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AboutOur ProductsContactDownload Catalog





THE GLOBAL LEADER IN HIGH-QUALITY SPF PRODUCTS AND SERVICES

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INNOVATIVE PROVIDER OF BIOPROCESSING MATERIALS, LABORATORY PRODUCTS, AND
DIAGNOSTIC SERVICES THAT SUPPORT BIOLOGIC DEVELOPMENT AND MANUFACTURING  

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UNRIVALED COMMITMENT TO QUALITY, BIOSECURITY, AND RELIABILITY

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INTRODUCING AVS BIO

After 30 years of operation as a subsidiary of Charles River Laboratories, AVS
Bio is now an independent company


ABOUT AVS BIO

 * We are the world’s largest and most trusted producer of Specific Pathogen
   Free (SPF) eggs and adjacent laboratory products and services for the
   development and manufacture of biologics
 * We are committed to quality, biosecurity, and scientific innovation and have
   set the standard for our industry for over five decades
 * We are dedicated to the relentless improvement and expansion of our offerings
   to meet the evolving needs of our dynamic customer base across both human and
   animal health markets




KEY FACTS & FIGURES

60+
Years of Experience
1Bn+
SPF Eggs Produced Since Inception
40+
US Production Houses
24
Years Licensed by USDA
2020
Supported Our First IgY Clinical Study
200+
Employees


OUR PROJECT EXPERIENCE & CAPABILITIES

We provide our customers with a broad range of products and services to address
their development and large-scale manufacturing needs. We supply leading
manufacturers with critical bioprocessing inputs, including SPF eggs, antigens,
and cell products. In addition, we offer numerous diagnostic testing and
manufacturing support services, including virus propagation and isolation,
custom cell production, and quality control testing. We also support the
development of new therapeutics by providing antibodies such as IgY for use in
clinical trials.


OUR PRODUCTS & SERVICES


SPF EGGS


SPECIFIC PATHOGEN FREE CHICKEN (SPF) EGGS

AVS Bio provides specific pathogen free (SPF) chicken eggs for use in veterinary
and human vaccine production.

We produce SPF chicken eggs through the use of filtered-air positive-pressure
(FAPP) poultry housing, critical biosecurity measures and the careful selection
of layer flocks. Validated biological assays are utilized to confirm the SPF
status of every flock and compliance with USDA memorandum 800.65 and European
Pharmacopoeia 5.2.2 guidelines. A quality control sheet documenting this status
accompanies each product shipment. This high degree of quality control and
technical expertise is continued through product processing, packing and
shipping.

SPF EGG QUALITIES

We offer three quality levels of SPF chicken eggs:

 * Research: Tested for 32 agents
 * Premium Plus: Tested for all Research-grade agents except endogenous gs
   antigen
 * Premium: Tested for all Research-grade agents except endogenous gs antigen
   and chicken anemia virus


PRIMARY CELLS


CHICKEN CELL PRODUCTS

Cell viability and virus contamination are enormous concerns when you need
pristine cell products in your drug research and manufacturing process. AVS Bio
alleviates those concerns by providing you with the industry standard for
tightly monitored, quality tissue culture cell products.

PRIMARY CHICKEN EMBRYO CELLS

We routinely prepare small and bulk production lots of chicken embryo
fibroblasts (CEF), chicken embryo kidney cells (CEKC), chicken embryo liver
cells (CELC) and chicken embryo dermal cells (CED). Custom cell preparations are
also available.

Cells are prepared fresh daily to order using our SPF chicken embryos and media
containing irradiated serum from countries with a negligible risk of bovine
spongiform encephalopathy (BSE). We offer three quality groups of cells:
standard, chicken anemia virus (CAV) negative, and CAV-negative group-specific
(GS) antigen-free cells which are C/O and not resistant to any of the Avian
Leukosis Virus subgroups.

Standard Cells
Material #*
Fibroblasts
10100795
Kidney Cells
10100797
*400 million cells or greater per 50 ml vial.

