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 1. Home
 2. Research
 3. Key Initiatives
 4. Cancer Moonshot℠
 5. Cancer Moonshot℠ Blue Ribbon Panel

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 * Cancer Moonshot℠
   * About the Cancer Moonshot
   * Progress
   * Research Initiatives
   * Seminar Series
   * Funding Opportunities
   * Blue Ribbon Panel
     * Panel Members


CANCER MOONSHOT℠ BLUE RIBBON PANEL

The Cancer Moonshot Task Force was directed to consult with external experts
from relevant scientific sectors, including the presidentially appointed
National Cancer Advisory Board (NCAB). A Blue Ribbon Panel (BRP) of scientific
experts was created to advise the NCAB.

ON THIS PAGE

 * Panel Process and Milestones
 * Blue Ribbon Panel Report


PANEL PROCESS AND MILESTONES

The BRP members were announced on April 4, 2016, and the first (virtual) meeting
took place on April 11. At this meeting the members agreed to establish seven
working groups to focus on major topic areas. The working group members were
announced on May 2, and the groups met frequently until mid-July. In addition,
the BRP met several more times—in person on April 18 and July 20, and virtually
on July 13.

The working groups began with broad discussions of the state of the field for
their respective topics and considered ideas from the members and the community
at large. The panel considered more than 1,600 ideas submitted by the broader
cancer community through a dedicated website, email, and other routes. Some
working groups created subgroups with focused expertise in particular areas to
carefully craft their recommendations. As the working groups narrowed in on
their specific recommendations, the chairs of multiple groups also met to
discuss cross-cutting themes and to merge similar topics into joint
recommendations.

The BRP reviewed the working groups’ draft recommendations at its June 13
meeting and reviewed their final recommendations at its July 20 (in-person)
meeting. The BRP presented a final report to the NCAB in September 2016.


BLUE RIBBON PANEL REPORT

Blue Ribbon Panel 2016 Overview

The BRP report describes 10 transformative research recommendations for
achieving the Cancer Moonshot's ambitious goal of making a decade's worth of
progress in cancer prevention, diagnosis, and treatment in just 5 years.
Download the complete report.

A. Establish a network for direct patient involvement
Engage patients to contribute their comprehensive tumor profile data to expand
knowledge about what therapies work, in whom, and in which types of cancer.

B. Create a translational science network devoted exclusively to immunotherapy
Establish a cancer immunotherapy network to discover why immunotherapy is
effective in some patients but not in others.

C. Develop ways to overcome cancer’s resistance to therapy
Identify therapeutic targets to overcome drug resistance through studies that
determine the mechanisms that lead cancer cells to become resistant to
previously effective treatments.

D. Build a National Cancer Data Ecosystem
Create a national ecosystem for sharing and analyzing cancer data so that
researchers, clinicians, and patients will be able to contribute data, which
will facilitate efficient data analysis.

E. Intensify research on the major drivers of childhood cancers
Improve our understanding of fusion oncoproteins in pediatric cancer and use new
preclinical models to develop inhibitors that target them.

F. Minimize cancer treatment’s debilitating side effects
Accelerate the development of guidelines for routine monitoring and management
of patient-reported symptoms to minimize debilitating side effects of cancer and
its treatment.

G. Expand use of proven cancer prevention and early detection strategies
Reduce cancer risk and cancer health disparities through approaches in
development, testing, and broad adoption of proven prevention strategies.

H. Mine past patient data to predict future patient outcomes
Predict response to standard treatments through retrospective analysis of
patient specimens.

I. Develop a 3-D cancer atlas
Create dynamic 3-D maps of human tumor evolution to document the genetic lesions
and cellular interactions of each tumor as it evolves from a precancerous lesion
to advanced cancer.

J. Develop new cancer technologies
Develop new enabling cancer technologies to characterize tumors and test
therapies.

The recommendations described in the BRP report emerged from the reports of the
BRP’s seven working groups. These reports discuss the groups’ recommendations in
detail:

 * Tumor Evolution and Progression Working Group Report
 * Clinical Trials Working Group Report
 * Precision Prevention and Early Detection Working Group Report
 * Pediatric Cancer Working Group Report
 * Enhanced Data Sharing Working Group Report
 * Cancer Immunology Working Group Report
 * Implementation Science Working Group Report

Or download all seven working group reports.

These working group reports outline a total of 13 recommendations, which form
the basis for NCI’s consideration of implementation. (A 14th recommendation was
converted into a demonstration project.) For the purposes of the report
submitted to the NCAB, the 13 recommendations were combined into 10 as follows:

 * The Pediatric Cancer and Tumor Evolution and Progression working groups
   jointly recommended efforts to identify new therapeutic targets to overcome
   cancer resistance. (This joint idea is included in both working group
   reports.)
 * The Tumor Evolution and Progression, Cancer Immunology, and Precision
   Prevention and Early Detection working groups all proposed generation of
   human atlases of cancer.
 * Both the Precision Prevention and Early Detection and Implementation Science
   working groups focused on the importance of screening.
 * Development of technologies cited throughout the recommendations was combined
   into a single recommendation.

Also available is a report about the public idea submission site, which received
more than 1,600 ideas and comments that were forwarded to the BRP for
consideration.

 * Updated: April 26, 2017

If you would like to reproduce some or all of this content, see Reuse of NCI
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permitted digital reproduction, please credit the National Cancer Institute as
the source and link to the original NCI product using the original product's
title; e.g., “Cancer Moonshot℠ Blue Ribbon Panel was originally published by the
National Cancer Institute.”

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