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Text Content

Learn how AbbVie could help you save on RINVOQ.
Call 1-800-2RINVOQ or click to learn more >

Skip to Main content
 * Important Safety Information
 * Full Prescribing Information & Patient Information
    * Full Prescribing Information (English)
    * Medication Guide

 * Healthcare Professionals Site
 * View All Conditions

 * 1-800-2RINVOQ
 * Cost & Savings
 * Sign up for RINVOQ updates

 * 

 * Choose your Condition
    * Moderate to Severe Eczema (Atopic Dermatitis)*
    * Moderate to Severe Rheumatoid Arthritis
    * Active Psoriatic Arthritis
    * Active Ankylosing Spondylitis
    * Active Non-radiographic Axial Spondyloarthritis
    * Moderate to Severe Ulcerative Colitis
    * Moderate to Severe Crohn’s Disease
    * Not well controlled with other pills or injections, including biologics.
    * When TNF blockers did not work well or could not be tolerated.

 * RINVOQ Resources
    * About RINVOQ Complete
    * Save on RINVOQ
    * Your Nurse Ambassador
    * RINVOQ Complete App
    * Preparing for RINVOQ
    * Insurance Explained
    * Building Your Routine

 * *Not well controlled with other pills or injections, including biologics.
 * When TNF blockers did not work well or could not be tolerated.
 * 1-800-2RINVOQ
 * Cost & Savings
 * Sign up for Rinvoq updates
 * 

 * Important Safety Information
 * Full Prescribing Information & Patient Information
    * Full Prescribing Information (English)
    * Medication Guide

 * Healthcare Professionals Site
 * View All Conditions


IMPORTANT SAFETY INFORMATION & USES

Warning: Serious Infections, Increased Risk of Death, Cancer, Major
Cardiovascular Events, Blood Clots


ON RINVOQ



On this page:

Commercial Insurance
Insurance Specialist
Medicare/Medicaid/Uninsured
RINVOQ Complete Rebate



YOU COULD PAY $5 A MONTH* FOR RINVOQ



Wondering how much you could save on the cost of your medicine? If you have
commercial insurance, you may be eligible to pay as little as $5 a month for
your prescription with the RINVOQ Complete Savings Card.

Sign up for RINVOQ Complete to get your card today.

Request your card


Here's another way you could save

Use the RINVOQ Complete Rebate

*For eligible, commercially insured patients. Please see Terms and Conditions
here.



Store your Savings Card in the App

Get the RINVOQ Complete App and use it to access your Savings Card. The App can
also be used to help you stay on track with your prescribed treatment plan.

Download the App now

Search for “RINVOQ Complete” at the App Store® or Google Play™.

Text APP to 33101 to receive a link to download the RINVOQ Complete App

Message and data rates may apply. Visit SeeRTerms.com and see Terms of Use at
abbv.ie/s-use. Text STOP to 33101 to unsubscribe.

Download the App now

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FIND POTENTIAL WAYS TO SAVE WITH AN INSURANCE SPECIALIST

US-RNQ-210252 RIN Commercial Cost Resolution Video


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US-RNQ-210252 RIN COMMERCIAL COST RESOLUTION VIDEO



Transcript

Transcript

TEXT ON SCREEN: Please see Use and Important Safety Information within the
website. Please see full Prescribing Information, including Medication Guide,
and discuss with your doctor.

ANNOUNCER 1 VOICE-OVER (A1VO): Please see Use and Important Safety Information
within the website. Please see full Prescribing Information, including
Medication Guide, and discuss with your doctor.

TEXT ON SCREEN: Is there any way to lower my cost for RINVOQ?

ANNOUNCER 2 VOICE-OVER (A2VO): Is there any way to lower my cost for RINVOQ?

PATIENT AUDIO: Well yeah, expenses are really adding up these days. So that was
my first question when I was prescribed RINVOQ—“how much will this cost?”

PATIENT AUDIO: I figured it would be a good idea to call RINVOQ Complete and see
if there were any savings options available that could help lower any
out-of-pocket costs I’d have to pay and they connected me with an Insurance
Specialist.

PATIENT AUDIO: They explained that with a Savings Card I could be paying as
little as $5 a month. Five dollars a month? That’s less than lunch for these
two.

TEXT ON SCREEN: How does the RINVOQ Complete Savings Card work?

A2VO: How does the RINVOQ Complete Savings Card work?

PATIENT AUDIO: So I was able to request my Savings Card right from my phone with
the RINVOQ Complete App. Since you can pull it up whenever you need it, just
have it open when you talk to your Specialty Pharmacy about filling your
prescription. Read the number on the card, and you’re good to go! If you don’t
have a Savings Card, you can request one on the RINVOQ Complete website or the
Complete App, and access it anytime.

PATIENT AUDIO: Now, if you happen to have an issue getting or using your card,
or maybe you don’t qualify, just ask an Insurance Specialist. They can help you
figure things out, or even find other potential options to help you save on
RINVOQ.

PATIENT AUDIO: Hey! Aren’t you forgetting something?

TEXT ON SCREEN: Can I still save if I don’t have a Savings Card?

A2VO: Can I still save if I don’t have a Savings Card?

PATIENT AUDIO: If you don’t have a Savings Card or can’t use it, you may be
eligible for rebates. Check out the RINVOQ Complete website for more information
on those.

PATIENT AUDIO: Some things may pop up that can affect coverage. Like if we lost
insurance, or our plan changed. I know I can always call RINVOQ Complete and
they’ll connect me with an Insurance Specialist who may be able to help find
other ways to save.

PATIENT AUDIO: Doesn’t hurt to give them a call and see what you qualify for.
Leaving you with more time for yourself... and who doesn’t need that?

TEXT ON SCREEN: Here are the steps you can take right now:

 * Call RINVOQ Complete for an Insurance Specialist
 * Have them look up your current out-of-pocket costs
 * Request a RINVOQ Complete Savings Card
 * Give your Savings Card info when filling your prescription
 * Ask the Specialist about other savings options

PATIENT AUDIO: So here are a few things you can do right now:

 * Give RINVOQ Complete a call to get in touch with an Insurance Specialist
 * Ask them to go over out-of-pocket costs with you
 * Request a RINVOQ Complete Savings Card
 * If you already have one, have it ready when you fill prescriptions
 * And you can always talk to the specialist about other savings options.

TEXT ON SCREEN: For help finding ways to save on RINVOQ, call 1.800.2RINVOQ
(1.800.274.6867) and speak with an Insurance Specialist.

PATIENT AUDIO: If you need help finding ways to save, don’t forget to call
1.800.2RINVOQ so you can be connected with an Insurance Specialist.