CAV-Negative Cells
Material #*
Fibroblasts*
10100795
Kidney Cells*
10100797
Dermal Cells**
10100797
NOTE: Flock source is CAV-negative.
*400 million cells or greater per 50 ml vial.
**1 billion cells or greater per 125 ml vial. Requires a 2 week notice prior to
ship date.

CAV-Negative GS Antigen-Free Cells
Material #*
Fibroblasts (Formerly Genetic Specific)
10100808
Kidney Cells (Formerly Genetic Specific)
10100811
Liver Cells (Formerly Genetic Specific)
10100814
NOTE: Flock source is CAV-negative.
*400 million cells or greater per 50 ml vial.
**1 billion cells or greater per 125 ml vial. Requires a 2 week notice prior to
ship date.



PREPARATION OF CELLS


PROTOCOL FOR HARVESTING AND PREPARING CHICKEN EMBRYO CELLS

Cells are prepared where only tissue culture media and cell preparation are
performed and employee access is restricted. Cells are prepared under Class A
laminar flow hoods using aseptic technique throughout the harvesting process.
Batch records for all the steps in the process, including cell batch records,
documentation of the sources, media components and cell performance/viability,
are maintained. After the cells are harvested, a sample is seeded into tissue
culture flasks and maintained for 48 hours to verify cell performance. A sample
of the cells is also taken, plated onto blood agar and then incubated for 48
hours. The plates are checked after 24 and 48 hours of incubation. Checking
after 24 hours assures that bioburden is not likely present before our customers
receive the cells. If a bioburden issue occurs, customers are notified
immediately.


TISSUE CULTURE MEDIA


Basal Medium Eagle (BME) containing irradiated fetal calf serum (FCS) and/or
newborn calf serum (NBCS) sourced from negligible risk BSE countries. Sold in 1L
quantities as 2 x 500 ml. Custom media is also available upon request.
Media Type
Material #*
2.5% (2.5% FCS; for use with CEF)
10100802
5% (1% FCS & 4% NBCS; for use with CEF)
10100799
8% (2% FCS & 6% NBCS; for use with CEK & CEL)
10100801


EGG YOLK ANTIBODIES


CHICKEN IGY ANTIBODIES


AVS Bio offers a standard three-hen, 100-egg chicken immunoglobulin Y (”IgY)
product and can customize procedures and egg yolk quantities to meet your needs.

IMMUNOGLOBULIN APPLICATIONS

Immunoglobulins have been used in applications from diagnostic assays to
therapeutics. The most widely used immunoglobulin, IgG, is derived from mammals.
Chickens, however, produce a slightly different antibody, IgY, which contains a
longer Fc region.
The greater evolutionary distance between chickens and mammals makes chickens an
attractive source of antibody production. Chickens do not recognize mammalian
proteins as “self”. Therefore these “self” proteins become more immunogenic,
leading to an increased antibody diversity in chickens compared to the mammalian
host. Therefore, if you want to increase your diagnostic assay's sensitivity to
mammalian host cell proteins (HCPs), IgY antibody is an ideal reagent to use.
There are also benefits of using IgY for prophylactic and therapeutic
non-systemic applications. IgY does not activate the mammalian complement, react
with rheumatoid factors, or bind to mammalian Fc receptors. In addition, due to
the stability of IgY at low pH conditions, it can be used to combat
gastrointestinal infections.
We have been involved in developing gastrointestinal treatments using IgY in
agriculture and respiratory treatments to prevent COVID-19.

WHY USE SPECIFIC PATHOGEN FREE (SPF) HENS FOR YOUR IGY ANTIBODY PRODUCTION?

Our hens are kept in filtered-air, positive-pressure rooms with strict
biosecurity. Hens under these conditions have a naïve immune system, which
allows them to ramp up IgY production quickly compared to commercial layers. SPF
hens are also free of pathogens as listed under United States Department of
Agriculture (USDA) and European Pharmacopeia (Ph. Eur.) guidelines leading to
less risk of contamination in your product.

