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Martin Stauber PhD PRIVATE CV Curriculum Vitae prepared on September 16th 2017 Name Martin Stauber Company GratXray AG Address PARK innovAARE 5234 Villigen Switzerland Email martin.stauber@gratxray.com Vox / Fax +41 44 545 8530 / +41 44 545 8531 Place of Birth Chur, Switzerland Date of Birth 9 October 1974 Work Experience 2017 — Co-founder, CEO — GratXray AG 2012 — 2017 Senior Scientist — Scanco Medical AG 2012 Trade sale: Sold b-cube AG to Scanco Medical AG 2008 — 2012 Co-founder, CEO and member of the board — b-cube AG 2007 — 2012 Lecturer — ETH Zürich, Switzerland 2005 — 2007 Research Fellow — ETH Zürich, Switzerland Education 2000 — 2005 Dr. sc. ETH Zürich — ETH Zürich, Switzerland “Volumetric spatial decomposition of porous microstructures – A framework for element based analysis of trabecular bone” 2000 — 2002 Dipl. NDS ETHZ in Medizinphysik — ETH Zürich, Switzerland “Assessment of Dose and Cell Survival in μCT Imaging Systems” 1995 — 2000 Dipl. Phys. ETH — ETH Zürich, Switzerland “Analysis of 3D bone samples from SRμCT at the European Synchrotron Radiation Facility (ESRF): Characterization based on skeletonization” 1989 — 1994 Matura Type C — Kantonsschule Chur, Switzerland Experience Abroad 2000 (6 month) Diploma thesis at the European Synchrotron Radiation Facility (ESRF), Grenoble, France 2001 (1 month) Scientific guest at the Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Awards & Honors 2001 Finalist, Young Investigator Award, International Society of Biomechanics (ISB) 2002 Best Commented Poster Award, European Society of Biomechanics (ESB) 2006 Young Investigator Scholarship, Deutsche Akademie der osteologischen und rheumatologischen Wissenschaften 2006 SSBE Research Award, Swiss Society for Biomedical Engineering (SSBE) 2006 ISBM Young Investigator Award, International Society of Bone Morphometry (ISBM) Teaching 2006, 2008, 2010, 2012 Computers in Medicine Professional Societies 2003 — Swiss Society for Biomedical Engineering (SSBE) 2008 — European Society for Biomechanics (ESB) 2010 — American Society for Bone and Mineral Research (ASBMR) Original Articles 2021 L. Alsofi, M. Al Harbi, M. Stauber, K. Balto, Analysis of the Morpho-Geometrical Changes of the Root Canal System Produced by TF Adaptive vs. BioRace: A Micro-Computed Tomography Study, Materials, 14(3):531, 2021. L. Alsofi, M. Al Harbi, M. Al-Habib, M. Stauber, K. Balto, Micro-cleanliness of Hard Tissue Debris After Advanced Irrigation and Comparison Between EndoVac and XP-endo Finisher: A Microcomputed Tomographic Study, J Int Soc Prev Community Dent, 11(4):457–462, 2021. 2019 K.E. Becker, K. Jandik, M. Stauber, I. Mihatovic, D. Drescher, F. Schwarz, Microstructural volumetric analysis of lateral ridge augmentation using differently conditioned tooth roots, Clin Oral Investig, 23(7):3063-3071, 2019. 2018 H.M. Kjer, J. Fagertun, W. Wimmer, N. Gerber, S. Vera, L. Barazzetti, N. Mangado Lopez, M. Ceresa, G. Piella, T. Stark, M. Stauber, M. Reyes, S. Weber, M. Caversaccio, M.A. González-Ballester, R. Paulsen, Patient-specific estimation of detailed cochlear shape from clinical CT images, Int J Comput Assist Radiol Surg, 13:389-396, 2018. 2017 K.E. Becker, I. Klitzsch, M. Stauber, F. Schwarz, Three-dimensional assessment of crestal bone levels at titanium implants with different abutment microstructures and insertion depths using micro-computed tomography, Clin Oral Impl Res, 28(6):671–676, 2017. H.S. Hosseini, A. Dünki, J. Fabech, M. Stauber, N. Vilayphiou, D. Pahr, M. Pretterklieber, J. Wandel, B. Van Rietbergen, P. Zysset, Fast estimation of Colles' fracture load of the distal section of the radius by homogenized finite element analysis based on HR-pQCT, Bone, 97(4):65-75, 2017. N. Gerber, M. Reyes, L. Barazzetti, H.M. Kjer, S. Vera, M. Stauber, P. Mistrik, M. Ceresa, N. Mangado Lopez, W. Wimmer, T. Stark, R. Paulsen, S. Weber, M. Caversaccio, M.A. González-Ballester, A multiscale imaging and modelling dataset of the human inner ear, Scientific Data, 4:170132, 2017. E.L. Lundin, M. Stauber, P. Papageorgiou, M. Ehrbar, C. Ghayor, F.E. Weber, Automatic registration of 2D histological sections to 3D microCT volumes: Trabecular bone, Bone, 105:173–183, 2017. 