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Submitted URL: http://neurostructures.com/
Effective URL: https://www.neurostructures.com/
Submission: On March 11 via api from US — Scanned from DE
Effective URL: https://www.neurostructures.com/
Submission: On March 11 via api from US — Scanned from DE
Form analysis 4 forms found in the DOM
POST /
<form method="post" enctype="multipart/form-data" id="gform_42" action="/" novalidate="">
<input type="hidden" class="gforms-pum" value="{"closepopup":false,"closedelay":0,"openpopup":false,"openpopup_id":0}">
<div class="gform_body gform-body">
<ul id="gform_fields_42" class="gform_fields top_label form_sublabel_below description_below">
<li id="field_42_1" class="gfield top gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible"><label class="gfield_label" for="input_42_1">Name<span class="gfield_required"><span
class="gfield_required gfield_required_asterisk">*</span></span></label>
<div class="ginput_container ginput_container_text"><input name="input_1" id="input_42_1" type="text" value="" class="large" placeholder="Your Name*" aria-required="true" aria-invalid="false"> </div>
</li>
<li id="field_42_5" class="gfield gfield--width-full gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible"><label class="gfield_label" for="input_42_5">Company<span
class="gfield_required"><span class="gfield_required gfield_required_asterisk">*</span></span></label>
<div class="ginput_container ginput_container_text"><input name="input_5" id="input_42_5" type="text" value="" class="large" placeholder="Company*" aria-required="true" aria-invalid="false"> </div>
</li>
<li id="field_42_7" class="gfield gfield--width-full field_sublabel_below field_description_above hidden_label gfield_visibility_visible"><label class="gfield_label">Method of Contact</label>
<div class="gfield_description" id="gfield_description_42_7"><span class="orange">Preferred Method of Contact*</span></div>
<div class="ginput_container ginput_container_radio">
<ul class="gfield_radio" id="input_42_7">
<li class="gchoice gchoice_42_7_0">
<input name="input_7" type="radio" value="Email" id="choice_42_7_0">
<label for="choice_42_7_0" id="label_42_7_0">Email</label>
</li>
<li class="gchoice gchoice_42_7_1">
<input name="input_7" type="radio" value="Phone" id="choice_42_7_1">
<label for="choice_42_7_1" id="label_42_7_1">Phone</label>
</li>
</ul>
</div>
</li>
<li id="field_42_2" class="gfield gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible" style="display: none;"><label class="gfield_label" for="input_42_2">Email<span
class="gfield_required"><span class="gfield_required gfield_required_asterisk">*</span></span></label>
<div class="ginput_container ginput_container_email">
<input name="input_2" id="input_42_2" type="email" value="" class="large" placeholder="Your Email*" aria-required="true" aria-invalid="false" disabled="disabled">
</div>
</li>
<li id="field_42_6" class="gfield gfield--width-full gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible" style="display: none;"><label class="gfield_label" for="input_42_6">Phone<span
class="gfield_required"><span class="gfield_required gfield_required_asterisk">*</span></span></label>
<div class="ginput_container ginput_container_phone"><input name="input_6" id="input_42_6" type="tel" value="" class="large" placeholder="Phone*" aria-required="true" aria-invalid="false" disabled="disabled"></div>
</li>
<li id="field_42_8" class="gfield gfield--width-full field_sublabel_below field_description_above hidden_label gfield_visibility_visible"><label class="gfield_label gfield_label_before_complex">Products</label>
<div class="gfield_description" id="gfield_description_42_8">Product(s) interested in (select all that apply):</div>
<div class="ginput_container ginput_container_checkbox">
<ul class="gfield_checkbox" id="input_42_8">
<li class="gchoice gchoice_42_8_1">
<input class="gfield-choice-input" name="input_8.1" type="checkbox" value="Arco™-SA" id="choice_42_8_1" aria-describedby="gfield_description_42_8">
<label for="choice_42_8_1" id="label_42_8_1">Arco™-SA</label>
</li>
<li class="gchoice gchoice_42_8_2">
<input class="gfield-choice-input" name="input_8.2" type="checkbox" value="Belvedere™" id="choice_42_8_2">
<label for="choice_42_8_2" id="label_42_8_2">Belvedere™</label>
</li>
<li class="gchoice gchoice_42_8_3">
<input class="gfield-choice-input" name="input_8.3" type="checkbox" value="Cavetto®" id="choice_42_8_3">
<label for="choice_42_8_3" id="label_42_8_3">Cavetto®</label>
</li>
<li class="gchoice gchoice_42_8_4">
<input class="gfield-choice-input" name="input_8.4" type="checkbox" value="Cavetto® Phusion Metal®" id="choice_42_8_4">
<label for="choice_42_8_4" id="label_42_8_4">Cavetto® Phusion Metal®</label>
</li>
<li class="gchoice gchoice_42_8_5">
<input class="gfield-choice-input" name="input_8.5" type="checkbox" value="Cavetto®-SA" id="choice_42_8_5">
<label for="choice_42_8_5" id="label_42_8_5">Cavetto®-SA</label>
</li>
<li class="gchoice gchoice_42_8_6">
<input class="gfield-choice-input" name="input_8.6" type="checkbox" value="Cantonale™ TLIF" id="choice_42_8_6">
<label for="choice_42_8_6" id="label_42_8_6">Cantonale™ TLIF</label>
</li>
<li class="gchoice gchoice_42_8_7">
<input class="gfield-choice-input" name="input_8.7" type="checkbox" value="Controvolte™" id="choice_42_8_7">
<label for="choice_42_8_7" id="label_42_8_7">Controvolte™</label>
</li>
<li class="gchoice gchoice_42_8_8">
<input class="gfield-choice-input" name="input_8.8" type="checkbox" value="Cortina™" id="choice_42_8_8">
<label for="choice_42_8_8" id="label_42_8_8">Cortina™</label>
</li>
<li class="gchoice gchoice_42_8_9">
<input class="gfield-choice-input" name="input_8.9" type="checkbox" value="Extrados™ CMF" id="choice_42_8_9">
<label for="choice_42_8_9" id="label_42_8_9">Extrados™ CMF</label>
</li>
<li class="gchoice gchoice_42_8_11">
<input class="gfield-choice-input" name="input_8.11" type="checkbox" value="MIS Retractors" id="choice_42_8_11">
<label for="choice_42_8_11" id="label_42_8_11">MIS Retractors</label>
</li>
<li class="gchoice gchoice_42_8_12">
<input class="gfield-choice-input" name="input_8.12" type="checkbox" value="Palladian™" id="choice_42_8_12">
<label for="choice_42_8_12" id="label_42_8_12">Palladian™</label>
</li>
<li class="gchoice gchoice_42_8_13">
<input class="gfield-choice-input" name="input_8.13" type="checkbox" value="Palladian™ Cross Connector" id="choice_42_8_13">
<label for="choice_42_8_13" id="label_42_8_13">Palladian™ Cross Connector</label>
</li>
<li class="gchoice gchoice_42_8_14">
<input class="gfield-choice-input" name="input_8.14" type="checkbox" value="Palladian™[MAX] MIS" id="choice_42_8_14">
<label for="choice_42_8_14" id="label_42_8_14">Palladian™[MAX] MIS</label>
</li>
<li class="gchoice gchoice_42_8_15">
<input class="gfield-choice-input" name="input_8.15" type="checkbox" value="Pinnacle Lateral Cage" id="choice_42_8_15">
<label for="choice_42_8_15" id="label_42_8_15">Pinnacle Lateral Cage</label>
</li>
<li class="gchoice gchoice_42_8_16">
<input class="gfield-choice-input" name="input_8.16" type="checkbox" value="Portico™ TLIF" id="choice_42_8_16">
<label for="choice_42_8_16" id="label_42_8_16">Portico™ TLIF</label>
</li>
<li class="gchoice gchoice_42_8_17">
<input class="gfield-choice-input" name="input_8.17" type="checkbox" value="Resolute®" id="choice_42_8_17">
<label for="choice_42_8_17" id="label_42_8_17">Resolute®</label>
</li>
<li class="gchoice gchoice_42_8_18">
<input class="gfield-choice-input" name="input_8.18" type="checkbox" value="Tirante™" id="choice_42_8_18">
<label for="choice_42_8_18" id="label_42_8_18">Tirante™</label>
</li>
<li class="gchoice gchoice_42_8_19">
<input class="gfield-choice-input" name="input_8.19" type="checkbox" value="Transom™" id="choice_42_8_19">