CHICKEN IGY ANTIBODY PRODUCTION PROCESS

Our standard chicken IgY antibody production process includes three SPF hens per
customer supplied antigen. One hundred eggs are collected over a three-month
period. Pre-immune blood samples are tested on ELISA and Western Blot before
each bird is inoculated with antigen. Boosts and serum sampling occur every
other week until week six, when egg collection begins. Then, boosts and serum
sampling continue every two weeks, and the yolks are separated from the eggs and
frozen weekly basis until 100 yolks in total are processed. IgY antibody
extraction occurs via water dilution and pH change and is concentrated and
bottled for shipment on dry ice.

CHICKEN IMMUNIZATION STRATEGY


3R IMPACT

SPF chickens are efficient producers of immunoglobulin Y antibodies and a single
egg yolk can generate 100-200 mg of IgY; to put it into perspective, one hen can
produce the equivalent in one month quantity of antibodies in their eggs as a
goat. This fits perfectly into the principles of the 3Rs (Replacement,
Reduction, and Refinement).


HUMAN INFLUENZA  & SENDAI VIRUS

AVS Bio offers human influenza type A and B viruses, and Sendai virus (Cantell
strain), supplied as allantoic fluid and sucrose gradient-purified. We also
provide virus preparations with customer-supplied Biosafety Level 1 and 2
viruses. Viruses are grown in specific-pathogen-free (SPF) embryonated eggs and
final preparations can be delivered in crude (bulk fluids), concentrated,
fractioned, or purified forms. Click here for additional information about our
Human Influenza virus preparations.
Chicken serum antibodies to Influenza A/PR/8/34 and Sendai Cantell are readily
available. These are prepared in our SPF chickens raised under strict
biosecurity and HEPA-filtered air under positive pressure (FAPP) rooms.


HUMAN INFLUENZA TYPE A AND B STRAINS

 * Influenza A/PR/8/34 (H1N1)
 * Influenza A X-31, A/Aichi/68 (H3N2)
 * Influenza A/Victoria/3/75 (H3N2)
 * Influenza A/Hong Kong/8/68 (H3N2)
 * Influenza B/Lee/40
 * Customer-Supplied Virus

HUMAN INFLUENZA TYPE A AND B STRAINS

We provide expert support to help propagate and process influenza strains for
your research or diagnostic kit production.


SENDAI VIRUS (CANTELL STRAIN)

The original virus was obtained from American Type Culture Collection (ATCC),
product code VR-907, identified as Parainfluenza 1, Sendai/Cantell strain. It
was passaged several times by inoculating the virus into the chorioallantoic sac
of 9 to 11 day-old embryonated SPF chicken eggs. Virus is supplied as sterile,
clarified allantoic fluid at a minimum titer of 2000 HA units/ml, or purified to
2 mg/ml.


AVIAN ANTIGENS & ANTISERA

AVS Bio offers a comprehensive portfolio of antisera and antigen reagents, which
are available in liquid and lyophilized aliquots for most common poultry
pathogens.


AVIAN ANTIGENS

Biological preparations of common poultry pathogens prepared in specific
pathogen free (SPF) premium eggs, cell cultures or artificial media are
available in a variety of forms, such as tissue homogenates, concentrates and
allantoic fluid. All reagents are tested for potency, verified for specificity
and can be used for applications such as agar gel immunodiffusion, HI, VN, SN,
and many others.

