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Reuters


EXCLUSIVE-WHO'S CANCER RESEARCH AGENCY TO SAY ASPARTAME SWEETENER A POSSIBLE
CARCINOGEN -SOURCES

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WHO TO LABEL SWEETENER POSSIBLE CANCER RISK: SOURCES

STORY: It’s used in everything from diet sodas to chewing gum. Now artificial
sweetener aspartame could be labeled a possible cancer risk. Reuters sources say
the International Agency for Research on Cancer - an arm of the World Health
Organization - will make the move next month. It will list aspartame as
“possibly carcinogenic to humans”. The ruling is based on all published
evidence, and is meant to spur more research into the product. It doesn’t take
into account how much a person can consume before facing a heightened risk. The
news has drawn a furious response from drinks makers. The International
Sweeteners Association said the IARC was acting on “widely discredited
research”. Aspartame has been investigated for years. One French study showed
slightly increased cancer risks in people who consumed a lot of the sweetener.
But the results have been disputed and the product remains widely used. It’s in
products including Diet Coke, and Mars’ Extra chewing gum. The IARC is due to
make public its decision on July 14. Its past rulings have forced makers to
change recipes, and sparked waves of lawsuits. Critics say it’s too prone to
causing consumer alarm. The body has previously listed working overnight, eating
red meat, and using mobile phones as possible cancer risks.


1.2k
Jennifer Rigby and Richa Naidu
Thu, June 29, 2023 at 2:03 AM EDT·6 min read


By Jennifer Rigby and Richa Naidu

LONDON (Reuters) - One of the world's most common artificial sweeteners is set
to be declared a possible carcinogen next month by a leading global health body,
according to two sources with knowledge of the process, pitting it against the
food industry and regulators.

Aspartame, used in products from Coca-Cola diet sodas to Mars' Extra chewing gum
and some Snapple drinks, will be listed in July as "possibly carcinogenic to
humans" for the first time by the International Agency for Research on Cancer
(IARC), the World Health Organization's (WHO) cancer research arm, the sources
told Reuters.

The IARC ruling, finalised earlier this month after a meeting of the group's
external experts, is intended to assess whether something is a potential hazard
or not, based on all the published evidence.

It does not take into account how much of a product a person can safely consume.
This advice for individuals comes from a separate WHO expert committee on food
additives, known as JECFA (the Joint WHO and Food and Agriculture Organization's
Expert Committee on Food Additives), alongside determinations from national
regulators.

However, similar IARC rulings in the past for different substances have raised
concerns among consumers about their use, led to lawsuits, and pressured
manufacturers to recreate recipes and swap to alternatives. That has led to
criticism that the IARC's assessments can be confusing to the public.

JECFA, the WHO committee on additives, is also reviewing aspartame use this
year. Its meeting began at the end of June and it is due to announce its
findings on the same day that the IARC makes public its decision – on July 14.

Since 1981, JECFA has said aspartame is safe to consume within accepted daily
limits. For example, an adult weighing 60 kg (132 pounds) would have to drink
between 12 and 36 cans of diet soda – depending on the amount of aspartame in
the beverage – every day to be at risk. Its view has been widely shared by
national regulators, including in the United States and Europe.

Story continues

An IARC spokesperson said both the IARC and JECFA committees' findings were
confidential until July, but added they were "complementary", with IARC's
conclusion representing "the first fundamental step to understand
carcinogenicity". The additives committee "conducts risk assessment, which
determines the probability of a specific type of harm (e.g. cancer) to occur
under certain conditions and levels of exposure."

However, industry and regulators fear that holding both processes at around the
same time could be confusing, according to letters from U.S. and Japanese
regulators seen by Reuters.

"We kindly ask both bodies to coordinate their efforts in reviewing aspartame to
avoid any confusion or concerns among the public," Nozomi Tomita, an official
from Japan's Ministry of Health, Labour and Welfare, wrote in a letter dated
March 27 to WHO's deputy director general, Zsuzsanna Jakab.

The letter also called for the conclusions of both bodies to be released on the
same day, as is now happening. The Japanese mission in Geneva, where the WHO is
based, did not respond to a request for comment.

DEBATE

The IARC's rulings can have huge impact. In 2015, its committee concluded that
glyphosate is "probably carcinogenic". Years later, even as other bodies like
the European Food Safety Authority (EFSA) contested this, companies were still
feeling the effects of the decision. Germany’s Bayer in 2021 lost its third
appeal against U.S. court verdicts that awarded damages to customers blaming
their cancers on use of its glyphosate-based weedkillers.

The IARC's decisions have also faced criticism for sparking needless alarm over
hard to avoid substances or situations. It has four different levels of
classification - carcinogenic, probably carcinogenic, possibly carcinogenic and
not classifiable. The levels are based on the strength of the evidence, rather
than how dangerous a substance is.

The first group includes substances from processed meat to asbestos, which all
have convincing evidence showing they cause cancer, IARC says.

Working overnight and consuming red meat are in the "probable" class, which
means that there is limited evidence these substances or situations can cause
cancer in humans and either better evidence showing they cause cancer in
animals, or strong evidence showing that they have similar characteristics as
other human carcinogens.

The "radiofrequency electromagnetic fields" associated with using mobile phones
are "possibly cancer-causing". Like aspartame, this means there is either
limited evidence they can cause cancer in humans, sufficient evidence in
animals, or strong evidence about the characteristics.

The final group - "not classifiable" - means there is not enough evidence.

"IARC is not a food safety body and their review of aspartame is not
scientifically comprehensive and is based heavily on widely discredited
research," Frances Hunt-Wood, secretary general of the International Sweeteners
Association (ISA), said.

The body, whose members include Mars Wrigley, a Coca-Cola unit and Cargill, said
it had "serious concerns with the IARC review, which may mislead consumers".

The International Council of Beverages Associations' executive director Kate
Loatman said public health authorities should be "deeply concerned" by the
"leaked opinion", and also warned it "could needlessly mislead consumers into
consuming more sugar rather than choosing safe no- and low-sugar options."

Aspartame has been extensively studied for years. Last year, an observational
study in France among 100,000 adults showed that people who consumed larger
amounts of artificial sweeteners – including aspartame – had a slightly higher
cancer risk.

It followed a study from the Ramazzini Institute in Italy in the early 2000s,
which reported that some cancers in mice and rats were linked to aspartame.

However, the first study could not prove that aspartame caused the increased
cancer risk, and questions have been raised about the methodology of the second
study, including by EFSA, which assessed it.

Aspartame is authorised for use globally by regulators who have reviewed all the
available evidence, and major food and beverage makers have for decades defended
their use of the ingredient. The IARC said it had assessed 1,300 studies in its
June review.

Recent recipe tweaks by soft drinks giant Pepsico demonstrate the struggle the
industry has when it comes to balancing taste preferences with health concerns.
Pepsico removed aspartame from sodas in 2015, bringing it back a year later,
only to remove it again in 2020.

Listing aspartame as a possible carcinogen is intended to motivate more
research, said the sources close to the IARC, which will help agencies,
consumers and manufacturers draw firmer conclusions.

But it will also likely ignite debate once again over the IARC's role, as well
as the safety of sweeteners more generally.

Last month, the WHO published guidelines advising consumers not to use non-sugar
sweeteners for weight control. The guidelines caused a furore in the food
industry, which argues they can be helpful for consumers wanting to reduce the
amount of sugar in their diet.

(Reporting by Jennifer Rigby and Richa Naidu; Editing by Michele Gershberg, Mark
Potter and Susan Fenton)




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