2016 O. Bissinger, J.S. Kirschke, F.A. Probst, M. Stauber, K. Wolff, B. Haller, C. Götz, C. Plank, A. Kolk, Micro-CT vs. Whole Body Multirow Detector CT for Analysing Bone Regeneration in an Animal Model, PLoS One, 11(11):e0166540, 2016. 2015 A. Celzard, A. Szczurek, P. Jana, V. Fierro, M. Basso, S. Bourbigot, M. Stauber, A. Pizzi, Latest progresses in the preparation of tannin-based cellular solids, J Cell Plast, 51(1):89-102, 2015. A. Szczurek, V. Fierro, A. Pizzi, M. Stauber, A. Celzard, Corrigendum to “A new method for preparing tannin-based foams” [Ind. Crops Prod. 54, 40–53], Industrial Crops and Products, 67:510, 2015. K.E. Becker, M. Stauber, F. Schwarz, T. Beissbarth, Automated 3D-2D registration of X-ray microcomputed tomography with histological sections using chamfer matching and simulated annealing, Comput Med Imaging Gr, 44:62-68, 2015. 2014 F.A. Schulte, F.M. Lambers, T.L. Mueller, M. Stauber, R. Müller, Image interpolation allows accurate quantitative bone morphometry in registered micro-computed tomography scans, Comput Methods Biomech Biomed Engin, 17(5):539-548, 2014. M. Stauber, A. Nazarian, R. Müller, Limitations of global morphometry in predicting trabecular bone failure, J Bone Miner Res, 29(1):134-141, 2014. A. Szczurek, V. Fierro, A. Pizzi, M. Stauber, A. Celzard, A new method for preparing tannin-based foams, Industrial Crops and Products, 54:40-53, 2014. 2013 A. Szczurek, V. Fierro, A. Pizzi, M. Stauber, A. Celzard, Carbon meringues derived from flavonoid tannins, CARBON, 65:214-227, 2013. 2012 A. Mirsaidi, K.N. Kleinhans, M. Rimann, A.N. Tiaden, M. Stauber, K.L. Rudolph, P.J. Richards, Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice, J Tissue Eng Regen Med, 6(5):378-390, 2012. I. Parkinson, A. Badiei, M. Stauber, J. Codrington, R. Müller, N. Fazzalari, Vertebral body bone strength: the contribution of individual trabecular element morphology, Osteoporos Int, 23(7):1957-1965, 2012. 2011 R. Voide, P. Schneider, M. Stauber, G.H. van Lenthe, M. Stampanoni, R. Müller, The importance of murine cortical bone microstructure for microcrack initiation and propagation, Bone, 49(6):1186-1193, 2011. 2010 M.R. Rubin, D.W. Dempster, T. Kohler, M. Stauber, H. Zhou, E. Shane, T.L. Nickolas, E. Stein, J. Sliney Jr, S.J. Silverberg, J.P. Bilezikian, R. Müller, Three dimensional cancellous bone structure in hypoparathyroidism, Bone, 46(1):190-195, 2010. T.P. Krähenbühl, M. Stauber, M. Ehrbar, F.E. Weber, H. Hall-Bozic, R. Müller, Effects of μCT radiation on tissue engineered bone-like constructs, Biomed. Tech., 55(4):245-50, 2010. 2009 T.L. Mueller, G.H. van Lenthe, M. Stauber, C. Gratzke, F. Eckstein, R. Müller, Regional, age and gender differences in architectural measures of bone quality and their correlation to bone mechanical competence in the human radius of an elderly population, Bone, 45(5):882-891, 2009. T.L. Mueller, M. Stauber, T. Kohler, F. Eckstein, R. Müller, G.H. van Lenthe, Non-invasive bone competence analysis by high-resolution pQCT: An in vitro reproducibility study on structural and mechanical properties at the human radius, Bone, 44(2):364-371, 2009. R. Voide, P. Schneider, M. Stauber, P. Wyss, M. Stampanoni, U. Sennhauser, G.H. van Lenthe, R. Müller, Time-lapsed assessment of microcrack initiation and propagation in murine cortical bone at submicrometer resolution, Bone, 45(2):164-173, 2009. 