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* * Original Article Restricted Calories and Eating Times in Weight Loss D. Liu
and Others
This trial evaluated the efficacy and safety of time-restricted eating as
compared with daily calorie restriction for weight loss at 1 year among
patients with obesity. Time-restricted eating did not produce additional
benefits with regard to the reduction from baseline in body weight, body
fat, and metabolic risk factors as compared with daily calorie restriction.
Apr 21
Editorial Calorie and Time Restriction in Weight Loss
* * Editorial Covid-19 Update for April 19 The Effects of Covid-19 on Children
E.J. Rubin and Others
In this audio interview conducted on April 19, the editors are joined by
pediatrician and Deputy Editor Julie Ingelfinger to discuss the effects of
Covid-19 on children and adolescents and to provide advice to parents.
Apr 21
* Original Article Monoclonal Antibodies for Prevention of Covid-19 M.J.
Levin and Others
This randomized, controlled trial evaluated AZD7442 (a combination of
tixagevimab and cilgavimab, monoclonal antibodies targeting the SARS-CoV-2
spike protein) for the prevention of Covid-19 in adults at high risk for
SARS-CoV-2 infection. AZD7442 was found to have approximately 77% efficacy
in preventing symptomatic infection.
Apr 20
* * Medicine and Society The Quality Movement — Part 2 Metric Myopia L.
Rosenbaum
Proliferating measures of health care quality may distract clinicians from
what matters to individual patients and from larger public health problems.
Has the quality-improvement movement gone astray by ignoring the complexity
of both high-quality care and physicians’ motivations?
Apr 20
* Perspective Physicians as Political Pawns A. Kirkland
State efforts to prohibit gender-affirming care place physicians’ duties to
avoid discrimination, protect privacy, meet standards of care, fulfill
reporting requirements, and avoid committing crimes in direct conflict with
one another.
Apr 20
* Perspective Addressing Threats to the Nursing Workforce D.K. Costa and C.R.
Friese
U.S. nurses reported pervasive unsafe working conditions before the
pandemic and have cited a range of stressors and traumatic experiences
during it. Pressures on the nursing workforce may only worsen as Covid-19
subsides.
Apr 20
* * Correspondence Current Causes of Death in U.S. Children and Adolescents
J.E. Goldstick, R.M. Cunningham, and P.M. Carter
Firearm-related injury is now the leading cause of death among children and
teens. We continue to fail to protect our youth from a preventable cause of
death.
Apr 20
* Perspective Crossing Lines L.K. Lee, K. Douglas, and D. Hemenway
For more than 60 years, motor vehicle crashes were the leading cause of
injury-related death among young people. Beginning in 2017, however,
firearm-related injuries took their place to become the most common cause
of death from injury.
Apr 16
* Perspective Covid-19’s Devastating Effect on Tuberculosis Care M. Pai, T.
Kasaeva, and S. Swaminathan
Amid pandemic-related disruptions in services, tuberculosis case
notifications have plummeted and mortality has increased. The path to
recovery will require immediate, short-term steps and longer-term actions.
Apr 21
* Covid-19 Vaccine Resource Center
Practical guidance for your practice and patients
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* Editorial Apr 13, 2022
Covid-19 Boosters — Where from Here?
P. A. Offit
* Original Article Apr 13, 2022
Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
O. Magen and Others
* Original Article Apr 5, 2022
Protection by a Fourth Dose of BNT162b2 against Omicron in Israel
Y. M. Bar-On and Others
ORIGINAL RESEARCH
* * Original Article Asthma Therapy in Black and Latinx Adults E. Israel and
Others
Although reliever-triggered inhaled glucocorticoid therapy can reduce
asthma exacerbations, this approach has not been well studied in Black and
Latinx populations, who bear disproportionate asthma morbidity and
mortality. In a pragmatic trial involving Black and Latinx patients, the
asthma exacerbation rate was lower with reliever-triggered inhaled
glucocorticoid use than with usual care.
Apr 21
Editorial Breaking the Skin Color Barriers for Asthma Medications — It’s
Not Black, Brown, or White
* * Original Article Ivosidenib in IDH1-Mutated Acute Myeloid Leukemia P.
Montesinos and Others
In 6 to 10% of patients with acute myeloid leukemia, mutant isocitrate
dehydrogenase 1 is thought to contribute to leukemogenesis. Ivosidenib is
an oral inhibitor of mutant IDH1. In a randomized trial, event-free
survival was significantly longer with ivosidenib and azacitidine than with
placebo and azacitidine.
Apr 21
* Original Article Vaccine Boost Effects on Protection against Omicron N.
Andrews and Others
In a large case–control study in England, immunity to the omicron variant
was very low and less than that to the delta variant 20 weeks after the
second vaccine dose, regardless of the initial vaccine type. A booster dose
of one of the mRNA vaccines improved efficacy to approximately 65 to 70%,
but protection waned over a 10-week period.
Apr 21
* * Original Article Treatment of Acute Achilles’ Tendon Rupture S.B. Myhrvold
and Others
In this multicenter trial involving patients with acute Achilles’ tendon
rupture, surgery (open repair or minimally invasive surgery) did not result
in better outcomes than nonoperative treatment at 12 months.
Apr 14
Editorial Acute Achilles’ Tendon Rupture — Surgery or No Surgery
* * Correspondence Neutralization of Omicron BA.1 and BA.2 Variants J. Yu and
Others
Although two doses of BNT162b2 vaccine produce immunity that wanes over
time, the administration of a booster dose substantially increases the
level of neutralizing antibodies against both the BA.1 and BA.2 variants.