AVIAN ANTIGENS

Agent
Strain
Material
Avian Adenovirus Group I (specify Serotype)
Serotypes 1-12*
TC
Avian Adenovirus Group I Type 1*
CELO-Phelps
AF
Adenovirus Group I Type 1*
CELO-Phelps
AC
Avian Adenovirus Group II (HEV)
Domermuth
SPH
Avian Adenovirus Group III (EDS-76)
CLKK115D
AF/I
Avian Encephalomyelitis
van Roekel
BH
Avian Encephalomyelitis
van Roekel
AC
Avian Influenza Type A (H9N2)
Turkey/Wis/66
AF
Avian Influenza Type A
Turkey/Wis/66
CAM/H/I
Avian Influenza Type A (H9N2)
Turkey/Wis/66
AF/I
Avian Leukosis - Subgroup J
Hc-1
TC
Avian Nephritis Virus
Serotypes 1-12*
TC
Avian Paramyxovirus Type 2
Yucaipa
AF
Avian Paramyxovirus Type 3
61/PMV/Wis/68
AF
Avian Reovirus
S1133
CAMH
Avian Reovirus
S1133
TC
Avian Rotavirus
Ch-2
AC
Chicken Anemia Virus
CL-1
TC
Chicken Anemia Virus
CL-1
SS
Fowl Pox
Connecticut
CAMH
Infectious Bronchitis
Arkansas 99
AC/I
Infectious Bronchitis
Arkansas
AF
Infectious Bronchitis
Beaudette (Massachusetts)
AF
Infectious Bronchitis
Connecticut A5968
AF
Infectious Bronchitis
Connecticut A5968
AC/I
Infectious Bronchitis
DE-072
AC/I
Infectious Bronchitis
DE-072
AF
Infectious Bronchitis
JMK
AC/I
Infectious Bronchitis
JMK
AF
Infectious Bronchitis
Massachusetts 66579
AC/I
Infectious Bursal Disease, Serotype 1
M4040 (2512)
BURH
Infectious Bursal Disease, Serotype 1
M4040 (2512)
AF
Infectious Bursal Disease, Serotype 1
M4040 (2512)
TC
Infectious Laryngotracheitis
Cover
AF
Infectious Laryngotracheitis
Cover
AC
Marek’s Disease
SB-1
AC
Mycoplasma Gallisepticum**
A5969
WO
Mycoplasma Gallisepticum
A5969
SA
Mycoplasma Meleagridis
NA
SA
Mycoplasma Synoviae**
WVU1853
WO
Mycoplasma Synoviae
WVU1853
SA
Newcastle Disease
LaSota
AF
Newcastle Disease
LaSota
AC/I
Newcastle Disease
LaSota
AF/I
Pullorum
Polyvalent
SA
Reticuloendotheliosis
T
TC
Reticuloendotheliosis
T
AC
Rous Sarcoma Virus A
RSV(RAV)-A
TC
Rous Sarcoma Virus B
RSV(RAV)-B
TC
*American Association of Avian Pathologists
**Restoring Buffer (30% glycerin) supplied at no additional charge when
purchasing MG or MS antigen. Material #10100705 for $15.00/ml if sold
separately.

Legend for Material Abbreviations
AC = Antigen Concentrate
TC = Tissue Culture
BURH = Bursal Homogenate
SA = Stained Antigen
CAMH = Chorioallantoic Membrane Homogenate
BH = Brain Homogenate
WO = Whole Organism
SS = Spotted Slides
AF = Allantoic Fluid
I = Inactivated
SPH = Spleen Homogenate