<label for="choice_42_8_19" id="label_42_8_19">Transom™</label>
</li>
<li class="gchoice gchoice_42_8_21">
<input class="gfield-choice-input" name="input_8.21" type="checkbox" value="Trifore™" id="choice_42_8_21">
<label for="choice_42_8_21" id="label_42_8_21">Trifore™</label>
</li>
</ul>
</div>
</li>
<li id="field_42_4" class="gfield field_sublabel_below field_description_above hidden_label gfield_visibility_visible"><label class="gfield_label" for="input_42_4">Additional Message</label>
<div class="ginput_container ginput_container_textarea"><textarea name="input_4" id="input_42_4" class="textarea large" placeholder="Additional Information" aria-invalid="false" rows="10" cols="50"></textarea></div>
</li>
<li id="field_42_9" class="gfield gform_validation_container field_sublabel_below field_description_below gfield_visibility_visible"><label class="gfield_label" for="input_42_9">Comments</label>
<div class="ginput_container"><input name="input_9" id="input_42_9" type="text" value="" autocomplete="new-password"></div>
<div class="gfield_description" id="gfield_description_42_9">This field is for validation purposes and should be left unchanged.</div>
</li>
</ul>
</div>
<div class="gform_footer top_label"> <input type="submit" id="gform_submit_button_42" class="gform_button button" value="Submit"
onclick="if(window["gf_submitting_42"]){return false;} if( !jQuery("#gform_42")[0].checkValidity || jQuery("#gform_42")[0].checkValidity()){window["gf_submitting_42"]=true;} "
onkeypress="if( event.keyCode == 13 ){ if(window["gf_submitting_42"]){return false;} if( !jQuery("#gform_42")[0].checkValidity || jQuery("#gform_42")[0].checkValidity()){window["gf_submitting_42"]=true;} jQuery("#gform_42").trigger("submit",[true]); }">
<input type="hidden" class="gform_hidden" name="is_submit_42" value="1">
<input type="hidden" class="gform_hidden" name="gform_submit" value="42">
<input type="hidden" class="gform_hidden" name="gform_unique_id" value="">
<input type="hidden" class="gform_hidden" name="state_42" value="WyJbXSIsImZkMWM0ZDgyNjliYzQwZTNkZDdlNzk0N2JlODA2MjdjIl0=">
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<input type="hidden" class="gform_hidden" name="gform_source_page_number_42" id="gform_source_page_number_42" value="1">
<input type="hidden" name="gform_field_values" value="">
</div>
<input type="hidden" name="pum_form_popup_id" value="3914">
</form>Name: login — POST
<form name="login" id="login" method="post" action="" autocomplete="off" novalidate="novalidate">
<input type="hidden" name="option" value="ap_user_login">
<input type="hidden" name="redirect" value="https://www.neurostructures.com/neuro-resources/">
<div class="log-form-group">
<label for="userusername">Username </label>
<input type="text" name="userusername" id="userusername" title="Please enter username" required="" aria-required="true">
</div>
<div class="log-form-group">
<label for="userpassword">Password </label>
<input type="password" name="userpassword" id="userpassword" title="Please enter password" required="" aria-required="true">
</div>
<div class="login-submit"><input name="login" type="submit" value="Login"></div>
<div class="log-form-group extra-links">
</div>
<input type="hidden" name="pum_form_popup_id" value="3384">
</form>POST /
<form method="post" enctype="multipart/form-data" id="gform_41" action="/" novalidate="">
<input type="hidden" class="gforms-pum" value="{"closepopup":false,"closedelay":0,"openpopup":false,"openpopup_id":0}">
<div class="gform_body gform-body">
<ul id="gform_fields_41" class="gform_fields top_label form_sublabel_below description_below">
<li id="field_41_2" class="gfield gfield--width-full gfield_contains_required field_sublabel_hidden_label field_description_below hidden_label gfield_visibility_visible"><label class="gfield_label gfield_label_before_complex">Name<span
class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label>
<div class="ginput_complex ginput_container no_prefix has_first_name no_middle_name has_last_name no_suffix gf_name_has_2 ginput_container_name" id="input_41_2">
<span id="input_41_2_3_container" class="name_first">
<input type="text" name="input_2.3" id="input_41_2_3" value="" aria-required="true" placeholder="First Name*">
<label for="input_41_2_3" class="hidden_sub_label screen-reader-text">First</label>
</span>
<span id="input_41_2_6_container" class="name_last">
<input type="text" name="input_2.6" id="input_41_2_6" value="" aria-required="true" placeholder="Last Name*">
<label for="input_41_2_6" class="hidden_sub_label screen-reader-text">Last</label>
</span>
</div>
</li>
<li id="field_41_3" class="gfield gfield--width-full gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible"><label class="gfield_label" for="input_41_3">Email<span
class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label>
<div class="ginput_container ginput_container_email">
<input name="input_3" id="input_41_3" type="email" value="" class="large" placeholder="Email*" aria-required="true" aria-invalid="false">
</div>
</li>
<li id="field_41_7" class="gfield gfield--width-full field_sublabel_below field_description_above hidden_label gfield_visibility_visible"><label class="gfield_label gfield_label_before_complex">Systems</label>
<div class="gfield_description" id="gfield_description_41_7">(Please select all that apply*)</div>
<div class="ginput_container ginput_container_checkbox">
<ul class="gfield_checkbox" id="input_41_7">
<li class="gchoice gchoice_41_7_1">
<input class="gfield-choice-input" name="input_7.1" type="checkbox" value="Arcate™ AlloGrafts" id="choice_41_7_1" aria-describedby="gfield_description_41_7">
<label for="choice_41_7_1" id="label_41_7_1">Arcate™ AlloGrafts</label>
</li>
<li class="gchoice gchoice_41_7_2">
<input class="gfield-choice-input" name="input_7.2" type="checkbox" value="Arcate™ DBMs" id="choice_41_7_2">
<label for="choice_41_7_2" id="label_41_7_2">Arcate™ DBMs</label>
</li>
<li class="gchoice gchoice_41_7_3">
<input class="gfield-choice-input" name="input_7.3" type="checkbox" value="Arcate™ Synthetics" id="choice_41_7_3">
<label for="choice_41_7_3" id="label_41_7_3">Arcate™ Synthetics</label>
</li>
<li class="gchoice gchoice_41_7_4">
<input class="gfield-choice-input" name="input_7.4" type="checkbox" value="Belvedere™" id="choice_41_7_4">
<label for="choice_41_7_4" id="label_41_7_4">Belvedere™</label>
</li>
<li class="gchoice gchoice_41_7_5">
<input class="gfield-choice-input" name="input_7.5" type="checkbox" value="Cavetto®" id="choice_41_7_5">
<label for="choice_41_7_5" id="label_41_7_5">Cavetto®</label>
</li>
<li class="gchoice gchoice_41_7_6">
<input class="gfield-choice-input" name="input_7.6" type="checkbox" value="Cavetto® Phusion Metal®" id="choice_41_7_6">
<label for="choice_41_7_6" id="label_41_7_6">Cavetto® Phusion Metal®</label>
</li>
<li class="gchoice gchoice_41_7_7">
<input class="gfield-choice-input" name="input_7.7" type="checkbox" value="Cavetto®-SA" id="choice_41_7_7">
<label for="choice_41_7_7" id="label_41_7_7">Cavetto®-SA</label>
</li>
<li class="gchoice gchoice_41_7_8">
<input class="gfield-choice-input" name="input_7.8" type="checkbox" value="Cantonale™ TLIF" id="choice_41_7_8">
<label for="choice_41_7_8" id="label_41_7_8">Cantonale™ TLIF</label>
</li>
<li class="gchoice gchoice_41_7_9">
<input class="gfield-choice-input" name="input_7.9" type="checkbox" value="Controvolte™" id="choice_41_7_9">
<label for="choice_41_7_9" id="label_41_7_9">Controvolte™</label>
</li>
<li class="gchoice gchoice_41_7_11">
<input class="gfield-choice-input" name="input_7.11" type="checkbox" value="Cortina™" id="choice_41_7_11">
<label for="choice_41_7_11" id="label_41_7_11">Cortina™</label>
</li>
<li class="gchoice gchoice_41_7_12">
<input class="gfield-choice-input" name="input_7.12" type="checkbox" value="Extrados™ CMF" id="choice_41_7_12">