2008 R. Voide, G.H. van Lenthe, M. Stauber, P. Schneider, P.J. Thurner, P. Wyss, M. Stampanoni, R. Müller, Functional microimaging: a hierarchical investigation of bone failure behavior, JJSBM, 18:9-21, 2008. B. Schäffer, M. Stauber, T.L. Mueller, R. Müller, R. Schulin, Soil and macro-pores under uniaxial compression. I. Mechanical stability of repacked soil and deformation of different types of macro-pores, Geoderma, 146(2):183-191, 2008. B. Schäffer, T.L. Mueller, M. Stauber, R. Müller, M. Keller, R. Schulin, Soil and macro-pores under uniaxial compression. II. Morphometric analysis of macro-pore stability in undisturbed and repacked soil, Geoderma, 146(2):175-182, 2008. 2007 M. Stauber, R. Müller, A sensitivity analysis of the volumetric spatial decomposition algorithm, Comput Methods Biomech Biomed Engin, 10(1):25-37, 2007. T. Kohler, M. Stauber, L.R. Donahue, R. Müller, Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models, Bone, 41(4):659-667, 2007. B. Schäffer, M. Stauber, R. Müller, R. Schulin, Changes in the macro-pore structure of restored soil caused by compaction beneath heavy agricultural machinery: a morphometric study, Europ J Soil Sci, 58(5):1062-1073, 2007. P. Schneider, M. Stauber, R. Voide, M. Stampanoni, L.R. Donahue, R. Müller, Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT, J Bone Miner Res, 22(10):1557-1570, 2007. 2006 M. Stauber, R. Müller, Age-related changes in trabecular bone microstructures: global and local morphometry, Osteoporos Int, 17(4):616-626, 2006. M. Stauber, L. Rapillard, G.H. van Lenthe, P. Zysset, R. Müller, Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness, J Bone Miner Res, 21(4):586-595, 2006. J. Goldhahn, M. Reinhold, M. Stauber, C. Knop, R. Frei, E. Schneider, B. Linke, Improved anchorage in osteoporotic vertebrae with new implant designs, J Orthop Res, 24(5):917-925, 2006. G.H. van Lenthe, M. Stauber, R. Müller, Specimen-specific beam models for fast and accurate prediction of human trabecular bone mechanical properties, Bone, 39(6):1182-1189, 2006. A. Nazarian, M. Stauber, D. Zurakowski, B.D. Snyder, R. Müller, The interaction of microstructure and volume fraction in predicting failure in cancellous bone, Bone, 39(6):1196-1202, 2006. P.J. Thurner, P. Wyss, R. Voide, M. Stauber, M. Stampanoni, U. Sennhauser, R. Müller, Time-lapsed investigation of three-dimensional failure and damage accumulation in trabecular bone using synchrotron light, Bone, 39(2):289-299, 2006. M. Stauber, R. Müller, Volumetric spatial decomposition of trabecular bone into rods and plates - a new method for local bone morphometry, Bone, 38(4):475-484, 2006. 2005 A. Nazarian, M. Stauber, R. Müller, Design and implementation of a novel mechanical testing system for cellular solids, J Biomed Mater Res Part B, 73(2):400-411, 2005. 2004 M. Stauber, M. Huber, G.H. van Lenthe, S.K. Boyd, R. Müller, A finite element beam-model for efficient simulation of large-scale porous structures, Comput Methods Biomech Biomed Engin, 7(1):9-16, 2004. Chapters and Proceedings 2013 M. Ceresa, H.M. Kjer, S. Vera, N. Carranza, F. Perez, L. Barazzetti, P. Mistrik, A. Dhanasingh, M. Caversaccio, M. Stauber, M. Reyes, R. Paulsen, M.A. González-Ballester, Finite element model for patient-speci c functional simulations of cochlear implants, Workshop on Mesh Processing in Medical Image Analysis, MICCAI 2013, :1-8, 2013. 2010 P. Schneider, R. Voide, M. Stauber, G.H. van Lenthe, M. Stampanoni, R. Müller, How bone ultrastructure relates to microdamage accumulation, Trans Orthop Res Soc, 35:455, 2010. 