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DEMONSTRATE

Risk stratification for progression of cancer and Alzheimer's disease

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POSTS

Posted on 12. August 2023.13. August 2023.


RETINAL MICROVASCULAR COMPLEXITY AS A PUTATIVE BIOMARKER OF BIOLOGICAL AGE: A
PILOT STUDY

Retinal microvascular complexity could be a promising new biomarker of
biological age. Decreased box-counting fractal dimension was present in old
patients, and this decrease was 2.1 times faster in participants who had
age-related diseases (p=0.047). Click here to read more at the Biogeronotology
web-page.

Microvascular complexity measured by Box-counting fractal dimension (Db) and
Sholl’s sum in healthy vs. unhealthy aging. Healthy aging model shown in black,
unhealthy aging model shown in gray,
Posted on 6. May 2023.6. May 2023.


SCIENTIFIC PAPER IN ONCOLOGY LETTERS

Researchers from DEMONSTRATE team published a new paper “The role of miRNA in
colorectal cancer diagnosis: A pilot study” by M. Zdralevic et al. in Oncology
Letters. The paper is available at the following link.

ABSTRACT – Despite recent advances in diagnosis and treatment, colorectal cancer
(CRC) remains the third most common cancer worldwide, and has both a poor
prognosis and a high recurrence rate, thus indicating the need for new,
sensitive and specific biomarkers. MicroRNAs (miRNAs/miRs) are important
regulators of gene expression, which are involved in numerous biological
processes implicated in tumorigenesis. The objective of the present study was to
investigate the expression of miRNAs in plasma and tissue samples from patients
with CRC, and to examine their potential as CRC biomarkers. Using reverse
transcription‑quantitative PCR, it was revealed that miR‑29a, miR‑101, miR‑125b,
miR‑146a and miR‑155 were dysregulated in the formalin‑fixed paraffin‑embedded
tissues of patients with CRC, compared with the surrounding healthy tissue, and
these miRNAs were associated with several pathological features of the tumor.
Bioinformatics analysis of overlapping target genes identified AGE‑RAGE
signaling as a putative joint regulatory pathway. miR‑146a was also upregulated
in the plasma of patients with CRC, compared with the healthy control group, and
had a fair discriminatory power (area under the curve, 0.7006), with 66.7%
sensitivity and 77.8% specificity. To the best of our knowledge, this distinct
five‑miRNA deregulation pattern in tumor tissue, and upregulation of plasma
miR‑146a, were shown for the first time in patients with CRC; however, studies
on larger patient cohorts are warranted to confirm their potential to be used as
CRC diagnostic biomarkers.

Click on image to open
Posted on 26. March 2023.1. November 2023.


WHAT HAS CANCER TAUGHT US ABOUT ALZHEIMER’S DISEASE – NEW INSIGHTS AND POTENTIAL
APPLICATION OF MICRORNA-101

Dr. Isidora Rovčanin Dragović presented the most recent results of the
DEMONSTRATE study at the The 17th World Congress on Controversies in Neurology
(CONy) that was held in Dubrovnik, Croatia from March 23rd to 25th 2023.

Click for the link to the Digital Abstract Book at the conference web-site here.

Posted on 4. October 2022.11. April 2024.


DAYS OF SCIENCE AND INNOVATION

Results from the DEMONSTRATE project were presented at the mini-symposium
organised at the Faculty of Medicine of the University of Montenegro on
September 29th, 2022. This event is one of the series of events for the Days of
Science and Innovation organized by the Ministry of Science and Technological
Development and took place from September 29th to October 3rd 2022, with the
main goal to popularize science.

Read more on Days of Science and Innovation at the Faculty of Medicine official
web site
Posted on 23. September 2022.23. September 2022.


PARTICIPATION AT THE 3RD REGIONAL CONGRESS OF PHYSIOLOGICAL SOCIETIES AND THE
5TH CONGRESS OF CROATIAN PHYSIOLOGICAL SOCIETY

Dr. Natasa Popovic participated at the 3 rd Regional Congress of Physiological
Societies and the 5 th Congress of Croatian Physiological Society that was held
in Plitvice, Croatia, from 22nd to 24th of September 2022.

She presented the poster titled “Retinal Microvascular Complexity reflects
Accelerated Aging Associated with Severe Chronic Diseases Including Alzheimer‘s
Dementia“.

Poster presented at the conference organized by the Croatian Physiological
Society
Posted on 23. September 2022.24. October 2022.


INFLAMMATION-RELATED MICRORNAS-146A AND -155 ARE UPREGULATED IN MILD COGNITIVE
IMPAIRMENT SUBJECTS AMONG OLDER AGE POPULATION IN MONTENEGRO

A research paper titled “Inflammation-Related microRNAs-146a and -155 Are
Upregulated in Mild Cognitive Impairment Subjects Among Older Age Population in
Montenegro” authored by I. Rovčanin Dragović, N. Popovic, M Ždralević, Lj.
Radulović, T. Vuković, F. Marzano, A. Tullo, and M. Radunović was published in
the Journal of Alzheimer’s Disease. The paper represents one of the major
achievements of the DEMONSTRATE project, and it is an integral part of doctoral
thesis of Dr. Isidora Rovčanin Dragović. The paper can be accessed at the
following link.

Posted on 22. September 2022.23. September 2022.


PARTICIPATION IN EMBO WORKSHOP

Dr. Maša Ždralević participated at the EMBO Workshop „Cancer cell signalling:
Linking molecular knowledge to cancer therapy” in Cavtat, Croatia,that was held
from 16th to 20th of September 2022.

She presented the poster titled “miRNAs in colorectal carcinoma –
clinicopathological relevance“. The poster was well received with many positive
comments from the audience.

EMBO Workshop 2022 Poster presentation
Posted on 18. July 2022.18. July 2022.


WEB PORTAL APPEARANCE

To read the full text click here.

The interview with Dr. Isidora Rovčanin Dragović featured on the web page
Portalanalitika. She discussed the results of the recently completed project
DEMONSTRATE and the recognition she received for the abstract: “Cognitive
Impairment without subjective Cognitive Decline/ Clinical, Molecular and Ethical
aspects.”

Posted on 18. July 2022.18. July 2022.


LOCAL NEWSPAPER FEATURE

The interview with Dr. Isidora Rovčanin Dragović was featured in the local
newspaper “Pobjeda”. She discussed the results of the recently completed project
DEMONSTRATE and the recognition she received for the abstract: “Cognitive
Impairment without subjective Cognitive Decline/ Clinical, Molecular and Ethical
aspects.”

Posted on 16. July 2022.18. July 2022.


TV APPEARANCE

For the YouTube link to the video click here.

Dr. Isidora Rovčanin Dragović was a guest on the TV program “Weekend at the City
TV“ to talk about the results of the recently completed project DEMONSTRATE and
the recognition she received for the abstract: “Cognitive Impairment without
subjective Cognitive Decline/ Clinical, Molecular and Ethical aspects.”


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RECENT POSTS

 * Retinal microvascular complexity as a putative biomarker of biological age: a
   pilot study
 * Scientific paper in Oncology Letters
 * What has cancer taught us about Alzheimer’s Disease – new insights and
   potential application of microRNA-101
 * Days of Science and Innovation
 * Participation at the 3rd Regional Congress of Physiological Societies and the
   5th Congress of Croatian Physiological Society


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