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OZEMPIC COULD HELP CURB ALCOHOL ABUSE, STUDY REVEALS

By
Angelica Stabile, Fox News


Thanks for contacting us. We've received your submission.

Back to Reading
Published Dec. 10, 2023, 11:53 a.m. ET


ORIGINALLY PUBLISHED BY:


 * Ozempic diabetes and weight loss medication under investigation after a few
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The latest weight loss craze could also help people control their drinking.

Semaglutide treatments such as Ozempic and Wegovy have been shown to reduce the
symptoms of alcohol use disorder (AUD), according to a study published in The
Journal of Clinical Psychiatry on Nov. 27.

The collaborative study from The University of Oklahoma (OU) and Oklahoma State
University (OSU) found a “significant and noteworthy decrease” in the Alcohol
Use Disorders Identification Test (AUDIT) scores of six patients who were
receiving semaglutide treatment for weight loss.

Lead study author Dr. Jesse Richards, director of obesity medicine and assistant
professor of medicine at the OU-TU School of Community Medicine, said the study
was inspired by his conversation with Dr. Kyle Simmons, professor of
pharmacology and physiology at the OSU Center for Health Sciences.

“I had been hearing from a significant number of patients that their alcohol
intake was spontaneously decreasing while [they were] on the medication,”
Richards told Fox News Digital.

As a bariatric surgery clinic employee, Richards noted that it’s standard to
screen patients for alcohol use.

5
Studies found that there was a decrease in Alcohol Use Disorders Identification
Test (AUDIT) scores for six patients receiving weight-loss treatments. AP

At the clinic, a number of patients tested positive for alcohol consumption,
sometimes in concerning amounts.

Later, while on semaglutide medication, they reported reduced alcohol intake.

One of Richards’ patients — who previously drank large amounts of alcohol —
shared a new inability to drink more than two cans of beer now because it “just
doesn’t sound good.”

5
After semaglutide medication, a patient who formerly drank beer regularly began
to think that alcohol just didn’t “sound good.” Getty Images

This response piqued Richards’ interest in learning more about patients’
aversion to alcohol, which directly correlated to his research.


SEE ALSO


‘OZEMPIC TREE, OH HOW I’D LOVE TO BE SKINNY’: WE DECORATED OUR TREE WITH NEEDLES
INSTEAD OF ORNAMENTS

Research has shown that this effect is “mediated through adjustments in the
reward pathway in the brain,” he said.

“The GLP-1s are actually modifying dopamine, decreasing the craving and
decreasing the motivation to acquire things in that compulsive intake category.”

The most surprising takeaway from the study, Richards said, was that the same
significant treatment response was seen even at very low doses.

“We found that even patients on the lowest dose of semaglutide — a quarter
milligram — had a quite significant and relatively … quick onset reduction in
alcohol intake,” he said.

Of the six patients studied, all but one were on low doses — from a quarter to a
half milligram.

“And that’s very encouraging because we know that the lower doses of these
medications are tolerated much better,” said Richards.

While the results seem promising, the doctor said he does not recommend that
patients use semaglutide treatments for alcohol use disorder at this time, due
to supply and safety issues.

“If patients have [obesity and diabetes] indications for the medication and they
also struggle with alcohol intake … having them on this treatment may
potentially be beneficial,” Richards said.

5
Due to medication shortages and a lack of long-term data, it may not be
advisable to take Ozempic to target alcoholism specifically. NurPhoto via Getty
Images

“But because there has been a global medication shortage, and because we don’t
have prospective trials and don’t know what the specific safety is versus the
well-established safety data in obesity and diabetes, [I] would not recommend it
just for patients who have AUD.”

There are three FDA-approved drugs available for alcoholic use disorder that are
currently underused, the doctor noted.

Given that five million people in the U.S. are currently taking semaglutide
medications, if it is proven that those drugs have a significant effect on
alcohol use disorder, “by default, they are going to become the most widely used
drug to improve these symptoms — just by virtue of the fact that so many people
are on them for diabetes or obesity,” Richards noted.

5
Trials are underway to gather more information on the weight-loss medication and
its effect on alcohol intake. UCG/Universal Images Group via G

He confirmed that additional research is underway with two ongoing trials.

“Since we were able to show clinically meaningful reductions in alcohol intake
and AUD symptomatology in a real-world setting, that bodes very well for these
types of medications,” he said.

Looking ahead, Richard said there is a need for higher-quality evidence of the
medication’s impact on AUD compared to placebo drugs or environmental factors.

5
People struggling with alcohol use should speak with their healthcare provider.
Getty Images

Even though it’s unclear whether GLP-1 producers will market the medication to
AUD patients in the future, Richards said this could become an “established
medical practice once the safety and efficacy has been determined.”

For patients who struggle with AUD, Richards recommended they talk to their
health care providers about available treatment.


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He also alerted patients that if they experience a reduced appetite and usually
consume “a bunch of calories” in alcohol, it may be necessary to look into a
more balanced diet.

Avantika Waring, 9amHealth’s chief medical officer and a trained physician and
endocrinologist in San Francisco, applauded the OU and OSU study findings for
further supporting what clinicians “are already seeing in practice,” she told
Fox News Digital.

“GLP-1 medications have a lot of effects that we are still learning about, and
the ability to decrease cravings and the reward signals related to alcohol use
are just some of the benefits,” she said.

“It’s an important starting point for further clinical trials,” she added.

Waring also warned that GLP-1 medications should not be used to treat AUD
specifically, as they can cause side effects such as nausea and changes in
appetite.

“People struggling with alcohol use disorder should consult with their
physicians before starting GLP-1 medications to make sure that they can stay
hydrated and safe on therapy,” she said.

35
What do you think? Post a comment.

Waring noted that if ongoing clinical trials find semaglutide treatments to be
effective for AUD, the medical community will “have another tool to help people
living with alcohol addiction and we’ll see expanded use of these already
popular drugs.”



Fox News Digital reached out to Novo Nordisk for comment on the potential link
between semaglutide medications and alcohol use disorder.




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Filed under
 * alcoholism
 * ozempic
 * weight loss
 * 12/10/23

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Studies found that there was a decrease in Alcohol Use Disorders Identification
Test (AUDIT) scores for six patients receiving weight-loss treatments. AP
After semaglutide medication, a patient who formerly drank beer regularly began
to think that alcohol just didn't "sound good." Getty Images
Due to medication shortages and a lack of long-term data, it may not be
advisable to take Ozempic to target alcoholism specifically. NurPhoto via Getty
Images
Trials are underway to gather more information on the weight-loss medication and
its effect on alcohol intake. UCG/Universal Images Group via G
People struggling with alcohol use should speak with their healthcare provider.
Getty Images
You are viewing 1 of 5 images Previous Image Next Image

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