2008 M. Stauber, R. Müller, Micro-computed tomography: a method for the non-destructive evaluation of the three-dimensional structure of biological specimens., Osteoporosis - Methods in Molecular Medicine, Humana Press, 455:273-292, 2008. T.L. Mueller, M. Stauber, T. Kohler, F. Eckstein, R. Müller, G.H. van Lenthe, Non-invasive bone monitoring by high-resolution pQCT: a reproducibility study on structural and mechanical properties at the human radius, Trans Orthop Res Soc, 33:0178, 2008. 2007 T.L. Mueller, G.H. van Lenthe, M. Stauber, C. Gratzke, F. Eckstein, R. Müller, Virtual bone mechanics as determined from microstructural morphometry: a population study for the non-destructive prediction of bone strength, Computer Methods in Biomechanics & Biomedical Engineering - 7, FIRST Numerics:16ORT:1-6, 2007. 2006 P. Schneider, M. Stauber, R. Voide, M. Stampanoni, L.R. Donahue, R. Müller, A new imaging strategy reveals ultrastructural differences in cortical bone tissue properties of two genetically distinct inbred mouse strains, Proc Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Biomedizinische Technik, V113:1-2, 2006. P. Schneider, M. Stauber, R. Voide, M. Stampanoni, L.R. Donahue, R. Müller, A novel strategy to assess ultrastructural tissue properties of murine bone using synchrotron based nano-tomography, Trans Orthop Res Soc, 31:0381, 2006. B. Schäffer, M. Stauber, R. Müller, R. Schulin, Compaction-induced changes in macro-pore structure of restored soil, Soil Management for Sustainability. Advances in Geoecology, Chapter II, 38:31-37, 2006. R. Müller, A. Nazarian, P. Schneider, M. Stauber, P.J. Thurner, G.H. van Lenthe, R. Voide, Functional microimaging at the interface of bone mechanics and biology, Mechanics of Biological Tissue, Part V, :473-487, 2006. R. Voide, G.H. van Lenthe, P. Schneider, P.J. Thurner, P. Wyss, U. Sennhauser, M. Stampanoni, M. Stauber, J.G. Snedeker, R. Müller, Functional microimaging: an integrated approach for advanced bone biomechanics and failure analysis, Proceedings of SPIE, Vol. 6143:1-12, 2006. M. Stauber, A. Nazarian, R. Müller, Heterogeneous failure behaviour in human trabecular bone depends critically on microarchitectural configuration and orientation, Trans Orthop Res Soc, 31:1769, 2006. R. Voide, M. Stauber, P. Schneider, G.H. van Lenthe, P. Wyss, U. Sennhauser, M. Stampanoni, R. Müller, Microdamage initiation and propagation in cortical bone, Proc Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Biomedizinische Technik, V008:1-2, 2006. M. Stauber, L. Rapillard, G.H. van Lenthe, P. Zysset, R. Müller, Models based on local morphometry help improving our understanding of the relative importance of local structural changes in the determination of the stiffness of bone, Proc Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Biomedizinische Technik, V009:1-2, 2006. T.L. Mueller, G.H. van Lenthe, M. Stauber, C. Gratzke, F. Eckstein, R. Müller, Non-Destructive prediction of individual radius bone strength: a population study as assessed by high-resolution 3D-pQCT, Proc Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Biomedizinische Technik, V013:1-2, 2006. A. Nazarian, M. Stauber, D. Zurakowski, R. Müller, B.D. Snyder, The interaction of microstructure and volume fraction in predicting failure in cancellous bone, Trans Orthop Res Soc, 31:0128, 2006. R. Voide, M. Stauber, P. Schneider, G.H. van Lenthe, P. Wyss, U. Sennhauser, M. Stampanoni, R. Müller, Time-lapsed assessment of bone microcracks initiation and propagation, Trans Orthop Res Soc, 31:0125, 2006. P. Schneider, R. Voide, M. Stauber, M. Stampanoni, L.R. Donahue, P. Wyss, U. Sennhauser, R. Müller, Assessment of murine bone ultrastructure using synchrotron light - towards nano-computed tomography, Proceedings of SPIE, Vol. 6318:63180C, 2006. 