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Advertisement * * news * careers * commentary * Journals * Covid-19 * * * Log in * Become A Member science science advances science immunology science robotics science signaling science translational medicine science partner journals Quick Search anywhere Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Searching: Anywhere AnywhereScienceScience AdvancesScience ImmunologyScience RoboticsScience SignalingScience Translational Medicine Advanced Search Search TRENDING TERMS: * covid-19 * climate * science policy * genome editing * batteries Log In Become A Member Quick Search anywhere Enter Search Term science.org * news * careers * commentary * Journals * science * science advances * science immunology * science robotics * science signaling * science translational medicine * science partner journals * Custom publishing * collections * videos * podcasts * blogs * visualizations * prizes and awards * authors & reviewers * librarians * advertisers * about * help * * * * * * * Terms of Service * Privacy Policy * Accessibility * Custom Publishing * Advertising Kits * Custom Publishing Info * Webinars GET OUR E-ALERTS HomeCustom Publishing Back To Home CUSTOM PUBLISHING Technology Feature24 Sep 2021by * Alan Dove COMBINE AND CONQUER: SINGLE-CELL OMICS MULTIPLIES Recent advances enable researchers to drill down to the single-cell level and simultaneously extract gene and protein data. podcast 21 Apr 2022 nPOD and the fight to cure type 1 diabetes: A conversation with Dr. Alberto Pugliese Advertorial 13 May 2022 The future of new materials at POSTECH webinar 22 Jun 2022 Autoinflammatory diseases in adults: Behind the scenes of chronic inflammation Booklet 25 Mar 2022 Pohang University of Science & Technology: Accelerating innovation for a brighter future ADVERTISEMENT SPONSORED COLLECTIONS POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY: ACCELERATING INNOVATION FOR A BRIGHTER FUTURE South Korea’s POSTECH imagines a brighter future through science and technology innovation. LABEL-FREE BINDING ANALYSIS: EXPLORING ADVANCES AND APPLICATIONS IN VACCINE DEVELOPMENT We are closer to the climax of the COVID-19 pandemic thanks to the structure-based design now used in COVID-19 vaccine production. THE FRONTIERS OF MEDICAL RESEARCH An innovative spirit and the dedication to finding answers underpins the extraordinary work being done by researchers and clinicians at the Icahn School of Medicine at Mount Sinai. LEGACY OF LEADING RESEARCH: INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES 65TH ANNIVERSARY The Institute of Chemistry, Chinese Academy of Sciences (ICCAS), turns 65 this year and has no intention of slowing down. View more WEBINARS 22 Jun 2022 Register Now Technology22 Jun 2022 Sponsored by Novartis AUTOINFLAMMATORY DISEASES IN ADULTS: BEHIND THE SCENES OF CHRONIC INFLAMMATION Autoinflammatory diseases are characterized by periodic or persistent systemic inflammatory episodes and represent disorders of the innate immune response. These diseases are rare and usually diagnosed in childhood, but many cases go undiagnosed until adulthood, including certain adult-onset disorders. In some exceptional cases, the hyperinflammatory syndrome may be severe, and if not promptly identified and treated, can lead rapidly to critical illness and even death. Accordingly, pediatricians as well as primary care physicians, internal medicine specialists, dermatologists, and rheumatologists play a critical role in diagnosing and treating autoinflammatory conditions. This webinar highlights the role of autoinflammation as a potential cause of recurrent or persistent inflammation of variable severity and discusses the challenges inherent in identifying and diagnosing the specific disorder responsible, including the presentation of nonspecific clinical symptoms that can mimic other conditions. During this webinar, the panelists will: * Highlight examples of how autoinflammatory diseases (AIDs) present in adults, and how these differ from childhood AIDs * Describe the patient journey for delays in reaching an accurate diagnosis, as well as the consequences of delayed diagnosis and treatment * Outline when a physician should consider an AID as a potential diagnosis * Discuss current knowledge gaps in the field of AIDs, particularly in adults * Answer audience questions during the live broadcast. This webinar will last for approximately 60 minutes. 