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Catalog
 * Bestsellers
     
   * Viagra €0.26
   * Cialis €0.64
   * Clomid €0.41
   * ED Sample Pack 1 €2.17
   * Brand Viagra €1.66
   * Doxycycline €0.28
   * Propecia €0.48
   * Levitra €0.94
   * Amoxil €0.37
   * Viagra Professional €0.54
   * Prednisone €0.28
   * Brand Cialis €2.9
   * Dapoxetine €0.9
   * Zithromax €0.52
   * Nolvadex €0.49
   * Cytotec €1.6
   * Cialis Professional €1.13
   * Viagra Super Active €1.17
   * Extra Super Viagra €2.69
   * Cialis Extra Dosage €1.93
   * Cialis Soft €1.04
   * Viagra Soft €0.85
   * Kamagra €0.84
   * Cipro €0.21
   * Cialis Super Active €1.24
   * Extra Super Cialis €2.88
   * Female Viagra €0.64
   * Lasix €0.24
   * Zoloft €0.26
   * Tadapox €1.02
   * Propranolol €0.25
   * Xenical €0.74
   * Prednisolone €0.3
   * Metformin €0.25
   * Antabuse €0.4
   * Sildalis €0.89
   * Valtrex €2.5
 * ED Sample Packs
     
   * ED Sample Pack 1 €2.17
   * ED Sample Pack 2 €1.9
   * ED Sample Pack 3 €2.14
 * Erectile Dysfunction
     
   * Viagra €0.26
   * Cialis €0.64
   * Levitra €0.94
   * Brand Viagra €1.66
   * Brand Cialis €2.9
   * Brand Levitra €3.49
   * Sildalis €0.89
   * Silvitra €2.63
   * Dapoxetine €0.9
   * Kamagra €0.84
   * Kamagra Polo €1.49
   * Kamagra Effervescent €24.03
   * Kamagra Super €2.8
   * Malegra FXT €1.09
   * Malegra FXT Plus €1.26
   * Malegra DXT €1.09
   * Malegra DXT Plus €1.25
   * Tadapox €1.02
   * Extra Super Viagra €2.69
   * Extra Super Cialis €2.88
   * Extra Super Levitra €2.8
   * Super Viagra €2.57
   * Super Cialis €1.02
   * Super Levitra €2.36
   * Viagra Super Active €1.17
   * Cialis Super Active €1.24
   * Levitra Super Active €1.13
   * Viagra Professional €0.54
   * Cialis Professional €1.13
   * Levitra Professional €2.64
   * Viagra Extra Dosage €1.84
   * Cialis Extra Dosage €1.93
   * Levitra Extra Dosage €2.29
   * Viagra Soft €0.85
   * Cialis Soft €1.04
   * Levitra Soft €0.96
   * Avana €2.87
   * Top Avana €2.95
   * Super Avana €4.62
   * Extra Super Avana €6.57
   * Tadacip €0.9
   * Nizagara €0.8
   * Viagra Plus €0.62
   * Levitra Plus €0.68
   * Silagra €0.61
   * Tadalis SX €1.3
   * Viagra Jelly €2.01
   * Cialis Jelly €2.79
   * Levitra Jelly €4.16
   * Zenegra €0.56
   * Cialis Sublingual €1.09
   * Viagra Sublingual €0.69
   * Suhagra €0.57
   * Apcalis SX €1.66
   * Caverta €4.32
   * Forzest €4.7
   * Himcolin €28.43
   * Viagra Soft Flavoured €2.08
   * Super P-Force €2.57
   * Super P-Force Oral Jelly €5.98
   * Erectafil €1.23
   * Tadala Black €1.53
   * Cialis Black €1.11
   * Red Viagra €2.43
   * Viagra Vigour €2.43
   * Eriacta €1.13
   * Fildena €0.68
   * Aurogra €0.72
   * Sildigra €0.65
   * Tadora €1.11
   * Zudena €6.45
   * Vidalista €0.64
   * Cenforce €0.26
   * Cenforce Professional €0.85
   * Cenforce Soft €0.9
   * Cenforce-D €2.62
 * Allergies
     
