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Submission: On April 17 via api from DE — Scanned from DE
Submission: On April 17 via api from DE — Scanned from DE
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WEBINAR: ROLE OF SULFOTRANSFERASES IN DRUG METABOLISM AND POTENTIAL FOR
DRUG-DRUG INTERACTIONS
About Events Webinar: Role of Sulfotransferases in Drug Metabolism and Potential
for Drug-Drug Interactions
* May 4, 2022
* Webinar
Presenter: Maciej Czerwinski, Ph.D., SEKISUI XenoTech Director of Scientific
Consulting
ABSTRACT:
Continuing our series on non-CYP-mediated metabolism pathways, we will be
discussing another of the most requested enzymes: Sulfotransferases (SULTs).
SULTs participate in Phase 2 metabolism of xenobiotics in humans and are
characterized by the abundance and broad tissue distribution of the enzymes.
Gene regulation and genetic polymorphism of SULTs also contribute to our
understanding of the significance of these enzymes in the process of drug
development. Basic biochemical characteristics of SULTs will be reviewed and
examples of major forms of sulfonates formed in humans will be presented. Some
properties of SULTs-mediated metabolism will be compared to other major Phase 2
enzymes, particularly UDP-glucuronosyltransferases (UGTs).
KEY CONCEPTS DISCUSSED IN THIS WEBINAR WILL INCLUDE:
* Significance of SULT-mediated metabolism in the drug development process
* Tissue distribution of human SULTs
* Gene regulation of SULT enzymes
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ABOUT THE PRESENTER:
Dr. Maciej Czerwinski serves as a Director in the Scientific Consulting
department at SEKISUI XenoTech. He received his Ph.D. from the University of
Maryland at Baltimore Medical School in the Department of Pathology. Dr.
Czerwinksi conducted his doctoral thesis research in the Laboratory of Dr. Frank
Gonzalez at the National Cancer Institute in Bethesda, followed by a post-doc at
the Department of Pharmaceutics, the University of Washington in Seattle. He has
been with SEKISUI XenoTech since 1999 and guides the development
of products and services for the in vitro analysis of drug safety. Dr.
Czerwinski designed a patented method to analyze the in vitro cytokine-mediated
drug-drug interactions between biologics and small molecule drugs, and he is
also the inventor of SEKISUI XenoTech’s CryostaX single-freeze pooled
hepatocytes.
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