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ALVEOGENE RECEIVES RARE PEDIATRIC DISEASE DESIGNATION (RPDD) FROM FDA FOR
AVG-002, ITS NOVEL, INHALED GENE THERAPY FOR LETHAL NEONATAL SURFACTANT PROTEIN
B (SP-B) DEFICIENCY

[AlveoGene] AlveoGene announced that it has been granted a RPDD by the US FDA
for AVG-002, its novel inhaled gene therapy for lethal neonatal SP-B deficiency.
Cell Therapy NewsNewsletters
November 15, 2024
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ENDOTHELIAL HETEROGENEITY IN BONE MARROW: INSIGHTS ACROSS DEVELOPMENT, ADULT
LIFE, AND LEUKEMIA

[Leukemia] The authors highlight key milestones and recent advances in
understanding vascular heterogeneity within bone marrow microenvironment during
development, adulthood, and aging.
Endothelial Cell NewsNewsletters
November 15, 2024
Read more...


HUD IMPAIRS NEUROMUSCULAR JUNCTIONS AND INDUCES APOPTOSIS IN HUMAN IPSC AND
DROSOPHILA ALS MODELS

[Nature Communications] Using human iPSCs, investigators showed that the
RNA-binding protein HuD contributed to neuromuscular junction defects and
apoptosis in FUS-amyotrophic lateral sclerosis (ALS).
ESC & iPSC NewsNewsletters
November 15, 2024
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THE GLUCOCORTICOID RECEPTOR POTENTIATES ALDOSTERONE-INDUCED TRANSCRIPTION BY THE
MINERALOCORTICOID RECEPTOR

[Proceedings of The National Academy of Sciences of The United States of
America] Researchers analyzed the impact of glucocorticoid receptor coexpression
on mineralocorticoid receptor genome-wide transcriptional responses and
chromatin binding upon activation by aldosterone and glucocorticoids, both
physiological ligands of this receptor.
Immune Regulation NewsNewslettersOrganoid News
November 15, 2024
Read more...


MIST1 REGULATES ENDOPLASMIC RETICULUM STRESS-INDUCED HEPATIC APOPTOSIS AS A
CANDIDATE MARKER OF FATTY LIVER DISEASE PROGRESSION

Scientists investigated the dynamics of gene expression associated with the
progression of liver disease. They analyzed changes in gene expression over time
in a...
Hepatic Cell NewsNewsletters
November 15, 2024
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CHIMERIC SFT2D2-TBX19 PROMOTES PROSTATE CANCER PROGRESSION BY ENCODING TBX19-202
PROTEIN AND STABILIZING MITOCHONDRIAL ATP SYNTHASE THROUGH ATP5F1A
PHOSPHORYLATION

[Advanced Materials] Scientists identified the chimeric SFT2D2-TBX19 as a novel
transcript encoding the TBX19-202 protein. Both TBX19-202 and its parental
TBX19, which share homologous amino acid sequences, enhanced prostate cancer
cell proliferation, migration, and invasion.
NewslettersProstate Cell News
November 15, 2024
Read more...


HSD3B1, PROSTATE CANCER MORTALITY, AND MODIFIABLE OUTCOMES

[Nature Reviews Urology] Multiple clinical studies, including data derived from
prospective Phase III studies, have linked adrenal-permissive allele inheritance
to inferior clinical responses to androgen deprivation therapy and increased
mortality, but reversal is possible with upfront adrenal androgen blockade.
NewslettersProstate Cell News
November 15, 2024
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CELL ADHESION AND LOCAL CYTOKINE CONTROL ON PROTEIN-FUNCTIONALIZED PNIPAM-CO-AAC
HYDROGEL MICROCARRIERS

[Small] Scientists introduced hydrogel particles co-polymerized from
poly(N-isopropylacrylamide) (PNIPAM) and acrylic acid (AAc) as a platform
technology for cell expansion. The resulting microcarriers exhibited an
adjustable extracellular matrix-like softness, an adaptable gel charge, and
functional carboxyl groups.
Extracellular Matrix NewsNewsletters
November 15, 2024
Read more...


MATRIX METALLOPROTEINASE-RESPONSIVE CONTROLLED RELEASE OF SELF-ASSEMBLY
NANOPARTICLES ACCELERATES HEART VALVE REGENERATION IN SITU BY ORCHESTRATING
IMMUNOMODULATION

[Advanced Science] Researchers introduced a matrix metalloproteinase
(MMP)-response hydrogel system in which infiltrating immune cells produced the
MMP to degrade hydrogel and engulfed nanoparticles to convert to
anti-inflammatory phenotype.
Extracellular Matrix NewsNewsletters
November 15, 2024
Read more...


RECENT DEVELOPMENT OF FIBROUS HYDROGELS: PROPERTIES, APPLICATIONS AND
PERSPECTIVES

[Advanced Science] Scientists review the main advantages of fibrous hydrogels,
including enhanced mechanical properties, high conductivity, high antimicrobial
and anti-inflammatory properties, stimulus responsiveness, and an ECM-like
structure.
Extracellular Matrix NewsNewsletters
November 15, 2024
Read more...


MAP3K1 MUTATIONS CONFER TUMOR IMMUNE HETEROGENEITY IN HORMONE RECEPTOR-POSITIVE
HER2-NEGATIVE BREAST CANCER

[Journal of Clinical Investigation] The authors performed a multi-omics analysis
of a large cohort of HR+/HER2- breast cancer patients and revealed that
HR+/HER2- breast cancer possessed a highly heterogeneous tumor immune
microenvironment.
Mammary Cell NewsNewsletters
November 15, 2024
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CELL TYPE–SPECIFIC GENE THERAPY CONFERS PROTECTION AGAINST MOTOR NEURON DISEASE
CAUSED BY A TFG VARIANT

[Proceedings of The National Academy of Sciences of The United States of
America] Scientists demonstrated that the reintroduction of wild-type TFG into
synapsin 1-positive neurons provided robust protection against motor neuron
disease, whereas its expression in GFAP-positive glial cells provided no
significant improvement in quantitative measures of gait.
Neural Cell NewsNewsletters
November 15, 2024
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