interestingengineering.com Open in urlscan Pro
34.247.236.121  Public Scan

Form analysis
3 forms found in the DOM

https://interestingengineering.com/s/search

<form id="search" class="header-box" action="https://interestingengineering.com/s/search"> <button class="search-button" type="submit" aria-label="Search"><i class="fa fa-search" aria-hidden="true"></i></button> <input type="search" name="q"
    id="search-input" placeholder="Search"> <input type="hidden" name="sort" value="new"> <button class="search-toggle-button" aria-label="Search Toggle" type="button" name="search-toggle"><i class="fa fa-search" aria-hidden="true"></i></button>
</form>

POST https://interestingengineering.com/subscription?utm_source=article_page_signup_box&utm_medium=email_submit&utm_campaign=Newsletter_article_page_box

<form method="POST" action="https://interestingengineering.com/subscription?utm_source=article_page_signup_box&amp;utm_medium=email_submit&amp;utm_campaign=Newsletter_article_page_box" accept-charset="UTF-8" class="subscription small-box text-center"
  style="width:100%;"><input name="_token" type="hidden" value="gXt573n0qOid9EbVzQMTBaPzUXqeFjmYKz3mItVP">
  <div class="clearfix">
    <div class="clearfix b-margin-20">
      <h2>GET YOUR DAILY NEWS DIRECTLY IN YOUR INBOX</h2> <span>Stay ahead with the latest science, technology and innovation news, for free:</span>
    </div>
    <div class="clearfix b-margin-10">
      <div class="frm">
        <div class="input-group"> <input class="form-control" placeholder="Enter your email address" name="email" type="email"> </div> <button type="submit" class="btn btn-info">JOIN FREE</button>
      </div>
    </div>
  </div>
  <p class="ua-nl">By subscribing, you agree to our <a href="https://interestingengineering.com/terms-of-service" target="_blank">Terms of Use</a> and <a href="https://interestingengineering.com/privacy-policy" target="_blank">Privacy Policy</a>. You
    may unsubscribe at any time.</p>
</form>

POST https://interestingengineering.com/subscription?utm_source=popup_signup_box&utm_medium=email_submit&utm_campaign=Newsletter_popup_box

<form method="POST" action="https://interestingengineering.com/subscription?utm_source=popup_signup_box&amp;utm_medium=email_submit&amp;utm_campaign=Newsletter_popup_box" accept-charset="UTF-8" class="text-center"><input name="_token" type="hidden"
    value="gXt573n0qOid9EbVzQMTBaPzUXqeFjmYKz3mItVP"> <label class="input-group"> <input class="form-control no-border" aria-label="Email" placeholder="Enter your email address" name="email" type="email"> </label> <button type="submit"
    class="btn btn-success newsletter-submit no-border popup-sub-btn" name="submitbutton" value="CANCEL" data-push-category="Daily Newsletter Popup">JOIN FREE</button>
  <p class="ua-nl ng">By subscribing, you agree to our <a href="https://interestingengineering.com/terms-of-service" target="_blank">Terms of Use</a> and <a href="https://interestingengineering.com/privacy-policy" target="_blank">Privacy Policy</a>.
    You may unsubscribe at any time.</p>
</form>

Text Content

Interesting Engineering
 * Innovation
 * Science
 * Culture
 * Health
 * Transportation
 *  Videos
 * DIY


 * 
 * 
 * 
 * 
 * 
 * 
 * 
 * 
 * 
 * 
 *    


Health


1704691
Advertisement


 1. Health


STUDY FINDS VIAGRA USAGE COULD REDUCE ALZHEIMER'S RISK BY 70 PERCENT

The drug was found to increase brain cell growth.

By  Ameya Paleja
Dec 07, 2021

Could the blue pill treat Alzheimer's too? Vlad Vulturar/iStock

A recently published study from researchers at the Cleveland Clinic has found
that sildenafil, an approved drug for erectile dysfunction, popularly known as
Viagra, can help in treating Alzheimer's disease.

The neurodegenerative disease that currently does not have a cure is estimated
to impact 13.8 million Americans by 2050, the press release said. With new drug
development being a time and cost-intensive process, researchers in the pharma
industry have turned to repurpose already approved drugs. The team led
by Feixiong Cheng, at Genomic Medicine Institute at Cleveland, was studying
subtypes of neurodegenerative diseases to find common mechanisms that could be
targeted with FDA-approved drugs.

In the case of Alzheimer's disease, two proteins, namely beta-amyloid and tau,
begin accumulating inside the brain, leading to clots and tangles. Clinical
trials targeting these proteins have failed in the past decade, the press
release said. Recent research has also shown that the two proteins that work
together cause the disease. The researchers began investigating which of the
approved drugs could act on both the proteins at the same time instead of
targeting just one. 

PLAY Top Articles Video Settings Full Screen About Connatix V158500 Read More
Read More Read More Read More Read More Read More Here's how to turn a stream
into a minihydropower dam 1/1 Skip Ad Continue watching after the ad Visit
Advertiser websiteGO TO PAGE



To their surprise, sildenafil turned up to have the best scores. The database
that the researchers used consisted of data of more than seven million people in
the U.S. and even included drugs such as losartan or metformin, that are
currently under active clinical trials to treat Alzheimer's. After six years of
follow-up, sildenafil users were 69 percent less likely to develop the
neurodegenerative disease, the press release said. 