<label for="choice_41_7_12" id="label_41_7_12">Extrados™ CMF</label>
</li>
<li class="gchoice gchoice_41_7_13">
<input class="gfield-choice-input" name="input_7.13" type="checkbox" value="MIS Retractors" id="choice_41_7_13">
<label for="choice_41_7_13" id="label_41_7_13">MIS Retractors</label>
</li>
<li class="gchoice gchoice_41_7_14">
<input class="gfield-choice-input" name="input_7.14" type="checkbox" value="Palladian™" id="choice_41_7_14">
<label for="choice_41_7_14" id="label_41_7_14">Palladian™</label>
</li>
<li class="gchoice gchoice_41_7_15">
<input class="gfield-choice-input" name="input_7.15" type="checkbox" value="Palladian™ Cross Connector" id="choice_41_7_15">
<label for="choice_41_7_15" id="label_41_7_15">Palladian™ Cross Connector</label>
</li>
<li class="gchoice gchoice_41_7_16">
<input class="gfield-choice-input" name="input_7.16" type="checkbox" value="Palladian™[MAX] MIS" id="choice_41_7_16">
<label for="choice_41_7_16" id="label_41_7_16">Palladian™[MAX] MIS</label>
</li>
<li class="gchoice gchoice_41_7_17">
<input class="gfield-choice-input" name="input_7.17" type="checkbox" value="Pinnacle Lateral Cage" id="choice_41_7_17">
<label for="choice_41_7_17" id="label_41_7_17">Pinnacle Lateral Cage</label>
</li>
<li class="gchoice gchoice_41_7_18">
<input class="gfield-choice-input" name="input_7.18" type="checkbox" value="Portico™ TLIF" id="choice_41_7_18">
<label for="choice_41_7_18" id="label_41_7_18">Portico™ TLIF</label>
</li>
<li class="gchoice gchoice_41_7_19">
<input class="gfield-choice-input" name="input_7.19" type="checkbox" value="Resolute®" id="choice_41_7_19">
<label for="choice_41_7_19" id="label_41_7_19">Resolute®</label>
</li>
<li class="gchoice gchoice_41_7_21">
<input class="gfield-choice-input" name="input_7.21" type="checkbox" value="Tirante™" id="choice_41_7_21">
<label for="choice_41_7_21" id="label_41_7_21">Tirante™</label>
</li>
<li class="gchoice gchoice_41_7_22">
<input class="gfield-choice-input" name="input_7.22" type="checkbox" value="Transom™" id="choice_41_7_22">
<label for="choice_41_7_22" id="label_41_7_22">Transom™</label>
</li>
<li class="gchoice gchoice_41_7_23">
<input class="gfield-choice-input" name="input_7.23" type="checkbox" value="Trifore™" id="choice_41_7_23">
<label for="choice_41_7_23" id="label_41_7_23">Trifore™</label>
</li>
</ul>
</div>
</li>
<li id="field_41_8" class="gfield gform_validation_container field_sublabel_below field_description_below gfield_visibility_visible"><label class="gfield_label" for="input_41_8">Email</label>
<div class="ginput_container"><input name="input_8" id="input_41_8" type="text" value="" autocomplete="new-password"></div>
<div class="gfield_description" id="gfield_description_41_8">This field is for validation purposes and should be left unchanged.</div>
</li>
</ul>
</div>
<div class="gform_footer top_label"> <input type="submit" id="gform_submit_button_41" class="gform_button button" value="Submit"
onclick="if(window["gf_submitting_41"]){return false;} if( !jQuery("#gform_41")[0].checkValidity || jQuery("#gform_41")[0].checkValidity()){window["gf_submitting_41"]=true;} "
onkeypress="if( event.keyCode == 13 ){ if(window["gf_submitting_41"]){return false;} if( !jQuery("#gform_41")[0].checkValidity || jQuery("#gform_41")[0].checkValidity()){window["gf_submitting_41"]=true;} jQuery("#gform_41").trigger("submit",[true]); }">
<input type="hidden" class="gform_hidden" name="is_submit_41" value="1">
<input type="hidden" class="gform_hidden" name="gform_submit" value="41">
<input type="hidden" class="gform_hidden" name="gform_unique_id" value="">
<input type="hidden" class="gform_hidden" name="state_41" value="WyJbXSIsImZkMWM0ZDgyNjliYzQwZTNkZDdlNzk0N2JlODA2MjdjIl0=">
<input type="hidden" class="gform_hidden" name="gform_target_page_number_41" id="gform_target_page_number_41" value="0">
<input type="hidden" class="gform_hidden" name="gform_source_page_number_41" id="gform_source_page_number_41" value="1">
<input type="hidden" name="gform_field_values" value="">
</div>
<input type="hidden" name="pum_form_popup_id" value="3281">
</form>GET https://www.neurostructures.com/
<form method="get" action="https://www.neurostructures.com/" class="wp-search-form rt_form">
<ul>
<li><input type="text" class="search showtextback" placeholder="search" name="s"><span class="icon-search-1"></span></li>
</ul>
</form>Text Content
* Company
* About
* Careers
* Medical Advisory Board
* Research & Development
* Solutions
*
* All Products
* Arco-SA
* Belvedere
* CantonaleMAX TLIF
* Cavetto
* Cavetto-SA
* Cavetto Phusion Metal
* Controvolte
* Cortina
* Orion
* Palladian
* Cross Connectors
* MIS
* Pinnacle Lateral Cage
* Resolute
* Transept
* Transom
* Trident
* Clinical
* News & Events
* News
* Upcoming Events
* Contact Us
* DISTRIBUTOR ACCESS
* Order Form
* Resources
* Log Out
* DISTRIBUTOR
*
* Company
* About
* Careers
* Medical Advisory Board
* Research & Development
* Solutions
*
* All Products
* Arco-SA
* Belvedere
* CantonaleMAX TLIF
* Cavetto
* Cavetto-SA
* Cavetto Phusion Metal
* Controvolte
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QUALITY INNOVATIVE IMPLANTABLE SURGICAL SOLUTIONS
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EXCELLENT RESULTS
NeuroStructures is dedicated to providing spine surgeons with unique and
innovative technologies that improve patient outcomes. Our expertise in
designing medical devices, coupled with our ability to effectively collaborate
with surgeons, allow us to develop products that are less invasive and provide
optimal clinical results.
UPCOMING EVENTS
We would be more than happy to see you at the next convention. Take a look at
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EVENTS
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We are constantly developing new solutions to keep up with the evolving medical
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bring new products from concept to market.
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COMING SOON
TORUS-SA
EXPANDABLE STAND-ALONE LATERAL CAGE
19 & 22mm Widths
Up to 20° Lordosis
TORUS
EXPANDABLE LATERAL CAGE
19 & 22mm Widths
Up to 20° Lordosis
PYLON
EXPANDABLE PLIF/TLIF CAGE
9, 10.5, & 12mm Widths
Up to 25° Lordosis
Learn More
PRONAOS
EXPANDABLE PLIF/TLIF CAGE
9, 10.5, & 12mm Widths
Up to 22° Lordosis
TRANSEPT
CERVICAL PLATING SYSTEM
Solid patent awarded for screw angulation and locking incorporated into plate
design.
Learn More ExpandableTransept
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Our lordotic Cavetto Phusion Metal cages are here! This proprietary and novel
porous intermetallic technology is optimized for bone ingrowth. Along with
elastic modulus within the range of human cancellous bone, the open-celled,
fully interconnected and irregular structures consist of macro, micro, and nano
sized pores.
Learn More
The materials on this website are for your general educational information only.
Information you read on this website cannot replace the relationship that you
have with your healthcare professional. We do not practice medicine or provide
medical services or advice as a part of this website. You should always talk to
your healthcare professional for diagnosis and treatment.
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2021 July
INTERBODY SPACER PATENT US 11,071,629 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
11,071,629 B2 “Interbody Spacer”. This patent is incorporated into the design of
the Oculus-SA Lumbar Cage System.
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2021 February
INTERBODY SPACER PATENT US 10,980,641 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
10,980,641 B2 “Interbody Spacer”. This patent is incorporated into the design of
the Arco-SA Stand-Alone ALIF System.