TEXT ON SCREEN: SAFETY CONSIDERATIONS

RINVOQ may cause serious side effects, including:

 * Serious infections. RINVOQ can lower your ability to fight infections.
   Serious infections, some fatal, occurred while taking RINVOQ, including
   tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
 * Increased risk of death in people 50 years and older with at least 1 heart
   disease risk factor.
 * Cancer and immune system problems. RINVOQ may increase your risk of certain
   cancers, including lymphoma and skin cancer. Current or past smokers are at
   higher risk for lymphoma and lung cancer.
 * Increased risk of major cardiovascular events such as heart attack, stroke,
   or death in people 50 years and older with at least 1 heart disease risk
   factor, especially in current or past smokers.
 * Blood clots, some fatal, in the veins of the legs or lungs and arteries. This
   occurred more often in people 50 years and older with at least 1 heart
   disease risk factor.
 * Serious allergic reactions. Do not take if allergic to RINVOQ or any of its
   ingredients.
   Tears in the stomach or intestines and changes in certain laboratory test
   results.



A1VO: Safety Considerations

RINVOQ may cause serious side effects, including:

 * Serious infections. RINVOQ can lower your ability to fight infections.
   Serious infections, some fatal, occurred while taking RINVOQ, including
   tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
 * Increased risk of death in people 50 years and older with at least 1 heart
   disease risk factor.
 * Cancer and immune system problems. RINVOQ may increase your risk of certain
   cancers, including lymphoma and skin cancer. Current or past smokers are at
   higher risk for lymphoma and lung cancer.
 * Increased risk of major cardiovascular events such as heart attack, stroke,
   or death in people 50 years and older with at least 1 heart disease risk
   factor, especially in current or past smokers.
 * Blood clots, some fatal, in the veins of the legs or lungs and arteries. This
   occurred more often in people 50 years and older with at least 1 heart
   disease risk factor.
 * Serious allergic reactions. Do not take if allergic to RINVOQ or any of its
   ingredients.
 * Tears in the stomach or intestines and changes in certain laboratory test
   results.

TEXT ON SCREEN: Please see Use and additional Important Safety Information
within the website. Please see full Prescribing Information, including
Medication Guide, and discuss with your doctor.

TEXT ON SCREEN: RINVOQ Complete Savings Card Terms & Conditions

TEXT ON SCREEN: Eligibility: Available to patients with commercial insurance
coverage for RINVOQ® (upadacitinib) who meet eligibility criteria. This co-pay
assistance program is not available to patients receiving prescription
reimbursement under any federal, state, or government-funded insurance programs
(for example, Medicare [including Part D], Medicare Advantage, Medigap,
Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where
prohibited by law. Offer subject to change or termination without notice.
Restrictions, including monthly maximums, may apply. This is not health
insurance. For full Terms and Conditions, visit RINVOQSavingsCard.com or call
1.800.2RINVOQ for additional information. To learn about AbbVie’s privacy
practices and your privacy choices, visit https://privacy.abbvie

TEXT ON SCREEN: Please see Use and additional Important Safety Information
within the website. Please see full Prescribing Information, including
Medication Guide, and discuss with your doctor.






GET SUPPORT REGARDLESS OF YOUR INSURANCE COVERAGE

Connect with an Insurance Specialist who can talk you through your coverage and
help identify potential savings options.

Have insurance questions?

Call 1.800.2RINVOQ (1.800.274.6867)


MORE POTENTIAL WAYS TO SAVE ON RINVOQ

Select your insurance status to learn about potential financial assistance
available to you.




MEDICARE



People on Medicare who need help paying for their prescriptions may be eligible
to receive a low-income subsidy (also known as Extra Help).

What is Extra Help?

Extra Help is a government program that helps pay for the cost of your
prescriptions beyond what your plan already covers. With Extra Help, you may pay
no more than $10.35 per prescription in 2023 in your formulary

The list of medicines that your health insurance plan will pay for or cover.

. Eligibility is determined by your income and resources.

Are you eligible for Extra Help?

About 1 in 3 people on Medicare currently receives Extra Help—which means you
may qualify.

3 ways to apply:

 * Online at www.socialsecurity.gov/i1020
 * Call Social Security at 1.800.772.1213 (TTY 1.800.325.0778)
 * At your local State Medical Assistance (Medicaid) office

If you’re not eligible for Extra Help, RINVOQ may still be available at no
additional cost. Call 1.800.2RINVOQ (1.800.274.6867) to speak to an Insurance
Specialist to learn more.

For more information on RINVOQ and Medicare, go to Insurance Explained.


MEDICAID



State Medicaid programs may provide coverage for RINVOQ—depending on where you
live.

To find out the specific coverage policy and information for your particular
state's Medicaid program, please call 1.800.2RINVOQ (1.800.274.6867).


UNINSURED



If you are uninsured, unemployed, or have recently lost your insurance coverage,
RINVOQ may be available—at no additional cost to you—through AbbVie Patient
Access Support. See if you qualify.

Everyone’s situation is different, and prescription drug plans vary widely. Be
sure to speak with your plan’s representatives or a RINVOQ Complete Insurance
Specialist about the prescription drug benefit on your plan. To speak with an
Insurance Specialist, call 1.800.2RINVOQ (1.800.274.6867).

Insurance Specialists are available Monday through Friday from 8:00 AM to 8:00
PM ET, except for holidays.


RINVOQ COMPLETE REBATE

If you are an eligible, commercially insured patient, RINVOQ Complete Rebates
may help you save on the costs of your prescription as well as lab testing
related to RINVOQ treatment. If your pharmacy is unable to process your RINVOQ
Complete Savings Card for instant savings, you may still be able to get RINVOQ
for as little as $5 a month by receiving a rebate for the amount you paid for
your prescription.

Simply call 1.800.2RINVOQ (1.800.274.6867) to speak to one of our Insurance
Specialists, who can help determine if this option is right for you.

RINVOQ Complete offers 3 ways to submit your RINVOQ prescription or lab receipts
for a rebate on your eligible out-of-pocket costs.


ONLINE



Submit your prescription or lab receipts online for reimbursement. Submit online
>


APP



Download the RINVOQ Complete App to submit your prescription or lab receipts for
reimbursement directly from your mobile device.



Search for "RINVOQ Complete" at the App Store® or Google Play™.

Text APP to 33101 to receive a link to download the RINVOQ Complete App

Message and data rates may apply. Visit SeeRTerms.com and see Terms of Use at
abbv.ie/s-use. Text STOP to 33101 to unsubscribe.


REBATE FORM



Request paper forms to submit your prescription or lab receipts for
reimbursement by calling 1.800.2RINVOQ (1.800.274.6867).

For prescriptions, you should receive your rebate check from Opus Health in
approximately 5 business days. For the lab rebate, once processed and approved,
you could be reimbursed within 3 business days.

AbbVie is committed to helping you understand all of your options for saving on
RINVOQ. Just give us a call at 1.800.2RINVOQ (1.800.274.6867).