"We found that sildenafil use reduced the likelihood of Alzheimer’s in
individuals with coronary artery disease, hypertension, and type 2 diabetes, all
of which are comorbidities significantly associated with risk of the disease,"
added Dr. Cheng. 

To further verify their findings, the team created model cells of Alzheimer's
disease in the lab using stem cells and treated them with sildenafil. The drug
not only increased brain cell growth but also decreased hyperphosphorylation of
tau proteins, a process that usually leads to tangles.

Advertisement


The research team will now carry out a phase II randomized clinical trial to
confirm their findings, following which the approach will be applied to other
neurodegenerative diseases like Parkinson's or Amyotrophic Lateral Sclerosis
(ALS). 

"This is an example of a growing area of research in precision medicine where
big data is key to connecting the dots between existing drugs and complex
diseases," said Jean Yuan, M.D., Ph.D., at the National Institute on Aging
(NIA), which funded the work. The study was published in Nature Aging. 

A trial for a nasal vaccine for Alzheimer's is also scheduled to begin soon.  

Advertisement

Follow Us on



GET YOUR DAILY NEWS DIRECTLY IN YOUR INBOX

Stay ahead with the latest science, technology and innovation news, for free:

JOIN FREE

By subscribing, you agree to our Terms of Use and Privacy Policy. You may
unsubscribe at any time.


SPONSORED STORIES


 
Recommended by



How gearboxes keep our world running


RECOMMENDED

Science


A NEW BLOOD TEST DETECTS ALZHEIMER'S DEMENTIA WITH 93 PERCENT ACCURACY

Loukia Papadopoulos
1 month ago
Health


STUDY FINDS CANCER DRUG MAY ALSO FLUSH OUT DORMANT HIV

Loukia Papadopoulos
2 months ago
Health


STUDY REVEALS COVID-19 INFECTION INCREASES THE RISK OF MENTAL HEALTH DISORDERS

Deena Theresa
1 month ago
Health


NEW STUDY FINDS THAT THERE IS LIKELY NO CURE-ALL FOR A HANGOVER

Loukia Papadopoulos
3 months ago
Advertisement

604
Popular Stories

 * 
   Ukraine fired a ballistic missile at a Russian ship. Here's everything we
   know.
 * 
   Round 2: Elon Musk now says he will fight Putin using only his left hand
 * 
   Ukraine captures a Russian electronic warfare system. Why it is a jackpot
   for…
 * 
   23 People Who Ended Up Marrying Their Celebrity Crush POPSUGAR | Sponsored
 * 
   Germany is buying F-35 fighter jets, but why?
 * 
   Anyone With Type 2 Diabetes Should Watch This! healthgoodtop | Sponsored


Advertisement


INTERESTING ENGINEERING
 * About Us
 * Advertise
 * Jobs
 * Newsletter
 * Contact Us

CATEGORIES
 * Innovation
 * Science
 * Culture
 * Health
 * Transportation

© Copyright 2021 | Interesting Engineering, Inc. | All Rights Reserved
 * Terms of Service
 * Policies

×


GET YOUR DAILY NEWS DIRECTLY IN YOUR INBOX

JOIN FREE

By subscribing, you agree to our Terms of Use and Privacy Policy. You may
unsubscribe at any time.

user-signalWir schätzen Ihre Privatsphäre
Alles ablehnenAlles akzeptieren
Wir und unsere Partner informationen auf einem gerät speichern und/oder abrufen.
Für die Ihnen angezeigten Verarbeitungszwecke können Cookies, Geräte-Kennungen
oder andere Informationen auf Ihrem Gerät gespeichert oder abgerufen werden.
Anzeigen und Inhalte können basierend auf einem Profil personalisiert werden. Es
können Daten hinzugefügt werden, um Anzeigen und Inhalte besser zu
personalisieren. Die Leistung von Anzeigen und Inhalten kann gemessen werden.
Erkenntnisse über die Zielgruppen, die die Anzeigen und Inhalte gesehen haben,
können abgeleitet werden. Ihre Daten können verwendet werden, um bestehende
Systeme und Software zu verbessern und neue Produkte zu entwickeln.

Einige Partner bitten nicht um Ihre Zustimmung zur Verarbeitung Ihrer Daten und
verlassen sich stattdessen auf deren berechtigtes Interesse. Sehen Sie sich
unsere Liste der Partner an, um zu sehen, für welche Zwecke sie ein berechtigtes
Interesse haben und wie Sie dagegen Einwände erheben können.

Ihre Auswahl auf dieser Website wird für diese Website angewendet. Sie können
Ihre Einstellungen jederzeit ändern, indem Sie Ihre Einwilligung widerrufen,
indem Sie auf das Schlosssymbol in der unteren rechten oder linken Ecke klicken.

checklistZweckesettings-toggle-horizontalPartner
Powered By