sepsis-update.de
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Submission: On July 18 via automatic, source certstream-suspicious — Scanned from DE
Submission: On July 18 via automatic, source certstream-suspicious — Scanned from DE
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LOGIN Username Password Login Register | Lost your password? SUPPORT Lorem ipsum dolor sit amet: 24h / 365days We offer support for our customers Mon - Fri 8:00am - 5:00pm (GMT +1) GET IN TOUCH Cybersteel Inc. 376-293 City Road, Suite 600 San Francisco, CA 94102 Have any questions? +44 1234 567 890 Drop us a line info@yourdomain.com ABOUT US Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec. Login LOGIN Remember me Forgot your password? * Company * Team * History * Vision * Support Have any Questions? +01 123 444 555 info@company.com -------------------------------------------------------------------------------- Menu * 1. Home 2. Topics & Program 3. Endorsements 4. Abstracts 5. Speakers * 1. Highlights 2. General Information * 1. Awards * 1. Industry 2. Contact * About us * Team * History * Vision * Support * Testimonials * * PROGRAM The meeting will give outstanding researchers the opportunity to report on the latest advances in immunomodulatory approaches to the adaptive immune response in sepsis. Get up to date on the current state of knowledge! INDUSTRY The Sepsis Update 2023 is a central hub to meet key industry leaders, learn about the latest developments and research, and expand and maintain your network. SPEAKERS Get ready for controversial and trend-setting speeches by innovative thought leaders. YouTube has been restricted due to privacy settings WELCOME ... to the 11th Weimar Sepsis Update of the German Sepsis Society (GSS)! Dear colleagues, In the past 36 months, the critical care community has been confronted with the Corona pandemic, which has added SARS-CoV-2 as a new pathogen to the diverse range of sepsis pathogens. This has accelerated vaccine and drug development in a way that has never been seen before. SARS-CoV-2 has shown us once again how different the specific (adaptive) immune response to a specific pathogen can be and how differently organ dysfunctions may develop as a result. In contrast to other sepsis pathogens, the immunotherapy of severe COVID-19 has reached important advances, being the first sepsis pathogen in which a strong level of evidence permits the recommendation of immunotherapy. Apparently ineffective or even harmful therapeutic approaches based on evidence extrapolated from other sepsis conditions may be appropriate in the face of novel pathogens with a different immunopathology. Indeed, the initial expert opinion to avoid corticosteroids and IL-6 receptor antagonists (IL-6ra) as an immunomodulatory treatment for COVID-19, while later on, they became standard-of-care (SoC), underscores the importance of obtaining solid evidence based on robust clinical trials. These advances provide impetus to better understand the effects of IL-6 on different compartments and pathways, i.e. the endothelium, complement activation, and coagulation which might improve management of other forms of sepsis in the future. Another lesson from COVID-19 clinical research is that traditional trial designs are not well-suited for efficient evaluation of differential treatment effects in different patient groups. Most of the evidence supporting SoC options has come from adaptive platform trials, such as RECOVERY or REMAP-CAP. These designs are more flexible for the evaluation of combinations of therapies and evaluation of effects across different subgroups. However, as pointed out in a recent review by van de Veerdonk et al. (Nat Med 2022, 28, 39–50), the host response to SARS-CoV-2 – and other sepsis pathogens – is complex, characterized by a plethora of pathways that can be both beneficial and deleterious. Not surprisingly, agents that modify these pathways can be beneficial for some patients and ineffective or even harmful for others. The way forward is to perform trials based on robust biomarkers, so that patients that are more likely to benefit from a given treatment will receive it. The meeting will give outstanding researchers the opportunity to report on the latest advances in immunomodulatory approaches to the adaptive immune response in sepsis. Get up to date on the current state of knowledge! Frank M. Brunkhorst Secretary General GSS GET THE LATEST UPDATES! NEWSLETTER Subscribe to our newsletter to receive the latest news and updates about Sepsis Update! You can unsubscribe from the mailing list at any time. Email* Subscribe www.CleverReach.de By clicking on 'Subscribe' you agree to receive the newsletter with information on Sepsis Update, as well as to its analysis through individual measurement, storage, and evaluation of opening rates and the click rates in recipient profiles for the purpose of designing future newsletters according to the interests of our readers. You can unsubscribe at any time. Please find detailed information in our privacy policy. Copyright 2024. All Rights Reserved. Imprint Privacy Policy * Home * Topics & Program * Endorsements * Abstracts * Speakers * Highlights * General Information * Awards * Industry * Contact Settings saved PRIVACY SETTINGS We use cookies on our website. Some of them are essential, while others help us to improve this website and your experience. Essential* Allow necessary cookies for the website to function correctly External media Allow Youtube videos Statistics Allow Matomo website analytics Data Privacy Legal Notice Cookie-Details * Essential cookies are necessary for security reasons and cannot be deactivated. Close Menu * 1. Home 2. Topics & Program 3. Endorsements 4. Abstracts 5. Speakers * 1. Highlights 2. General Information * 1. Awards * 1. Industry 2. Contact * About us * Team * History * Vision * Support * Testimonials * Home * Topics & Program * Endorsements * Abstracts * Speakers * Highlights * General Information * Awards * Industry * Contact * Home * Topics & Program * Endorsements * Abstracts * Speakers * Highlights * General Information * Awards * Industry * Contact LoginContact You are using an outdated browser. The website may not be displayed correctly. Close previousnextstart slideshow