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CBD IS EFFECTIVE IN TREATING ANXIETY, DEPRESSION AND POOR SLEEP, STUDY FINDS


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SCIENCE & HEALTH


CBD IS EFFECTIVE IN TREATING ANXIETY, DEPRESSION AND POOR SLEEP, STUDY FINDS

Published

3 seconds ago

on

May 29, 2024

By

Ben Adlin

New industry-backed research into the potential anti-anxiety effects of
cannabidiol found that an oral CBD solution effectively treated mild to moderate
anxiety, as well as associated depression and poor sleep quality, with no
serious adverse events observed.

“Our findings indicate that administering 300-600 mg of nanodispersible CBD oral
solution for 12 weeks is effective in treating mild to moderate anxiety
disorders and associated depression and sleep quality disturbances,” authors
wrote. “These findings align with the growing body of evidence indicating that
CBD may have anxiolytic effects if administered for a longer duration, ranging
from 4 to 12 weeks.”

The report, published this month in the Asian Journal of Psychiatry, was penned
by a seven-person research team from Asha Hospital and Leiutis Pharmaceuticals
LLP, both in India, and New Jersey-based Biophore Pharma Inc. All authors, the
paper says, participated “as employees of or consultants to Leiutis
Pharmaceuticals,” which funded the study.

CBD Can Help Treat Pain, Cancer, Schizophrenia, COVID And Other Conditions

CBD Can Help Treat Pain, Cancer, Schizophrenia, COVID And Other Conditions
A new scientific review highlights CBD's potential to treat various conditions
such as epilepsy, pain, cancer, schizophrenia, diabetes, and COVID-19.  The
review aims to summarize cannabis's impact on human health, noting its
“neuroprotective, anti-inflammatory, and pain-relieving properties”. The study
delves into CBD's pharmacological properties, mechanisms of action, and its
potential medical applications.  It discusses CBD's role in treating epilepsy,
pain relief, managing schizophrenia symptoms, and its potential as a COVID-19
inhibitor.  The review also touches upon CBD's promising anticancer properties
and its effects on diabetes-related processes.  “Cannabis exhibits
neuroprotective, anti-inflammatory, anti-thrombotic, anti-bacterial, analgesic,
and antiepileptic properties.” Additionally, it acknowledges the industrial
applications of CBD and hemp in pharmaceuticals, skincare, fuel, paper,
clothing, rope, and massage oil production.
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Use of the CBD solution “showed therapeutic efficacy, excellent safety, and
tolerability in treating not only mild to moderate anxiety disorders (primary
end point of the study), but also associated depression and disturbances in
sleep quality (Secondary endpoint of the study)” the paper says, “with no
incidences of withdrawal anxiety upon dose tapering at the end of the
treatment.”

> “CBD oral solution was effective treating mild to moderate anxiety.”



“Our research supports the importance of investigating the potential
effectiveness of nanodispersible CBD oral solution in treating other forms of
psychiatry disorders,” authors wrote, “and exploring its possible applications
in clinical practice.”

Participants in the study were split into either a CBD or control group. Those
in the CBD group received 300 milligrams of CBD per day at first, which
increased over time to 600 mg per day and was later reduced to 150 mg per day
toward the end of the study period. Those in the control group received a
placebo.



A test of generalized anxiety disorder, GAD-7, found drops in anxiety markers
among participants who took CBD compared to the placebo group. Mean scores
“gradually decreased in the CBD group from week 2 (visit 4), which continued
till week 13,” the study says, noting that the “mean GAD-7 score for CBD arm at
baseline was 11.8±1.52 and the score at the end of treatment (visit-9) was
4.8±1.60, at visit-10 (dose taper) was 3.7±1.27, and at end of study (visit-11)
was 3.1±1.06.”