22 Jun 2022 Register now 08 Jun 2022 Register Now Technology8 Jun 2022 Sponsored by Sartorius STORM CHASING: CYTOKINE PROFILING VIA FLOW CYTOMETRY IN AGE-RELATED NEURODEGENERATIVE DISEASES Although some treatments are available for neurodegenerative diseases, their incidence is growing as our aging population expands. These diseases include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, dementia with Lewy bodies, frontotemporal diseases, and multiple system atrophy. Many neurodegenerative disorders can be characterized by the abnormal formation and aggregation of proteins in the brain, such as tau, amyloid-beta, and alpha-synuclein. However, evidence increasingly reveals the contribution of the immune system in the onset and progression of these diseases. It is critical to establish appropriate in vitro cell models and associated cytokine profiling of cytokine storms if we are to increase our understanding of the role of immune cells and inflammatory response in the etiology of neurodegenerative diseases. In this webinar, our expert panel will discuss techniques to monitor cytokine storms, such as flow cytometry. This webinar will also detail neuroimmune interactions, cells models for the study of disease, and the outlook for the development of therapeutics to significantly delay or prevent progression of neurodegenerative diseases. During this webinar, our expert speakers will: * Detail the role of the immune system in controlling the central nervous system * Discuss insights into the role of immune cells in neurodegenerative diseases * Explore some critical in vitro laboratory techniques used in the interrogation of cytokine storms * Expand on the latest findings and novel therapeutics for neurodegenerative diseases * Answer questions during the live broadcast. This webinar will last for approximately 60 minutes. 08 Jun 2022 Register now 26 May 2022 Register Now Science and Life26 May 2022 Sponsored by Fondation IPSEN COMBATING THE FRAGMENTATION OF DATA AND DISCIPLINES: INNOVATION HUBS TO ADDRESS RARE DISEASES Data show that collaborative endeavors are more impactful in biomedical science than are solo operatives. This issue is particularly relevant to the rare disease research community because it is formed as a conglomerate of labs or centers—each with their own cluster of scientists, clinicians, and patients— studying different, uncommon diseases. Although each rare disease may have only a few patients, there are many commonalities. Common needs include access to genetic testing, ethically regulated data access, psychological counseling, advocacy tools, and the need for fundraising to race for cures. Techniques, technologies, or treatments applicable to one disease might be transferable to others. Collaborative networks need to be fostered to meet the shared needs of the 350 million-plus patients affected. Innovation hubs could provide a viable option to leverage common goals and opportunities, providing shared protocols for handling phenotypic, clinical, and genetic data, while also prioritizing and amplifying the voices of patients. They could bring together the best international policy structures to streamline efficient and effective medical and scientific advances in rare disease detection, diagnosis, and treatment. This webinar brings together key opinion leaders to discuss the current and future needs of patients, and how innovators, doctors, scientists, drugmakers, and policymakers can work efficiently together to deliver solutions to the millions of diagnosed and undiagnosed patients in need. This webinar will last for approximately 60 minutes. 