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Oct 27, 2022


PERFORMANCE EVALUATION OF HIPEE S2 POINT-OF-CARE TESTING URINE DIPSTICK
ANALYSER: A CROSS-SECTIONAL STUDY

Qiang Zhang, Guoqing Wang, Xiaolong Zong, Jinghua Sun

BMJ Open. 2022 Oct 27; 12(10): e063781

OBJECTIVE With advances in mobile technology, smartphone-based point-of-care
testing (POCT) urinalysis hold great potential for disease screening and health
management for clinicians and individual users. The purpose of this study is to
evaluate the analytical performance of Hipee S2 POCT urine dipstick analyser.
DESIGN A multicentre, hospital-based, cross-sectional study. SETTING Analytical
performance of the POCT analyser was conducted at a clinical laboratory, and
method comparison was performed at three clinical laboratories in China.
PARTICIPANTS Urine samples were collected from 1603 outpatients and inpatients
at three hospitals, and 5 health check-up population at one of the hospitals.
OUTCOME MEASURES All tests were performed by clinical laboratory technicians.
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ADITYA BARDIA, MD, MPH

0.75 CME / MOC / NCPD


ADVANCES WITH TARGETING TROP2 IN BREAST CANCER: COMMUNITY CONTEXT

Receive expert practical guidance for incorporating ADCs into modern practice
and hear patient perspectives...read more
article continues here
Precision, drift, carry-over, interference and method comparison of Hipee S2
were evaluated. Diagnostic accuracy of semiquantitative albumin-to-creatinine
ratio (ACR) for albuminuria was carried out using quantitative ACR as the
standard. RESULTS The precision for each parameter, assessed by control
materials, was acceptable. No sample carry-over or drift was observed. Ascorbate
solution with 1 g/L had an inhibitory effect for the haemoglobin test. Agreement
for specific gravity (SG) varied between moderate to substantial (κ values
0.496-0.687), for pH was moderate (κ values 0.423-0.569) and for other
parameters varied between substantial to excellent (κ values 0.669-0.991), on
comparing the Hipee S2 with laboratory analysers. The semiquantitative
microalbumin and creatinine were highly correlated with the quantitative
results. The sensitivity of semiquantitative ACR to detect albuminuria was
87.2%-90.7%, specificity was 70.7%-78.4%, negative predictive value was
85.3%-87.9% and positive predictive value was 73.9%-83%. CONCLUSIONS Hipee S2
POCT urine analyser showed acceptable analytical performance as a
semiquantitative method. It serves as a convenient alternate device for
clinicians and individual users for urinalysis and health management. In
addition, the POCT semiquantitative ACR would be useful in screening for
albuminuria.
Source: BMJ Open

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PERFORMANCE EVALUATION OF HIPEE S2 POINT-OF-CARE TESTING URINE DIPSTICK
ANALYSER: A CROSS-SECTIONAL STUDY

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management for clinicians and individual users. The purpose of this
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PERFORMANCE EVALUATION OF HIPEE S2 POINT-OF-CARE TESTING URINE DIPSTICK
ANALYSER: A CROSS-SECTIONAL STUDY

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