules –a
fascination that is sure to grip and never wanes.

At Behrendslab, electrophysiology is the basis of everything we do. Together
with partners in microelectronics, microsystems technology and engineering,
including companies spun out from the lab, we innovate to push it to new limits
of resolution and throughput and combine it with other high resolution
measurement techniques, such as optical recording, to enhance information
content.

A current focus is the use of biological nanopores as sensors for single
molecules in the context of future medical diagnostics. We play a central role
in the Cluster4Future nanodiagBW, a large consortium of basic and applied
research institutions and companies focusing on nanopore technology in the
southwest of Germany.

Fig. 3: Single molecule detection (above) at high-resolution (110 kHz bandwidth)
using an integrated nanopore-CMOS-amplifier device (below) developed in
collaboration with the Hahn-Schickard Institute and Ionera GmbH. Freiburg 2022.


RECENT NEWS




MEMPHYSTECH @ SMPS3 DELFT


NEW PAPER IN JACS


NEW NANOPORE CLUSTER


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© Behrends Lab – High precision electrophysiological measurement.

Jan C. Behrends
Professor of Physiology
Physiological Institute, University of Freiburg
Hermann-Herder-Str. 7, 79104 Freiburg
Germany



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