X
2012 May
TEMPUS ANTERIOR CERVICAL PLATE SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market a
new technology cervical plate design with a unique patented double locking
mechanism. This new easy to use patented locking mechanism provides the surgeon
with both visual, audible and tactile confirmation of the cervical screw being
locked.
X
2012 August
CAVETTO CERVICAL CAGE SYSTEM
NeuroStructures Inc. announces the 510(k) U.S. FDA clearance of the Cavetto
Cervical Cage IBF System. Cavetto Cages are designed to optimize endplate
contact and resist subsidence. Made from radiolucent PEEK material enhancing
visualization of the fusion process and with intuitive, ergonomic surgeon
friendly instrumentation. Cavetto cages incorporate tantalum markers for clear
intra-operative placement and visualization.
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2012 October
RESOLUTE MIS SPINAL FACET SCREW SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market a
new technology MIS approach, cannulated facet screw system. The over-the-wire
approach allows for additional tissue preservation and reduced hardware
requirements. The Resolute screws are designed with a unique low-profile
no-washer design minimizing soft tissue disruption and preserves adjacent level
anatomy.
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2014 March
ANTERIOR CERVICAL PLATE PATENT US 8,668,723 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
8,668,723 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Tempus Anterior Cervical Plate System.
X
2014 June
A SUCCESSFUL AUDIT BY THE US FOOD AND DRUG ADMINISTRATION (FDA) AT
NEUROSTRUCTURES
In June 2014, NeuroStructures Inc., was audited by the United States Food and
Drug Administration (FDA). The FDA audit confirms that the quality system
implemented by NeuroStructures, Inc. is in full compliance with GMP (current
Good Manufacturing Practices) regulations. This outcome proves the conformity of
our company to the standards indicated by the FDA.
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2014 December
DISTRIBUTION AGREEMENT AWARDED TO STRYKER SPINE
NeuroStructures, Inc. announces that they have concluded a manufacturing and
distribution agreement with Stryker Spine (Allendale, N.J.) for the Tempus
Anterior Cervical Plating System. NeuroStructures, Inc. remains the manufacturer
of record and Stryker owns the Tempus IP.
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2014 December
DISTRIBUTION AGREEMENT AWARDED TO INTEGRA LIFESCIENCES (SEASPINE)
NeuroStructures, Inc. announces that they have concluded a manufacturing and
distribution agreement with Integra LifeSciences (SeaSpine) for the Transom
Anterior Cervical Plating System. NeuroStructures, Inc. remains the manufacturer
of record and Integra Lifesciences (SeaSpine) owns the Transom IP.
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2015 February
ARCO-SA STAND-ALONE ALIF SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Arco-SA,
Stand-Alone ALIF System. Arco-SA is a PEEK spacer supplied prepacked sterile
with multiple footprints and lordotic angles to accommodate patient anatomy.
Surgeon friendly ergonomically design instrumentation allows for easy insertion
and positioning. Titanium plate with locking screws provides substantial stable
fixation.
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2014 November
TRANSOM ANTERIOR CERVICAL PLATE SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
Transom Anterior Cervical Plate System. This new technology cervical plate
system incorporates more of NeuroStructures, Inc. patented technologies allowing
for a one-step locking mechanism with visual and tactile lock verification.
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2017 May
SPINAL FACET BONE SCREW PATENT US 9,649,138 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,649,138 B2 “Spinal Facet Bone Screw”. This patent is incorporated into the
design of the Resolute MIS Spinal Facet Screw System.
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2017 June
BELVEDERE LATERAL PLATING SYSTEM HONORED AS WINNER IN THE 2017 MEDICAL DESIGN
EXCELLENCE AWARDS (MDEA)
NeuroStructures today announced that their Belvedere Lateral Plating System has
been selected as the a Winner in the 19th Annual Medical Design Excellence
Awards competition. The 2017 winning products were announced at the MDEA
Ceremony held Tuesday, June 13, 2017 in conjunction with the MD&M East event at
the Jacob K. Javits Convention Center in New York. The MDEA’s are the medical
technology industry’s premier design competition committed to searching for the
world’s highest caliber finished medical devices, products, systems, or
packaging available on the market. The awards program celebrates the
achievements of the medical device manufacturers, their suppliers, and the many
people behind the scenes—engineers, scientists, designers, and clinicians—who
are responsible for the cutting-edge products that are saving lives; improving
patient healthcare; and transforming medtech—one innovation at a time.
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2017 October
LATERAL PLATING SYSTEM PATENT US 9,775,652 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,775,652 B2 “Lateral Plating System”. This patent is incorporated into the
design of the Belvedere Lateral Plating System.
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2017 October
CORTINA LUMBAR CAGE SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Cortina
Lumbar Cage System. The Cortina Lumbar Cage System comprises of Cortina cages
designed to optimize endplate contact and resist subsidence along with
intuitive, ergonomic surgeon-friendly instrumentation. The Cortina cages are
made from radiolucent PEEK material enhancing visualization of the fusion
process while incorporating tantalum markers for clear intra-operative
placement.
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2018 February
CAVETTO-SA STAND ALONE CERVICAL CAGE
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Cavetto-SA
Stand Alone Cervical Cage System. The Cavetto-SA Stand Alone Cervical Cage
System comprises of Cavetto–SA cages and Screws designed to optimize endplate
contact and resist subsidence. The system uses a simple and unique One-Step
locking mechanism to allow a Zero – Profile construct. Along with intuitive,
ergonomic surgeon-friendly instrumentation Cavetto-SA provides a state of the
art solution. The Cavetto cages are made from radiolucent PEEK material
enhancing visualization of the fusion process while incorporating tantalum
markers for clear intra-operative placement.
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2018 February
CAVETTO CERVICAL CAGE SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Cavetto
Cervical Cage System. The Cavetto Cervical Cage System comprises of Cavetto
cages designed to optimize endplate contact and resist subsidence along with
intuitive, ergonomic surgeon-friendly instrumentation. The Cavetto cages are
made from radiolucent PEEK material enhancing visualization of the fusion
process while incorporating tantalum markers for clear intra-operative
placement.
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2018 March
ARCO-SA LUMBAR CAGE SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Arco-SA
Lumbar Cage System. The Arco-SA Lumbar Cage System comprises of Arco-SA cages
and screws designed to optimize endplate contact and resist subsidence. The
system uses a simple and unique One-Step locking mechanism to allow a Zero –
Profile construct. Along with intuitive, ergonomic surgeon-friendly
instrumentation, Arco-SA provides a state of the art solution. The Arco-SA cages
are made from radiolucent PEEK material enhancing visualization of the fusion
process while incorporating tantalum markers for clear intra-operative
placement.
X
2018 March
ANTERIOR CERVICAL PLATE PATENT US 9,918,749 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,918,749 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Tempus Anterior Cervical Plate System.
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2018 July
DISTRIBUTION AGREEMENT AWARDED TO CENTINEL SPINE
NeuroStructures, Inc. announces that they have concluded a manufacturing and
distribution agreement with Centinel Spine for the Trifore Anterior Cervical
Plating System. NeuroStructures, Inc. remains the manufacturer of record and
Centinel Spine owns the Trifore IP and will add it to their product portfolio
under the name Fortos C.
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2018 July
ANTERIOR CERVICAL PLATE PATENT US 10,016,224 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
10,016,224 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Trifore Cervical Plating System.
X
2018 October
ARCO-SA TI STAND-ALONE TITANIUM ALIF SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Arco-SA Ti
Stand-Alone Titanium ALIF System. The Arco-SA Ti System comprises of Arco-SA Ti
cages and screws designed to optimize endplate contact and resist subsidence.
The system uses a simple and unique One-Step locking mechanism to allow a Zero –
Profile construct. Along with intuitive, ergonomic surgeon-friendly
instrumentation, Arco-SA Ti provides a state of the art solution. The Arco-SA Ti
cages are made from porous Titanium to provide excellent long-term fixation with
a trabecular structure for multi-axial new bone in-growth.
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2019 August
BONE FIXATION SYSTEM PATENT US 10,368,923 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
10,368,923 B2 “Bone Fixation System”. This patent is incorporated into the
design of the Palladian Pedicle Screw System.
