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Health Conditions Medications & Treatments Healthcare Well-being More Go to GoodRx Homechevron_rightDrug Comparisons COMPARE CYMBALTA VS. LEVORPHANOL Head-to-head comparisons of medication uses, side effects, warnings, and more. Duloxetine (Cymbalta) Levorphanol Duloxetine (Cymbalta) Levorphanol SUMMARY Summary for SNRI Prescription only Duloxetine (Cymbalta) is taken by mouth to treat depression, anxiety, and some forms of long-term pain. It can cause side effects if you stop taking it too suddenly. If you want to stop this medication, your provider will help lower your dose slowly over time before you can stop altogether. Duloxetine (Cymbalta) isn't the best choice for people who have heavy alcohol use because combining this medication with alcohol can lead to liver damage. Summary for Opioid Prescription only Levorphanol is an older opioid medication that's used to help with pain that isn't relieved by non-opioid pain medications. While it typically works well to relieve pain, it's a controlled substance because it has a high risk of misuse, dependency, and addiction. Because of these risks, it might not be the best choice for everyone. INDICATIONS Indications for •Major depressive disorder in adults •Generalized anxiety disorder in people age 7 years and older •Diabetic neuropathy (nerve pain caused by high blood sugar) in adults •Fibromyalgia in adults (brand Cymbalta approved for people age 13 years and older) •Long-term muscle pain in adults Indications for •Pain that isn't relieved by non-opioid pain medications alone PROS AND CONS Pros and Const for SNRI Pros •Helps lower nerve pain from high blood sugar and other forms of long-term pain •Can treat several conditions, so might be good for people with multiple conditions •Dose can be adjusted based on your response •Available as a lower-cost generic Cons •Can take several weeks before you feel the full effects on your mood •Might not be a good option for people who engage in heavy drinking, or have liver or kidney problems •Can cause higher risk of suicidal thoughts and behavior in people 24 years and younger •Might raise your risk of bleeding Pros and Const for Opioid Pros •Pain-relieving effect starts within 1 hour and lasts for 6 to 15 hours •Can take with or without food •Available as a lower-cost generic Cons •High risk of misuse and dependency •Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms •Might need to take every 6 to 8 hours for continued pain relief, depending on how long the effects last for you •A controlled medication, so there are special requirements to get a prescription filled COMMON SIDE EFFECTS Common Side Effects for •Nausea (23%) •Headache (14%) •Dry mouth (13%) •Drowsiness (10%) •Trouble sleeping (9%) •Feeling tired (9%) •Constipation (9%) •Dizziness (9%) •Diarrhea (9%) •Low appetite (7%) •Excessive sweating (6%) •Stomach pain (5%) Common Side Effects for •Sleepiness •Feeling tired •Headache •Dizziness •Constipation •Nausea •Vomiting •Stomach pain WARNINGS Common Side Effects for •Suicidal thoughts and behavior •Serotonin syndrome •Withdrawal •Severe skin reaction •Higher bleeding risk •Mania •Liver damage •Changes in blood pressure and risk of falls •Sexual problems Common Side Effects for •Potential for addiction and misuse •Dangerously slow breathing (respiratory depression) •Opioid overdose •Difficulty concentrating and extreme sleepiness •Harm to newborn babies •Physical dependence and withdrawal •Low blood pressure •Low adrenal hormone levels •Seizures •Drug interactions PRICES WITH OUR COUPONS Duloxetine30 capsules / 60mg $133.03 $6.00 Get free coupons Levorphanol90 tablets / 2mg $4245.90 $970.70 Get free coupons Learn more about Duloxetine Learn more about Levorphanol Prices & Discounts InsuranceMobile AppsGoodRx Prescription Discount CardDrugs A-ZDrugs by Health ConditionsDrug ClassesMost Prescribed DrugsGoodRx for PetsBrand-Name DrugsGoodRx GoldGoodRx CareTelehealth MarketplaceLabs Marketplace Tools & Info How GoodRx WorksFind a Pharmacy Near MeHealthcare Professionals Health Latest Health NewsVideoCOVID-19 VaccineCOVID-19Seasonal Flu Support Help & FAQsAdvertising NoticeAccessibility Company About GoodRxPressResearchSocial ImpactJobsInvestorsCorporate News Prices & Discounts InsuranceMobile AppsGoodRx Prescription Discount CardDrugs A-ZDrugs by Health ConditionsDrug ClassesMost Prescribed DrugsGoodRx for PetsBrand-Name DrugsGoodRx GoldGoodRx CareTelehealth MarketplaceLabs Marketplace Tools & Info How GoodRx WorksFind a Pharmacy Near MeHealthcare Professionals Health Latest Health NewsVideoCOVID-19 VaccineCOVID-19Seasonal Flu Support Help & FAQsAdvertising NoticeAccessibility Company About GoodRxPressResearchSocial ImpactJobsInvestorsCorporate News DOWNLOAD THE GOODRX APP NOW Don’t miss out on savings! 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