RINVOQ Co-pay Full Terms and Conditions
Terms and Conditions apply. This benefit covers RINVOQ® (upadacitinib) alone or,
for rheumatology patients, RINVOQ plus one of the following medications:
methotrexate, leflunomide, or hydroxychloroquine. Benefit also covers certain
lab tests to monitor for specific parameters as recommended in the product label
where the full cost is not covered by patients’ insurance through the Complete
Rebate program (Maximum savings limit of $1,000.00 per year applies).
Eligibility: Available to patients with commercial insurance coverage for RINVOQ
who meet eligibility criteria. Co-pay assistance program is not available to
patients receiving reimbursement under any federal, state, or government-funded
insurance programs (for example, Medicare [including Part D], Medicare
Advantage, Medigap, Medicaid, TRICARE, Department of Defense, or Veterans
Affairs programs) or where prohibited by law or by the patient’s health
insurance provider. If at any time a patient begins receiving prescription drug
coverage under any such federal, state, or government-funded healthcare program,
patient will no longer be able to use the RINVOQ Complete Savings Card and
patient must call RINVOQ Complete at 1-800-2RINVOQ to stop participation. By
enrolling in the co-pay assistance program, you agree that this program is
intended solely for the benefit of you, the patient. Some health plans have
established programs referred to as “accumulator adjustment” or “co-pay
maximizer” programs. An accumulator adjustment program is one in which payments
made by you that are subsidized by manufacturer assistance do not count toward
your deductibles and other out-of-pocket cost sharing limitations. Co-pay
maximizers are programs in which the amount of your out-of-pocket costs is
increased to reflect the availability of support offered by a manufacturer
assistance program. Except where prohibited by applicable state law, if your
insurance company or health plan implements either an accumulator adjustment or
co-pay maximizer program, you will not be eligible for, and agree not to use,
co-pay assistance because these programs are inconsistent with our agreed intent
that this program is solely for your benefit. You also agree that you are
personally responsible for paying any amount of co-pay required after the
savings card is applied. Any out-of-pocket costs remaining after the application
of the savings card may not be paid by your health plan, pharmacy benefit
programs, or any other program. If you learn your insurance company or health
plan has implemented either an accumulator adjustment program or a co-pay
maximizer program, you agree to inform AbbVie of this fact by calling
1-800-2RINVOQ to discuss alternative options that may be available to support
you. Since you may be unaware whether you are subject to a co-pay maximizer
program when you enroll in the copay assistance program, AbbVie will monitor
program utilization data and reserves the right to discontinue co-pay assistance
at any time if AbbVie determines that you are subject to a co-pay maximizer
program. For such patients, except where prohibited by applicable state law,
AbbVie may discontinue the availability of co-pay support at an amount not to
exceed $4,000.00. This amount is subject to change without notice. If your
health plan removes RINVOQ from a co-pay maximizer program, you will return to
eligibility for co-pay assistance up to the maximum annual benefit listed below.
Subject to all other terms and conditions, the maximum annual benefit that may
be available solely for the patient’s benefit under the co-pay assistance
program is $14,000 per calendar year. The actual application and use of the
benefit available under the co-pay assistance program may vary on a monthly,
quarterly, and/or annual basis depending on each individual patient’s plan of
insurance and other prescription drug costs. This co-pay assistance program is
subject to change, reduction in monetary amount, or discontinuation without any
notice. AbbVie in its sole discretion may unilaterally reduce or discontinue the
maximum annual benefit for any reason. Except where prohibited by applicable
law, this includes potential reduction or discontinuation to ensure that co-pay
assistance is utilized solely for the patient’s benefit. Patients may not seek
reimbursement for value received from the RINVOQ Complete Program from any
third-party payers. Offer subject to change or discontinuance without notice.
Restrictions, including monthly maximums, may apply. This assistance offer is
not health insurance. By utilizing this co-pay assistance program, you hereby
accept and agree to abide by these terms and conditions. Any individual or
entity who enrolls or assists in the enrollment of a patient in the co-pay
assistance program represents that the patient meets the eligibility criteria
and other requirements described herein. Further, you agree that you currently
meet the eligibility criteria and other requirements described herein every time
you use the co-pay assistance program. To learn about AbbVie’s privacy practices
and your privacy choices, visit https://abbv.ie/corpprivacy.

Understanding Insurance



We’re here to help explain your health insurance coverage and to find answers.

See all the ways we can help >


Get prepared



See how to verify your health insurance, find potential savings, and get your
RINVOQ prescription.

Take these steps now >




USES

RINVOQ is a prescription medicine used to treat:

 * Adults with moderate to severe rheumatoid arthritis (RA) when 1 or more
   medicines called tumor necrosis factor (TNF) blockers have been used, and did
   not work well or could not be tolerated.
 * Adults with active psoriatic arthritis (PsA) when 1 or more medicines called
   TNF blockers have been used, and did not work well or could not be tolerated.
 * Adults with active ankylosing spondylitis (AS) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.
 * Adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with
   objective signs of inflammation when a TNF blocker medicine has been used,
   and did not work well or could not be tolerated.
 * Adults with moderate to severe ulcerative colitis (UC) when 1 or more
   medicines called TNF blockers have been used, and did not work well or could
   not be tolerated.
 * Adults with moderate to severe Crohn’s disease (CD) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.

It is not known if RINVOQ is safe and effective in children with juvenile
idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis,
non-radiographic axial spondyloarthritis, ulcerative colitis, or Crohn’s
disease.

 * Adults and children 12 years of age and older with moderate to severe eczema
   (atopic dermatitis [AD]) that did not respond to previous treatment and their
   eczema is not well controlled with other pills or injections, including
   biologic medicines, or the use of other pills or injections is not
   recommended.

RINVOQ is safe and effective in children 12 years of age and older weighing at
least 88 pounds (40 kg) with atopic dermatitis.

It is not known if RINVOQ is safe and effective in children under 12 years of
age with atopic dermatitis.

IMPORTANT SAFETY INFORMATION


What is the most important information I should know about RINVOQ?

RINVOQ may cause serious side effects, including:

 * Serious infections. RINVOQ can lower your ability to fight infections.
   Serious infections have happened while taking RINVOQ, including tuberculosis
   (TB) and infections caused by bacteria, fungi, or viruses that can spread
   throughout the body. Some people have died from these infections. Your
   healthcare provider (HCP) should test you for TB before starting RINVOQ and
   check you closely for signs and symptoms of TB during treatment with RINVOQ.
   You should not start taking RINVOQ if you have any kind of infection unless
   your HCP tells you it is okay. If you get a serious infection, your HCP may
   stop your treatment until your infection is controlled. You may be at higher
   risk of developing shingles (herpes zoster).
 * Increased risk of death in people 50 years and older who have at least 1
   heart disease (cardiovascular) risk factor.
 * Cancer and immune system problems. RINVOQ may increase your risk of certain
   cancers. Lymphoma and other cancers, including skin cancers, can happen.
   Current or past smokers are at higher risk of certain cancers, including
   lymphoma and lung cancer. Follow your HCP's advice about having your skin
   checked for skin cancer during treatment with RINVOQ. Limit the amount of
   time you spend in sunlight. Wear protective clothing when you are in the sun
   and use sunscreen.
 * Increased risk of major cardiovascular (CV) events, such as heart attack,
   stroke, or death, in people 50 years and older who have at least 1 heart
   disease (CV) risk factor, especially if you are a current or past smoker.
 * Blood clots. Blood clots in the veins of the legs or lungs and arteries can
   happen with RINVOQ. This may be life-threatening and cause death. Blood clots
   in the veins of the legs and lungs have happened more often in people who are
   50 years and older and with at least 1 heart disease (CV) risk factor.
 * Allergic reactions. Symptoms such as rash (hives), trouble breathing, feeling
   faint or dizzy, or swelling of your lips, tongue, or throat, that may mean
   you are having an allergic reaction have been seen in people taking RINVOQ.
   Some of these reactions were serious. If any of these symptoms occur during
   treatment with RINVOQ, stop taking RINVOQ and get emergency medical help
   right away.
 * Tears in the stomach or intestines. This happens most often in people who
   take nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. Get
   medical help right away if you get stomach-area pain, fever, chills, nausea,
   or vomiting.
 * Changes in certain laboratory tests. Your HCP should do blood tests before
   you start taking RINVOQ and while you take it. Your HCP may stop your RINVOQ
   treatment for a period of time if needed because of changes in these blood
   test results.

