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IAVI Skip to content
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AFFORDABLE, ACCESSIBLE
VACCINES & ANTIBODIES
We are a nonprofit scientific research organization that develops vaccines and
antibodies for HIV, tuberculosis, and emerging infectious diseases.
About us
OUR APPROACH
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We take a full-circle approach to product development, from the grassroots level
to the lab to legislative bodies.
MISSION
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To translate scientific discoveries into affordable, globally accessible public
health solutions.
VISION
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A world where all people have equitable access to innovative vaccines and
therapeutics.
OUR HEALTH AREAS
* HIV
* Tuberculosis
* Lassa fever
* Marburg virus
* Sudan Ebolavirus
* COVID-19
HIV
THE CHALLENGE
HIV/AIDS remains one of the deadliest infectious diseases, with 1.3 million
people acquiring HIV in 2022. Given the complexities of HIV, traditional
approaches to vaccine development have so far failed to result in a vaccine that
provides protection against HIV. However, a vaccine is still needed to bring a
true end to the HIV pandemic. Source: UNAIDS
OUR SOLUTION
IAVI scientists and our collaborators are developing next-generation HIV
vaccines to address the challenges of HIV vaccine design. Together, we have
pioneered promising new vaccination strategies and the discovery of broadly
neutralizing antibodies (bnAbs) against HIV. IAVI and our partners are
developing HIV bnAbs to prevent HIV acquisition while we advance vaccine
candidates.
TUBERCULOSIS
THE CHALLENGE
Tuberculosis (TB) is the world’s leading infectious disease killer. In 2022,
10.6 million people fell ill with TB and 1.3 million people died of TB disease.
The only available TB vaccine is the century-old Bacille Calmette-Guérin, or
BCG. While this vaccine has efficacy in protecting against severe TB disease in
infants and young children, it is largely ineffective in adolescents and adults,
among whom most transmission and disease occurs. Source: WHO
OUR SOLUTION
IAVI works across our global hubs with a diverse network of partners to advance
the most promising TB vaccine candidates from discovery through clinical trials,
and eventually, to post-licensure access. Our work extends to policy and
advocacy initiatives that support TB vaccine development and access in regions
where new vaccines are needed most.
LASSA FEVER
THE CHALLENGE
Lassa fever is an acute viral hemorrhagic illness endemic to West Africa that
causes significant annual outbreaks of disease. Lassa fever is difficult to
diagnose, and surveillance data is limited. Current estimates range from 300,000
to 500,000 cases and 5,000 related deaths each year. No licensed vaccines for
Lassa fever exist. Source: WHO
OUR SOLUTION
IAVI is developing a single-dose vaccine candidate for Lassa that is based on a
recombinant vesicular stomatitis virus (rVSV) vector. This technology is similar
to that underlying an approved Ebola Zaire virus vaccine. IAVI’s Lassa vaccine
candidate was well tolerated and immunogenic over a wide dose range in a Phase I
clinical study. IAVI also conducts Lassa epidemiological studies and modeling to
support future vaccine access.
MARBURG VIRUS
THE CHALLENGE
Marburg virus is a filovirus and the causative agent of Marburg virus disease
(MVD), which has a case fatality ratio of up to 88%. Marburg virus has the
capacity to cause outbreaks with high fatality rates and is a potential
bioterror threat. No vaccines or antiviral treatments are approved for MVD. A
Marburg vaccine is urgently needed to respond to future outbreaks. Source: WHO
OUR SOLUTION
IAVI is developing a vaccine candidate for Marburg that is based on a
recombinant vesicular stomatitis virus (rVSV) vector. This technology is similar
to that underlying an approved Ebola Zaire virus vaccine, which is now approved
by the U.S. FDA and registered for use in several African countries. Preclinical
data demonstrates that IAVI’s Marburg vaccine candidate is highly protective in
an animal model with one dose.
SUDAN EBOLAVIRUS
THE CHALLENGE
Sudan ebolavirus is a filovirus and causes outbreaks of Ebola disease, most
recently in 2022 in Uganda. Case fatality rates of Ebola disease caused by Sudan
ebolavirus have varied from 41% to 100% in past outbreaks. The licensed vaccine
for Ebola Zaire virus does not provide cross protection against the Sudan
strain. An Ebola Sudan vaccine is urgently needed to prevent and respond to
future outbreaks. Source: WHO
OUR SOLUTION
IAVI is developing a vaccine candidate for Sudan ebolavirus that is based on a
recombinant vesicular stomatitis virus (rVSV) vector similar to the technology
underlying an approved Ebola Zaire virus vaccine. During the 2022 Ebola outbreak
in Uganda, the WHO selected IAVI’s Sudan ebolavirus vaccine candidate for a
planned ring vaccination trial. While the trial did not go forward due to
outbreak control, IAVI has continued clinical development to prepare for future
outbreaks.
COVID-19
THE CHALLENGE
Since December 2019, over 760 million cases of COVID-19 and 6.9 million deaths
have been recorded worldwide, but the actual number is thought to be higher.
While highly effective, approved COVID-19 vaccines do not fully block
transmission or breakthrough infection. Additional COVID-19 vaccines continue to
be an urgent need, particularly vaccines suitable for widespread use in middle
and low-income countries. Source: WHO
OUR SOLUTION
IAVI is developing a COVID-19 vaccine candidate that is based on a recombinant
vesicular stomatitis virus (rVSV) vector. The vaccine candidate has demonstrated
safety in humans when administered intramuscularly and has been produced at
scale to support larger future clinical trials. IAVI is also investigating an
intranasal formulation of our COVID-19 vaccine candidate to prevent infection.
