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THE FIRST PEOPLE HAVE RECEIVED AN EXPERIMENTAL MRNA HIV VACCINE

Moderna is hoping its mRNA technology will succeed where other HIV vaccines
failed.

By Hannah Seo | Published Feb 2, 2022 12:00 PM

 * Science
 * Health

Moderna's clinical trials are officially underway for the first HIV vaccine of
its kind. Unsplash
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Moderna announced last week that it has begun dosing its first participants in
Phase I clinical trials for an HIV vaccine that uses the same mRNA technology as
the company’s COVID-19 vaccine. 

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The company, which is conducting the trial in partnership with the nonprofit
International AIDS Vaccine Initiative (IAVI), hopes the trial will confirm
whether the vaccine can deliver HIV-specific antigens to the body and induce an
immune response. 



Researchers will study 56 HIV-negative adults for six months. Forty-eight of the
volunteers will receive at least one dose of the primary vaccine, 32 of whom
will also receive the booster. The remaining eight will receive the booster
vaccine alone. The first participants were just vaccinated at George Washington
University School of Medicine and Health Sciences in Washington, D.C.



With mRNA-based vaccines, such as the one being tested, mRNA strands enter human
cells and take our immune systems on a test run. This gives immune cells a heads
up for what they can expect if they encounter a virus. This process works
incredibly well against SARS-CoV-2, and so there’s hope that it may be
protective against HIV as well. 

[Related: For the second time ever, someone was spontaneously cured of HIV]



“We are tremendously excited to be advancing this new direction in HIV vaccine
design with Moderna’s mRNA platform,” Mark Feinberg, president and CEO of IAVI,
said in a statement. “The search for an HIV vaccine has been long and
challenging, and having new tools in terms of immunogens and platforms could be
the key to making rapid progress toward an urgently needed, effective HIV
vaccine.”



Researchers have long sought a vaccine to protect against HIV. Various
medications and treatments mean that HIV prognosis is often manageable, and no
longer the death sentence it once was—but HIV is notoriously difficult to
vaccinate against.

The virus integrates itself into the human genome within 72 hours of
transmission, producing an irreversible infection. Many previous attempts to
create a vaccine have made it to the clinical trial phase, but later failed as
they didn’t generate high enough protective antibodies at a fast enough rate to
completely prevent infection.

Hannah Seo

Hannah is a freelance science journalist, podcast writer, and poet based in
Brooklyn. In addition to Popular Science, her work can be found in WIRED,
Scientific American, The Walrus, and Environmental Health News, among others.



clinical trials
HIV
immune system
moderna vaccine
mRNA vaccine

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