Do not take RINVOQ if you are allergic to upadacitinib or any of the ingredients
in RINVOQ. See the Medication Guide or Consumer Brief Summary for a complete
list of ingredients.

What should I tell my HCP BEFORE starting RINVOQ?

Tell your HCP if you:

 * Are being treated for an infection, have an infection that won't go away or
   keeps coming back, or have symptoms of an infection, such as:
   * - Fever, sweating, or chills
   * - Shortness of breath
   * - Warm, red, or painful skin or sores on your body
   * - Muscle aches
   * - Feeling tired
   * - Blood in phlegm
   * - Diarrhea or stomach pain
   * - Cough
   * - Weight loss
   * - Burning when urinating or urinating more often than normal
 * Have TB or have been in close contact with someone with TB.
 * Are a current or past smoker.
 * Have had a heart attack, other heart problems, or stroke.
 * Have or have had any type of cancer, hepatitis B or C, shingles (herpes
   zoster), blood clots in the veins of your legs or lungs, diverticulitis
   (inflammation in parts of the large intestine), or ulcers in your stomach or
   intestines.
 * Have other medical conditions, including liver problems, low blood cell
   counts, diabetes, chronic lung disease, HIV, or a weak immune system.
 * Live, have lived, or have traveled to parts of the country, such as the Ohio
   and Mississippi River valleys and the Southwest, that increase your risk of
   getting certain kinds of fungal infections. If you are unsure if you've been
   to these types of areas, ask your HCP.
 * Have recently received or are scheduled to receive a vaccine. People who take
   RINVOQ should not receive live vaccines.
 * Are pregnant or plan to become pregnant. Based on animal studies, RINVOQ may
   harm your unborn baby. Your HCP will check whether or not you are pregnant
   before you start RINVOQ. You should use effective birth control
   (contraception) to avoid becoming pregnant during treatment with RINVOQ and
   for 4 weeks after your last dose.
 * There is a pregnancy surveillance program for RINVOQ. The purpose of the
   program is to collect information about the health of you and your baby. If
   you become pregnant while taking RINVOQ, you are encouraged to report the
   pregnancy by calling 1-800-633-9110.
 * Are breastfeeding or plan to breastfeed. RINVOQ may pass into your breast
   milk. Do not breastfeed during treatment with RINVOQ and for 6 days after
   your last dose.

 

Tell your HCP about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements. RINVOQ and other
medicines may affect each other, causing side effects.

Especially tell your HCP if you take:

 * Medicines for fungal or bacterial infections
 * Rifampicin or phenytoin
 * Medicines that affect your immune system

If you are not sure if you are taking any of these medicines, ask your HCP or
pharmacist.

What should I avoid while taking RINVOQ?

Avoid food or drink containing grapefruit during treatment with RINVOQ as it may
increase the risk of side effects.

What should I do or tell my HCP AFTER starting RINVOQ?

 * Tell your HCP right away if you have any symptoms of an infection. RINVOQ can
   make you more likely to get infections or make any infections you have worse.
 * Get emergency help right away if you have any symptoms of a heart attack or
   stroke while taking RINVOQ, including:
   * - Discomfort in the center of your chest that lasts for more than a few
     minutes or that goes away and comes back
   * - Severe tightness, pain, pressure, or heaviness in your chest, throat,
     neck, or jaw
   * - Pain or discomfort in your arms, back, neck, jaw, or stomach
   * - Shortness of breath with or without chest discomfort
   * - Breaking out in a cold sweat
   * - Nausea or vomiting
   * - Feeling lightheaded
   * - Weakness in one part or on one side of your body
   * - Slurred speech
 * Tell your HCP right away if you have any signs or symptoms of blood clots
   during treatment with RINVOQ, including:
   * - Swelling
   * - Pain or tenderness in one or both legs
   * - Sudden unexplained chest or upper back pain
   * - Shortness of breath or difficulty breathing
   *  
   *  
 * Tell your HCP right away if you have a fever or stomach-area pain that does
   not go away, and a change in your bowel habits.

What are other possible side effects of RINVOQ?

Common side effects include upper respiratory tract infections (common cold,
sinus infections), shingles (herpes zoster), herpes simplex virus infections
(including cold sores), bronchitis, nausea, cough, fever, acne, headache,
increased blood levels of creatine phosphokinase, allergic reactions,
inflammation of hair follicles, stomach-area (abdominal) pain, increased weight,
flu, tiredness, lower number of certain types of white blood cells (neutropenia,
lymphopenia, leukopenia), muscle pain, flu-like illness, rash, increased blood
cholesterol levels, increased liver enzyme levels, pneumonia, low number of red
blood cells (anemia), and infection of the stomach and intestine
(gastroenteritis).

A separation or tear to the lining of the back part of the eye (retinal
detachment) has happened in people with atopic dermatitis treated with RINVOQ.
Call your HCP right away if you have any sudden changes in your vision during
treatment with RINVOQ.

Some people taking RINVOQ may see medicine residue (a whole tablet or tablet
pieces) in their stool. If this happens, call your healthcare provider.

These are not all the possible side effects of RINVOQ.

How should I take RINVOQ?

RINVOQ is taken once a day with or without food. Do not split, crush, or chew
the tablet. Take RINVOQ exactly as your HCP tells you to use it. RINVOQ is
available in 15 mg, 30 mg, and 45 mg extended-release tablets.

This is the most important information to know about RINVOQ. For more
information, talk to your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

USES

RINVOQ is a prescription medicine used to treat:

 * Adults with moderate to severe rheumatoid arthritis (RA) when 1 or more
   medicines called tumor necrosis factor (TNF) blockers have been used, and did
   not work well or could not be tolerated.
 * Adults with active psoriatic arthritis (PsA) when 1 or more medicines called
   TNF blockers have been used, and did not work well or could not be tolerated.
 * Adults with active ankylosing spondylitis (AS) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.
 * Adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with
   objective signs of inflammation when a TNF blocker medicine has been used,
   and did not work well or could not be tolerated.
 * Adults with moderate to severe ulcerative colitis (UC) when 1 or more
   medicines called TNF blockers have been used, and did not work well or could
   not be tolerated.
 * Adults with moderate to severe Crohn's disease (CD) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.