OUR IMPACT
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WE CONDUCT PRECLINICAL AND CLINICAL TRIALS OF OUR OWN VACCINES AND ANTIBODIES.
OUR FOCUS IS ON DISEASES OF GLOBAL IMPORTANCE FOR WHICH THERE IS NO MARKET AND
LITTLE FINANCIAL INCENTIVE FOR DEVELOPMENT. WE ALSO COLLABORATE WITH AND SUPPORT
OTHER SCIENTIFIC ORGANIZATIONS TO CONDUCT THEIR OWN CLINICAL TRIALS OF PRIORITY
DISEASE PREVENTION AND THERAPEUTIC INTERVENTIONS.
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255 partners from academic, biotech, pharma sectors, civil society, and global
health initiatives
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53 biologics candidates supported by the IAVI Product Development Center, out of
which 25 advanced to clinical trials
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70,000 volunteers enrolled in observational epidemiology studies
OUR LOCATIONS
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IAVI AFRICA
* Cape Town Office, South Africa
* Nairobi Office, Kenya
IAVI EUROPE
* Amsterdam Office, The Netherlands
* Human Immunology Lab, London, U.K.
IAVI INDIA
* Gurugram, Haryana Office
* Antibody Translational Research Program, IAVI-THSTI, Faridabad
IAVI U.S.
* New York Office
* Vaccine Design & Development Lab, New York
* Neutralizing Antibody Center, California
RECENT NEWS & MEDIA
Previous Next
Features
MEET THE SCIENTIST PODCAST: AN INTERVIEW WITH DR. ELANA VAN BRAKEL, MEDICAL
DIRECTOR AT IAVI, ON IAVI’S TB VACCINE PROGRAM
June 26, 2024
In the latest episode of Meet the Scientist, IAVI’s podcast series, we sat down
with Elana Van Brakel, medical director at IAVI in Cape Town, South Africa, to
discuss her work at IAVI in support of our TB vaccine program. In this episode,
we explore IAVI’s diverse engagement in the development of the MTBVAC TB vaccine
candidate and learn about how Elana and IAVI’s TB team are preparing for the
Phase 2b clinical trial of MTBVAC in adolescents and adults in sub-Saharan
Africa. Tune in to learn more about Elana’s work and IAVI’s TB vaccine program.
See below for a full transcription o
Read More
Features
ADVOCATES PUSH FOR LOCAL MANUFACTURING TO ACHIEVE HEALTH EQUITY IN AFRICA
June 24, 2024
Often, Africa is seen through the lens of a polycrisis where health is
concerned. Yet, despite a heavy disease burden compounded by climate change
effects and other socioeconomic challenges, Africa’s Agenda 2063 for prosperity
emphasizes health as a key factor for success. To achieve Africa’s vision of
leadership in research and development (R&D), pandemic preparedness, […]
Read More
IAVI Report
BUILDING BETTER B CELLS: AN INTERVIEW WITH JAMES VOSS
June 18, 2024
The immune system can make antibodies against HIV. The problem is that most of
them aren’t that effective at eliminating or neutralizing the virus. This is
largely because HIV evolves so quickly that by the time the antibodies are
around, the virus has already mutated enough to avoid neutralization. HIV is
always a step ahead. […]
Read More
Features
DON’T MISS OUT ON THE 7TH GLOBAL FORUM ON TB VACCINES THIS OCTOBER
June 18, 2024
We’re less than four months away from the 7th Global Forum on TB Vaccines,
taking place for the first time in the Americas in Rio de Janeiro, Brazil, from
October 8-10, 2024. This Forum, expected to be the largest edition to date, aims
to bring more than 400 stakeholders from over 35 countries and all […]
Read More
Features
RESEARCH FROM THE IAVI NEUTRALIZING ANTIBODY CENTER AND PARTNERS PROVIDES
ADDITIONAL EVIDENCE FOR GERMLINE-TARGETING STRATEGY OF HIV VACCINE DEVELOPMENT
May 31, 2024
New research published May 30 in two papers in Nature Immunology demonstrates
that vaccination can induce broadly neutralizing antibody (bnAb) precursors to
HIV glycoprotein 41 (gp41), an important potential vaccination target, in mice
and non-human primates. Results from both studies, which focus on
membrane-proximal external region (MPER) antibodies, provide additional evidence
supporting and guiding the […]
Read More
IAVI Report
WILL MONOCLONAL ANTIBODIES BE A NEW WEAPON IN THE FIGHT AGAINST MALARIA?
May 20, 2024
Monoclonal antibodies have revolutionized the treatment of cancer, autoimmune
diseases, and inflammation in wealthier countries. But their role in treating
and preventing infectious diseases was limited. Until COVID-19. The emergence of
SARS-CoV-2 heralded the first time that mAbs were mass produced — millions of
doses were manufactured and administered in the U.S. alone — to […]
Read More
When women are given the opportunity to lead in science, they bring a unique
perspective that is invaluable to the field. This is not just a matter of
equality; it’s a matter of unleashing the full potential of science. Women
leaders in science bring a fresh perspective to the field that is essential for
driving innovation and progress.
Kawela Mumba-Mwangelwa
Graduate of IAVI’s Leadership Development Program, Co-principal Investigator at
the Center for Family Health Research in Zambia
We are a nonprofit scientific research organization that develops vaccines and
antibodies for HIV, tuberculosis, and emerging infectious diseases.
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