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SMYD2-METHYLATED PPARΓ FACILITATES HYPOXIA-INDUCED PULMONARY HYPERTENSION BY
ACTIVATING MITOPHAGY

[Circulation Research] Pulmonary hypertension (PH) animal models were generated
by treating mice/rats with chronic hypoxia for four weeks. SMYD2-vTg mice or
wild-type rats and mice treated with LLY-507 were used to investigate the
function of suppressor of variegation, enhancer of zeste, trithorax and myeloid
Nervy DEAF-1 domain-containing protein 2 (SMYD2) on PH development in vivo.
Muscle Cell NewsNewsletters
May 21, 2024
Read more...


PI3K/HSCB AXIS FACILITATES FOG1 NUCLEAR TRANSLOCATION TO PROMOTE ERYTHROPOIESIS
AND MEGAKARYOPOIESIS

[eLife] Investigators identified heat shock cognate B as an indispensable
protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis
of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs,
as well as during megakaryopoiesis of the CD34+CD90+HSCs.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


EVIDENCE META-ANALYSIS: EVALUATING MINIMAL RESIDUAL DISEASE AS AN INTERMEDIATE
CLINICAL ENDPOINT FOR MULTIPLE MYELOMA

[Blood] This meta-analysis was based on the FDA guidance for considerations for
a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and
evaluates MRD-negativity as an early endpoint reasonably likely to predict
long-term clinical benefit.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


RUNX1 C-TERMINAL MUTATIONS IMPAIR BLOOD CELL DIFFERENTIATION BY PERTURBING
SPECIFIC ENHANCER-PROMOTER NETWORKS

[Blood Advances] Researchers characterized RUNX1 mutations outside of the runt
homology domain. Their analysis of the patient data sets revealed that mutations
within the C-terminus frequently occur in hematopoietic disorders.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


BRG1/BRM INHIBITOR TARGETS AML STEM CELLS AND EXERTS SUPERIOR PRECLINICAL
EFFICACY COMBINED WITH BET OR MENIN INHIBITOR

[Blood] Investigators showed that FHD-286 induced differentiation and lethality
in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing
perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.
Cancer Stem Cell NewsHematopoiesis NewsNewsletters
May 21, 2024
Read more...


THE GLUTAMINASE INHIBITOR CB-839 TARGETS METABOLIC DEPENDENCIES OF JAK2-MUTANT
HEMATOPOIESIS IN MPN

[Blood Advances] Scientists showed that CB-839 strongly reduced the
mitochondrial respiration rate of bone marrow cells from JAK2-V617F mutant mice,
demonstrating a marked dependence of these cells on glutamine-derived ATP
production.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


SDHAF1 CONFERS METABOLIC RESILIENCE TO AGING HEMATOPOIETIC STEM CELLS BY
PROMOTING MITOCHONDRIAL ATP PRODUCTION

[Cell Stem Cell] Researchers reported that HSCs acquired metabolic resilience
that promoted cell survival. High-resolution real-time ATP analysis with glucose
tracing and metabolic flux analysis revealed that old HSCs reprogrammed their
metabolism to activate the pentose phosphate pathway.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


BIOLOGICAL RELEVANCE OF ALTERNATIVE SPLICING IN HEMATOLOGIC MALIGNANCIES

[Molecular Medicine] Investigators provide an extensive overview of the
biological relevance of aberrant isoforms of genes involved in the regulation of
apoptosis, activation of key cellular signaling pathways, and cell metabolism.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


DIPERSIO RECEIVES INNOVATION AWARD

[Washington University School of Medicine in St. Loui] John F. DiPersio has
received the Chancellor’s Award for Innovation and Entrepreneurship for his
research contributions to the field of oncology that are paving the way for
novel cancer therapies.
Hematopoiesis NewsNewsletters
May 21, 2024
Read more...


MESENCHYMAL STROMAL CELLS PROTECT TISSUES FROM TH1 IMMUNE RESPONSES VIA IL-11
SECRETION

[FASEB Journal] In vitro culture assays demonstrated that MSCs suppressed the
activation and function of CD4+ T cells by secreting interleukin 11, and
neutralization of IL11 abrogated MSC-mediated suppression of CD4+ T cell
function.
Mesenchymal Cell NewsNewsletters
May 21, 2024
Read more...


HMGA1 REGULATES TRABECTEDIN SENSITIVITY IN ADVANCED SOFT-TISSUE SARCOMA (STS): A
SPANISH GROUP FOR RESEARCH ON SARCOMAS (GEIS) STUDY

[Cellular and Molecular Life Sciences] The prognostic/predictive value of HMGA1
expression was assessed in a cohort of 301 STS patients at mRNA and protein
level, by HTG EdgeSeq transcriptomics and immunohistochemistry, respectively.
Mesenchymal Cell NewsNewsletters
May 21, 2024
Read more...


LINEAGE-SPECIFIC MESENCHYMAL STROMAL CELLS DERIVED FROM HUMAN IPSCS SHOWED
DISTINCT PATTERNS IN TRANSCRIPTOMIC PROFILE AND EXTRACELLULAR VESICLE PRODUCTION

[Advanced Science] A stepwise human induced pluripotent stem cells-to-MSCs
differentiation method was employed via intermediate cell stages of neural crest
and cytotrophoblast to generate lineage-specific MSCs with varying
differentiation efficiencies and gene expression.
Mesenchymal Cell NewsNewsletters
May 21, 2024
Read more...
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