It is not known if RINVOQ is safe and effective in children with juvenile
idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis,
non-radiographic axial spondyloarthritis, ulcerative colitis, or Crohn's
disease.

 * Adults and children 12 years of age and older with moderate to severe eczema
   (atopic dermatitis [AD]) that did not respond to previous treatment and their
   eczema is not well controlled with other pills or injections, including
   biologic medicines, or the use of other pills or injections is not
   recommended.

RINVOQ is safe and effective in children 12 years of age and older weighing at
least 88 pounds (40 kg) with atopic dermatitis.

It is not known if RINVOQ is safe and effective in children under 12 years of
age with atopic dermatitis.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

US-RNQ-220259

Please see the Full Prescribing Information, including the Medication Guide, for
RINVOQ.

Legal Notices/Privacy Policy. © 2023 AbbVie. All rights reserved. If you have
any questions about AbbVie's RINVOQ.com website that have not been
answered, click here. This website and the information contained herein is
intended for use by US residents only, is provided for informational purposes
only and is not intended to replace a discussion with a healthcare provider. All
decisions regarding patient care must be made with a healthcare provider and
consider the unique characteristics of each patient.



RINVOQ (UPADACITINIB)

 * Moderate to Severe Eczema (Atopic Dermatitis)
 * Moderate to Severe Rheumatoid Arthritis
 * Active Psoriatic Arthritis
 * Active Ankylosing Spondylitis
 * Active Non-radiographic Axial Spondyloarthritis
 * Moderate to Severe Ulcerative Colitis
 * Moderate to Severe Crohn’s Disease
 * RINVOQ Complete
 * Cost & Savings

IMPORTANT INFORMATION FOR PATIENTS

 * Important Safety Information
 * Medication Guide
 * Full Prescribing Information (English)

INFORMATION FROM ABBVIE

 * Healthcare Professionals Site
 * COVID-19 Information
 * Accessibility Statement
 * Contact Us
 * Terms of Use
 * Privacy Notice
 * Cookies Settings
 * Your Privacy Choices

RINVOQ Complete Savings Card Terms and Conditions

‡Eligibility: Available to patients with commercial insurance coverage for
RINVOQ® (upadacitinib) who meet eligibility criteria. This co-pay assistance
program is not available to patients receiving prescription reimbursement under
any federal, state, or government-funded insurance programs (for example,
Medicare [including Part D], Medicare Advantage, Medigap, Medicaid, TRICARE,
Department of Defense, or Veterans Affairs programs) or where prohibited by law.
Offer subject to change or termination without notice. Restrictions, including
monthly maximums, may apply. This is not health insurance. For full Terms and
Conditions, visit RINVOQSavingsCard.com or call 1.800.2RINVOQ for additional
information. To learn about AbbVie’s privacy practices and your privacy choices,
visit https://abbv.ie/corpprivacy.

US-RNQ-230200





The list of medicines that your health insurance plan will pay for or cover.


LEAVING ABBVIE WEB SITE

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not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

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US-RNQR-190268


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

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US-RNQR-190268


US HEALTHCARE
PROFESSIONALS ONLY

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continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

I am a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

Yes
No

US-RNQ-220499


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-RNQ-220499


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-RNQR-220513


US HEALTHCARE
PROFESSIONALS ONLY

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

I am a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

Yes
No

US-RNQ-220010





LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-RNQ-220499


US HEALTHCARE
PROFESSIONALS ONLY

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

I am a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

Yes
No

US-RNQ-220499


TERMS AND CONDITIONS

AbbVie Inc. is providing this service to help patients find rheumatologists in
their area who have experience with RINVOQ (upadacitinib).
 

No fees have been received by or paid to rheumatologists for inclusion in this
specialist locator directory. Inclusion of a physician in this directory does
not represent an endorsement by or a recommendation from AbbVie Inc., nor does
it imply that the rheumatologists on the list will determine that RINVOQ is
right for you.
 

You are ultimately responsible for the selection of a physician and it is an
important decision that you should consider carefully. This rheumatologist
locator tool is just one source of information available to you. AbbVie Inc. is
the maker and marketer of RINVOQ (upadacitinib).


 

Close

US-RNQR-210387

IMPORTANT SAFETY INFORMATION


What is the most important information I should know about RINVOQ?

RINVOQ may cause serious side effects, including:

 * Serious infections. RINVOQ can lower your ability to fight infections.
   Serious infections have happened while taking RINVOQ, including tuberculosis
   (TB) and infections caused by bacteria, fungi, or viruses that can spread
   throughout the body. Some people have died from these infections. Your
   healthcare provider (HCP) should test you for TB before starting RINVOQ and
   check you closely for signs and symptoms of TB during treatment with RINVOQ.
   You should not start taking RINVOQ if you have any kind of infection unless
   your HCP tells you it is okay. If you get a serious infection, your HCP may
   stop your treatment until your infection is controlled. You may be at higher
   risk of developing shingles (herpes zoster).
 * Increased risk of death in people 50 years and older who have at least 1
   heart disease (cardiovascular) risk factor.
 * Cancer and immune system problems. RINVOQ may increase your risk of certain
   cancers. Lymphoma and other cancers, including skin cancers, can happen.
   Current or past smokers are at higher risk of certain cancers, including
   lymphoma and lung cancer. Follow your HCP's advice about having your skin
   checked for skin cancer during treatment with RINVOQ. Limit the amount of
   time you spend in sunlight. Wear protective clothing when you are in the sun
   and use sunscreen.
 * Increased risk of major cardiovascular (CV) events, such as heart attack,
   stroke, or death, in people 50 years and older who have at least 1 heart
   disease (CV) risk factor, especially if you are a current or past smoker.
 * Blood clots. Blood clots in the veins of the legs or lungs and arteries can
   happen with RINVOQ. This may be life-threatening and cause death. Blood clots
   in the veins of the legs and lungs have happened more often in people who are
   50 years and older and with at least 1 heart disease (CV) risk factor.
 * Allergic reactions. Symptoms such as rash (hives), trouble breathing, feeling
   faint or dizzy, or swelling of your lips, tongue, or throat, that may mean
   you are having an allergic reaction have been seen in people taking RINVOQ.
   Some of these reactions were serious. If any of these symptoms occur during
   treatment with RINVOQ, stop taking RINVOQ and get emergency medical help
   right away.
 * Tears in the stomach or intestines. This happens most often in people who
   take nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. Get
   medical help right away if you get stomach-area pain, fever, chills, nausea,
   or vomiting.
 * Changes in certain laboratory tests. Your HCP should do blood tests before
   you start taking RINVOQ and while you take it. Your HCP may stop your RINVOQ
   treatment for a period of time if needed because of changes in these blood
   test results.