26 May 2022 Register now View More ADVERTORIALS THE FUTURE OF NEW MATERIALS AT POSTECH Researchers at POSTECH want to transform everyday life using technological breakthroughs to create innovative new materials. PROTECTING THE PLANET WITH BIOTECHNOLOGY The BioInnovation Institute aims to fuel innovation to make life on Earth more sustainable for the environment and healthier for people. TAKING ON REPRODUCIBILITY WITH A TEAM Methods and protocols are the foundation of research science. Bio-protocol is building a community to share and refine protocols for the benefit of all. CELL SIGNALING TECHNOLOGY: THE LIFE SCIENCE COMPANY THAT LIFE SCIENTISTS BUILT Cell Signaling Technology distinguishes itself by putting the science, and scientists, first. View More SPONSORED PODCASTS 21 Apr 2022 By * Alberto Pugliese, M.D. nPOD and the fight to cure type 1 diabetes: A conversation with Dr. Alberto Pugliese View More POSTERS & INFOGRAPHICS Data that delivers There are many factors to consider when optimizing the experimental throughput of your confocal microscope. We highlight the most important ones. Taming the Imaging Triangle Compromise is never easy. But when it comes to microscopy, choosing between speed, resolution, and sensitivity sometimes feels impossible. Find out how to make this choice less paralyzing. The Human Brain Atlas Deepening our understanding of the brain is now easier, thanks to the Human Brain Atlas. Learn about it here. The Human Blood Atlas Discover and explore the Human Blood Atlas, a unique database of proteins expressed in blood immune-cell populations. View More CURRENT ISSUE REVERSIBLE CD8 T CELL–NEURON CROSS-TALK CAUSES AGING-DEPENDENT NEURONAL REGENERATIVE DECLINE * By * Luming Zhou * Guiping Kong * et al. SINGLE-NUCLEUS CROSS-TISSUE MOLECULAR REFERENCE MAPS TOWARD UNDERSTANDING DISEASE GENE FUNCTION * By * Gökcen Eraslan * Eugene Drokhlyansky * et al. THE TABULA SAPIENS: A MULTIPLE-ORGAN, SINGLE-CELL TRANSCRIPTOMIC ATLAS OF HUMANS * By * The Tabula Sapiens Consortium* Table of Contents ADVERTISEMENT GET OUR E-ALERTS SUBSCRIBE AND GET THE LATEST NEWS STRAIGHT IN YOUR INBOX! Sign up here TECHNOLOGY FEATURES 24 Sep 2021By * Alan Dove Combine and conquer: Single-cell omics multiplies Recent advances enable researchers to drill down to the single-cell level and simultaneously extract gene and protein data. 23 Apr 2021By * Sarah O’Meara Small images, big picture: Artificial intelligence to revolutionize microscopy The microscope, a mainstay of most laboratories, gets a makeover. Enter the age of AI- and deep-learning-powered microscopes. 26 Mar 2021By * Mike May Catching cancer extremely early Liquid gold: Simple blood tests can detect one or more cancers years before symptoms. 22 Jan 2021By * Alan Dove Pandemic pivot: How scientists answered the call for diagnostic tests COVID-19 vaccines are coming. But first diagnostic tests are need to stave off the pandemic and buy time until they do. View More ADVERTISEMENT CREATIVE MARKETING SOLUTIONS Custom website15 Nov 2021 JACOBS FOUNDATION 2021 RESEARCH PRIZE – CHARLES NELSON Prof. Charles A. Nelson receives the 2021 Klaus J. Jacobs Research Prize for his groundbreaking research on the impacts of childhood adversities on brain development, behavioral disorders, and social stability. Custom website15 Nov 2021 JACOBS FOUNDATION 2021 RESEARCH PRIZE – DANIEL L. SCHWARTZ Prof. Daniel L. Schwartz receives the 2021 Klaus J. Jacobs Research Prize for his studies addressing cognitive questions through innovative learning experiments, bringing new insight to areas of educational research. Custom website8 Oct 2021 TACKLING GLOBAL CHALLENGES THROUGH CUTTING-EDGE RESEARCH KAUST is an oasis of innovation, advancing science, education, economic development, and entrepreneurism. Custom website20 Nov 2020 THE HUMAN PROTEIN ATLAS – A 20-YEAR