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Experience Charles River Laboratories

Boldly challenge scientific possibility.


A position of responsibility

Bringing and sustaining vital drugs to market safely, and as quickly as
possible.

20,000+

Employees working across 100+ facilities in over 20 countries

100%

Renewable electricity expected globally by 2030

See how our purpose-driven Environmental, Social and Governance (ESG) strategies
empower and drive us.

View our commitment

4,000+

Employees in 11 dedicated global resource groups (18% of our employees), helping
to foster diversity, equity, inclusion and belonging.

53%

Women representation as managers and 42% of our executive leaders (VP+) are
women – globally

Learn about our commitment to creating a workplace where everyone can succeed
and thrive, and how it enables us to deliver the highest quality each day.

Explore our culture

$300M

US investment goal over the next five years across technology innovations,
partnerships, and advocacy efforts to drive industry-wide adoption of
alternatives.

70+

Years of innovation in responsibly advancing refinement, reduction, and
replacement of animals in research.

Learn about our dedication to the pursuit of scientific and technological
innovation to develop alternatives to animals in testing.

Learn about our responsibility

80%

Of the FDA-approved drugs over the past five years were worked on by Charles
River

1,500

IND studies supported in the last 12 months

Listen to the stories behind the bold science from those developing and
receiving life-changing therapies.

Explore the Vital Science Podcast
Corporate Citizenship

Diversity, Equity, Inclusion

Alternative Methods Advancement Project

Stories of Science



HOPE FOR THE FUTURE

When it comes to neurodegenerative diseases, patients and their families desire
one thing above all: more time. At Charles River, we are driven to partner with
Disruptors fighting every day to unlock the secrets of the brain.

Meet the Disruptors

News and Insights

View All

FEATURED STORY

Ask the Scientist: Antigen-Specific T Cells | Charles River

Trained assassins of the immune system-how these antigen-experience T cell wax
and wane over time, and why they are important in cell therapy.

FEATURED MODEL

JAX® Mice from Charles River Europe

FEATURED WEBINAR

Selecting the Optimal In Vivo Platform for Oncology Drug Development

FEATURED STORY

New Frontiers in Animal Research | Charles River

FEATURED WEBINAR

A Charles River-Hosted JAX® Webinar: Comparing Mouse Models for Metabolic
Disease – Diabetes, Obesity, and NASH





THIS IS YOUR MOMENT

Our people are the heart of our organization. Their passion and skills are
critical to our success and achieving our purpose of creating healthier lives.
We strive to create a culture of inclusion, continuous learning, and wellbeing
for our people from day one.

Join our team


Events and Training

View all

Aug 05 - 09, 2024 | Amsterdam, Netherlands | Conference

IASP 2024 World Congress on Pain

Join Charles River at IASP’s World Congress on Pain from August 5-9 in
Amsterdam, Netherlands. IASP brings together more than 5,000 scientists,
clinicians, and healthcare providers from around the world and across pain
disciplines.

Aug 07, 2024| Durham, NC | Conference

PDA Southeast Chapter 2024 Vendor Showcase

Sep 09 - 11, 2024 | Carlsbad, CA | Symposium

Biotech Symposium 2024

Sep 10 - 11, 2024 | Philadelphia, PA | Symposium

8th Annual Viral Safety and Viral Clearance Summit

Sep 15 - 18, 2024 | Honolulu, HI | Conference

North American ISSX and 39th JSSX Meeting

Sep 17 - 20, 2024 | Boston, MA | Conference

2024 CAR-TCR Conference





SUPPORTING THE FULL DRUG DISCOVERY
AND DEVELOPMENT CONTINUUM

NO MATTER WHERE YOU ARE IN YOUR DRUG DEVELOPMENT JOURNEY, WE CAN PROVIDE YOU
WITH A WIDE RANGE OF PRODUCTS, MODELS, SERVICES AND GUIDANCE THAT ARE TAILORED
TO YOUR SPECIFIC NEEDS.

Basic ResearchDiscoveryPreclinical TestingClinical DevelopmentManufacturing and
CommercializationScientific and Regulatory Guidance

BASIC RESEARCH

Basic research is the foundation of all scientific breakthroughs, improving our
understanding of biology and advancing our knowledge of the life sciences. From
an expansive selection of research animal models and human-derived products to
the management of genetically modified models and health surveillance, your next
breakthrough starts here.

Explore the Portfolio

Research Models and Services

Support your basic research with help from the leading global supplier of
laboratory animal models and services.

Human Immune and Stem Cells

The leading developers of cutting-edge cell therapies and basic research trust
us as their cell sourcing provider.