2005 B. Schäffer, M. Stauber, R. Müller, R. Schulin, Auswirkungen der Befahrung mit schwerem landwirtschaftlichem Gerät auf die mechanischen und strukturellen Eigenschaften einer Rekultivierung, Bulletin der Bodenkundlichen Gesellschaft der Schweiz (BGS), 28:31-34, 2005. P. Schneider, M. Stauber, R. Müller, M. Stampanoni, Bone vasculature varies in the femoral diaphysis of two genetically distinct mouse strains (b6-lit/lit and c3.b6-lit/lit), PSI Scientific Report 2004, Synchrotron Radiation and Nanotechnology, VII:85, 2005. B. Schäffer, M. Stauber, R. Müller, R. Schulin, Effects of trafficking by agricultural machinery on mechanical and structural properties of freshly restored soil, Proceedings International Conference on Human Impacts on Soil Quality Attributes in Arid and Semiarid Regions, S1(157):1-4, 2005. 2004 G.H. van Lenthe, M. Stauber, R. Müller, A fast and efficient finite element model for accurate prediction of bone mechanical properties in man, Proc 14th Conference of the European Society of Biomechanics, :280, 2004. G.H. van Lenthe, M. Stauber, R. Müller, Beam finite element models accurately predict trabecular bone stiffness, Trans Orthop Res Soc, 29:38, 2004. M. Stauber, A. Nazarian, R. Müller, Competence of trabecular bone is dominated by local failure and can be predicted best by local morphometry, Proc 14th Conference of the European Society of Biomechanics, :542, 2004. P.J. Thurner, P. Wyss, R. Voide, M. Stauber, B. Müller, M. Stampanoni, J.A. Hubbell, R. Müller, U. Sennhauser, Functional micro-imaging of soft and hard tissue using synchrotron light, PSI Scientific Report 2004, Synchrotron Radiation and Nanotechnology, Vol. 5535:112-128, 2004. R. Müller, M. Stauber, A. Nazarian, P.J. Thurner, R. Voide, G.H. van Lenthe, Functional microimaging at the interface of bone mechanics and biology, Proc 10th Mediterranean Conference of the IFMBE, :64.1-64.4, 2004. A. Nazarian, M. Stauber, R. Müller, Local morphometry predicts weakest link in human cancellous bone, Trans Orthop Res Soc, 29:504, 2004. 2003 M. Stauber, L. Rapillard, P. Zysset, R. Müller, Element based morphometry - a new tool for the assessment of mechano-structure relationships in trabecular bone, Trans Orthop Res Soc, 28:109, 2003. 2002 M. Stauber, S.K. Boyd, A. Nazarian, R. Müller, A computationally efficient algorithm for in-vivo bone failure prediction on the trabecular level: A combined experimental and computational approach, Proc IVth World Congress Biomechanics, :5166, 2002. M. Stauber, M. Huber, S.K. Boyd, R. Müller, An FE beam-model for efficient simulation of large-scale porous structures, Proc 13th Conference of the European Society of Biomechanics, :143-144, 2002. S.K. Boyd, M. Stauber, A. Nazarian, R. Müller, Computation of local strains in trabecular bone using image-guided failure analysis, Computer Methods in Biomechanics & Biomedical Engineering - 4, Chapter 4:7C, 2002. M. Stauber, A. Nazarian, R. Müller, Element based morphometric characterization of trabecular bone, Trans Europ Orthop Res Soc, 12:O-89, 2002. R. Müller, T. Bösch, D. Jarak, M. Stauber, A. Nazarian, M.A. Tantillo, S.K. Boyd, Micro-mechanical evaluation of bone microstructures under load, Proceedings of SPIE, Vol. 4503:189-200, 2002. A. Nazarian, M. Stauber, R. Müller, Microstructural assessment of trabecular bone failure behavior, Proc IVth World Congress Biomechanics, :778, 2002. S.K. Boyd, U. Fasel, M. Stauber, R. Müller, The effects of osteocytic lacunae distribution, bone resorption cavities and under-mineralized bone on bone tissue stress: a finite element study, Proc 13th Conference of the European Society of Biomechanics, :164-165, 2002. M. Stauber, A. Nazarian, R. Müller, Element based morphometric characterization of trabecular bone, Trans Europ Orthop Res Soc, 12:P-18, 2002. © Martin Stauber, Zürich, Switzerland, 2013 — 2017