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About The Aging, Dementia and TBI Study


AGING, DEMENTIA AND TRAUMATIC BRAIN INJURY STUDY

The Aging, Dementia and Traumatic Brain Injury Study is a detailed
neuropathologic, molecular and transcriptomic characterization of brains of
control and TBI exposure cases from a unique aged population-based cohort from
the Adult Changes in Thought (ACT) study.




CONSORTIUM MEMBERS



The Aging, Dementia and Traumatic Brain Injury Study was developed by a
consortium consisting of the University of Washington, Kaiser Permanente
Washington Health Research Institute and the Allen Institute for Brain Science.




FUNDING SUPPORT



The study was supported by the Paul G. Allen Family Foundation (PIs: Richard
Ellenbogen and C. Dirk Keene, University of Washington; PI: Eric Larson, Kaiser
Permanente Washington Health Research Institute; and PI: Ed Lein, Allen
Institute for Brain Science).




ADDITIONAL DATA IN THE ACT STUDY AND HOW TO ACCESS IT



The ACT study is a longitudinal population-based prospective cohort study of
brain aging and incident dementia in the Seattle metropolitan area. ACT is a
repository at the Kaiser Permanente Washington Health Research Institute, which
has established policies and procedures for sharing data with external
investigators. Data available from this study web site do not require any
additional Institutional Review Board (IRB) approval or permissions. Linking
those data with other ACT study or Kaiser Permanente Washington data would
require additional review. All of those steps are initiated after contacting
KPWA.actproposals@kp.org.



Data Overview

The Aging, Dementia and Traumatic Brain Injury Study includes the following data
sets:



 * Histology and immunohistochemistry (IHC): Image data and quantitative image
   metrics to assess β-amyloid, tau, and α-synuclein pathologies as well as the
   overall local pathological state of tissue samples from each donor.

   

   

 * In situ hybridization (ISH): High-resolution ISH image data of six canonical
   marker genes for astrocytes, oligodendrocytes, and neuronal subtypes in
   parietal cortex, temporal cortex, and hippocampus.

   

   

 * RNA-Seq: RNA sequencing data for temporal cortex, parietal cortex, cortical
   white matter, and hippocampus isolated by macrodissection.

   

   

 * Protein quantification by Luminex: Luminex assays to assess protein levels of
   neuropathological and immune system targets, complementing measurements from
   traditional antibody-based (IHC) methods.

   

   

 * Isoprostane quantification: Gas chromatography mass spectrometry (GC/MS)
   quantitation of isoprostanes to measure oxidative stress and to assess free
   radical injury.

   

   

 * Specimen metadata: De-identified clinical data (including Alzheimer’s
   disease, dementia, and TBI diagnoses) for each case.

   

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