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2019 August
MANUFACTURING & DISTRIBUTION COLLABORATION WITH THE PINNACLE SPINE
We are very pleased with our new collaboration with Pinnacle Spine. This new
partnership accelerates NeuroStructures long term strategy to enter the lateral
access spine procedure market. NeuroStructures can now immediately present a
full complement of innovative and unique procedural solutions for the lateral
access approach for spine surgery. This solution is now available for all our
distributors, clinicians, and any potential new partners. With today’s
announcement, NeuroStructures can now offer a full set of innovative lateral
access retractors, instruments, and interbody implants, as well as lateral
plates. More specifically, this product offering is inclusive of angled
instruments designed to address the more complex L4-5 procedures. Pinnacle Spine
has been recognized for pioneering the novel design concept of placing bone
graft material into an implanted device in situ, maximizing the graft material
volume within the disc space. The InFill technology allows for complete,
endplate-to-endplate contact – a critical element in positive fusion outcomes.
This announcement is an exciting phase of innovation and growth for
NeuroStructures in 2019. We also have several key projects moving through the
FDA, set to be released in Q4 of 2019. This integration of the Pinnacle Spine
products into NeuroStructures product offerings is an excellent fit and will be
an impactful addition for our current and new distributors. All of the Pinnacle
Spine products are currently available through NeuroStructures emailing us at
customerservice@neurostructures.com. NeuroStructures is a medical device company
focused on designing, developing, manufacturing, and marketing proprietary,
high-quality medical device systems. All of our products provide comprehensive
medical solutions to improve and enhance the quality of life for patients.
NeuroStructures is dedicated to exceeding expectations in product quality,
customer service, and product cost. The company is led by a team of experienced
marketing, engineering, and sales individuals with extensive knowledge and
training in the domestic and international spine surgery device markets.
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2019 December
INTERBODY SPACER PATENT US 10,512,547 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
10,512,547 B2 “Interbody Spacer”. This patent is incorporated into the design of
the Cavetto SA Stand-Alone Cervical Cage System.
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2017 April
ANTERIOR CERVICAL PLATE PATENT US 9,629,664 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,629,664 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Transom Anterior Cervical Plate System.
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2017 February
NEUROSTRUCTURES WINS THE PRESTIGIOUS GOLDEN MOUSETRAP AWARDS FOR 2017
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
latest technology pedicle screw based spinal system and Minimally Invasive
Spinal System – Palladian. Palladian Spinal Systems incorporate a large array of
implants for both the Percutaneous and mini-open approaches. Double lead thread
design reduces insertion time and friction screw head allows for easy rod
insertion. All screws incorporate the Helical Flange technology which has been
proven to minimize cross threading of set screws while allowing for the lowest
of profile screw design. Multiple patents have been filed for the Palladian
Screw technology.
We are pleased to announce that Neurostructures has won the prestigious Golden
Mousetrap Awards 2017, for our Belvedere Lateral Plating System. The Golden
Mousetrap Awards acknowledge the American people, companies, and technologies
driving innovation in product design and manufacturing. Specifically, we
celebrate the renaissance of manufacturing in North America by honoring the
companies and people who make it possible while promoting engineering and
manufacturing as rewarding career choices for our next generation of stars. The
annual Golden Mousetrap Awards was on February 7th, 2017 in conjunction with the
MD&W, ATX West, Electronics West, WestPack, Pacific Design & Manufacturing, and
PLASTEC West shows in Anaheim, California. For more information on the Golden
Mousetrap Awards please visit GoldenMousetraps.com.
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2015 February
PRODUCT DEVELOPMENT CONTRACT CONCLUDED WITH STRYKER SPINE
NeuroStructures, Inc. announces the signing of an agreement with Stryker Spine
as an approved Product Development/design contractor for Stryker Spine
development projects.
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2015 February
PALLADIAN SPINAL FIXATION SYSTEM & PALLADIAN MIS SPINAL SCREW SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
latest technology pedicle screw based spinal system and Minimally Invasive
Spinal System – Palladian. Palladian Spinal Systems incorporate a large array of
implants for both the Percutaneous and mini-open approaches. Double lead thread
design reduces insertion time and friction screw head allows for easy rod
insertion. All screws incorporate the Helical Flange technology which has been
proven to minimize cross threading of set screws while allowing for the lowest
of profile screw design. Multiple patents have been filed for the Palladian
Screw technology.
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2015 March
ANTERIOR CERVICAL PLATE PATENT US 8,992,584 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
8,992,584 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Tempus Anterior Cervical Plate System.
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2015 July
RETRACTOR PATENT US 9,084,591 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,084,591 “Retractor” to NeuroStructures, Inc. This patent is incorporated into
the design of the Modillion L | Lateral Thoracolumbar Expandable Retractor
System and the Modillion P | Posterior Thoracolumbar Expandable Retractor
System.
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2015 August
ANTERIOR CERVICAL PLATE PATENT US 9,101,407 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,101,407 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Tempus Anterior Cervical Plate System.
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2015 August
ANTERIOR CERVICAL PLATE PATENT US 9,113,964 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,113,964 B2 Anterior Cervical Plate to NeuroStructures, Inc. This patent is
incorporated into the design of the Tempus.
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2015 September
ISO 13485 CERTIFICATION ANNOUNCEMENT
NeuroStructures, Inc., is proud to announce it is now certified as ISO 13485
compliant. The certification is accredited by Lloyd’s Register Quality
Assurance, Inc. (LRQA). To become certified as ISO 13485 compliant,
NeuroStructures, Inc. underwent a thorough evaluation process that included
quality management system development, a management system documentation review,
pre-audit, initial assessment, and clearance of non-conformances, all of which
work to identify corrective actions that elimination non-conformance to the
quality management standard. NeuroStructures received its ISO 13485 certificate
of registration on September 11, 2015. The certification of compliance with ISO
13485 recognizes that the policies, practices and procedures of our company
ensure consistent quality in the services and work product we provide our
customers. With this certification, our clients can be confident that
Neurostructures is dedicated to maintaining the highest efficiency and
responsiveness in achieving our ultimate goal – guaranteed customer
satisfaction. To maintain our certification, LRQA will perform annual audits to
ensure compliance and to assess initiatives for continued improvement. Our
customers can be confident that NeuroStructures will continue to provide the
high quality services they have come to expect well into the future. We believe
that our decision to become ISO 13485 Certified is a proactive one that not only
anticipates the demands of our customers, but also demonstrates our commitment
to providing quality services to all our customers in the medical industry.
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2015 September
NEUROSTRUCTURES, INC. CHOSEN AS ONE OF THE FASTEST-GROWING PRIVATE COMPANIES
NeuroStructures, Inc. has been recognized by the Orange County Business Journal
(OCBJ) as one of the fastest-growing private companies in Orange County.
Recording an impressive 110% revenue growth from June 2014 through June 2015,
the company ranked 21st in the Journal’s 2015 “Fastest-Growing Private
Companies: Small Companies” list.
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2016 July
DISTRIBUTION AGREEMENT AWARDED TO XTANT MEDICAL
NeuroStructures, Inc. announces that they have concluded a manufacturing and
distribution agreement with XTANT Medical for the Palladian Spinal Fixation
System.
X
2016 July
BELVEDERE LATERAL PLATING SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
Belvedere Lateral Plating System. This new technology lateral plate system
incorporates more of NeuroStructures, Inc. patented technologies allowing for
its expanding mechanism with tactile lock verification.
X
2016 July
DISTRIBUTION AGREEMENT AWARDED TO NEUROSTRUCTURES, INC.
NeuroStructures, Inc. announces that they have concluded a distribution
agreement with Pinnacle Spine Group for the InFill System.
X
2016 August
NEUROSTRUCTURES NAMED TO INC. 5000 | AMERICA’S FASTEST GROWING PRIVATE COMPANIES
Inc. magazine ranked NeuroStructures, Inc. number 64 on it’s 35th annual Inc.
5000, the most prestigious ranking of the nation’s fastest-growing private
companies. The list represents a unique look at the most successful companies
within the American economy’s most dynamic segment – it’s independent small
businesses. About the Inc. 500|5000 The Inc. 500|5000 is a list of the
fastest-growing private companies in the nation. Started in 1982, this
prestigious list of the nation’s most successful private companies has become a
hallmark of entrepreneurial success. The Inc. 500|5000 Conference & Awards
Ceremony is an annual event that celebrates their remarkable achievements. The
event also offers informative workshops, celebrated keynote speakers, and
evening functions. For more information on Inc. and the Inc. 500|5000
Conference, www.inc.com.