JOURNEY The Human Protein Atlas is a free, open-access database hosting over 10 million annotated images and associated information, including mass spectrometry-based proteomics, transcriptomics, and systems biology. View more SCIENCE * Volume 376 * Issue 6594 * May 2022 View Cover COVER A survey of cell types across tissues as part of the Human Cell Atlas, mapped with single-cell transcriptomics in three papers in this issue, lays the foundation for understanding how cellular composition and gene expression vary across the human body in health, and for understanding how genes act in disease. See pages See pages 695 and eabl4896, eabl4290, eabl5197. Illustration: N. Fuller & C. Agosti of SayoStudio ReportsBy * Yoshimitsu Itoh * Shuo Chen * et al. ULTRAFAST WATER PERMEATION THROUGH NANOCHANNELS WITH A DENSELY FLUOROUS INTERIOR SURFACE Research ArticlesBy * Luming Zhou * Guiping Kong * et al. REVERSIBLE CD8 T CELL–NEURON CROSS-TALK CAUSES AGING-DEPENDENT NEURONAL REGENERATIVE DECLINE ReportsBy * Z. Jane Wang * James Melfi * et al. RECOVERY MECHANISMS IN THE DRAGONFLY RIGHTING REFLEX Research ArticlesBy * David Wei * Antonio Rubio-Abadal * et al. QUANTUM GAS MICROSCOPY OF KARDAR-PARISI-ZHANG SUPERDIFFUSION View Table of Contents SCIENCE ADVANCES * Volume 8 * Issue 20 * May 2022 View Cover ONLINE COVER Artistic rendering of the animal basement membrane, an extracellular structure that surrounds most tissues. Basement membranes exist across the animal kingdom but are yet to be fully understood. Using bioinformatic and in vivo approaches, Jayadev et al. defined a network of 222 human proteins, and the related genes in other species, that constitute basement membranes. By screening more than 63,000 genomes from families with rare disorders, the authors identified genes that regulate basement membrane composition and function. This framework could lead to earlier detection, more accurate prognosis, and new therapies for basement membrane-related disease. Credit: Siddharthan Balachandar Thendral, Duke University Earth, Environmental, Ecological, and Space SciencesBy * Ed L. Pope * Matthieu J. B. Cartigny * et al. FIRST SOURCE-TO-SINK MONITORING SHOWS DENSE HEAD CONTROLS SEDIMENT FLUX AND RUNOUT IN TURBIDITY CURRENTS Physical and Materials SciencesBy * Radovan Kukobat * Motomu Sakai * et al. ULTRAPERMEABLE 2D-CHANNELED GRAPHENE-WRAPPED ZEOLITE MOLECULAR SIEVING MEMBRANES FOR HYDROGEN SEPARATION NeuroscienceBy * Hyeokmoon Kweon * Gökhan Aydogan * et al. HUMAN BRAIN ANATOMY REFLECTS SEPARABLE GENETIC AND ENVIRONMENTAL COMPONENTS OF SOCIOECONOMIC STATUS Physical and Materials SciencesBy * Sichao Qu * Nan Gao * et al. UNDERWATER METAMATERIAL ABSORBER WITH IMPEDANCE-MATCHED COMPOSITE View Table of Contents SCIENCE IMMUNOLOGY * Volume 7 * Issue 71 * May 2022 View Cover ONLINE COVER Boosting Locally Buffs Up Vaccine-Induced Immunity. This month’s cover shows an immunofluorescence image of a germinal center in a mouse lymph node 5 weeks after a priming immunization with influenza hemagglutinin. Primed B cells fate-mapped for AID expression (green) are present in the central area of a follicle of IgD-expressing B cells (red) near CD21/35-expressing follicular dendritic cells (blue). Kuraoka et al. observed more fate-mapped memory B cells in lymph node germinal centers when booster immunizations were given at the same tissue site as the original immunization rather than on the opposite side. Credit: Masayuki Kuraoka and Ryutaro Kotaki/Duke University Research ArticlesBy * Agata K. Krzyzanowska * Rashade A. H. Haynes II * et al. ZBTB20 IDENTIFIES AND CONTROLS A THYMUS-DERIVED POPULATION OF REGULATORY T CELLS THAT PLAY A ROLE IN INTESTINAL HOMEOSTASIS Research ArticlesBy * Alice E. Denton * James Dooley * et al. TARGETING TLR4 DURING VACCINATION BOOSTS MADCAM-1+ LYMPHOID STROMAL CELL ACTIVATION AND PROMOTES THE AGED GERMINAL CENTER RESPONSE Research ArticlesBy * Håvard T. Lindholm * Naveen Parmar * et al. BMP SIGNALING IN THE