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CURRENT TOPICS IN MEDICINAL CHEMISTRY


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PEER REVIEW REQUEST - ACCEPTANCE CONFIRMATION


BMS-CTMC-2024-169

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Article Title:
Innovative Therapies: A Major Breakthrough in Combating Multi-Drug-resistant
Bacterial Infections Using Mixture Design and Multi-Objective Optimization with
NSGA-II Algorithm
Abstract:
Introduction/Objective: The increasing resistance of pathogens to antibiotics
poses a major public health challenge. This study aims to develop an innovative
approach to combat this resistance by exploring synergies between standard
antibiotics and marine metabolites. Methods: The methodology combines disk
diffusion testing and mixture design to assess the antimicrobial efficacy of the
combinations. Results and Discussion: The results demonstrate promising
synergies between carotenoids, polyphenols, and alkaloids with standard
antibiotics, offering potential targeted use in the fight against clinical
multidrug-resistant bacteria. Specifically, Gram-negative bacteria (BGN) showed
increased resistance to antibiotics such as amoxicillin-clavulanic acid (AMC),
ceftazidime, cefotaxime, tetracycline, and cefazolin. These antibiotics, when
combined with marine compounds, exhibited substantial inhibitory effects against
specific isolates, circumventing antibiotic resistance mechanisms. Similarly,
substantial synergies were observed in Gram-positive bacteria.

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