Do not take RINVOQ if you are allergic to upadacitinib or any of the ingredients
in RINVOQ. See the Medication Guide or Consumer Brief Summary for a complete
list of ingredients.

What should I tell my HCP BEFORE starting RINVOQ?

Tell your HCP if you:

 * Are being treated for an infection, have an infection that won't go away or
   keeps coming back, or have symptoms of an infection, such as:
   * - Fever, sweating, or chills
   * - Shortness of breath
   * - Warm, red, or painful skin or sores on your body
   * - Muscle aches
   * - Feeling tired
   * - Blood in phlegm
   * - Diarrhea or stomach pain
   * - Cough
   * - Weight loss
   * - Burning when urinating or urinating more often than normal
 * Have TB or have been in close contact with someone with TB.
 * Are a current or past smoker.
 * Have had a heart attack, other heart problems, or stroke.
 * Have or have had any type of cancer, hepatitis B or C, shingles (herpes
   zoster), blood clots in the veins of your legs or lungs, diverticulitis
   (inflammation in parts of the large intestine), or ulcers in your stomach or
   intestines.
 * Have other medical conditions, including liver problems, low blood cell
   counts, diabetes, chronic lung disease, HIV, or a weak immune system.
 * Live, have lived, or have traveled to parts of the country, such as the Ohio
   and Mississippi River valleys and the Southwest, that increase your risk of
   getting certain kinds of fungal infections. If you are unsure if you've been
   to these types of areas, ask your HCP.
 * Have recently received or are scheduled to receive a vaccine. People who take
   RINVOQ should not receive live vaccines.
 * Are pregnant or plan to become pregnant. Based on animal studies, RINVOQ may
   harm your unborn baby. Your HCP will check whether or not you are pregnant
   before you start RINVOQ. You should use effective birth control
   (contraception) to avoid becoming pregnant during treatment with RINVOQ and
   for 4 weeks after your last dose.
 * There is a pregnancy surveillance program for RINVOQ. The purpose of the
   program is to collect information about the health of you and your baby. If
   you become pregnant while taking RINVOQ, you are encouraged to report the
   pregnancy by calling 1-800-633-9110.
 * Are breastfeeding or plan to breastfeed. RINVOQ may pass into your breast
   milk. Do not breastfeed during treatment with RINVOQ and for 6 days after
   your last dose.

 

Tell your HCP about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements. RINVOQ and other
medicines may affect each other, causing side effects.

Especially tell your HCP if you take:

 * Medicines for fungal or bacterial infections
 * Rifampicin or phenytoin
 * Medicines that affect your immune system

If you are not sure if you are taking any of these medicines, ask your HCP or
pharmacist.

What should I avoid while taking RINVOQ?

Avoid food or drink containing grapefruit during treatment with RINVOQ as it may
increase the risk of side effects.

What should I do or tell my HCP AFTER starting RINVOQ?

 * Tell your HCP right away if you have any symptoms of an infection. RINVOQ can
   make you more likely to get infections or make any infections you have worse.
 * Get emergency help right away if you have any symptoms of a heart attack or
   stroke while taking RINVOQ, including:
   * - Discomfort in the center of your chest that lasts for more than a few
     minutes or that goes away and comes back
   * - Severe tightness, pain, pressure, or heaviness in your chest, throat,
     neck, or jaw
   * - Pain or discomfort in your arms, back, neck, jaw, or stomach
   * - Shortness of breath with or without chest discomfort
   * - Breaking out in a cold sweat
   * - Nausea or vomiting
   * - Feeling lightheaded
   * - Weakness in one part or on one side of your body
   * - Slurred speech
 * Tell your HCP right away if you have any signs or symptoms of blood clots
   during treatment with RINVOQ, including:
   * - Swelling
   * - Pain or tenderness in one or both legs
   * - Sudden unexplained chest or upper back pain
   * - Shortness of breath or difficulty breathing
   *  
   *  
 * Tell your HCP right away if you have a fever or stomach-area pain that does
   not go away, and a change in your bowel habits.

What are other possible side effects of RINVOQ?

Common side effects include upper respiratory tract infections (common cold,
sinus infections), shingles (herpes zoster), herpes simplex virus infections
(including cold sores), bronchitis, nausea, cough, fever, acne, headache,
increased blood levels of creatine phosphokinase, allergic reactions,
inflammation of hair follicles, stomach-area (abdominal) pain, increased weight,
flu, tiredness, lower number of certain types of white blood cells (neutropenia,
lymphopenia, leukopenia), muscle pain, flu-like illness, rash, increased blood
cholesterol levels, increased liver enzyme levels, pneumonia, low number of red
blood cells (anemia), and infection of the stomach and intestine
(gastroenteritis).

A separation or tear to the lining of the back part of the eye (retinal
detachment) has happened in people with atopic dermatitis treated with RINVOQ.
Call your HCP right away if you have any sudden changes in your vision during
treatment with RINVOQ.

Some people taking RINVOQ may see medicine residue (a whole tablet or tablet
pieces) in their stool. If this happens, call your healthcare provider.

These are not all the possible side effects of RINVOQ.

How should I take RINVOQ?

RINVOQ is taken once a day with or without food. Do not split, crush, or chew
the tablet. Take RINVOQ exactly as your HCP tells you to use it. RINVOQ is
available in 15 mg, 30 mg, and 45 mg extended-release tablets.

This is the most important information to know about RINVOQ. For more
information, talk to your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

USES

RINVOQ is a prescription medicine used to treat:

 * Adults with moderate to severe rheumatoid arthritis (RA) when 1 or more
   medicines called tumor necrosis factor (TNF) blockers have been used, and did
   not work well or could not be tolerated.
 * Adults with active psoriatic arthritis (PsA) when 1 or more medicines called
   TNF blockers have been used, and did not work well or could not be tolerated.
 * Adults with active ankylosing spondylitis (AS) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.
 * Adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with
   objective signs of inflammation when a TNF blocker medicine has been used,
   and did not work well or could not be tolerated.
 * Adults with moderate to severe ulcerative colitis (UC) when 1 or more
   medicines called TNF blockers have been used, and did not work well or could
   not be tolerated.
 * Adults with moderate to severe Crohn's disease (CD) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.

It is not known if RINVOQ is safe and effective in children with juvenile
idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis,
non-radiographic axial spondyloarthritis, ulcerative colitis, or Crohn's
disease.

 * Adults and children 12 years of age and older with moderate to severe eczema
   (atopic dermatitis [AD]) that did not respond to previous treatment and their
   eczema is not well controlled with other pills or injections, including
   biologic medicines, or the use of other pills or injections is not
   recommended.

RINVOQ is safe and effective in children 12 years of age and older weighing at
least 88 pounds (40 kg) with atopic dermatitis.