AVIAN ANTISERA

Monospecific polyclonal antisera are produced in our CAV-negative SPF chickens.
The birds used in the production of antiserum are housed in filtered-air
positive-pressure (FAPP) barrier facilities. The birds are monitored to optimize
antibody levels and to ensure the best product possible. Our standardized
antisera are produced to obtain high levels of neutralizing activity, but also
have been used for other laboratory applications, such as immunodiffusion,
hemagglutination inhibition (HI) and immunoblotting. More than 40 tests are
performed on each antiserum, and a quality control sheet is provided that
confirms specificity.
AVS Bio offers the following liquid and lyophilized avian antisera in various
aliquots (e.g., 1 ml, 5 ml, 10 ml, 50 ml, 100 ml).
 * Avian Adenovirus Group 1 Type 1
 * Avian Adenovirus Group 1 Type 3
 * Avian Adenovirus Group 1 Type 5
 * Avian Adenovirus Group II (HEV)
 * Avian Adenovirus Group III (EDS) – polyclonal antibody
 * Avian Encephalomyelitis
 * Avian Influenza (T/W/66) – H9N2
 * Avian Influenza (H5N2)
 * Avian Leukosis Subgroup J
 * Avian Leukosis RSV-A
 * Avian Leukosis RSV-B
 * Avian Nephritis Virus
 * Avian Paramyxovirus Type 2
 * Avian Paramyxovirus Type 3
 * Avian Pneumovirus
 * Avian Reovirus
 * Avian Rotavirus
 * Chicken Anemia Virus
 * Fowl Pox
 * Infectious Bronchitis (Ark.)
 * Infectious Bronchitis (Conn.)
 * Infectious Bronchitis (DE-072)
 * Infectious Bronchitis (JMK)
 * Infectious Bronchitis (Mass.)
 * Infectious Bursal Disease (Standard)
 * Infectious Bursal Disease (Variant E)
 * Infectious Laryngotracheitis
 * Marek’s Disease
 * Mycoplasma Gallisepticum
 * Mycoplasma Meleagridis
 * Mycoplasma Synoviae
 * Negative Serum
 * Newcastle Disease
 * Reticuloendotheliosis


MYCOPLASMA & PULLORUM PLATE ANTIGENS

Flocks must be continually monitored for Mycoplasma and Salmonella pullorum to
reduce the risk of disease transmission to other poultry populations. AVS Bio
makes it easier for you to safeguard your flocks and to satisfy regulatory
authorities by offering: an antigen portfolio backed by years of dependable
production; step-by-step tests that are quick, simple and easy to read;
USDA-licensed plate antigens; and all reagents for the plate agglutination test
(MG, MM, MS, Salmonella pullorum), including control sera.


USDA-LICENSED PLATE ANTIGENS FOR PLATE AGGLUTINATION TEST

MYCOPLASMA GALLISEPTICUM ANTIGEN

SPAFAS MG Plate Antigen for Plate Agglutination Test (Material No. 10100760)
‍This antigen is a suspension of killed, stained A5969 strain of Mycoplasma
gallisepticum (MG) for serum plate agglutination testing of chicken and turkey
flocks.

MYCOPLASMA MELEAGRIDIS ANTIGEN

SPAFAS MM Plate Antigen for Plate Agglutination Test (Material No. 10100825)
This antigen is a suspension of killed Mycoplasma meleagridis (MM) for serum
plate agglutination testing of turkey flocks.

MYCOPLASMA SYNOVIAE ANTIGEN

SPAFAS MS Plate Antigen for Plate Agglutination Test (Material No. 10100761)
This antigen is a suspension of killed, stained WVU1853 strain of Mycoplasma
synoviae (MS) for serum plate agglutination testing of chicken flocks.

PULLORUM ANTIGEN

Stained Antigen Polyvalent for Plate Agglutination Test (Material No. 10105346
(40 ml) & 10102217 (14 ml))
This antigen is a suspension of five (5) killed, stained strains (4, 11, 77, 79
and 296) of Salmonella pullorum for use in the whole-blood or serum plate
agglutination test for the detection of pullorum disease and fowl typhoid in
poultry flocks.


SERUM PLATE ANTISERUM/ANTIBODY

Positive and negative control antibodies are available for MG, MM, MS, and
Salmonella polyvalent (Groups B & D).
Serum Plate Antiserum/Antibody
Material No.*
Mycoplasma gallisepticum
10100703
Mycoplasma meleagridis
10100708
Mycoplasma synoviae
10100706
Salmonella polyvalent (Group B & D)
10100702
Negative SPA
10100511
*1 ml per vial (liquid; store at 4 °C)