   * Alavert €0.41
   * Allegra €0.25
   * Aristocort €0.87
   * Astelin €21.21
   * Atarax €0.34
   * Beconase AQ €27.59
   * Benadryl €1.62
   * Clarinex €0.51
   * Claritin €0.38
   * Decadron €0.33
   * Deltasone €0.27
   * Entocort €37.72
   * FML Forte €18.29
   * Flonase €26.89
   * Haridra €47.14
   * Nasonex nasal spray €27.33
   * Periactin €0.43
   * Phenergan €0.36
   * Prednisolone €0.3
   * Prednisone €0.28
   * Promethazine €0.61
   * Quibron-t €0.41
   * Rhinocort €30.66
   * Seroflo €78.31
   * Zyrtec €1.01
 * Anti Fungal
     
   * Diflucan €0.66
   * Grifulvin V €0.31
   * Gyne-lotrimin €7.29
   * Lamisil €2.17
   * Lotrisone €6.71
   * Mentax €20.88
   * Mycelex-g €2.73
   * Nizoral €1.08
 * Anti Viral
     
   * Aciclovir €0.39
   * Acivir Cream €17.86
   * Acivir Pills €0.53
   * Adalat €0.26
   * Albendazole €0.32
   * Amantadine €0.66
   * Famvir €4.51
   * Lasuna €24.15
   * Mobic €0.26
   * Movfor €5.22
   * Procardia €0.71
   * Valtrex €2.5
   * Vermox €0.36
   * Zovirax €0.24
   * Zovirax Cream €13.7
 * Antibiotics
     
   * Amoxil €0.37
   * Ampicillin €0.23
   * Augmentin €0.93
   * Bactrim €0.32
   * Biaxin €2.25
   * Brand Amoxil €0.53
   * Cefadroxil €0.92
   * Cefixime €2.69
   * Ceftin €1.68
   * Cephalexin €1.24
   * Chloramphenicol €0.43
   * Chloromycetin €0.32
   * Ciplox €1.15
   * Cipro €0.21
   * Cleocin €1.91
   * Clindamycin €1.02
   * Doxycycline €0.28
   * Erythromycin €0.41
   * Flagyl ER €0.24
   * Floxin €0.35
   * Fosfomycin €31.58
   * Fucidin €23.36
   * Keflex €0.83
   * Keftab €0.54
   * Ketoconazole Cream €15.67
   * Lquin €1.16
   * Minocin €1.74
   * Minocycline €2.19
   * Minomycin €1.66
   * Myambutol €0.28
   * Nitrofurantoin €0.41
   * Noroxin €0.36
   * Omnicef €2.97
   * Panmycin €0.6
   * Roxithromycin €0.73
   * Stromectol €2.48
   * Sumycin €0.26
   * Suprax €0.89
   * Terramycin €0.25
   * Tetracycline €0.27
   * Tinidazole €0.78
   * Trimox €0.32
   * Vantin €1.79
   * Zithromax €0.52
   * Zyvox €6.71
 * Anxiety
     
   * Ashwagandha €20.23
   * Atarax €0.34
   * Buspar €0.28
   * Cymbalta €0.66
   * Desyrel €0.35
   * Effexor XR €0.58
   * Emsam €0.92
   * Lexapro €0.26
   * Luvox €0.95
   * Pamelor €0.49
   * Phenergan €0.36
   * Serpina €24.35
   * Sinequan €0.25
   * Tofranil €0.47
   * Venlor €0.89
 * Arthritis
     
   * Arcoxia €0.61
   * Celebrex €0.5
   * Colchicine €0.48
   * Decadron €0.33
   * Deltasone €0.27
   * Diclofenac €0.26
   * Diclofenac Gel €6.52
   * Etodolac €0.61
   * Feldene €0.48
   * Indocin €0.33
   * Medrol €0.65
   * Mobic €0.26
   * Motrin €0.74
   * Naprosyn €0.67
   * Plaquenil €2.26
   * Prednisolone €0.3
   * Prednisone €0.28
   * Shuddha Guggulu €28.87
   * Voltaren €0.26
 * Asthma
     
