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Skip to main content MENU - UTILITY NAVIGATION * Prescribing Information * Patient Information * Important Safety Information * Request a Representative * Prescription Form * Patient Website * Get Updates * Facebook This site requires JavaScript and cookies to be enabled. This site requires JavaScript and cookies to be enabled. UTILITY NAVIGATION - MOBILE * Important Information About Tradename gocovrihcp.com OPTIONAL LINKS * About GOCOVRI * Treatment Paradigm * Efficacy * Safety * Dosing/PK * Access & Resources * Peer Perspectives MENU - HEADER - MAIN * About GOCOVRI * Treatment Paradigm * Efficacy * Safety * Dosing/PK * Access & Resources * Peer Perspectives MENU - UTILITY NAVIGATION * Prescribing Information * Patient Information * Important Safety Information * Request a Representative * Prescription Form * Patient Website * Get Updates * Facebook GO WITH MORE GOOD ON TIME Treat dyskinesia and OFF time without compromising on either. GOCOVRI® is the only medication proven to reduce both in patients with Parkinson's disease for more GOOD ON time. Just 1 nightly dose can mean all-day coverage.1,2 Request A Rep Peer Perspectives Kendall, GOCOVRI patient. HEAR FROM REAL CLINICIANS PRESCRIBING GOCOVRI Video cover, click to watch interview with Stuart Isaacson, MD, FAAN. The daily impact of dyskinesia and OFF time See the challenges real people with Parkinson’s disease face, as well as some strategies for identifying and managing dyskinesia and OFF time. "It's my belief that we need to shift the paradigm, to focus on giving patients GOOD ON time as consistently as possible throughout the day without disruptions." –Dr. Isaacson Video cover, click to watch interview with Robert A. Hauser, MD, MBA, FAAN and … Who is GOCOVRI right for? Explore 2 case vignettes that represent patients commonly seen in clinical practice and discover what more GOOD ON time means to them. "With a better understanding of how dyskinesia and OFF affect patients, we may be able to make more informed treatment decisions." –Dr. Hauser Watch More Peer Perspectives PROVEN RESULTS IN SHORT-TERM STUDIES AND EVALUATED IN A LONG-TERM OLE STUDY GOCOVRI was studied in a 12-week Phase 3 trial, a 24-week Phase 3 trial, and a long-term OLE study.1,3 View Study Results 1 NIGHTLY DOSE FOR ALL-DAY MEDICATION COVERAGE GOCOVRI is formulated to release slowly while your patients sleep and gradually increases plasma concentrations until the morning.2 See PK Data GET GOING WITH GOCOVRI With a high claims approval rate, it's easy to get your patients started with GOCOVRI Onboard®. Learn More WHY CONSIDER GOCOVRI? With GOCOVRI, you don’t have to accept a trade-off between dyskinesia and OFF time. Take a closer look at how GOCOVRI works to treat both dyskinesia and OFF time in patients like yours. Treatment Paradigm GET CLINICAL INFORMATION ON GOCOVRI Get the latest news and updates about GOCOVRI®, learn about upcoming events, and more. Connect Back to top IMPORTANT SAFETY INFORMATION IMPORTANT SAFETY INFORMATION AND INDICATION CONTRAINDICATIONS GOCOVRI is contraindicated in patients with creatinine clearance below 15 mL/min/1.73 m2. WARNINGS AND PRECAUTIONS Falling Asleep During Activities of Daily Living and Somnolence: Patients treated with Parkinson’s disease medications have reported falling asleep during activities of daily living. If a patient develops daytime sleepiness during activities that require full attention (e.g., driving a motor vehicle, conversations, eating), GOCOVRI should ordinarily be discontinued or the patient should be advised to avoid potentially dangerous activities. Suicidality and Depression: Monitor patients for depression, including suicidal ideation or behavior. Prescribers should consider whether the benefits outweigh the risks of treatment with GOCOVRI in patients with a history of suicidality or depression. Hallucinations/Psychotic Behavior: Patients with a major psychotic