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 * Virus mix-up by lab could have resulted in pandemic

This story is from March 6, 2009


VIRUS MIX-UP BY LAB COULD HAVE RESULTED IN PANDEMIC

Agencies / Mar 6, 2009, 00:02 IST
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It's emerged that virulent H5N1 bird flu was sent out by accident from an
Austrian lab last year and given to ferrets in the Czech Republic before anyone
realised. As well as the risk of it escaping into the wild, the H5N1 got mixed
with a human strain, which might have spawned a hybrid that could unleash a
pandemic.
Last December, the Austrian branch of US vaccine company Baxter sent a batch of
ordinary human H3N2 flu, altered so it couldn't replicate, to Avir Green Hills
Biotechnology, also in Austria. In February, a lab in the Czech Republic working
for Avir alerted Baxter that, unexpectedly, ferrets inoculated with the sample
had died. It turned out the sample contained live H5N1, which Baxter uses to
make vaccine. The two seem to have been mixed in error.
Markus Reinhard of Baxter says no one was infected because the H3N2 was handled
at a high level of containment. But Ab Osterhaus of Erasmus University in the
Netherlands says: "We need to go to great lengths to make sure this kind of
thing doesn't happen."
Accidental release of a mixture of live H5N1 and H3N2 viruses could have
resulted in dire consequences. While H5N1 doesn't easily infect people, H3N2
viruses do. If someone exposed to a mixture of the two had been simultaneously
infected with both strains, he or she could have served as an incubator for a
hybrid virus able to transmit easily to and among people.


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