CONFIRMATORY TESTING REAGENTS

Reagent*
Material #*
Mycoplasma gallisepticum Whole Organism
10100704
Mycoplasma synoviae Whole Organism
10100707
Mycoplasma gallisepticum Antiserum
10100478
Mycoplasma synoviae Antiserum
10100482
Negative Serum
10100380
*1 ml per vial


SERUM PLATE AGGLUTINATION TEST PRINCIPLE

The serum plate agglutination (SPA) test is used to detect specific antibodies
that will bind to an antigen and cause visible “clumping” or agglutination. The
antigen is prepared from cultures of Mycoplasma gallisepticum (MG), Mycoplasma
meleagridis (MM), Mycoplasma synoviae (MS), or Salmonella pullorum and a dye is
added to improve visibility of the reactions. A prescribed amount of antigen is
placed on a solid support, such as a glass plate or mirror, keeping each drop of
antigen separate. An equal amount of test serum is placed next to the antigen
and these are then mixed together. After a short incubation, the mixture is
examined for evidence of agglutination, which appears as discrete clumps of the
stained particles with a clearer background. If no antibodies are detected, the
mixture will remain opaque. Click here to view a copy of our Mycoplasma &
Pullorum Plate Antigen poster.


SPF CHICKENS


SPECIFIC PATHOGEN FREE CHICKEN (SPF) EGGS

Specific pathogen free (SPF) chickens are used for veterinary vaccine production
and research, plus as sentinels for virus isolation.
AVS Bio has grow houses in the US for the production of SPF chickens ranging
from one day to seven weeks old to meet your exact requirements. Older birds may
be available upon request.

Click here to view the Tech Sheet for SPF Eggs.


DIAGNOSTIC & 9 CFR REGULATORY TESTING


AVIAN TESTING SERVICES

AVS offers a wide array of avian diagnostic and regulatory testing services,
including serological profiling, virus isolation and vaccine testing. Protocols
are available for standard testing methods and customized services.

MULTIPLEXED FLUOROMETRIC IMMUNOASSAY® (MFIA®) TESTS

Test Description
Test #
14 Panel MFIA® Test
(HEV, AE, ANV, PMV-2, Reo, F. Pox, IBV, IBDV, ALV-A, ALV-B, ALV-J, NDV, AI &
ILT)
15100327
22 Panel MFIA® Test
(14 panel and Adeno Grp I, Adeno Grp III, Rota, MD, Rev, MG, MS, & Salmonella
Pullorum-Gallinarum)
15100329
Single Plex - Individual analytes as listed above
Call for more info
MFIA® testing can only be performed on SPF and research flocks and is performed
on individual chicken samples. Please provide 0.05 ml per sample.


SERUM PLATE AGGLUTINATION TESTS

Pathogen
Test #
Mycoplasma Gallisepticum
15100012
Mycoplasma SynoviaeGallinarum)
15100013
Salmonella Pullorum-Gallinarum
15100016
Please provide 0.1 ml serum per test.


HA-HI ASSAYS

Pathogen
Test #
Adenovirus Group III (EDS 76)
15100019
Avian Influenza Type A
15100020
Avian Paramyxovirus Type 2
15100029
Avian Paramyxovirus Type 3
15100030
Human Influenza A/PR/8/34
15100098
Infectious Bronchitis (Ark.)
15100021
Infectious Bronchitis (Conn.)
15100022
Infectious Bronchitis (DE-072)
15100025
Infectious Bronchitis (JMK)
15100023
Infectious Bronchitis (Mass.)
15100024
Mycoplasma Gallisepticum
15100026
Mycoplasma Synoviae
15100027
Newcastle Disease
15100028
Please provide 0.025 ml serum per hemagglutination (HA) and
hemagglutination-inhibition (HI) test.