disorder should ordinarily not be treated with GOCOVRI because of the risk of exacerbating psychosis. Observe patients for the occurrence of hallucinations throughout treatment, especially at initiation and after dose increases. Dizziness and Orthostatic Hypotension: Monitor patients for dizziness and orthostatic hypotension, especially after starting GOCOVRI or increasing the dose. Withdrawal-Emergent Hyperpyrexia and Confusion: Rapid dose reduction or abrupt discontinuation of GOCOVRI, may cause an increase in the symptoms of Parkinson’s disease or cause delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, or slurred speech. Avoid sudden discontinuation of GOCOVRI. Impulse Control/Compulsive Behaviors: Patients may experience urges (e.g. gambling, sexual, money spending, binge eating) and the inability to control them. It is important for prescribers to ask patients or their caregivers about the development of new or increased urges. Consider dose reduction or stopping medications. ADVERSE REACTIONS The most common adverse reactions (>10%) were hallucination, dizziness, dry mouth, peripheral edema, constipation, fall, and orthostatic hypotension. INDICATION GOCOVRI® (amantadine) extended release capsules is indicated: * For the treatment of dyskinesia in patients with Parkinson’s disease receiving levodopa-based therapy, with or without concomitant dopaminergic medications * As adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease experiencing “off” episodes It is not known if GOCOVRI is safe and effective in children. Please see full Prescribing Information and Patient Information. Abbreviations: OLE, open-label extension; PK, pharmacokinetic. References: 1. GOCOVRI® (amantadine). Prescribing Information. Adamas Pharma LLC. 2. Hauser RA, Pahwa R, Wargin WA, et al. Pharmacokinetics of ADS-5102 (amantadine) extended release capsules administered once daily at bedtime for the treatment of dyskinesia. Clin Pharmacokinet. 2019;58(1):77-88. doi:10.1007/s40262-018-0663-4 3. Tanner CM, Pahwa R, Hauser RA, et al. EASE LID 2: a 2-year open-label trial of Gocovri (amantadine) extended release for dyskinesia in Parkinson’s disease. J Parkinsons Dis. 2020;10(2):543-558. doi:10.3233/JPD-191841 IMPORTANT SAFETY INFORMATION IMPORTANT SAFETY INFORMATION AND INDICATION CONTRAINDICATIONS GOCOVRI is contraindicated in patients with creatinine clearance below 15 mL/min/1.73 m2. WARNINGS AND PRECAUTIONS Falling Asleep During Activities of Daily Living and Somnolence: Patients treated with Parkinson’s disease medications have reported falling asleep during activities of daily living. If a patient develops daytime sleepiness during activities that require full attention (e.g., driving a motor vehicle, conversations, eating), GOCOVRI should ordinarily be discontinued or the patient should be advised to avoid potentially dangerous activities. Suicidality and Depression: Monitor patients for depression, including suicidal ideation or behavior. Prescribers should consider whether the benefits outweigh the risks of treatment with GOCOVRI in patients with a history of suicidality or depression. Hallucinations/Psychotic Behavior: Patients with a major psychotic disorder should ordinarily not be treated with GOCOVRI because of the risk of exacerbating psychosis. Observe patients for the occurrence of hallucinations throughout treatment, especially at initiation and after dose increases. Dizziness and Orthostatic Hypotension: Monitor patients for dizziness and orthostatic hypotension, especially after starting GOCOVRI or increasing the dose. Withdrawal-Emergent Hyperpyrexia and Confusion: Rapid dose reduction or abrupt discontinuation of GOCOVRI, may cause an increase in the symptoms of Parkinson’s disease or cause delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, or slurred speech. Avoid sudden discontinuation of GOCOVRI. Impulse Control/Compulsive Behaviors: Patients may experience urges (e.g. gambling, sexual, money