INTESTINAL EPITHELIUM DRIVES A CRITICAL FEEDBACK LOOP TO RESTRAIN IL-13–DRIVEN TUFT CELL HYPERPLASIA Research ArticlesBy * Christopher D. Lucas * Christopher B. Medina * et al. PANNEXIN 1 DRIVES EFFICIENT EPITHELIAL REPAIR AFTER TISSUE INJURY View Table of Contents SCIENCE ROBOTICS * Volume 7 * Issue 66 * May 2022 View Cover ONLINE COVER Special Issue on Robots in the Wild. Robots have been successfully deployed in a wide range of domains–including land, sea, air, and space–for a variety of applications such as search and rescue, oceanography, wildlife surveys, and space exploration. In this issue, Zhou et al. have developed a trajectory planner for swarms of micro drones that can be implemented using only an onboard computer. Their planner computes trajectories based on limited information from the drone's onboard sensors to enable collision-free flight in cluttered environments in the wild. This month's cover is a photo illustration of a swarm of micro-drones flying through a forest (see also the Focus by Soria). Credit: Zhou et al./Zhejiang University Research ArticlesBy * Songnan Bai * Qingning He * et al. A BIOINSPIRED REVOLVING-WING DRONE WITH PASSIVE ATTITUDE STABILITY AND EFFICIENT HOVERING FLIGHT Research ArticlesBy * Xin Zhou * Xiangyong Wen * et al. SWARM OF MICRO FLYING ROBOTS IN THE WILD ReviewsBy * Steven Macenski * Tully Foote * et al. ROBOT OPERATING SYSTEM 2: DESIGN, ARCHITECTURE, AND USES IN THE WILD Research ArticlesBy * Michael O’Connell * Guanya Shi * et al. NEURAL-FLY ENABLES RAPID LEARNING FOR AGILE FLIGHT IN STRONG WINDS View Table of Contents SCIENCE SIGNALING * Volume 15 * Issue 734 * May 2022 View Cover ONLINE COVER This week, Boëx et al. show that muscle-localized Vangl2 promotes the formation and function of neuromuscular junctions, where neurons meet muscle to stimulate contraction needed for movement and breathing. The confocal microscopy image shows acetylcholine receptor clusters (green) at phrenic nerve terminals in the diaphragm from a mouse embryo. Credit: Boëx et al./Science Signaling Research ArticlesBy * Myriam Boëx * Steve Cottin * et al. THE CELL POLARITY PROTEIN VANGL2 IN THE MUSCLE SHAPES THE NEUROMUSCULAR SYNAPSE BY BINDING TO AND REGULATING THE TYROSINE KINASE MUSK Research ArticlesBy * Wenbin Zhang * Weiliang Fan * et al. OSMOTIC STRESS ACTIVATES RIPK3/MLKL-MEDIATED NECROPTOSIS BY INCREASING CYTOSOLIC PH THROUGH A PLASMA MEMBRANE NA+/H+ EXCHANGER Editors' ChoiceBy * Amy E. Baek LYMPH NODE COLONIZATION AND METASTASIS View Table of Contents SCIENCE TRANSLATIONAL MEDICINE * Volume 14 * Issue 645 * May 2022 View Cover ONLINE COVER FAKIng It. In this image, a red Duroc pig naps in the sunlight. Chen et al. used the red Duroc pig as a clinically relevant model to study the healing of split-thickness skin grafts (STSGs). Single-cell RNA sequencing revealed up-regulation of mechanotransduction signaling pathways during graft healing. To disrupt these pathways, the authors applied a hydrogel containing a focal adhesion kinase inhibitor (FAKI) to the STSGs. They found that FAKI treatment improved wound healing with anti-inflammatory effects at early time points and pro-regenerative effects at later time points, suggesting that FAKI might be beneficial for the treatment of deep injuries that require STSGs. Credit: Wrangel/iStock Research ArticlesBy * Kellen Chen * Dominic Henn * et al. DISRUPTING MECHANOTRANSDUCTION DECREASES FIBROSIS AND CONTRACTURE IN SPLIT-THICKNESS SKIN GRAFTING Research ArticlesBy * Kazushige Obata-Ninomiya * Steven de Jesus Carrion * et al. EMERGING ROLE FOR THYMIC STROMAL LYMPHOPOIETIN–RESPONSIVE REGULATORY T CELLS IN COLORECTAL CANCER PROGRESSION IN HUMANS AND MICE Research ArticlesBy * Paulina Kaplonek * Deniz Cizmeci * et al. MRNA-1273 AND BNT162B2 COVID-19 VACCINES ELICIT ANTIBODIES WITH DIFFERENCES IN FC-MEDIATED EFFECTOR FUNCTIONS Research ArticlesBy * Zachary R. Crook * Emily J. Girard * et al. 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