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 * About
 * Research
   * Therapeutic Engineering
   * Regenerative Engineering
   * Immunoengineering
   * Previous Projects
 * People
   * Lab Members
   * Alumni
 * Publications
 * News
 *   


 * About
 * Research
   * Therapeutic Engineering
   * Regenerative Engineering
   * Immunoengineering
   * Previous Projects
 * People
   * Lab Members
   * Alumni
 * Publications
 * News

Therapeutic Engineering Biomaterials Innovation and Translation Regenerative
Engineering Immunoengineering







 


THE LAB

Our mission is to develop and translate innovative technologies through
biomaterials design at the interface of nanoscience, engineering, biology, and
medicine to address the unmet critical needs in healthcare.

Our lab specializes in engineering nanomaterials for delivery of nucleic acid
and protein therapeutics, soft tissue regeneration, and immunoengineering.
Specifically, we aim to understand the structure-property-function relationship
of biomaterials and technology platforms to enhance their therapeutic efficacy
and develop new methods for scalable manufacturing and translation.

Learn MoreLearn More






OUR WORK

REGENERATIVE ENGINEERING

Nanofiber-Hydrogel Composite

THERAPEUTIC ENGINEERING

Kinetically-assembled Nanoparticles

IMMUNOENGINEERING

Artificial Lymph Node


15

Funded Projects

Learn MoreLearn More







We build upon the strong collaborative projects with top scientists and
clinicians at Hopkins and beyond. We are part of the Institute for
NanoBioTechnology (INBT) and Department of Materials Science and Engineering
located on the engineering campus, and the Translational Tissue Engineering
Center (TTEC) and Department of Biomedical Engineering located on the medical
campus. Our research has a strong translational focus and enjoys strong
collaborations with industry partners.

Learn MoreLearn More





NEWS

May 15, 2024


MAO LAB AT 2024 ASGCT ANNUAL MEETING

March 29, 2024


YINING ZHU WINS THE HANS J. PROCHASKA RESEARCH AWARD

December 14, 2023


PROF. HAI-QUAN MAO ELECTED TO THE RANK OF NATIONAL ACADEMY OF INVENTORS FELLOW

December 11, 2023


NANOPARTICLES AMPLIFY POTENTIAL CANCER VACCINE POWER

September 20, 2023


JOSEPH CHOY RECEIVES ROY B. ADAMS FELLOWSHIP AND DONALD S. RODBELL MEMORIAL
GRADUATE FELLOWSHIP

July 20, 2023


JESSICA STELZEL RECEIVES ARCS FOUNDATION SCHOLARSHIP

April 19, 2023


YINING ZHU RECEIVES STAR AWARD

April 3, 2023


JOSEPH CHOY WINS GRADUATE TEACHING ASSISTANT AWARD

March 31, 2023


CHRISTINE WEI RECEIVES NSF GRFP FELLOWSHIP

September 23, 2022


MOLECULAR DETECTION PLATFORM PROVIDES NEW INSIGHTS INTO GENE MEDICINE
MANUFACTURING

August 5, 2022


NEW SCREENING PLATFORM FOR UNCOVERING POTENT LIPID NANOPARTICLES TO DELIVER GENE
MEDICINE

June 30, 2022


NATALIE LIVINGSTON RECEIVES NIH F31 FELLOWSHIP AWARD

Read More NewsRead More News


SELECTED RECENT PUBLICATIONS

Zhu Y, Ma J, et al., Screening for lipid nanoparticles that modulate the immune
activity of helper T cells towards enhanced antitumour activity. Nat. Biomed.
Eng. 2023 Dec 11. PMID: 38082180.



Li L’, Yao ZC’, et al., A nanofiber-hydrogel composite improves tissue repair in
a rat model of Crohn’s disease perianal fistulas. Sci. Adv. 2023 Jan
4;9(1):eade1067. PMID: 36598982.

Li S’, Hu Y’, et al., Payload distribution and capacity of mRNA lipid
nanoparticles. Nat Commun. 2022 Sep 23; 13(1): 5561. PMID: 36151112.



Zhu Y, et al., Multi-step screening of DNA/lipid nanoparticles and co-delivery
with siRNA to enhance and prolong gene expression. Nat Commun. 2022 Jul 25;
13(1): 4282. PMID: 35879315.

Yao ZC, et al., Biostimulatory micro-fragmented nanofiber-hydrogel composite
improves mesenchymal stem cell delivery and soft tissue remodeling. Small. 2022
Sep;18(36):e2202309. PMID: 35948487.



Li L’, Zhang Y’, et al., Quaternary nanoparticles enable sustained release of
bortezomib for hepatocellular carcinoma. Hepatology. 2022 May 21. PMID:
35596926. [Cover]

Hanwright PJ’, Qiu C’, et al., Sustained IGF-1 delivery ameliorates effects of
chronic denervation and improves functional recovery after peripheral nerve
injury and repair. Biomaterials. 280: 121244. 2021. PMID: 34794826.



Hu Y’, Zhu Y’, et al., Size-Controlled and Shelf-Stable DNA Particles for
Production of Lentiviral Vectors. Nano Lett. 21(13): 5697-5705 (2021). PMID:
34228937.

Hu Y, et al., Liter-scale manufacturing of shelf-stable plasmid DNA/PEI
transfection particles for viral vector production. Mol. Ther. Methods Clin.
Dev. 32(1): 101194 (2024).



Hu Y, et al., Kinetic control in assembly of plasmid DNA/polycation complex
nanoparticles. ACS Nano. 13 (9): 10161–10178 (2019). PMID: 31503450.

Li X, Cho B, et al., Nanofiber-hydrogel composite-mediated angiogenesis for soft
tissue reconstruction. Sci. Transl. Med. 2019; 11(490). pii: eaau6210. PMID:
31043572.



Hickey JW, et al., Engineering an artificial T-cell stimulating matrix for
immunotherapy. Adv. Mater. 2019 Apr 10: e1807359. PMID: 30968468 [Cover].

View PublicationsView Publications



JOIN OUR TEAM!

Apply NowApply Now



Our mission is to develop and translate innovative technologies through
biomaterials design to address the unmet critical needs in healthcare.


MAO LAB ON HOMEWOOD CAMPUS

Shaffer Hall 200F (Office)
Croft Hall 330 (Lab)
INBT
3400 N. Charles St.
Baltimore, MD 21218
(410) 516-3883 (INBT Lab)

MAO LAB ON MEDICAL CAMPUS

Smith Building 5015 (Office)
Smith Building 5002-J (Lab)
TTEC
400 N. Broadway
Baltimore, MD 21287
(410) 502-1297 (TTEC Lab)
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