Genetically Engineered Animals and Services

Genetically Engineered Animal Models and Services (GEMS) team helps you select,
customize, and maintain the right mice for your research. Services for
genetically engineered animals include mouse and rat model creation, breeding,
genotyping, and mouse embryo and sperm cryopreservation.

DISCOVERY

Drug discovery is a challenging journey. Too often, a novel compound’s road to
market is delayed – or blocked entirely – by limited resources or expertise.
With a comprehensive multi-modality discovery service portfolio and a staff of
hundreds of scientists, we have the scientific excellence and technological
capabilities to support our clients throughout the drug development life cycle.

Discover the Offerings

Integrated Drug Discovery

Reduce time to clinic by up to a year with an integrated drug discovery approach
in which target discovery, hit id, hit-to-lead, lead optimization, safety, and
toxicology are all managed by the same project team.

Discovery Pharmacology Studies

In vitro to in vivo translation is difficult, costly, and often fails. Advance
your discovery research with our translationally focused approach across a range
of therapeutic areas including oncology, neuroscience, and immunology.

Antibody Discovery Services

Antibody discovery services designed with your IND in mind. Comprehensive
solutions, tailored to your unique vision for your next antibody therapeutic.

PRECLINICAL TESTING

Determining a drug’s safety profile is perhaps one of the most critical stages
of the drug development pathway. Complications and inefficiencies with
preclinical studies can create costly delays. Using state-of-the-art
technologies in a global network of facilities, our skilled scientists execute
individual studies and custom testing programs that are designed with a client’s
goals in mind.

Learn What’s Possible

Non-GLP Integrated Toxicology

Two primary study offerings are available for non-GLP toxicology studies for
lead optimization and preclinical development.

IND-enabling Programs

Successfully initiate and complete your IND-enabling program while meeting
regulatory expectations with our unique range of IND-enabling studies.

Carcinogenicity Studies

Our carcinogenicity studies include expert support in project design, model
selection, and in vivo and ex vivo data for final submission.

CLINICAL DEVELOPMENT

Clinical trials are an exciting stage of drug development, representing the
fruition of years of hard work. By working with our scientists, you can ensure
cost-effective execution and front-load clinical timelines as early as the
preclinical phase.

Find Out More

Biologics Testing Solutions

Our tailored global testing and manufacturing services support clients
throughout the biologic development cycle, from discovery through preclinical
and clinical studies to marketed product release.

Biologics Contract Manufacturing

Accelerate the development of your biopharmaceutical from concept to cure with
our CGMP compliant biologics contract manufacturing services. 

RightsourceSM – Biologics Insourcing Solutions

A flexible testing platform that can be deployed where and when you need it,
whether it’s located at your facility, one of our satellite labs, or even within
the walls of the many Charles River facilities itself.

MANUFACTURING AND COMMERCIALIZATION

Our development, manufacturing, and testing support services enable our clients
to produce safe and compliant products. Our scientists, technicians, and expert
support teams can provide the insight, advice, and tools needed to streamline
the manufacture and release of safe products for patients in need.

Get the Details

Cell and Gene CDMO Solutions

Fastrack your cell and gene development and manufacturing with our end-to-end
scalable solutions from early stage-research and testing through commercial
release.

Biologics Testing and Manufacturing Solutions

Navigate seamlessly throughout the biologic development cycle, from early
concept to market-ready with our tailored, CGMP global testing and manufacturing
solutions.

Microbiology Quality Control Solutions

Elevate your contamination control strategy and accelerate production with
confidence. Our rapid, accurate, and compliant microbial testing solutions
optimize your QC workflow.

SCIENTIFIC AND REGULATORY GUIDANCE

Navigating the changing regulatory landscape is an ongoing challenge for many
involved in the development, approval, and manufacture of pharmaceuticals and
medical devices. We've built a unique global team of scientific advisors whose
expertise spans various drug modalities, therapeutic areas, and key stages in
the drug development process.

Meet the Experts

One Step Manufacturing

One Step by Charles River is a comprehensive, tailored suite of CRO drug
discovery and development services in target discovery, lead optimization,
development chemistry, GMP, drug product development and CMC strategy.

Fast Lane

Expedite your investigational new drug (IND) application with Fast Lane
Paradigm. Learn how to reduce white space between studies and accelerate time to
clinic for you INDs.

IND-Enabling Studies Toolbox

Charles River can conduct an investigational new drug (IND) study from start to
finish, and offers stand-alone studies needed for IND-enabling submissions. Our
IND experts have expertise in all major therapeutic areas, including medical
devices and gene and cell therapies.

Stay Connected

Keep up with the latest news and insights.



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