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CHEMISTRY OF HEALTH - SOFTWARE YUSUF HAMIED DEPARTMENT OF CHEMISTRY, UNIVERSITY
OF CAMBRIDGE



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CamSol Intrinsic   Sequence-based method of predicting protein solubility and
generic aggregation propensity. CamSol Intrinsic pH-dependent   Sequence-based
method of predicting protein solubility and generic aggregation propensity as a
function of pH. CamSol-PTM   Sequence-based method of predicting the solubility
of peptides and proteins containing post-translationally modified and/or non
natural amino acids. CamSol Structurally Corrected   Structure-based method of
calculating a solubility profile, which accounts for the proximity of the amino
acids in the structure and for their solvent exposure. The structurally
corrected profile can be color-coded on the structure of the protein to spot
patches of low solubility that may elicit self-assembly. CamSol Combination
automated design  

A method for the automated structure-based optimisation of solubility and
conformational stability of antibodies and proteins. (Otherwise go to the legacy
version of CamSol design from the 2015 paper)

AbNatiV   A deep-learning tool for assessing the nativeness of antibodies and
nanobodies. NanoMelt   Nanobody thermostability prediction (apparent melting
temperature) δ2D   A method of calculating secondary structure populations of
proteins from their chemical shifts. s2D   A method of predicting secondary
structure populations of proteins from the amino acid sequence. Camcoil   A
method of calculating random coil chemical shifts from protein sequences.
Parapred   A method of predicting from antibody sequences the residues in
contact with the antigen (the paratope). PDBcleaner   Cleans a PDB file so that
it can be used as input for computational calculations.

 



 

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