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ARTICLE PREVIEW

 * Abstract
 * References (63)
 * Cited by (4)
 * Recommended articles (6)


JOURNAL OF INTEGRATIVE MEDICINE

Volume 14, Issue 5, September 2016, Pages 389-399


RESEARCH ARTICLE
HUMAN BIOFIELD THERAPY DOES NOT AFFECT TUMOR SIZE BUT MODULATES IMMUNE RESPONSES
IN A MOUSE MODEL FOR BREAST CANCER

Author links open overlay panelGloriaGronowiczaPersonEnvelopeEric
R.SecorJr.bcJohn R.FlynnaLiisa T.Kuhnd
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Cited ByCite
https://doi.org/10.1016/S2095-4964(16)60275-3Get rights and content




ABSTRACT


OBJECTIVE

To assess the effect of human biofield therapy, an integrative medicine
modality, on the development of tumors and metastasis, and immune function in a
mouse breast cancer model.


METHODS

Mice were injected with 66cl4 mammary carcinoma cells. In study one, mice
received biofield therapy after cell injection. In study two, mice were treated
by the biofield practitioner only prior to cell injection. Both studies had two
control groups of mock biofield treatments and phosphate-buffered saline
injection. Mice were weighed and tumor volume was determined. Blood samples were
collected and 32 serum cytokine/chemokine markers were measured.
Spleens/popliteal lymph nodes were isolated and dissociated for
fluorescent-activated cell sorting (FACS) analysis of immune cells or metastasis
assays in cell culture.


RESULTS

No significant differences were found in weight, tumor size or metastasis.
Significant effects were found in the immune responses in study one but no
additional effects were found in study two. In study one, human biofield
treatment significantly reduced percentage of CD4+CD44loCD25+ and percentage of
CD8+ cells, elevated by cancer in the lymph nodes, to control levels determined
by FACS analysis. In the spleen, only CD11b+ macrophages were increased with
cancer, and human biofield therapy significantly reduced them. Of 11 cytokines
elevated by cancer, only interferon-γ, interleukin-1, monokine induced by
interferon-γ, interleukin-2 and macrophage inflammatory protein-2 were
significantly reduced to control levels with human biofield therapy.


CONCLUSION

Human biofield therapy had no significant effect on tumor size or metastasis but
produced significant effects on immune responses apparent in the down-regulation
of specific lymphocytes and serum cytokines in a mouse breast cancer model.






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CITED BY (4)


 * A RAPID EVIDENCE ASSESSMENT OF RECENT THERAPEUTIC TOUCH RESEARCH
   
   2021, Nursing Open
   
   


 * PERSPECTIVES, MEASURABILITY AND EFFECTS OF NON-CONTACT BIOFIELD-BASED
   PRACTICES: A NARRATIVE REVIEW OF QUANTITATIVE RESEARCH
   
   2021, International Journal of Environmental Research and Public Health
   
   


 * HUMAN BIOFIELD THERAPY AND THE GROWTH OF MOUSE LUNG CARCINOMA
   
   2019, Integrative Cancer Therapies
   
   


 * EFFECTS OF CRINUM JAGUS WATER/ETHANOL EXTRACT ON SHIGELLA FLEXNERI -INDUCED
   DIARRHEA IN RATS
   
   2019, Evidence-based Complementary and Alternative Medicine
   
   


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   IMPACT OF P38 MITOGEN-ACTIVATED PROTEIN KINASE INHIBITION ON
   IMMUNOSTIMULATORY PROPERTIES OF HUMAN 6-SULFO LACNAC DENDRITIC CELLS
   
   Immunobiology, Volume 221, Issue 2, 2016, pp. 166-174
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   p38 Mitogen-activated protein kinase (MAPK) plays a crucial role in the
   induction and regulation of innate and adaptive immunity. Furthermore, p38
   MAPK can promote tumor invasion, metastasis, and angiogenesis. Based on these
   properties, p38 MAPK inhibitors emerged as interesting candidates for the
   treatment of immune-mediated disorders and cancer. However, the majority of
   p38 MAPK inhibitor-based clinical trials failed due to poor efficacy or
   toxicity. Further studies investigating the influence of p38 MAPK inhibitors
   on immunomodulatory capabilities of human immune cells may improve their
   therapeutic potential.
   
   Here, we explored the impact of the p38 MAPK inhibitor SB203580 on the
   pro-inflammatory properties of native human 6-sulfo LacNAc dendritic cells
   (slanDCs). SB203580 did not modulate maturation of slanDCs and their capacity
   to promote T-cell proliferation. However, SB203580 significantly reduced the
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View full text
Copyright © 2016 Journal of Integrative Medicine Editorial Office. E-edition
published by Elsevier (Singapore) Pte Ltd. All rights reserved. Published by
Elsevier B.V. All rights reserved.

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