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HomeMEG2022-08-31T13:27:37+00:00


DELIVERING SPATIAL BIOLOGY
TO THE CLINIC

Spatial biology is revolutionizing the discipline of pathology and the practice
of medicine. Castle Biosciences is a pioneer in this field, using our spatial
analytics platform for biologically aware AI to provide solutions across the
precision medicine value chain from drug discovery to clinical diagnostics.

Our biologically aware AI platform delivered to the clinic the world’s first
precision medicine test to predict the risk of developing esophageal cancer –
one of the world’s most deadly cancers.

Learn more


Featured Webinars/Publications

All Webinars All Publications

Prediction of Progression in Barrett’s Esophagus Using a Tissue Systems
Pathology Test: A Pooled Analysis of International Multicenter Studies

Iyer PG, Codipilly DC, Chandar AK, Agarwal S, Wang KK, Leggett CL, Latuche LR,
Schulte PJ

Clinical Gastroenterolgy and Hepatology 2022

View

An Objective, Fully Automated Barrett’s Risk Prediction Assay Outperforms
Pathology in Risk Stratifying Barrett’s Esophagus with Low-Grade Dysplasia

A.M. Khoshiwal, N.F. Frei, L.C. Duits, R.E. Pouw, Barrett’s SURF LGD Study
Pathologist Consortium, E. Bossart, M. Wilhelm, R. Critchley-Thorne, J.J.
Bergman

Adapted from a DDW 2022 Podium Presentation

View

DELIVERING CLINICALLY ACTIONABLE INFORMATION FROM TISSUE BIOPSIES
IS DIFFICULT.

Tissue systems:

 * are highly complex
 * are composed of many cell types and tissue structures
 * can have 1000x of active genes, transcripts and expressed proteins

Clinicians need new ways to analyze, interpret and report data.

Only this revolution can change clinical practice.


Learn more



OUR TISSUECYPHER® PLATFORM BRINGS TOGETHER KEY COMPONENTS OF BIOLOGICALLY AWARE
AI.


MULTIPLEX ASSAY DEVELOPMENT

Library of fluorescent immunolabeling assays with robust SOPs for clinical use


FEATURE GENERATION

Automatic extraction of cellular and molecular information while allowing
user-directed generation of biologically relevant features


MODEL BUILDING & VALIDATION

Reduction of complexity, classifier development & validation through access to
scarce tissue sources and clinical outcomes


INTELLECTUAL PROPERTY

>30 issued patents covering spatially resolved analytical methods and first
clinical assay


WE ARE APPLYING OUR BIOLOGICALLY AWARE AI PLATFORM ACROSS MULTIPLE THERAPEUTIC
AREAS TO DEPLOY OUR PRECISION MEDICINE ASSAY IN THE FOLLOWING AREAS:

Oncology

 * Breast Cancer
 * Lung Cancer
 * Colorectal Cancer
 * Prostate Cancer
 * Gastric Cancer

Gastroenterology

 * Inflammatory Bowel Disease (Crohn’s and Ulcerative Colitis)
 * Pancreatic Cyst Evaluation & Pancreatic Cancer
 * NAFLD, NASH and Liver Cancer
 * Esophagitis




TissueCypher®

 * About Us
 * Medical Advisory Board


 * TissueCypher® Technology
 * How Does TissueCypher® Work?
 * The Science behind TissueCypher®
 * TissueCypher® Barrett’s Esophagus Assay
 * Frequently Asked Questions
 * Media Coverage
 * Press Releases



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Pittsburgh, PA  15238



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