SERUM NEUTRALIZATION TESTS IN SPF EGGS

Pathogen
Test #
Avian Adenovirus (CELO-Phelps)
15100032
Avian Encephalomyelitis
15100033
Infectious Bronchitis (Ark.)
15100034
Infectious Bronchitis (Conn.)
15100035
Infectious Bronchitis (JMK)
15100036
Infectious Bronchitis (Mass.)
15100037
Infectious Bursal Disease (Gumboro)
15100038
Infectious Bursal Disease (Variant E)
15100039
Infectious Laryngotracheitis
15100040
Newcastle Disease
15100041
Please provide 2.0 ml serum per test.


AGAR GEL PRECIPITIN TESTS

Pathogen
Test #
Avian Adenovirus Group I
15100042
Avian Adenovirus Group II (HEV)
15100048
Avian Encephalomyelitis
15100043
Avian Reovirus (Viral Arthritis)
15100045
Avian Rotavirus
15100046
Fowl Pox
15100047
Infectious Bursal Disease (Gumboro)
15100050
Infectious Bursal Disease Sero Type 2
15100052
Infectious Laryngotracheitis
15100051
Influenza
15100044
Marek’s Disease
15100053
Newcastle Disease
15100054
Reticuloendotheliosis
15100055
Please provide 2.0 ml serum per test.


MICRONEUTRALIZATION TESTS

Pathogen
Test #
Avian Adenovirus (each sample tested individually for 12 serotypes)
15100056
Avian Reovirus
15100057
RSV-A
15100083
RSV-B
15100084
Avian Leukosis Subgroup J
15100085
Please provide 0.25 ml serum per test.


IFA TESTING

Pathogen
Test #
Chicken Anemia Virus
15100075
Avian Nephritis Virus
15100078
Avian Reovirus
15100080
Reticuloendotheliosis Virus
15100081
Please provide 0.1 ml per serum sample. Chicken sera only.


9 CFR TESTING

9CFR #
Test Description
Test #
113.26
Detection of Viable Bacteria and Fungi Except in Live Vaccine*
15100071
113.27
113.27 Detection of Extraneous Viable Bacteria and Fungi in Live Vaccine (10 x
0.5 ml)
15100070
113.28
Detection of Mycoplasma Contamination (1.5 ml)
15100072
113.30
Detection of Salmonella Contamination (2.5 ml of cells or 11 ml of virus)
15100073
113.31
Detection of Avian Lymphoid Leukosis
(A p27 ELISA is performed in place of CF; 5 ml of cells or 1 ml of virus with 1
ml of antiserum)
15100059
113.34
Detection of Hemagglutinating Viruses (2.5 ml)
15100067
113.37
Detection of Pathogens by the Chicken Embryo Inoculation Test**
15100068
113.46
Detection of Cytopathogenic and/or Hemadsorbing Agents (2.5 ml)
15100069
* Each final product serial: 10 x 2.5 ml. Cells & cell lines and ingredients of
animal origin: 1 x 22 ml.
** 5 ml of cells or 1 ml of virus with 10 ml of antiserum.



PCR TESTS

GEL-BASED PCR

Pathogen
Test #
Avian Adenovirus Group I, Serotypes 1–12
15100099
Avian Adenovirus Group III (EDS)
15100309
Avian Encephalomyelitis
15100101
Avian Reovirus
15100105
Avian Leukosis Subgroup A
15100102
Avian Leukosis Subgroup B
15100103
Avian Leukosis Subgroup J
15100104
Chicken Anemia Virus (Minimum of 10 samples)
15100106
Mycoplasma synoviae and gallisepticum
15100107
Reticuloendotheliosis
15100108
Salmonella pullorum
15100109
Please provide 0.1 ml serum per test.


REAL-TIME PCR

Pathogen
Test #
Avian Encephalomyelitis
15100003
Avian Influenza
15100004
Avian Reovirus
15100006
Avian Rhinotracheitis Virus
15100007
Chicken Anemia Virus
15100008
Infectious Bronchitis
15100009
Infectious Bursal Disease
15100010
Infectious Laryngotracheitis
15100011
Please provide 0.1 ml chicken serum per test. There is a 30 sample minimum per
pathogen for ELISA testing.


