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Submitted URL: http://mpse.jp/smclabj/v.p?-1636XXXXXXXX
Effective URL: https://www.smccro-lab.com/modellineup/bleomycin-induced-pulmonary-fibrosis-model/
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Submission: On October 23 via api from US — Scanned from JP
Effective URL: https://www.smccro-lab.com/modellineup/bleomycin-induced-pulmonary-fibrosis-model/
Submission Tags: falconsandbox
Submission: On October 23 via api from US — Scanned from JP
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* JP * EN * COMPANY * CSR * RECRUIT * HOME * SMC QUALITY * SERVICE * MODEL LINEUP * PUBLICATION * NEWS * COLUMN * CONTACT MODEL LINEUP * HOME * MODEL LINEUP * Bleomycin-induced pulmonary fibrosis model BLEOMYCIN-INDUCED PULMONARY FIBROSIS MODEL DISEASE AREA IPF THERAPEUTIC AREAS IPF MODEL The Bleomycin (BLM) induced pulmonary fibrosis model is our standard IPF model, widely used in pharmacology and fundamental research. For the BLM model there are four types of administration route: subcutaneous, intraperitoneal, tail intravenous and intratracheal, each route with their own pathological features and imaging. The disease IPF is defined as injury confined to the lungs. Since subcutaneous, intraperitoneal and tail vein routes of administration cause systemic injury and deviate from the clinical definition of IPF, SMC utilizes the Microsprayer to perform intratracheal administration of bleomycin (Figure 1). By administering bleomycin via Microsprayer, it can be evenly exposed to the lungs and thus, develops a reproducible and uniform pathology. In prevention studies we often recommend dexamethasone as a positive control. However, for therapeutic targeting studies we recommend using a positive control such as Nintedanib. To date, we have extensive experience in evaluating various categories of test substances such as small molecules, nucleic acids and antibodies. Figure 1. A Microsprayer can evenly expose lungs to the drugs. The picture shows the distribution of pigment Evans Blue. Back to list CONTACT US Page HOME SMC Laboratories Inc. Technoport Kamata Center Bldg. 2-16-1 Minami-Kamata Ota-City Tokyo, 144-0035 Japan TEL+81-3-6715-9101 LA Office（USA） 20250 Acacia St. STE 240 Newport Beach,CA 92660 TEL+1-949-756-8500 * HOME * COMPANY * CSR * RECRUIT * CONTACT * SMC QUALITY CRO CONSULTANT PATENTS CASE STUDY * SMC QUALITY CRO CONSULTANT PATENTS CASE STUDY * SERVICE CRO & CONSULTING SERVICE INFO HISTOLOGY TRIAL * MODEL LINEUP * PUBLICATION PUBLICATIONS PRESENTATIONS * NEWS EVENT NEWS RELEASE PRODUCTS AND SERVICE PUBLICATION UPDATE * COLUMN * PUBLICATION PUBLICATIONS PRESENTATIONS * NEWS EVENT NEWS RELEASE PRODUCTS AND SERVICE PUBLICATION UPDATE * COLUMN © 2024 SMC Laboratories,Inc.