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OUR JOURNALS

STEM CELLS

 * LATEST ISSUE  >
   Volume 39, Issue 12
   December 2021

STEM CELLS TRANSLATIONAL MEDICINE

 * LATEST ISSUE  >
   Volume 10, Issue 12
   December 2021


BROWSE BY TOPICS

 * Cancer Stem Cells
 * Drug and Cell-Based Therapy Development, Manufacturing and Regulations
 * Fetal and Neonatal Stem Cells
 * Human Clinical Articles
 * Perspectives

 * Pluripotent Stem Cells
 * Stem Cell Technology
 * Tissue Engineering and Regenerative Medicine
 * Tissue-Specific Cells


HIGHLIGHTED ARTICLES



ARYL HYDROCARBON RECEPTOR CONTROLS SKIN HOMEOSTASIS, REGENERATION, AND HAIR
FOLLICLE CYCLING BY ADJUSTING EPIDERMAL STEM CELL FUNCTION



Eva María Rico-Leo, et al., STEM CELLS

Aryl hydrocarbon receptor (AhR) has novel roles in skin homeostasis,
regeneration, and hair cycling by controlling epidermal stem cells (EpdSCs)
functions. During hair growth, AhR deficiency delays entry into anagen likely
through loss of the self-renewal capacity and multipotentiality of AhR−/− hair
follicle EpdSCs. The authors reinforce the idea that AhR plays important roles
in skin homeostasis and propose this receptor as a target for the treatment of
cutaneous pathologies, skin lesions, and skin regeneration. The feasibility to
manipulate the expression and/or activity of AhR in models that recapitulate the
architecture of the epidermis provides an opportunity to validate selective
molecular modulator useful in the treatment of skin pathologies.

--------------------------------------------------------------------------------



THE HETEROGENEITY OF MEGAKARYOCYTES AND PLATELETS AND IMPLICATIONS FOR EX VIVO
PLATELET GENERATION

Cuicui Liu, et al., STEM CELLS Translational Medicine 

Megakaryocytes (MKs) and platelets have much more diverse functions than
previously appreciated, but the exact molecular and cellular features underlying
the diverse functions remain largely unclear. This review summarizes the current
findings of the functional and developmental heterogeneity of MKs and its
potential link with platelet heterogeneity, providing new insights into the
ex vivo platelet generation from human pluripotent stem cells and the future
clinical treatment of related diseases.

--------------------------------------------------------------------------------



HUMAN INDUCED PLURIPOTENT STEM CELL‐DERIVED MACROPHAGES AMELIORATE LIVER
FIBROSIS



Somayeh Pouyanfard, et al., STEM CELLS

Improved treatment for diseased or degenerated tissues and organs is greatly
needed. These studies demonstrate the ability to efficiently derive macrophages
from human induced pluripotent stem cells(iPSCs) with the ability to improve
liver fibrosis in a mouse xenograft model. The present study enables clinical
translation to use these iPSC-derived cells to better treat diverse fibrotic
diseases.

--------------------------------------------------------------------------------



ROLE OF EXTRACELLULAR VESICLES FROM ADIPOSE TISSUE- AND BONE MARROW-MESENCHYMAL
STROMAL CELLS IN ENDOTHELIAL PROLIFERATION AND CHONDROGENESIS

Cansu Gorgun, et al., STEM CELLS Translational Medicine

Mesenchymal stromal cells are a great source for regenerative medicine
applications. Cells derived from different tissues might have distinctive
characteristics. Many studies suggest a critical therapeutic role for
extracellular vesicles secreted by stromal cells. The authors characterized
extracellular vesicles isolated from two different sources (bone marrow, adipose
tissue). Despite, minimal structural differences, the authors observed different
functional effects during the differentiation and maturation of cartilage
tissue. Therefore, a deep investigation of biological effects is essential
before selecting the optimal extracellular vesicle-cell source to be used in
specific therapeutic settings.

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PRESS RELEASES

 * Sara Palma-Tortosa earns STEM CELLS Translational Medicine’s 2021 Young
   Investigator Award
 * Lin Ma named 2021 STEM CELLS Young Investigator
 * Researchers report on new way to deliver healing stem cells to kidney injury
   patients


NEWS

Latest News

--------------------------------------------------------------------------------

 * Breaking new ground: Highlights from the translational Advances in Stem Cells
   for Diabetes Symposium in Doha
 * Promoting stem cell therapies, racial justice and fish breeding
 * Surviving ‘butterfly disease’: long-term success of a new gene and stem-cell
   therapy for EB verified


ARTICLE SCANS

Journal Club Discussions

--------------------------------------------------------------------------------

 * Autologous Adipose Micro-Grafts – A New Tendon Healing Strategy?
 * Niche Comparisons Identify PGI2 as a New Means to Support and Protect HSCs
 * Describing the Barriers to the Totipotent State of ESCs


VIDEO HIGHLIGHTS

Video: Dr. Kulkarni from the Kale lab, National Center for Cell Science, Pune,
India

Video Library






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