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2016 November
LATERAL PLATING SYSTEM PATENT US 9,486,250 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
9,486,250 B2 “Lateral Plating System”. This patent is incorporated into the
design of the Belvedere Lateral Plating System.
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2016 December
CAVETTO PHUSION METAL CERVICAL CAGE SYSTEM
NeuroStructures, Inc. has been transferred the 510(k) clearance from PorOsteon
Spine Inc. to market the Cavetto Phusion Metal Cervical Cage System. Phusion
Metal is a proprietary and novel porous intermetallic compound that obtains an
irregular open porous structure optimized for bone ingrowth with an elastic
modulus within the range of human cancellous bone.
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2016 December
DISTRIBUTION AGREEMENT AWARDED TO NEUROSTRUCTURES, INC.
NeuroStructures, Inc. announces that they have concluded a non-exclusive
distribution agreement with PorOsteon Spine Inc. for the Cavetto Phusion Metal
Cervical Cage System.
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2016 June
NEUROSTRUCTURES, INC. LAUNCHES NEW ORDERING APP
With direct product ordering form submission, the Neurostructures app is the
perfect tool to help streamline the ordering process. The app has a complete
order form for all of Neurostructures products.
X
2021 February
ANTERIOR CERVICAL PLATE PATENT US 10,912,591 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
10,912,591 B2 “Anterior Cervical Plate”. This patent is incorporated into the
design of the Tempus Anterior Cervical Plate System.
X
2020 July
TRANSEPT CERVICAL PLATING SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
Transept Cervical Plating System. This new technology cervical plate system
incorporates more of NeuroStructures, Inc. patented technologies with
hyper-angulation on the superior/inferior ends, one-step locking mechanism with
visual and tactile lock verification, and screw height variances.
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NS-300-104
CAVETTO PHUSION METAL SHORT-TERM BONE INGROWTH
INTRODUCTION
Cavetto Phusion Metal
Phusion Metal is a proprietary and novel porous intermetallic compound that
obtains an irregular open porous structure optimized for bone ingrowth. The
elastic modulus of 0.7-1.3 GPa lies within the range of human cancellous bone. A
low elastic modulus may preserve bone stock and reduce implant subsidence.
Surface friction allows for initial stability and reduces the risk of implant
migration. This unique and osteoconductive porous structure allows bone to grow
throughout the irregular pores resulting in a more rapid and robust fusion.
A short-term bone ingrowth study was designed to evaluate Phusion Metal in an
ovine model. Implants were evaluated for histological review at 2-week, 4-week,
6-week, 8-week and 12-week time points.
METHODS
Eight sheep underwent an instrumented 2-level lumbar intervertebral fusion at
L2-L3 and L4-L5. Each animal was implanted with two different types of interbody
fusion cages: commercially approved PEEK cage with autologous bone graft;
Phusion Metal cage with autologous bone graft. The animals were evenly divided
into 2 time points on the basis of follow-up period; 4 months and 6 months.
The right and left tibias were isolated free of soft tissue and the surgical
sites photographed using a digital camera. The surgical sites were examined for
signs of adverse reaction or infection. The distant organs (heart, liver, lung,
kidney, spleen, regional lymph nodes) were harvested, imaged and processed for
routine histopathology. All samples were processed for gross observation. Bones
were X-rayed in the anteroposterior and lateral views to determine implant
placement as well as for any adverse bony reactions.
Cortical implants were placed in 10% buffered formalin and sequentially
dehydrated in increasing concentrations of ethanol for embedding in
polymethylmethacrylate (PMMA). Embedded cortical implants were sectioned for
histological evaluation. Sections were stained with methylene blue and basic
fuchsin for examination under a light microscope for bone organization within
the porous implant and reaction at the implant-bone interface. Cortical
histology was assessed as per ISO 10993-6 for local tissue reactions.
Both the protocol and qualifications of the personnel involved in the study were
reviewed and approved by the Institutional Animal Care and Ethics Committee
(ACEC).
IN-VIVO & HARVEST
Surgery was successfully completed in all animals. No adverse events were noted
during the surgical procedures. Radiographs revealed no adverse events,
reactions or migrations to the implants at any time point. Radiographic
evaluation of the implantation size was uneventful with no evidence of fracture,
debris or implant related issues.
No adverse reactions were noted in any site in any animal. The underlying
response to the surgical procedure was normal. There were no adverse reactions
to the organs. The harvested bones were further evaluated using macro-zoom
photography. The cortical sites were carefully inspected for any evidence of
adverse reactions. No evidence of any adverse reaction was noted at any time
point in any animal.
HISTOLOGY
Histology at 2 weeks demonstrated an intimate bone-implant interface between the
implant and the bone. New bone formation integrating into the porous domains of
the implant was noted. No adverse reactions were noted from a cellular point of
view within the pores of the implant. No evidence of infection or any
inflammatory cells was noted. New bone formed directly on the surface and into
the pores at 2 weeks.
Histology at 4 weeks demonstrated an increase in new bone integration into the
porous domains of the implant compared to the 2-week time point. No changes were
observed in the features of the connective tissue within the center of the
implant. No adverse reactions were noted at the 4-week time point.
Histology at 6 weeks demonstrated complete new bone integration into the porous
domains of the implant. Complete bone ingrowth from one cortex to the other in
the medial and lateral sites was noted as early as the 6-week time point. No
adverse reactions were noted.
Histology at 8 weeks demonstrated new bone integration and remodeling within the
porous domains of the implant. No intervening fibrous tissue was noted at the
bone implant interface at the margins or within the center of the implant.
Complete bone ingrowth from one cortex to the other in the medial and lateral
sites was noted. Interestingly new bone was seen growing up the implant into the
medullary canal.
Histology at 12 weeks demonstrated to continue progression and remodeling of the
bone within the implant. No adverse reactions were noted at 12 weeks. As noted
at 8 weeks, there were areas of bone formation into the medullary canal of the
cortical implantation sites. This bone appeared to walk through the implant.
This supports the overall all osteoconductive nature of the fully porous
material implanted in the study.
CONCLUSSION
Surgical implantation of Phusion Metal was achieved in all animals without any
adverse events. The implants were implanted into their designated sites without
any issues. The wounds were all well-healed and normal ambulation recovery was
noted in all animals. There were no adverse reactions to the organs.
Radiographic evaluation of the implantation size was uneventful with no evidence
of fracture or implant related issues. Macroscopic evaluations did not reveal
any adverse reactions to the implants across any group. No evidence of any
adverse reactions was noted in the cortical histology at any time point.
New bone integration into the porous domains of the porous structure was noted
as early as 2 weeks and continual progression of new bone formation into the
porous domains of the implant improved with time. Complete bone ingrowth from
one cortex to the other in the medial and lateral sites was noted as early as 6
weeks.
As noted at the 8 and 12 weeks, interestingly, new bone formation was seen
growing up the implant into the medullary canal. All implants at 8 and 12 weeks
demonstrated complete bone growth from on cortex to the other in the medial and
lateral sites. Bone appeared to walk through and up the porous implant.
Phusion Metal has a unique and osteoconductive porous structure that allows bone
to grow throughout the irregular pores resulting in a more rapid and robust
fusion. The irregular pore size distribution and surface topography of the
material is very friendly to the body and supported direct bone formation onto
and throughout the implant.
This evidence supports biocompatibility, initial implant stability, short-term
bone ingrowth and the osteoconductive nature of a proprietary and novel porous
intermetallic compound used in an ovine study.
Refer to the Cavetto Phusion Metal Instructions for Use for proper use,
precautions, warnings, indications, and labeling.
X
DR. JOSHUA D. BECK
Fellowship Trained Board Certified Orthopaedic Spine Surgeon
Teton Orthopaedics
Jackson Hole, Wyoming
NS-300-105
TRANSOM & CAVETTO
CASE DESCRIPTION
Herniated Cervical Discs Cervical 5 – 7 with Cervical Radiculopathy
INTRODUCTION
Pre-Operative Diagnosis:
1. Cervical stenosis C5 – C7
2. Herniated nucleus pulposus C5 – C7
3. Cervical radiculopathy
4. Cervicogenic headaches
5. Axial neck pain
PATENT HISTORY
Patient is a 36 year old female who was diagnosed with continued severe neck
pain with the bilateral upper extremity radiculopathy left greater than right.