   * Advair Diskus €58.74
   * Astralean €1.92
   * Beconase AQ €27.59
   * Benadryl €1.62
   * Claritin €0.38
   * Decadron €0.33
   * Deltasone €0.27
   * Entocort €37.72
   * FML Forte €18.29
   * Haridra €47.14
   * Medrol €0.65
   * Nasonex nasal spray €27.33
   * Prednisolone €0.3
   * Prednisone €0.28
   * Promethazine €0.61
   * Proventil €22.54
   * Quibron-t €0.41
   * Rhinocort €30.66
   * Seroflo €78.31
   * Singulair €0.91
   * Ventolin €20.54
 * Birth Control
     
   * Alesse €0.39
   * Levlen €0.4
   * Mircette €0.66
   * Yasmin €1.26
 * Blood Pressure
     
   * Aceon €1.02
   * Adalat €0.26
   * Aldactone €0.69
   * Altace €0.66
   * Avalide €1.17
   * Avapro €0.66
   * Benicar €0.43
   * Betapace €0.69
   * Bystolic €0.71
   * Calan €0.31
   * Cardizem €0.39
   * Cardura €0.27
   * Clonidine €0.24
   * Coreg €1.24
   * Coumadin €0.27
   * Cozaar €0.75
   * Digoxin €0.4
   * Diovan €0.86
   * Dipyridamole €0.31
   * Doxazosin €0.31
   * Furosemide €0.32
   * Hydrochlorothiazide €0.26
   * Hytrin €0.68
   * Hyzaar €0.49
   * Inderal €0.24
   * Innopran XL €0.84
   * Isoptin €0.37
   * Lanoxin €0.37
   * Lasix €0.24
   * Lisinopril €0.35
   * Lopressor €0.64
   * Lozol €0.62
   * Micardis €0.94
   * Midamor €0.37
   * Moduretic €0.66
   * Nitroglycerin €0.85
   * Norvasc €0.29
   * Plavix €0.67
   * Plendil €0.36
   * Prazosin €0.9
   * Prinivil €0.19
   * Serpina €24.35
   * Tenormin €0.29
   * Toprol XL €0.64
   * Torsemide €0.32
   * Trandate €1.01
   * Triamterene €0.89
   * Vasodilan €0.47
   * Vasotec €0.48
   * Zebeta €0.26
   * Zestoretic €0.86
   * Zestril €0.29
 * Cholesterol Lowering
     
   * Abana €26.38
   * Atorlip-10 €0.7
   * Atorlip-20 €1.91
   * Atorlip-5 €0.41
   * Crestor €0.59
   * Lasuna €24.15
   * Lipitor €0.2
   * Lopid €1.12
   * Prazosin €0.9
   * Rosuvastatin €1.38
   * Shuddha Guggulu €28.87
   * Tricor €0.7
   * Vytorin €0.85
   * Zetia €1.04
   * Zocor €0.63
 * Depression
     
   * Abilify €0.52
   * Amitriptyline €0.31
   * Anafranil €0.3
   * Bupron SR €1.4
   * Bupropion €0.78
   * Celexa €0.27
   * Citalopram €0.5
   * Clozaril €0.26
   * Cymbalta €0.66
   * Desyrel €0.35
   * Effexor XR €0.58
   * Elavil €0.34
   * Emsam €0.92
   * Endep €0.33
   * Isoniazid €0.36
   * Lexapro €0.26
   * Lithium €0.25
   * Pamelor €0.49
   * Paroxetine €0.7
   * Paxil €0.57
   * Pristiq €1.79
   * Remeron €0.83
   * Sinequan €0.25
   * Trazodone €0.67
   * Venlor €0.89
   * Wellbutrin €1.66
   * Wellbutrin SR €0.79
   * Zoloft €0.26
   * Zyban €0.55
 * Diabetes
     
   * Actoplus Met €0.9
   * Actos €0.36
   * Amaryl €0.45
   * Avapro €0.66
   * Cozaar €0.75
   * Diabecon €34.12
   * Duetact €0.28
   * Forxiga €3.14
   * Glucophage €0.16
   * Glucotrol XL €0.31
   * Glycomet €0.19
   * Glyset €1.65
   * Januvia €4.22
   * Metformin €0.25
   * Micronase €0.25
   * Prandin €0.74
   * Precose €0.5
 * Gastrointestinal
     