Apr 21
* EXPLORE RECENTLY PUBLISHED RESEARCH FROM NEJM EVIDENCE
Discover recently published original research articles — from important
first-in-human studies to confirmatory trials — that validate or challenge
prior clinical findings.
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PHYSICIAN JOBS
April 22, 2022
Lexington, Kentucky
Hospitalist
Hospitalist - Lexington, Kentucky
Kalispell, Montana
Gastroenterology
Seeking Gastroenterologist - Logan Health
Saint Louis, Missouri
Surgery, Orthopedic
Academic Ortho Hand Surgery
South Dakota
Internal Medicine
Internal Medicine needs in the Beautiful Black Hills
Rochester, New York
Dermatology
Dermatologist
Seattle, Washington State
Psychiatry
Psychiatrist
CLINICAL PRACTICE AND REVIEW
* * Case Records of the Massachusetts General Hospital Woman with Transient
Ischemic Attack and Mitral Valve Masses M.A. Matza and Others
A 41-year-old woman with transient dysarthria and facial droop was
evaluated for mitral valve masses. Three weeks earlier, she had heavy
vaginal bleeding with crampy abdominal pain, fatigue, and lightheadedness.
CT imaging was notable for small chronic cerebral infarcts and uterine
fibroids. What is the diagnosis?
Apr 21
* Clinical Implications of Basic Research CAR T Cells — A Foe of Fibrosis?
S.L. Friedman
Autologous chimeric antigen receptor T cells, which are engineered to bind
and kill cells that express a specific antigen, are effective in the
treatment of certain cancers. A recent study involving a mouse model shows
that CAR T cells can be generated in vivo and may reduce fibrosis after
myocardial injury.
Apr 21
* Clinical Practice Cancer-Associated Hypercalcemia T.A. Guise and J.J.
Wysolmerski
Cancer-associated hypercalcemia often occurs late in the course of
solid-tumor development and is associated with a poor prognosis. Treatment
includes intravenous hydration followed by antiresorptive agents, typically
intravenous bisphosphonates. Successful management ultimately depends on
effective treatment of the underlying cancer.
Apr 14
* * Review Article Early-Onset Colorectal Cancer F.A. Sinicrope
Early-onset disease (at <50 years of age) accounts for 10% of colorectal
cancer cases, and the incidence is increasing, particularly in high-income
countries. Patients often present with advanced disease in the left colon.
One in six patients has deficient DNA mismatch repair. Screening is now
recommended to begin at 45 years of age.
Apr 21
* Perspective Strengthening the Medicaid Reentry Act U.G. Khatri and T.N.A.
Winkelman
Under the Reentry Act, Medicaid would be able to pay for health care for
eligible people who are incarcerated starting up to 30 days before their
release from jail or prison. Changes to this bill could bring care in these
facilities in line with community standards.
Apr 21
. opens in new tab
. opens in new tab
Which one of the following cardiac murmurs is most likely in a 22-year-old man
with a history of acute rheumatic fever who presents with dyspnea?
* Midsystolic ejection murmur over the second right intercostal space
* Holosystolic murmur at the apex
* Systolic and diastolic machine-like murmur over the second left intercostal
space
* Harsh systolic crescendo–decrescendo murmur in the second left intercostal
space, radiating to the neck
* Holosystolic murmur, at the lower-left sternal border, that increases with
inspiration
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FEATURED MULTIMEDIA
Quick Take
TIME-RESTRICTED EATING FOR WEIGHT LOSS
01:44
Quick Take
INHALED GLUCOCORTICOIDS IN BLACK AND LATINX ADULTS WITH ASTHMA
02:12
Quick Take
IVOSIDENIB IN IDH1-MUTATED ACUTE MYELOID LEUKEMIA
02:12
Visual Abstract
EFFECTIVENESS OF COVID-19 VACCINES AGAINST THE OMICRON VARIANT
Quick Take
NIRMATRELVIR FOR HIGH-RISK COVID-19 OUTPATIENTS
02:15
Quick Take
TREATMENT FOR ACUTE ACHILLES’ TENDON RUPTURE
01:55
Quick Take
RILZABRUTINIB IN IMMUNE THROMBOCYTOPENIA
02:01
Visual Abstract
MITAPIVAT VS. PLACEBO FOR PYRUVATE KINASE DEFICIENCY
More Multimedia
COMMENTARY
* Perspective Apr 21 Crossing Lines
L.K. Lee, K. Douglas, and D. Hemenway
* Perspective Apr 21 Strengthening the Medicaid Reentry Act
U.G. Khatri and T.N.A. Winkelman
* Editorial Apr 21 Breaking the Skin Color Barriers for Asthma Medications —
It’s Not Black, Brown, or White
T. Bryant-Stephens
* Editorial Apr 21 Calorie and Time Restriction in Weight Loss
B. Laferrère and S. Panda
* Perspective Apr 21 Covid-19’s Devastating Effect on Tuberculosis Care
M. Pai, T. Kasaeva, and S. Swaminathan
* Perspective Apr 21 Not Ready for the End Game
J.R. Horwitz and L.F. Wiley
* Perspective Apr 21 Misusing Public Health as a Pretext to End Asylum
A.G. Beckett and Others
* Perspective Apr 20 Physicians as Political Pawns
A. Kirkland
* Perspective Apr 20 Addressing Threats to the Nursing Workforce
D.K. Costa and C.R. Friese
CORRESPONDENCE
* Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants
* Cardiovascular Events with Finerenone in CKD and Diabetes
* Determination of Brain Death
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How aligned are payer and provider organizations in working together toward
achieving value-based care in the health care industry overall?
* Extremely aligned
* Very aligned
* Aligned
* Not very aligned
* Not at all aligned
Learn about
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