Treatment history included three years of physical therapy.
Cervical mobility is inhibited secondary to severe axial neck pain. Spurling’s
maneuver is positive bilaterally left greater than right. Symptoms are in the C6
and C7 dermatomes. She has some symptoms on the left upper extremity in the C8
distribution dermatomes. She has positive Tinel sign over the cubital tunnel on
the left side.
DEVICE DESCRIPTION
* NeuroStructures Transom Anterior Cervical Plating System
* NeuroStructures Cavetto Cervical Cage System
* Physio Moldable 5cc DBM allograft
SURGICAL PROCEDURE
* ACDF C5 – C7
RESULTS
3 MONTH POST OPERATIVE
5 MONTH POST OPERATIVE
Follow Up
Occurred at 3 and 5 months after procedure.
At the 3 month follow up, the patient reported no neck or arm pain. X-rays taken
and reviewed, included the AP and lateral views of the cervical spine. There is
a plate and screw construct in position from C5 – C7. Interbody fusion cage
appears to be consolidating nicely. There is some kyphosis above her fusion, but
no osteolysis is seen surrounding the hardware.
DISCUSSION
This case typifies common pathology seen by spine care providers on a frequent
basis. Having failed conservative treatments for a 3 year period consisting of
physical therapy, chiropractic care, medications and injections, this patient
was an excellent surgical candidate for this procedure. Surgery can in many
cases provide palliation of preoperative pain. The NeuroStructures Transom
Anterior Cervical Plating System has been used in this instance to provide a
stable construct, allowing for fusion to occur. It is a rigid construct with a
simple, well visualized locking mechanism and extremely low profile to minimize
dysphagia, engineered to facilitate minimum surgical exposure.
Refer to the Transom Cervical Plate System Instructions for Use for proper use,
precautions, warnings, indications, and labeling.
X
DR. JOSHUA D. BECK
Fellowship Trained Board Certified Orthopaedic Spine Surgeon
Teton Orthopaedics
Jackson Hole, Wyoming
NS-300-106
TRANSOM & CAVETTO
CASE DESCRIPTION
Herniated Cervical Discs Cervical 5 – 7
INTRODUCTION
Pre-Operative Diagnosis:
1. Cervical stenosis C5 – C7
2. Cervical radiculopathy
PATENT HISTORY
Patient is a 39 year old male with a longstanding history of neck pain with
bilateral upper extremity radiculopathy. He sustained an injury to his cervical
spine in a bridge collapse accident that occurred in December of 2012, where his
truck fell into a creek bed. He had severe cervicogenic headaches. Cervical
mobility is inhibited secondary to axial neck pain. Spurling’s maneuver is
positive bilaterally. It causes symptoms in the C6 – C7 dermatomes. MRI shows
severe cervical stenosis at C5 – C6 with a large left-sided disc herniation at
C6 – C7.
DEVICE DESCRIPTION
* NeuroStructures Transom Anterior Cervical Plating System
* NeuroStructures Cavetto Cervical Cage System
* Physio Moldable 5cc DBM allograft
SURGICAL PROCEDURE
* ACDF C5 – C7
RESULTS
4 MONTH POST OPERATIVE
6 MONTH POST OPERATIVE
Follow Up
Occurred at 3 and 5 months after procedure.
At the 3 month follow up, the patient reported no neck or arm pain. X-rays taken
and reviewed, included the AP and lateral views of the cervical spine. There is
a plate and screw construct in position from C5 – C7. Interbody fusion cage
appears to be consolidating nicely. There is some kyphosis above her fusion, but
no osteolysis is seen surrounding the hardware.
DISCUSSION
This case typifies common pathology seen by spine care providers on a frequent
basis. Having failed conservative treatments for a 3 year period consisting of
physical therapy, chiropractic care, medications and injections, this patient
was an excellent surgical candidate for this procedure. Surgery can in many
cases provide palliation of preoperative pain. The NeuroStructures Transom
Anterior Cervical Plating System has been used in this instance to provide a
stable construct, allowing for fusion to occur. It is a rigid construct with a
simple, well visualized locking mechanism and extremely low profile to minimize
dysphagia, engineered to facilitate minimum surgical exposure.
Refer to the Transom Cervical Plate System Instructions for Use for proper use,
precautions, warnings, indications, and labeling.
X
DR. JOSHUA D. BECK
Fellowship Trained Board Certified Orthopaedic Spine Surgeon
Teton Orthopaedics
Jackson Hole, Wyoming
NS-300-107
TRANSOM & CAVETTO
CASE DESCRIPTION
Cervical Stenosis with Myelopathy Cervical 3 – 6
INTRODUCTION
Pre-Operative Diagnosis:
1. Cervical stenosis C3 – C6
2. Cervical radiculopathy
3. Cervical myelopathy
PATENT HISTORY
Patient is a 69 year old woman with a long standing history of neck problems.
She has experienced increasing clumsiness and myelopathy over the last several
years.
DEVICE DESCRIPTION
* NeuroStructures Transom Anterior Cervical Plating System
* NeuroStructures Cavetto Cervical Cage System
* Physio Moldable 10cc DBM allograft
SURGICAL PROCEDURE
* ACDF C3 – C6
RESULTS
3 MONTH POST OPERATIVE
6 MONTH POST OPERATIVE
Follow Up
Occurred at 3 months and 6 months.
X-rays were reviewed including AP and lateral views of the cervical spine. There
is a plate and screw construct in position from C3 – C6. Interbody fusion cages
are well positioned. Bone graft is solidly consolidated. Hardware is well
positioned with well-maintained lordosis. No osteolysis or loosening is
appreciated.
DISCUSSION
In this case, the NeuroStructures Transom Anterior Plating System is used to
treat severe cervical stenosis in a patient with progressive cervical
myelopathy. With dysphagia a frequent complaint following multilevel ACDF
procedures, especially those extending to cervical 3, a low profile plate like
the Transom is an excellent choice.
Refer to the Transom Cervical Plate System Instructions for Use for proper use,
precautions, warnings, indications, and labeling.
X
BOB BARCOHANA, MD
Valley Presbyterian Hospital
Van Nuys, CA
NS-300-110
CAVETTO PHUSION METAL
CASE DESCRIPTION
Anterior cervical discectomy and instrumented fusion at C5 – C6 adjacent to
previous C6 – C7 ACDF for adjacent segment disease.
INTRODUCTION
Pre-Operative Diagnosis:
1. History of previous C6 – C7 ACDF with Transom cervical plate and structural
allograft
2. C5 – C6 adjacent cervical disk disease and stenosis
3. Cervical radiculopathy
PATENT HISTORY
This is a case of a 43-year old female who previously underwent an anterior
cervical discectomy and instrumented fusion at C6 – C7 for radiculopathy
utilizing structural allograft with a Transom anterior cervical plate. She did
well from this surgery but subsequently developed adjacent segment disease at C5
– C6 with stenosis and radiculopathy. MRI revealed a right paracentral
herniation at C5 – C6. She failed a course of conservative measures including
physical therapy, medications, and epidural injections. It was recommended that
she undergo removal of the anterior hardware at C6 – C7, as this level was
fused, coupled with an anterior cervical discectomy and instrumented fusion at
C5 – C6.
DEVICE DESCRIPTION
* NeuroStructures Cavetto Phusion Metal Cervical Interbody Cage System
* NeuroStructures Transom Cervical Plate System
* Prosidyan FIBERGRAFT BG MATRIX
SURGICAL PROCEDURE
* Removal of anterior cervical plate at C6 – C7
* Anterior cervical interbody fusion with Cavetto Phusion Metal Cage
* Anterior cervical fusion with Transom Cervical Plate
RESULTS
PRE-OPERATIVE AP
PRE-OPERATIVE LATERAL
POST-OPERATIVE AP
POST-OPERATIVE LATERAL
Follow Up
At 2 week follow-up, the patient is already experiencing improvement in her
radicular symptoms.
DISCUSSION
This case demonstrates adjacent segment disease next to a previously fused C6 –
C7 level. Having failed conservative measures consisting of physical therapy,
medications, and spinal injections, it was recommended that the patient undergo
removal of the C6 – C7 hardware followed with an anterior cervical discectomy
and instrumented fusion at C5 – C6 with the goal of alleviating her neck pain
and radicular symptoms utilizing the Cavetto Phusion Metal Cage. This
biomechanical intervertebral device provides stabilization to the spine while
promoting intervertebral fusion.