It is not known if RINVOQ is safe and effective in children under 12 years of
age with atopic dermatitis.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

US-RNQ-220259

Please see the Full Prescribing Information, including the Medication Guide, for
RINVOQ.

Legal Notices/Privacy Policy. © 2023 AbbVie. All rights reserved. If you have
any questions about AbbVie's RINVOQ.com website that have not been
answered, click here. This website and the information contained herein is
intended for use by US residents only, is provided for informational purposes
only and is not intended to replace a discussion with a healthcare provider. All
decisions regarding patient care must be made with a healthcare provider and
consider the unique characteristics of each patient.


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-RNQG-230183


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

US-RNQR-190268


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

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US-RNQR-220513


YOU ARE NOW LEAVING THE RINVOQ WEBSITE

By clicking “Agree and continue” below, you acknowledge and agree that AbbVie
does not, in any way, endorse or recommend Doctor.com, the qualifications of any
physician associated with Doctor.com, or the quality of medical care any of
those physicians can provide. Please be aware that Doctor.com may have its own
set of terms and conditions and privacy policy for which AbbVie has no
responsibility. If you agree to the above, click “Agree and continue” to proceed
to Doctor.com. If you do not agree to the above, click “Cancel” to remain on
RINVOQ.com.

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US-RNQR-220513


LEAVING ABBVIE WEB SITE

You are leaving the RINVOQ (upadacitinib) site and connecting to a site that is
not under the control of AbbVie. AbbVie is not responsible for the contents of
any such site or any further links from such site. AbbVie is providing these
links to you only as a convenience and the inclusion of any link does not imply
the endorsement of the linked site by AbbVie. You should also be aware that the
linked site may be governed by its own set of terms and conditions and privacy
policy for which AbbVie has no responsibility. Conversely, the presence of this
link does not imply the linked site's endorsement of RINVOQ.com or AbbVie.

Do you wish to leave this site?

Yes
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US-RNQR-221299


US HEALTHCARE
PROFESSIONALS ONLY

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

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professionals section of this site.

Yes
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US-RNQ-220010


US HEALTHCARE
PROFESSIONALS ONLY

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

I am a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

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US-RNQ-220010





IMPORTANT SAFETY INFORMATION & USES

Warning: Serious Infections, Increased Risk of Death, Cancer, Major
Cardiovascular Events, Blood Clots


IMPORTANT SAFETY INFORMATION & USES

Warning: Serious Infections, Increased Risk of Death, Cancer, Major
Cardiovascular Events, Blood Clots


IMPORTANT SAFETY INFORMATION & USES

Warning: Serious Infections, Increased Risk of Death, Cancer, Major
Cardiovascular Events, Blood Clots


IMPORTANT SAFETY INFORMATION & USES

Warning: Serious Infections, Increased Risk of Death, Cancer, Major
Cardiovascular Events, Blood Clots


USES

RINVOQ is a prescription medicine used to treat:

 * Adults with moderate to severe rheumatoid arthritis (RA) when 1 or more
   medicines called tumor necrosis factor (TNF) blockers have been used, and did
   not work well or could not be tolerated.
 * Adults with active psoriatic arthritis (PsA) when 1 or more medicines called
   TNF blockers have been used, and did not work well or could not be tolerated.
 * Adults with active ankylosing spondylitis (AS) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.
 * Adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with
   objective signs of inflammation when a TNF blocker medicine has been used,
   and did not work well or could not be tolerated.
 * Adults with moderate to severe ulcerative colitis (UC) when 1 or more
   medicines called TNF blockers have been used, and did not work well or could
   not be tolerated.
 * Adults with moderate to severe Crohn’s disease (CD) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.

It is not known if RINVOQ is safe and effective in children with juvenile
idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis,
non-radiographic axial spondyloarthritis, ulcerative colitis, or Crohn’s
disease.

 * Adults and children 12 years of age and older with moderate to severe eczema
   (atopic dermatitis [AD]) that did not respond to previous treatment and their
   eczema is not well controlled with other pills or injections, including
   biologic medicines, or the use of other pills or injections is not
   recommended.

RINVOQ is safe and effective in children 12 years of age and older weighing at
least 88 pounds (40 kg) with atopic dermatitis.

It is not known if RINVOQ is safe and effective in children under 12 years of
age with atopic dermatitis.

IMPORTANT SAFETY INFORMATION


What is the most important information I should know about RINVOQ?

RINVOQ may cause serious side effects, including:

 * Serious infections. RINVOQ can lower your ability to fight infections.
   Serious infections have happened while taking RINVOQ, including tuberculosis
   (TB) and infections caused by bacteria, fungi, or viruses that can spread
   throughout the body. Some people have died from these infections. Your
   healthcare provider (HCP) should test you for TB before starting RINVOQ and
   check you closely for signs and symptoms of TB during treatment with RINVOQ.
   You should not start taking RINVOQ if you have any kind of infection unless
   your HCP tells you it is okay. If you get a serious infection, your HCP may
   stop your treatment until your infection is controlled. You may be at higher
   risk of developing shingles (herpes zoster).
 * Increased risk of death in people 50 years and older who have at least 1
   heart disease (cardiovascular) risk factor.
 * Cancer and immune system problems. RINVOQ may increase your risk of certain
   cancers. Lymphoma and other cancers, including skin cancers, can happen.
   Current or past smokers are at higher risk of certain cancers, including
   lymphoma and lung cancer. Follow your HCP's advice about having your skin
   checked for skin cancer during treatment with RINVOQ. Limit the amount of
   time you spend in sunlight. Wear protective clothing when you are in the sun
   and use sunscreen.
 * Increased risk of major cardiovascular (CV) events, such as heart attack,
   stroke, or death, in people 50 years and older who have at least 1 heart
   disease (CV) risk factor, especially if you are a current or past smoker.
 * Blood clots. Blood clots in the veins of the legs or lungs and arteries can
   happen with RINVOQ. This may be life-threatening and cause death. Blood clots
   in the veins of the legs and lungs have happened more often in people who are
   50 years and older and with at least 1 heart disease (CV) risk factor.
 * Allergic reactions. Symptoms such as rash (hives), trouble breathing, feeling
   faint or dizzy, or swelling of your lips, tongue, or throat, that may mean
   you are having an allergic reaction have been seen in people taking RINVOQ.
   Some of these reactions were serious. If any of these symptoms occur during
   treatment with RINVOQ, stop taking RINVOQ and get emergency medical help
   right away.
 * Tears in the stomach or intestines. This happens most often in people who
   take nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. Get
   medical help right away if you get stomach-area pain, fever, chills, nausea,
   or vomiting.
 * Changes in certain laboratory tests. Your HCP should do blood tests before
   you start taking RINVOQ and while you take it. Your HCP may stop your RINVOQ
   treatment for a period of time if needed because of changes in these blood
   test results.

Do not take RINVOQ if you are allergic to upadacitinib or any of the ingredients
in RINVOQ. See the Medication Guide or Consumer Brief Summary for a complete
list of ingredients.

What should I tell my HCP BEFORE starting RINVOQ?