   * Aciphex €0.53
   * Allopurinol €0.63
   * Bentyl €0.45
   * Biaxin €2.25
   * Brand Amoxil €0.53
   * Cytotec €1.6
   * Decadron €0.33
   * Deltasone €0.27
   * Diarex €23.38
   * Ditropan €2.16
   * Doxazosin €0.31
   * Florinef €0.97
   * Gasex €23.9
   * Hytrin €0.68
   * Lasuna €24.15
   * Metoclopramide €0.53
   * Motilium €0.26
   * Nexium €0.41
   * Nitrofurantoin €0.41
   * Noroxin €0.36
   * Pariet €0.38
   * Prednisolone €0.3
   * Prevacid €0.39
   * Prilosec €0.46
   * Protonix €0.35
   * Pyridium €0.7
   * Ranitidine €0.28
   * Reglan €0.35
   * Renagel €2.82
   * Roxithromycin €0.73
   * Torsemide €0.32
   * Zantac €0.14
 * Hair Loss
     
   * Dutas €1.63
   * Finast €1.9
   * Finpecia €0.47
   * Propecia €0.48
   * Proscar €0.97
   * Rogaine 2 €24.88
   * Rogaine 5 €35.72
 * Heart Disease
     
   * Abana €26.38
   * Albendazole €0.32
   * Aldactone €0.69
   * Altace €0.66
   * Atorlip-10 €0.7
   * Atorlip-20 €1.91
   * Atorlip-5 €0.41
   * Betapace €0.69
   * Bystolic €0.71
   * Calan €0.31
   * Cardizem €0.39
   * Coreg €1.24
   * Digoxin €0.4
   * Diovan €0.86
   * Plavix €0.67
   * Prednisolone €0.3
   * Prinivil €0.19
   * Procardia €0.71
   * Propranolol €0.25
   * Tenormin €0.29
   * Toprol XL €0.64
   * Torsemide €0.32
   * Vasotec €0.48
   * Zestril €0.29
 * Herbals
     
   * Abana €26.38
   * Ashwagandha €20.23
   * Ayurslim €32.78
   * Brahmi €20.35
   * Confido €20.06
   * Diabecon €34.12
   * Diarex €23.38
   * Evecare €32.98
   * Gasex €23.9
   * Geriforte €29.12
   * Geriforte Syrup €24.35
   * Haridra €47.14
   * Himcolin €28.43
   * Himplasia €20.81
   * Hoodia €1.21
   * Lasuna €24.15
   * Liv 52 €22.74
   * Mentat €23.3
   * Mentat DS syrup €33.71
   * NPXL €22.73
   * Picrolax €19.14
   * Pilex €29.24
   * Renalka €23.59
   * Rumalaya €20.39
   * Rumalaya forte €20.94
   * Rumalaya gel €21.36
   * Rumalaya liniment €21.08
   * Serpina €24.35
   * Shallaki €20.09
   * Shuddha Guggulu €28.87
   * Slip Inn €1.45
   * Speman €20.14
   * V-gel €22.23
 * Men's Health
     
   * Avodart €0.63
   * Cardura €0.27
   * Cenforce €0.26
   * Cenforce Professional €0.85
   * Cenforce Soft €0.9
   * Cenforce-D €2.62
   * Confido €20.06
   * Dapoxetine €0.9
   * Doxazosin €0.31
   * Dutas €1.63
   * Eulexin €1.3
   * Finast €1.9
   * Finax €0.84
   * Fincar €1.36
   * Finpecia €0.47
   * Flomax €0.68
   * Himplasia €20.81
   * Hytrin €0.68
   * Kamagra Chewable €3.71
   * Kamagra Gold €2.11
   * Kamagra Oral Jelly €3.7
   * Kamagra Soft €3.76
   * Levitra Soft €0.96
   * Levothroid €0.32
   * Malegra DXT €1.09
   * Malegra FXT €1.09
   * Malegra FXT Plus €1.26
   * NPXL €22.73
   * Noroxin €0.36
   * Penegra €3.05
   * Pilex €29.24
   * Proscar €0.97
   * Rogaine 5 €35.72
   * Sildalis €0.89
   * Speman €20.14
   * Tadapox €1.02
   * Uroxatral €1.39
   * VPXL €30.46
   * Vidalista €0.64
   * Vimax €28.34
 * Muscle Relaxant
     
