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 * GIVEN THE RECENT DISCOVERY OF
   
   2024-06-22
   
   
   
   Given the recent discovery of regions of single-stranded DNA in the nuclei of
   hypoxic cells, the role for ATR in the response to hypoxic stress seems
   clearer . Zou and Elledge demonstrated that both Ddc 2 (the homolog of ATRIP)
   and ATRIP have a lower affinity for double-strand breaks than they do f

 * IN THIS REVIEW WE WILL PRESENT THE
   
   2024-06-22
   
   
   
   In this review, we will present the traditional and actual strategies to
   study orphan receptors and identify their ligands. An extensive description
   of the orphan GPCR field has been published in 2013 by Davenport et al. [22].
   Therefore, we will focus on the deorphanizations that were reported since

 * FURTHERMORE LOW AFFINITY SITES THAT SHARE NO STRUCTURAL HOMO
   
   2024-06-22
   
   
   
   Furthermore, low-affinity sites that share no structural homology with the
   aforementioned sites have been described in the transmembrane domain. It has
   been discovered that, in α1βγ2 receptors, potentiation of GABA-activated
   currents by high concentrations of diazepam is biphasic, with a high- and a

 * FROM AN HISTORICAL PERSPECTIVE LIGANDS FOR GPCRS ADRENALINE
   
   2024-06-22
   
   
   
   From an historical perspective, ligands for GPCRs (adrenaline, serotonin,
   Bisindolylmaleimide VIII acetate synthesis or morphine, to name a few) have
   been identified before their receptor counterparts, at a time when the
   concept of receptor itself was controversial [15]. Although many cognate
   recep

 * INTRODUCTION THE CORPUS LUTEUM CL IS A TRANSIENT ENDOCRINE
   
   2024-06-22
   
   
   
   Introduction The corpus luteum (CL) is a transient endocrine gland that
   differentiates from the thecal and granulosal cells of the ovarian follicle
   after ovulation. Its formation and limited lifespan in the mammalian ovary is
   important for fertility, as the CL produces progesterone (P4), the essent

 * SINCE THE BEGINNING OF S MORE THAN PAPERS ABOUT
   
   2024-06-22
   
   
   
   Since the beginning of 1990s, more than 17,000 papers about physiological
   relevance of antioxidants have been published according to data from web of
   science. Based on the available literature, it seems that assessing the
   antioxidant potential of food by means of in vitro assays or solely
   epidemiolo

 * JNK PATHWAY USING THIS CHEESE MIMICKING MATRIX
   
   2024-06-22
   
   
   
   Using this cheese-mimicking matrix, we screened the antifungal activity of 44
   LAB fermented milk-based products and 23 LAB isolates used as protective
   cultures against 4 fungal targets. The LAB were obtained from the culture
   collections of CIRM-BIA (Centre International de Ressources Microbienne-Bac

 * ASSESSMENT OF ANTIBIOTIC APPROPRIATENESS IS
   
   2024-06-22
   
   
   
   Assessment of antibiotic appropriateness is receiving increased attention in
   the face of growing concerns about the emergence of MDROs, as well as the
   rise in adverse outcomes associated with antibiotic use such as C. difficile
   infection. In this study, 15% of cultured Gram-negative organisms met th

 * OUR SURPRISING RESULTS SHOW THAT AAD
   
   2024-06-22
   
   
   
   Our surprising results show that AAD-treated tumors adjacent to adipose
   tissues and in steatotic liver continue to grow in the presence of a minimal
   number of microvessels. In non-adipose tumor models, the similar degree of
   vascular suppression is translated into marked suppression of tumor growth.

 * NVP-BEP800 BR G PROTEIN ACTIVATION THROUGH CROAKER ZIP AN ES
   
   2024-06-22
   
   
   
   G protein activation through croaker ZIP9 An essential criterion for
   designating a steroid binding protein as a membrane steroid receptor is to
   demonstrate that it can transduce steroid signals in order to elicit a
   cellular response. Treatment with 100nMT caused G protein activation in
   croaker ZI

 * LUO DEHM RAJ LUO ATTARD BALK BEVAN BURNSTEIN CATO CHERKASOV
   
   2024-06-22
   
   
   
   Luo, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De
   Bono, Dong, Gao, Gleave, Heemers, Kanayama, Kittler, Lang, Lee, Logothetis,
   Matusik, Plymate, Sawyers, Selth, Soule, Tilley, Weigel, Zoubeidi, Dehm, Raj.
   Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong,

 * RECENT WORK HAS DETAILED THE IMPACT OF GENETIC DELETION OF
   
   2024-06-22
   
   
   
   Recent work has detailed the impact of genetic ampa receptors of AMPK in the
   liver, revealing only minor phenotypes upon removal in mice (Boudaba et al.,
   2018). However, these studies very elegantly showed the potential for small
   molecule-mediated activation of AMPK to elicit large changes in lipid

 * ION CHANNEL COMPOUND LIBRARY IN ORDER TO POSTULATE ITS BINDI
   
   2024-06-22
   
   
   
   In order to postulate its binding mode in APN, Ion Channel Compound Library
   13v was docked into the active site of APN (PDB code: 2DQM) using Sybyl_X
   1.3. As illustrated in Fig. 5A, the catalytic zinc ion of APN was chelated by
   the hydroxamate moiety of 13v, and the S1, S1′ and S2′ pockets of APN w

 * KUDA ET AL REPORTED THAT THE
   
   2024-06-22
   
   
   
   Kuda et al. (1997) reported that the activity of aminopeptidase A (ApA) but
   not aminopeptidase B (ApB) nor aminopeptidase N (ApN) was decreased in plasma
   from patients with Alzheimer's disease (AD). More recently Puertas et al.
   (2013) reported that the activities of plasma ApA, ApB, ApN and IRAP wer

 * THIS SUGGESTION WAS CONFIRMED BY IMMUNOHISTOCHEMICAL STUDIES
   
   2024-06-22
   
   
   
   This suggestion was confirmed by immunohistochemical studies in which the
   immunoreactivity of the enzyme was actually higher at the earlier rather than
   at the advanced stages of the disease. Importantly, a later study showed that
   the biochemical signature of 12/15LO enzymatic activation (i.e., 12-HE

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