Tell your HCP if you:

 * Are being treated for an infection, have an infection that won't go away or
   keeps coming back, or have symptoms of an infection, such as:
   * - Fever, sweating, or chills
   * - Shortness of breath
   * - Warm, red, or painful skin or sores on your body
   * - Muscle aches
   * - Feeling tired
   * - Blood in phlegm
   * - Diarrhea or stomach pain
   * - Cough
   * - Weight loss
   * - Burning when urinating or urinating more often than normal
 * Have TB or have been in close contact with someone with TB.
 * Are a current or past smoker.
 * Have had a heart attack, other heart problems, or stroke.
 * Have or have had any type of cancer, hepatitis B or C, shingles (herpes
   zoster), blood clots in the veins of your legs or lungs, diverticulitis
   (inflammation in parts of the large intestine), or ulcers in your stomach or
   intestines.
 * Have other medical conditions, including liver problems, low blood cell
   counts, diabetes, chronic lung disease, HIV, or a weak immune system.
 * Live, have lived, or have traveled to parts of the country, such as the Ohio
   and Mississippi River valleys and the Southwest, that increase your risk of
   getting certain kinds of fungal infections. If you are unsure if you've been
   to these types of areas, ask your HCP.
 * Have recently received or are scheduled to receive a vaccine. People who take
   RINVOQ should not receive live vaccines.
 * Are pregnant or plan to become pregnant. Based on animal studies, RINVOQ may
   harm your unborn baby. Your HCP will check whether or not you are pregnant
   before you start RINVOQ. You should use effective birth control
   (contraception) to avoid becoming pregnant during treatment with RINVOQ and
   for 4 weeks after your last dose.
 * There is a pregnancy surveillance program for RINVOQ. The purpose of the
   program is to collect information about the health of you and your baby. If
   you become pregnant while taking RINVOQ, you are encouraged to report the
   pregnancy by calling 1-800-633-9110.
 * Are breastfeeding or plan to breastfeed. RINVOQ may pass into your breast
   milk. Do not breastfeed during treatment with RINVOQ and for 6 days after
   your last dose.

 

Tell your HCP about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements. RINVOQ and other
medicines may affect each other, causing side effects.

Especially tell your HCP if you take:

 * Medicines for fungal or bacterial infections
 * Rifampicin or phenytoin
 * Medicines that affect your immune system

If you are not sure if you are taking any of these medicines, ask your HCP or
pharmacist.

What should I avoid while taking RINVOQ?

Avoid food or drink containing grapefruit during treatment with RINVOQ as it may
increase the risk of side effects.

What should I do or tell my HCP AFTER starting RINVOQ?

 * Tell your HCP right away if you have any symptoms of an infection. RINVOQ can
   make you more likely to get infections or make any infections you have worse.
 * Get emergency help right away if you have any symptoms of a heart attack or
   stroke while taking RINVOQ, including:
   * - Discomfort in the center of your chest that lasts for more than a few
     minutes or that goes away and comes back
   * - Severe tightness, pain, pressure, or heaviness in your chest, throat,
     neck, or jaw
   * - Pain or discomfort in your arms, back, neck, jaw, or stomach
   * - Shortness of breath with or without chest discomfort
   * - Breaking out in a cold sweat
   * - Nausea or vomiting
   * - Feeling lightheaded
   * - Weakness in one part or on one side of your body
   * - Slurred speech
 * Tell your HCP right away if you have any signs or symptoms of blood clots
   during treatment with RINVOQ, including:
   * - Swelling
   * - Pain or tenderness in one or both legs
   * - Sudden unexplained chest or upper back pain
   * - Shortness of breath or difficulty breathing
   *  
   *  
 * Tell your HCP right away if you have a fever or stomach-area pain that does
   not go away, and a change in your bowel habits.

What are other possible side effects of RINVOQ?

Common side effects include upper respiratory tract infections (common cold,
sinus infections), shingles (herpes zoster), herpes simplex virus infections
(including cold sores), bronchitis, nausea, cough, fever, acne, headache,
increased blood levels of creatine phosphokinase, allergic reactions,
inflammation of hair follicles, stomach-area (abdominal) pain, increased weight,
flu, tiredness, lower number of certain types of white blood cells (neutropenia,
lymphopenia, leukopenia), muscle pain, flu-like illness, rash, increased blood
cholesterol levels, increased liver enzyme levels, pneumonia, low number of red
blood cells (anemia), and infection of the stomach and intestine
(gastroenteritis).

A separation or tear to the lining of the back part of the eye (retinal
detachment) has happened in people with atopic dermatitis treated with RINVOQ.
Call your HCP right away if you have any sudden changes in your vision during
treatment with RINVOQ.

Some people taking RINVOQ may see medicine residue (a whole tablet or tablet
pieces) in their stool. If this happens, call your healthcare provider.

These are not all the possible side effects of RINVOQ.

How should I take RINVOQ?

RINVOQ is taken once a day with or without food. Do not split, crush, or chew
the tablet. Take RINVOQ exactly as your HCP tells you to use it. RINVOQ is
available in 15 mg, 30 mg, and 45 mg extended-release tablets.

This is the most important information to know about RINVOQ. For more
information, talk to your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

USES

RINVOQ is a prescription medicine used to treat:

 * Adults with moderate to severe rheumatoid arthritis (RA) when 1 or more
   medicines called tumor necrosis factor (TNF) blockers have been used, and did
   not work well or could not be tolerated.
 * Adults with active psoriatic arthritis (PsA) when 1 or more medicines called
   TNF blockers have been used, and did not work well or could not be tolerated.
 * Adults with active ankylosing spondylitis (AS) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.
 * Adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with
   objective signs of inflammation when a TNF blocker medicine has been used,
   and did not work well or could not be tolerated.
 * Adults with moderate to severe ulcerative colitis (UC) when 1 or more
   medicines called TNF blockers have been used, and did not work well or could
   not be tolerated.
 * Adults with moderate to severe Crohn's disease (CD) when 1 or more medicines
   called TNF blockers have been used, and did not work well or could not be
   tolerated.

It is not known if RINVOQ is safe and effective in children with juvenile
idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis,
non-radiographic axial spondyloarthritis, ulcerative colitis, or Crohn's
disease.

 * Adults and children 12 years of age and older with moderate to severe eczema
   (atopic dermatitis [AD]) that did not respond to previous treatment and their
   eczema is not well controlled with other pills or injections, including
   biologic medicines, or the use of other pills or injections is not
   recommended.

RINVOQ is safe and effective in children 12 years of age and older weighing at
least 88 pounds (40 kg) with atopic dermatitis.

It is not known if RINVOQ is safe and effective in children under 12 years of
age with atopic dermatitis.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

US-RNQ-220259

Please see the Full Prescribing Information, including the Medication Guide, for
RINVOQ.

Legal Notices/Privacy Policy. © 2023 AbbVie. All rights reserved. If you have
any questions about AbbVie's RINVOQ.com website that have not been
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