   * Baclofen €0.58
   * Colospa €0.82
   * Imitrex €3.94
   * Imuran €0.8
   * Lioresal €0.66
   * Mestinon €1.42
   * Nimotop €0.89
   * Pletal €0.82
   * Ponstel €0.3
   * Robaxin €0.39
   * Rumalaya €20.39
   * Rumalaya forte €20.94
   * Rumalaya gel €21.36
   * Rumalaya liniment €21.08
   * Shallaki €20.09
   * Skelaxin €1.46
   * Tegretol €0.47
   * Tizanidine €2.26
   * Urispas €1.02
   * Voveran €0.39
   * Voveran sr €0.16
   * Zanaflex €0.75
 * Other
     
   * Abilify €0.52
   * Actonel €5.46
   * Albenza €0.33
   * Allopurinol €0.63
   * Amantadine €0.66
   * Antabuse €0.4
   * Antivert €0.32
   * Arava €1.17
   * Aricept €0.7
   * Asacol €0.92
   * Betoptic €9.74
   * Brahmi €20.35
   * Chloroquine €1.06
   * Clexane €120.72
   * Clozaril €0.26
   * Combivent €35.88
   * Compazine €0.31
   * Copegus €3.54
   * Coumadin €0.27
   * Cyklokapron €1.95
   * Cytoxan €1.11
   * Depakote €0.68
   * Detrol €0.93
   * Dilantin €0.45
   * Diltiazem €0.68
   * Dramamine €0.54
   * Dulcolax €0.41
   * Duphalac €29.65
   * Eldepryl €0.64
   * Epivir-HBV €0.82
   * Exelon €0.55
   * Flonase €26.89
   * Haldol €1.33
   * Hydrea €1.43
   * Indinavir €3.23
   * Isoniazid €0.36
   * Kaletra €3.76
   * Kemadrin €0.75
   * Keppra €1.64
   * Kytril €1.73
   * Lamictal €0.88
   * Liv 52 €22.74
   * Meclizine €0.38
   * Meldonium €0.72
   * Mentat €23.3
   * Mentat DS syrup €33.71
   * Methotrexate €1.19
   * Midamor €0.37
   * Minomycin €1.66
   * Naltrexone €6.29
   * Neurontin €0.52
   * Nootropil €0.95
   * Olanzapine €0.64
   * Oxytrol €0.78
   * Picrolax €19.14
   * Plaquenil €2.26
   * Reminyl €2.79
   * Renalka €23.59
   * Requip €0.45
   * Risperdal €1.2
   * Rocaltrol €1.41
   * Seroquel €0.63
   * Sinemet €0.79
   * Solian €2.39
   * Strattera €0.48
   * Synthroid €0.18
   * Topamax €1.72
   * Triamterene €0.89
   * Trileptal €0.62
   * V-gel €22.23
   * Xalatan €44.98
   * Zofran €0.32
   * Zyloprim €0.29
   * Zyprexa €0.28
 * Pain Relief
     
   * Aleve €0.69
   * Anacin €0.41
   * Arcoxia €0.61
   * Artane €0.4
   * Aspirin €19.17
   * Azulfidine €0.67
   * Cafergot €0.59
   * Colospa €0.82
   * Diclofenac Gel €6.52
   * Elavil €0.34
   * Imitrex €3.94
   * Imuran €0.8
   * Lioresal €0.66
   * Maxalt €6.63
   * Mestinon €1.42
   * Mobic €0.26
   * Motrin €0.74
   * Naprosyn €0.67
   * Nimotop €0.89
   * Periactin €0.43
   * Phenergan €0.36
   * Pletal €0.82
   * Ponstel €0.3
   * Prednisone €0.28
   * Pyridium €0.7
   * Rizact €5.38
   * Rumalaya €20.39
   * Rumalaya forte €20.94
   * Rumalaya gel €21.36
   * Rumalaya liniment €21.08
   * Shallaki €20.09
   * Tegretol €0.47
   * Tizanidine €2.26
   * Toradol €0.37
   * Trental €0.52
   * Urispas €1.02
   * Voltaren €0.26
   * Voveran €0.39
   * Voveran sr €0.16
 * Skincare
     