Refer to the Cavetto Phusion Metal Cervical Interbody Cage System Instructions
for Use for proper use, precautions, warnings, indications, and labeling.
X
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2020 July
OCULUS-SA LUMBAR CAGE SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Oculus-SA
Lumbar Cage System. The Oculus-SA System comprises of Oculus-SA cages and screws
designed to optimize endplate contact and resist subsidence. The system uses a
simple and unique One-Step locking mechanism to allow a Zero – Profile
construct. Along with intuitive, ergonomic surgeon-friendly instrumentation,
Oculus-SA provides a state of the art solution.
X
2017 July
TRIFORE ANTERIOR CERVICAL PLATING SYSTEM
NeuroStructures, Inc. received 510(k) clearance from the U.S. FDA to market the
Trifore Anterior Cervical Plating System. This new technology cervical plate
system incorporates more of NeuroStructures, Inc. patented technologies allowing
for a one-step locking mechanism with visual and tactile lock verification and
screw height variances.
X
2012 May
CORTINA PLIF CAGE SYSTEM
NeuroStructures, Inc. announces the 510(k) U.S. FDA clearance of the Cortina
PLIF cage IBF System. Bulleted (tissue dissecting) and Blunt nosed PEEK
innerbody with intuitive and ergonomic surgeon friendly instrumentation. Cortina
cages incorporate tantalum markers for clear intra-operative visualization.
X
NS-300-101
CAVETTO PHUSION METAL INTERBODY FUSION
INTRODUCTION
Cavetto Phusion Metal
Phusion Metal is a proprietary and novel porous intermetallic compound that
obtains an irregular open porous structure optimized for bone ingrowth. The
elastic modulus of 0.7 – 1.3 GPa lies within the range of human cancellous bone.
A low elastic modulus may preserve bone stock and reduce implant subsidence.
Surface friction allows for initial stability and reduces the risk of implant
migration. This unique and osteoconductive porous structure allows bone to grow
throughout the irregular pores resulting in a more rapid and robust fusion.
Poly-ether-ether-ketone (PEEK), a high-performance radiolucent thermoplastic
material with an elastic modulus of 4.1 GPa has been widely used for interbody
cage devices over the past decade. However, PEEK is nonporous, provides limited
cell response, has been known to form a fibrous connective interface and does
not integrate well with bone.
The main objective of this study was to compare a proprietary Phusion Metal
interbody fusion cage to a commercially available PEEK interbody fusion cage in
an ovine lumbar interbody fusion model. We hypothesized that this open-celled
and fully interconnected porous structure would encourage superior
bone-to-implant contact and allow bone ingrowth throughout the pores in all
directions with substantial implant incorporation, thus, resulting in a more
rapid and robust fusion.
MATERIAL COMPARISON
Material Properties Phusion Metal PEEK Bone Through Growth Bone Attachement
Osteoconductive Irregular Porous Structure High Friction Elastic Modulus (GPa)
0.7 – 1.3 4.1
METHODS
Eight sheep underwent an instrumented 2-level lumbar intervertebral fusion at
L2-L3 and L4-L5. Each animal was implanted with two different types of interbody
fusion cages: commercially approved PEEK cage with autologous bone graft;
Phusion Metal cage with autologous bone graft. The animals were evenly divided
into 2 time points on the basis of follow-up period; 4 months and 6 months.
Soft tissues (n=42) from heart, liver, lung, spleen, lymph node, and kidney were
fixed, dehydrated, cleared, infiltrated, and embedded using standard paraffin
histology techniques and equipment.
Sheep underwent lateral and dorsoventral lumbar radiographs as well as computed
tomographic scans of the lumbar spine following immediate post-op and
euthanasia.
Histological sections were stained with Sanderson’s Rapid Bone stain which
provided differentiation of cells and allowed detection of cartilage within the
tissue. Slides were then counterstained using a Van Gieson bone stain that
allows differentiation of collagen and detection of bone. Histomorphometric
measurements were made to quantify the area of new bone + fibrous reactive
tissue + osteoid filling the pores of Phusion Metal.
Both the protocol and qualifications of the personnel involved in the study were
reviewed and approved by the Institutional Animal Care and Use Committee
(IACUC). This preclinical study has been performed in compliance with Good
Laboratory Practice for Nonclinical Laboratory Studies (GLP) defined in the
current FDA, 21 CFR 58.
CAGE DIMENSIONS
Implant Size Height (mm) Widh (mm) Length (mm) Wall Thickness (mm) Phusion Metal
7 12.5 15 3.5 PEEK 6 12 14 2.5
IN-VIVO & HARVEST
No animals were lost or showed signs of infection, lameness or neurologic
deficits throughout the study period. Histological analysis of soft tissues
(n=42), including heart, liver, lung, spleen, kidney and lymph node was normal
for conventionally raised sheep. There were no changes that were considered as
potential toxic effects of the implants or procedures. Neither implant related
issues nor migrations occurred throughout the study.
HISTOLOGY & HISTOMORPHOMETRY
With regards to undecalcified bone sections, Phusion Metal demonstrated new
reactive bone completely capping the vertebral endplates adjacent to the
implants at 4-month and 6-month time points. Phusion Metal implants had less
fibrous encapsulation compared to PEEK and had variable amounts of reactive bone
directly in contact with the implant surface replacing the fibrous capsule
(Figure 2 & Figure 3).
Proportion of the filling by these tissue types was variable between individuals
and varied within portions of the Phusion Metal material. At 4 months, some
areas of the inner pores were completely filled with bone suggesting new bone
could form a complete bridge between the osteotomy sites with implant
incorporated into this boney bridging.
At 4 months, the interconnected pores of the Phusion Metal material were filled
with new reactive bone, fibrous reactive tissue, and osteoid (Figure 4). On
average at 4 months, 73.90% of the Phusion Metal pores are filled with new
reactive bone, fibrous reactive tissue and osteoid.
CT SCAN & RADIOGRAPHIC ANALYSIS
A comparison of radiographs and computed tomographic examinations at time=0 and
at euthanasia showed neither signs of implant related issues nor migrations at 4
months and 6 months (Figure 5).
CONCLUSSION
Surgical implantation was achieved in all animals without any adverse events.
The wounds were all well-healed and normal ambulation recovery was noted in all
animals. There were no adverse reactions to the organs. Radiographic and CT scan
evaluation confirmed there was neither evidence of migration nor implant related
issues at all time points. No evidence of any adverse reactions to the implants
was noted throughout the study.
In an attempt to increase the bone remodeling properties of PEEK, a number of
surface technologies have been recently introduced to the market. Although
plasma-sprayed titanium coatings on PEEK have been shown to improve bone
formation at the implant-bone interface, wear debris and delamination may occur
during impaction. Solid titanium cages with a nano-textured surface improves
bone ongrowth, however, they obtain high material stiffness with an elastic
modulus of 110-115 GPa which may lead to increased subsidence rates.
Phusion Metal has several unique properties and potential advantages compared to
PEEK and other surface coated intervertebral fusion cage materials. Phusion
Metal® has an irregular porous structure with interconnected passageways that
facilitates bone integration throughout the pores, thus, the material actively
participates during the entire fusion process.
As seen in the histology images, this intermetallic compound promotes
substantial through-growth of bone during the early stages of the healing
cascade.
The preclinical GLP study demonstrates the osteoconductive and osseointegrative
nature of Phusion Metal used in an interbody fusion ovine model. Unlike PEEK,
the proprietary and novel Phusion Metal intermetallic material allowed for early
osseointegration at the implant surface adjacent to both endplates and
osteoconduction throughout the pores. Phusion Metal, a biocompatible and
bone-friendly porous intermetallic compound, holds promise of more rapid and
complete bone growth to improve overall spinal fusion outcomes.
Refer to the Phusion Metal Instructions for Use for proper use, precautions,
warnings, indications, and labeling.
X
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2021 August
ANTERIOR CERVICAL PLATE PATENT US 11,076,892 B2 ISSUED
The U.S. Commissioner of Patents and Trademarks awards patent number US
11,076,892 “Anterior Cervical Plate”. This is a solid patent for the screw
angulation and locking, incorporated into the design of the Transept Cervical
Plating System.
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