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 * Understanding GA
   * Signs and Symptoms
   * Risk Factors
   * The Complement System
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 * GA Burden
   * Impact of GA
   * Patient Perspectives
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 * Recognize and Refer
   * Importance of Recognition
   * Imaging for GA
     * OCT B-scan
     * OCT en face and NIR
     * FAF
     * CFP
   * Patient Case Studies
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 * Resources
   * For Optometrists
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SEE THE SIGNS OF GEOGRAPHIC ATROPHY (GA)

GA can destroy so much



Look for choroidal hypertransmission, a marker of GA in OCT B-scans1

Geographic Atrophy (GA) is an advanced form of age-related macular degeneration
(AMD), a leading cause of significant vision loss worldwide. It is defined by
atrophic lesions, resulting from loss of photoreceptors, RPE, and underlying
choriocapillaris.1-3

See how GA can develop

Explore the impact of GA

It is critical to recognize GA and refer patients in a timely manner, as disease
progression is relentless and irreversible1,4-8


Learn how to recognize GA

OCT=optical coherence tomography.




Learn more about an FDA-approved treatment option for GA secondary to AMD


References: 1. Fleckenstein M, Mitchell P, Freund KB, et al. The progression of
geographic atrophy secondary to age-related macular degeneration. Ophthalmology.
2018;125(3):369-390. doi:10.1016/j.ophtha.08.038. 2. van Lookeren Campagne M,
LeCouter J, Yaspan BL, Ye W. Mechanisms of age-related macular degeneration and
therapeutic opportunities. J Pathol. 2014;232(2):151-164. doi:10.1002/path.4266.
3. Chakravarthy U, Bailey CC, Scanlon PH, et al. Progression from
early/intermediate to advanced forms of age-related macular degeneration in a
large UK cohort: rates and risk factors. Ophthalmol Retina. 2020;4(7):662-672.
doi:10.1016/j.oret.2020.01.012. 4. Boyer DS, Schmidt-Erfurth U, van Lookeren
Campagne M, Henry EC, Brittain C. The pathophysiology of geographic atrophy
secondary to age-related macular degeneration and the complement pathway as a
therapeutic target. Retina. 2017;37(5):819-835.
doi:10.1097/iae.0000000000001392. 5. American Optometric Association. AOA
Comprehensive adult eye and vision examination. Quick Reference Guide:
Evidence-Based Clinical Practice Guideline. 1st ed. Accessed June 29, 2023.
https://www.aoa.org/documents/EBO/Comprehensive_Adult_Eye_and_Vision_%20QRG.pdf.
6. Holz FG, Strauss EC, Schmitz-Valckenberg S, van Lookeren Campagne M.
Geographic atrophy: clinical features and potential therapeutic approaches.
Ophthalmology. 2014;121(5):1079-1091. doi:10.1016/j.ophtha.2013.11.023. 7.
Sunness JS, Margalit E, Srikumaran D, et al. The long-term natural history of
geographic atrophy from age-related macular degeneration: enlargement of atrophy
and implications for interventional clinical trials. Ophthalmology.
2007;114(2):271-277. doi:10.1016/j.ophtha.2006.09.016. 8. Lindblad AS, Lloyd PC,
Clemons TE, et al; Age-Related Eye Disease Study Research Group. Change in area
of geographic atrophy in the age-related eye disease study: AREDS report number
26. Arch Ophthalmol. 2009;127(9):1168-1174. doi:10.1001/archophthalmol.2009.198.
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The APELLIS® name and logo is a registered trademark of Apellis Pharmaceuticals,
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owners. © 2023 Apellis Pharmaceuticals, Inc. 4/24 US-GA-2300090 v3.0

This site is intended for US eye care professionals only.



Year 4

BCVA: 20/25
Choroidal hypertransmission defect indicative of atrophy.

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