   * Accutane €0.53
   * Acticin €10.15
   * Aldara €22.17
   * Bactroban €30.58
   * Benzac €11.29
   * Betnovate €5.13
   * Cleocin Gel €16.69
   * Decadron €0.33
   * Deltasone €0.27
   * Differin €12.87
   * Elimite €10.13
   * Eurax €22.17
   * Fucidin €23.36
   * Geriforte €29.12
   * Geriforte Syrup €24.35
   * Medrol €0.65
   * Minomycin €1.66
   * Omnicef €2.97
   * Prednisolone €0.3
   * Prednisone €0.28
   * Retin-A 0,025 €10.38
   * Retin-A 0,05 €11.16
   * Retin-A Gel 0,1 €10.6
   * Retino-A Cream 0,025 €11.09
   * Retino-A Cream 0,05 €13.9
   * Tretinoin 0,025 €8.36
   * Tretinoin 0,05 €9.11
 * Sleep Aid
     
   * Desyrel €0.35
   * Phenergan €0.36
   * Provigil €0.77
   * Slip Inn €1.45
   * Sominex €0.53
   * Unisom €0.61
 * Quit Smoking
     
   * Nicotinell €26.4
   * Wellbutrin €1.66
   * Wellbutrin SR €0.79
   * Zyban €0.55
 * Weight Loss
     
   * Alli €0.84
   * Astralean €1.92
   * Ayurslim €32.78
   * Hoodia €1.21
   * Orlistat €1.11
   * Shuddha Guggulu €28.87
   * Slimex €1.52
   * Xenical €0.74
 * Woman's Health
     
   * Alesse €0.39
   * Arimidex €4.66
   * Aygestin €0.77
   * Bimat €31.31
   * Cabgolin €3.75
   * Careprost €34.85
   * Clomid €0.41
   * Danazol €1.4
   * Diclofenac €0.26
   * Dostinex €3.07
   * Estrace €0.67
   * Etodolac €0.61
   * Evecare €32.98
   * Evista €0.95
   * Female Cialis €0.89
   * Female Viagra €0.64
   * Femara €1.75
   * Fertomid €1.21
   * Flagyl ER €0.24
   * Fluoxetine €0.29
   * Fosamax €0.54
   * Ginette-35 €1.52
   * Lady era €1.05
   * Levlen €0.4
   * Levothroid €0.32
   * Lumigan €46.6
   * Mircette €0.66
   * Mycelex-g €2.73
   * Naprosyn €0.67
   * Nolvadex €0.49
   * Pilex €29.24
   * Ponstel €0.3
   * Premarin €5.35
   * Prometrium €1.68
   * Provera €0.33
   * Sarafem €0.51
   * Serophene €0.41
   * Tamoxifen €0.55
   * V-gel €22.23
   * Xeloda €15.23
   * Yasmin €1.26

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methotrexate

Methotrexate is an antimetabolite used to treat certain types of cancer.
Active Ingredient: methotrexate
Availability: In Stock (31 packages)




Methotrexate 10mg

Product namePer PillSavingsPer PackOrder10 pills€5.88€58.84ADD TO CART20
pills€4.64€24.92€117.69 €92.77ADD TO CART30 pills€4.22€49.84€176.53 €126.69ADD
TO CART60 pills€3.81€124.61€353.06 €228.45ADD TO CART90 pills€3.67€199.38€529.60
€330.22ADD TO CART120 pills€3.60€274.14€706.12 €431.98ADD TO CART180
pills€3.53€423.68€1059.20 €635.52ADD TO CART

Methotrexate 5mg

Product namePer PillSavingsPer PackOrder10 pills€3.76€37.60ADD TO CART20
pills€3.08€13.67€75.20 €61.53ADD TO CART30 pills€2.85€27.33€112.80 €85.47ADD TO
CART60 pills€2.62€68.33€225.60 €157.27ADD TO CART90 pills€2.55€109.33€338.40
€229.07ADD TO CART120 pills€2.51€150.33€451.20 €300.87ADD TO CART180
pills€2.47€232.33€676.80 €444.47ADD TO CART270 pills€2.44€355.32€1015.20
€659.88ADD TO CART