Among those who took the placebo, the mean anxiety scores hardly changed. “The
mean GAD-7 score (SD) for placebo arm at baseline (visit-3) was 11.2±1.43 and
the score at end of treatment (visit-9) was 11.8±1.73, at Visit-10 (dose taper)
was 11.8±1.72, and end of study (visit-11) was 11.8±1.75,” according to the
report.

Another test, the Hamilton Anxiety Rating Scale (HAM-A), found similar drops in
anxiety measures in CBD participants compared to the placebo group.

> “CBD was therapeutically safe with no serious adverse events, well tolerated,
> and effective for the treatment of mild to moderate anxiety disorders, as well
> as associated depression and sleep quality disturbances.”



“The mean HAM-A score for CBD arm at baseline (visit-3) was 18.9±2.62 and the
score at end of treatment (visit-9) was 7.34±1.77, at visit-10 (dose taper) was
5.83±1.67, and at end of study (visit-11) was 4.57±1.39,” the study says, while
“the mean HAM-A score (SD) for placebo arm at baseline was 18.2±2.75 and the
score at end of treatment was 18.9±2.75, at Visit-10 (dose taper) was 19.0±2.84,
and end of study (visit-11) was 18.9±2.95.”

Participants in the CBD group also had their dosages reduced near the end of the
study period, and no immediate increase in their anxiety was observed.



“At Visit 10 (Week 12), the drug was tapered to 150 mg/day,” the report
describes, “and at the end of the study, at Visit 11 (Week 13), there was no
increase in anxiety scores.”

Separate research published earlier this year found that a component of
marijuana, the terpene D-limonene, may help ease anxiety and paranoia associated
with the psychoactive cannabinoid THC. That study found that subjects who
vaporized limonene along with a dose of THC experienced less anxiety and
paranoia compared to those who consumed THC alone.

Another substance, similar to the psychedelic LSD, was also recently awarded
breakthrough therapy status by the Food and Drug Administration (FDA) for the
treatment of generalized anxiety disorder. The drugmaker behind the substance,
known as MM120, said at the time that it plans to hold an end-of-Phase 2 meeting
with FDA in the first half of 2024 and begin a Phase 3 clinical trial in the
second half of the year.

According to a media representative the drugmaker, MindMed, MM120 is “a tartrate
salt form of lysergide, a synthetic drug commonly known as LSD.”



The breakthrough designation is the latest in a series of developments around
psychedelic-based therapies. Late last year, FDA granted priority status to its
review of MDMA-assisted therapy as a potential treatment option for
post-traumatic stress disorder (PTSD). The agency has set a target date to make
a determination by August 11, according to applicant Lykos Therapeutics
(formerly named MAPS Public Benefit Corporation).

If the new drug application is ultimately approved, the Drug Enforcement
Administration (DEA) would then need to reschedule MDMA accordingly. It would
become the first psychedelic in history to be approved as a pharmaceutical, to
be administered in tandem with talk therapy and other supportive services.



As for CBD and anxiety, a separate study earlier this year found that dogs
receiving daily doses of CBD saw “significant reductions” in stress and anxiety
related to car travel.

All 20 dogs involved in that study, published in the Journal of Animal Science,
exhibited signs of stress and anxiety when riding in a car, but canines treated
with CBD two hours before taking the trip showed meaningful improvements over a
24-week review period.

> Cannabis Use Before Bedtime Does Not Cause Next-Day Impairment Of Cognitive
> Ability Or Driving Performance, Study Shows



Photo courtesy of Kimzy Nanney.

Marijuana Moment is made possible with support from readers. If you rely on our
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Related Topics:featured

Don't Miss

Federal Health Agency Acknowledges Psilocybin’s Therapeutic Potential And Touts
Forthcoming Psychedelic Research

Ben Adlin


Ben Adlin, a senior editor at Marijuana Moment, has been covering cannabis and
other drug policy issues professionally since 2011. He was previously a senior
news editor at Leafly, an associate editor at the Los Angeles Daily Journal and
a Coro Fellow in Public Affairs. He lives in Washington State.



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