spending, binge eating) and the inability to control them. It is important for prescribers to ask patients or their caregivers about the development of new or increased urges. Consider dose reduction or stopping medications. ADVERSE REACTIONS The most common adverse reactions (>10%) were hallucination, dizziness, dry mouth, peripheral edema, constipation, fall, and orthostatic hypotension. INDICATION GOCOVRI® (amantadine) extended release capsules is indicated: * For the treatment of dyskinesia in patients with Parkinson’s disease receiving levodopa-based therapy, with or without concomitant dopaminergic medications * As adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease experiencing “off” episodes It is not known if GOCOVRI is safe and effective in children. Please see full Prescribing Information and Patient Information. GENERIC INTERSTITIAL TITLE 2 lorem ipsum 1 Yes No BRANDED INTERSTITIAL × you are leaving the site. ok? Yes No × Breakdown of Results From Individual Pivotal Studies 41% IMPROVEMENT in dyskinesia (UDysRS from baseline)3,7 PRIMARY ENDPOINT STUDY 1 GOCOVRI® demonstrated a 15.9-point reduction (baseline: 40.9) in the UDysRS total score vs. an 8.0 reduction with placebo (baseline: 38.5) through Week 12 (P = 0.0009)3,5 STUDY 2 GOCOVRI® demonstrated a 20.7-point reduction (baseline: 40.2) in the UDysRS total score vs. a 6.3 reduction with placebo (baseline: 41.2) through Week 12 (P < 0.0001)3,5 21% REDUCTION in OFF time (from baseline)3,7 SECONDARY ENDPOINT STUDY 1 GOCOVRI® decreased OFF time by 0.6 hours (baseline: 3.2) vs. an increase of 0.3 hours with placebo (baseline: 3.0) (P = 0.0171)3,5 STUDY 2 GOCOVRI® decreased OFF time by 0.5 hours (baseline: 2.6) vs. an increase of 0.6 hours with placebo (baseline: 2.0) (P = 0.0199)3,5 3.8-HOUR INCREASE in GOOD ON time (from baseline)3,7 SECONDARY ENDPOINT STUDY 1 GOCOVRI® increased GOOD ON time by 3.6 hours (baseline: 8.3) vs. 0.8 hours with placebo (baseline: 8.5) (P < 0.0001)3,5 STUDY 2 GOCOVRI® increased GOOD ON time by 4.0 hours (baseline: 8.8) vs. 2.1 hours with placebo (baseline: 7.8) (P = 0.0168)3,5 Diary States Summary Secondary efficacy endpoints based on patient diary data7,8 Results for dyskinesia, OFF time, and GOOD ON time, respectively; GOCOVRI® (vs. placebo) STUDY 1 Baseline hours: 4.7 (vs. 4.5), 3.2 (vs. 3.0), and 8.3 (vs. 8.5) Week 12 hours: 1.5 (vs. 3.0), 2.6 (vs. 3.4), and 12.0 (vs. 9.2) STUDY 2 Baseline hours: 4.7 (vs. 6.0), 2.6 (vs. 2.0), and 8.8 (vs. 7.8) Week 12 hours: 1.4 (vs. 3.2), 2.0 (vs. 2.7), and 12.5 (vs. 10.0) × SIGN UP FOR MORE CLINICAL INFORMATION ON GOCOVRI® Fill out the fields below to receive more information on GOCOVRI, including educational materials, patient support information, upcoming events, and more. Note: Items marked with * are required First Name Last Name Email Address Are you currently prescribing GOCOVRI? Yes No Specialty Neurologist Movement disorder specialist General practitioner Registered nurse Physician’s assistant Nurse practitioner Plan medical director Pharmacist By submitting this form, I understand that I may be contacted with information about GOCOVRI or other Supernus products in accordance with the Supernus Privacy Policy. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Submit × THE MODAL TITLE × hello col 2 t × × × × × × THIS SITE USES COOKIES This website stores data, such as cookies, to enable important site functionality including analytics, targeting, and personalization. More Info Accept FOOTER HORIZONTAL * About GOCOVRI * Treatment Paradigm * Efficacy * Safety * Dosing/PK * Access & Resources * Peer Perspectives MENU - FOOTER - PRIVACY * Privacy Policy * Cookies Policy * Terms & Conditions * Contact Us * Site Map GOCOVRI is a registered trademark of Adamas Pharma, LLC, a subsidiary of Supernus Pharmaceuticals, Inc. All other trademarks are property of their respective owners. © 2024 Supernus Pharmaceuticals, Inc. All rights reserved. GOC.2022-0915 V3.