Methotrexate 2.5mg

Product namePer PillSavingsPer PackOrder30 pills€1.83€54.99ADD TO CART60
pills€1.48€21.00€109.98 €88.98ADD TO CART90 pills€1.37€41.99€164.97 €122.98ADD
TO CART120 pills€1.31€62.99€219.96 €156.97ADD TO CART180
pills€1.25€104.98€329.94 €224.96ADD TO CART270 pills€1.21€167.97€494.91
€326.94ADD TO CART360 pills€1.19€230.96€659.88 €428.92ADD TO CART

 * Common use
   
   Methotrexate is an antimetabolite used to treat certain types of cancer. It
   inhibits dihydrofolate reductase, an important enzyme responsible for the
   synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA,
   DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow,
   embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral
   cavity are the most sensitive to it.
   Methotrexate is used in treatment of breast cancer, squamous cell carcinoma
   of the head and neck, lung cancer, trophoblastic tumor, cervical cancer,
   ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach
   cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia
   and many others.
   
   Dosage and direction
   
   Take exactly as prescribed by your physician. Take Methotrexate orally with
   or without food. Do not chew or crush the tablet. To treat rheumatoid
   arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of
   the medication once a week or 2.5 mg each twelve hours three times also once
   weekly. Treatment of cancer requires individual dosage and treatment only
   under control of your doctor.
   
   Precautions
   
   Caution should be exercised in the patients with ascites, dehydration,
   obstructive diseases of the digestive tract, pleural or peritoneal effusion,
   chronic renal failure, parasitic and infectious diseases of viral, fungal or
   bacterial origin due to the possible high risk of severe generalized disease
   development. Methotrexate toxicity increases in the individuals with herpes
   simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis
   (helminthosis caused by threadworm with allergic symptoms at the beginning of
   the disease), gout (also in history), infection and inflammation of mucosa in
   the mouth, nausea and vomiting (due to dehydration), stomach and duodenal
   ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy,
   asthenia. When Metheotrexate is used to treat cancer cautiousness is need in
   the patients with aciduria (urine pH less than 7) and inhibited bone marrow
   hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines
   should be avoided for 3-12 months since the course of treatment with
   Methotrexate was finished. Men and women should use safe contraception as
   this drug is very toxic for an unborn baby.
   
   Contraindications
   
   This medicine cannot be administered to the patients with hypersensitivity to
   its components, immune deficiency, pregnant and breastfeeding women. When
   Methotrexate is used to treat patents with psoriasis or rheumatic diseases it
   cannot be used if they also have heavy suppression of bone marrow
   hematopoiesis, severe kidney or liver failure.
   
   Possible side effect
   
   Methotrexate is usually well tolerated but some patients may develop mouth
   sores, stomach upset, and low white blood counts. Methotrexate is known to be
   toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done
   on a regular basis while treatment with this drug. Other adverse reactions
   may include headache, drowsiness and allergic reactions such as skin rash,
   itching, dizziness, and hair loss.
   
   Drug interaction
   
   Inform your doctor about all prescribed and over-the-counter medications,
   herbal products and food supplements you take and especially about NSAIDs
   such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen
   (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam
   (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity);
   azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine,
   sulfinpirazon) requires correction of the dose. Inform your doctor also about
   chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox),
   retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone
   and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin),
   theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid
   (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral
   anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide
   (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide
   (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal,
   Disalcid, Doan's Pills).
   
   Missed dose
   
   Consult your doctor if you miss a dose of this medicine.
   
   Overdose
   
   Contact your doctor immediately if you suspect overdose. Signs of overdose
   include nausea, vomiting, weakness, paleness, easy bruising or bleeding,
   mouth sores, black or bloody stools, coughing up blood, vomit similar to
   coffee grounds, decreased urination or anuria.
   
   Storage
   
   Store in a dry tight container away from sunlight at room temperature between
   15-30 C (59-86 F) away from children and pets.
   
   Disclaimer
   
   We provide only general information about medications which does not cover
   all directions, possible drug integrations, or precautions. Information at
   the site cannot be used for self-treatment and self-diagnosis. Any specific
   instructions for a particular patient should be agreed with your health care
   adviser or doctor in charge of the case. We disclaim reliability of this
   information and mistakes it could contain. We are not responsible for any
   direct, indirect, special or other indirect damage as a result of any use of
   the information on this site and also for consequences of self-treatment.

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