ELISA

ANTIBODY DETECTION

Pathogen
Test #
Avian Encephalomyelitis
15100003
Avian Influenza
15100004
Avian Reovirus
15100006
Avian Rhinotracheitis Virus
15100007
Chicken Anemia Virus
15100008
Infectious Bronchitis
15100009
Infectious Bursal Disease
15100010
Infectious Laryngotracheitis
15100011
Please provide 0.1 ml chicken serum per test. There is a 30 sample minimum per
pathogen for ELISA testing.


ANTIGEN DETECTION

Pathogen
Test #
Avian Leukosis (p27 antigen detection)
15100005
Please provide cloacal swabs, albumen, or 0.5 ml of supernatant from passaged
CEFs.


OTHER TEST

Testing Service
Test #
Avian Encephalomyelitis Flock Susceptibility
15100082
COFAL (Complement Fixation for Avian Leukosis) 10-day test
15100060
Salmonella pullorum microtiter
15100017
Vaccine Potency Test - Single Vaccine
15100064
Virus Titration
15100065
Virus Isolations
15100066
Please provide 1.0 ml per sample.



CUSTOMIZED VACCINE SUPPORT SERVICES

AVS Bio offers outsourcing of virus preparations in SPF embryonated eggs, tissue
culture and poultry. We offer pre-incubated extracted embryos and avian cell
production that can be produced in large or small quantities to meet your needs.
In addition to supporting your antigen production, our laboratories provide
progeny challenge studies and commercial poultry virus isolation. Isolated virus
can be expanded upon request. Fractional dose studies can be provided to support
your product’s technical data and marketing efforts. Custom research projects
and field safety trials can also help speed your progress to regulatory
approval.

KEY FIGURES

 * USDA-licensed facilities
 * Two laboratory campuses
 * Three chicken facilities - Over 22,000 ft2 of housing for bird projects
 * Newly constructed production suites for FFM products - Over 16,500 ft2 of lab
   and support space
 * Bulk virus production in eggs and birds autogenous and commercial strains -
   One to 40+ L batch sizes, Live or killed
 * Bulk bacterial antigen - Up to 100L batch sizes
 * USDA licensing, as needed (FFM)

Click here for Terms and Conditions of sale


OUR HISTORY


1961

Originally founded as SPAFAS (Specific Pathogen Free Avian Supplies), we started
as an egg production and testing laboratory in Connecticut


1992

We were acquired by Charles River Laboratories and have since more than doubled
our manufacturing capacity and laboratory footprint, cultivated relationships
with customers and manufacturing partners around the world, and built new
capabilities across diagnostic and bioprocessing applications


2022

After 30 years of operating as a subsidiary of Charles River Laboratories, we
reestablished ourselves as an independent company to begin a new chapter of
accelerated investment across the Immunology landscape


TODAY

We are a scientifically-driven and well-capitalized team devoted to innovation
and advancement in supporting our customers across both the human and animal
health markets


THE AVS ADVANTAGE

 * We are the global leader in SPF egg production, focused on providing
   high-quality SPF eggs and adjacent products and services for use in
   manufacturing vaccines, therapeutics, and other biologics.
 * At AVS Bio, we are committed to the humane treatment of animals. Our eggs are
   produced in our over 40 dedicated houses using sustainable practices, and we
   are dedicated to ensuring that our hens are treated with the utmost care and
   respect.
 * Our eggs are carefully inspected, cleaned, and tested to ensure they meet the
   strict quality standards required for vaccine production. We are committed to
   providing our customers with the highest quality eggs and cell-based
   products.
 * Our scientific and manufacturing expertise allows us to offer a broad range
   of products, including primary chicken embryo cells and USDA-licensed FFM and
   diagnostic products. Our IgY products are produced utilizing our SPF hens and
   are tested to ensure that they meet the highest quality and purity standards.


CONTACT US

Contact us if you would like to learn more about our products & services.
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