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Vaccines & Immunizations
Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives,
Protecting People Centers for Disease Control and Prevention. CDC twenty four
seven. Saving Lives, Protecting People

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USE OF COVID-19 VACCINES IN THE UNITED STATES

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Interim Clinical Considerations

Interim Clinical Considerations

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Related Pages

Summary of recent changes (last updated March 16, 2023):
 * New recommendation for children ages 6 months–4 years who previously
   completed a 3-dose monovalent Pfizer-BioNTech primary series to receive 1
   bivalent Pfizer-BioNTech booster dose at least 2 months after completion of
   the monovalent primary series.
 * Vaccination providers are now required to report cases of myocarditis and
   pericarditis after receipt of a Janssen COVID-19 Vaccine to the Vaccine
   Adverse Event Reporting System (VAERS).


Reference Materials
 * Summary Document for Interim Clinical Considerations (Updated 12/12/2022)
 * Interim COVID-19 Immunization Schedule (Updated 12/12/2022)
 * COVID-19 Vaccination Schedule Infographic
 * COVID-19 Vaccination Schedule Infographic (Immunocompromised)
 * Special Situations for COVID-19 Vaccination of Children and Adolescents: Age
   Transitions and Interchangeability (Updated 12/09/2022)
 * FAQs for the Interim Clinical Considerations

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COVID-19 Vaccines, Recommendations, and Schedules
 * Overview of COVID-19 vaccination
 * Guidance for people who are not immunocompromised
 * Guidance for people who are immunocompromised

Implementation
 * Timing, spacing, age transitions, and coadministration of COVID-19 vaccines
 * Interchangeability of COVID-19 vaccine products
 * Vaccination and SARS-CoV-2 laboratory testing
 * Patient counseling

Safety
 * Contraindications and precautions
 * Reporting of adverse events
 * Safety considerations for mRNA COVID-19 vaccines: Moderna and Pfizer-BioNTech
 * Safety considerations for Novavax COVID-19 Vaccine
 * COVID-19 vaccination and myocarditis and pericarditis

Special Situations and Populations
 * COVID-19 vaccination and SARS-CoV-2 infection
 * COVID-19 vaccination and MIS-C and MIS-A
 * Pregnancy, lactation, and fertility

Appendices
 * Guidance for use of Janssen COVID-19 Vaccine (Appendix A)
 * People who received COVID-19 vaccine outside the United States (Appendix B)
 * People who received COVID-19 vaccine as part of a clinical trial (Appendix C)
 * Vaccine administration errors and deviations (Appendix D)
 * Triage of people with a history of allergies or allergic reactions (Appendix
   E)


Last Reviewed: November 14, 2022
Source: National Center for Immunization and Respiratory Diseases
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homeCOVID-19 Vaccination
 * Product Info by U.S. Vaccineplus icon
   * Pfizer-BioNTech Vaccinesplus icon
     * Storage & Handling
     * Administration
   * Moderna Vaccineplus icon
     * Storage & Handling
     * Administration
   * Janssen/J&J Vaccineplus icon
     * Storage & Handling
     * Administration
   * Novavaxplus icon
     * Storage & Handling
     * Administration
   * EUA
   * EUI
 * Interim Clinical Considerationsplus icon
   * Use of COVID-19 Vaccines in the U.S.
   * Use of COVID-19 Vaccines in the U.S.: Appendices
   * FAQs for the Interim Clinical Considerations
   * Archived COVID-19 Vaccination Schedules
   * Myocarditis and Pericarditis Considerations
 * Clinical Careplus icon
   * Vaccinating Homebound Persons
   * Jurisdictions: Vaccinating Older Adults and People with Disabilities
   * Vaccination Sites: Vaccinating Older Adults and People with Disabilities
   * Vaccinating Patients upon Discharge from Hospitals, Emergency Departments &
     Urgent Care Facilities
 * Provider Requirements and Supportplus icon
   * How to Enroll as a Healthcare Provider
   * Vaccines for Children Program vs. CDC COVID-19 Vaccination Program
   * FAQs for Private & Public Healthcare Providers
   * FAQs for Federal Retail Pharmacies
 * Training and Education
 * Vaccine Recipient Educationplus icon
   * Talking with Patients about COVID-19 Vaccination
   * Talking to Patients with Intellectual and Developmental Disabilities
   * How to Tailor COVID-19 Information to Your Audience
   * How to Address COVID-19 Vaccine Misinformation
 * Health Departmentsplus icon
   * Community Features
   * Ways to Help Increase COVID-19 Vaccinations
 * Planning & Partnershipsplus icon
   * COVID-19 Vaccination Program Operational Guidanceplus icon
     * What to Consider When Planning to Operate a COVID-19 Vaccine Clinic
     * Using the COVID-Vac Tool to Assess COVID-19 Vaccine Clinic Staffing &
       Operations Needs
   * Considerations for Planning School-Located Vaccination Clinicsplus icon
     * How Schools and ECE Programs Can Support Vaccination
     * Customizable Content for Vaccination Clinics
     * Best Practices for Schools and ECE Programs
   * Federal Retail Pharmacy Programplus icon
     * Participating Pharmacies
     * Connecting with Federal Pharmacy Partners
   * COVID-19 Vaccination for Childrenplus icon
     * 6 Things to Know
     * Equity in Childhood COVID-19 Vaccination
     * Resources to Promote the COVID-19 Vaccine for Children & Teens
     * Vaccinating Children with Disabilities
   * COVID-19 Vaccine Access in Long-term Care Settingsplus icon
     * Information for Long-term Care Administrators & Managers
     * Information for Jurisdictions
     * Medical Consent FAQs
   * Mobile Vaccination Resources
   * Vaccinating Dialysis Patients and Healthcare Personnelplus icon
     * What Public Health Jurisdictions and Dialysis Partners Need to Know
 * Vaccine Effectiveness Research
 * COVID-19 Vaccine Data Systemsplus icon
   * