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<form action="decline-acknowledgement-confirmation.php" class="form-horizontal" method="post">
  <h4 class="m-b-10">Reason for Declining the Review Request:</h4>
  <div id="progressbarwizard" class="pull-in col-md-10">
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            <input type="hidden" id="au" name="au" value="75348567"><input type="hidden" id="Camp" name="Camp" value="105847"> <input type="radio" name="feedback" id="Unavailability_of_time" value="Unavailability of time" required="true">
            <label for="Unavailability_of_time">Unavailability of time</label>
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            <input type="radio" name="feedback" id="Article_is_out_of_expertise" value="Article is out of expertise">
            <label for="Article_is_out_of_expertise">Article is out of expertise</label>
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            <label for="decline_check"> I confirm that I must decline your invitation this time around because of the above reason </label>
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</form>

Text Content

CURRENT ALZHEIMER RESEARCH


 * Agree to Review
 * Declined to Review
 * Unsubscribe from the List




PEER REVIEW REQUEST - DECLINE CONFIRMATION


BMS-CAR-2024-297

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Article Title:
CSF Growth Associated Protein-43 and Brain atrophy in Mild Cognitive Impairment:
A cross sectional and longitudinal study
Abstract:
BACKGROUND: To diagnose and treat Alzheimer's disease (AD) in its initial stages
is the main goal of recent AD studies. Cerebrospinal fluid growth associated
protein (GAP)-43 has been proposed as a potential biomarker for AD and an
indicator of synaptic degeneration. OBJECTIVE: We aimed to find out whether CSF
GAP-43 is associated with brain atrophy and if it differs between mild cognitive
impairment and cognitive normal subjects. METHODS: We examined 22 cognitive
normal subjects and 29 mild cognitive impairment subjects enrolled in the
Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We evaluated subjects
brain atrophy rates using tensor-based morphometry-symmetric diffeomorphic image
normalization method (TBM-SyN) which demonstrates annual brain atrophy rates and
CSF GAP-43 levels. Data were analyzed in three time points: baseline, 24 and 48
month follow up. RESULTS: TBM scores and GAP-43 levels did not differ
significantly between the CN and MCI groups at any time point. However,
significant changes in TBM scores were observed over time in both groups. A
significant negative correlation between TBM scores and GAP-43 levels was found
in the CN group at baseline and at 48 months but this correlation was not
present in the MCI group. Mixed-effects models revealed significant associations
between time points and TBM scores, with no significant interaction involving
GAP-43. CONCLUSIONS: GAP-43 levels correlate with TBM scores in CN individuals
but not in those with MCI. Further studies are needed to validate its role in
tracking cognitive decline in MCI.

REASON FOR DECLINING THE REVIEW REQUEST:

Choose Reason:
Unavailability of time
Article is out of expertise


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I confirm that I must decline your invitation this time around because of the
above reason


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IF YOU WISH TO RECOMMEND ANYONE WHO COULD REVIEW THIS MANUSCRIPT, THEN PLEASE
PROVIDE THE DETAILS AS FOLLOWS:

I would like to suggest the reviewer for this manuscript

  SUGGESTED REVIEWER'S CONTACT DETAILS:

First Name:

Last Name:

Affiliation:

Country:

Email Address:


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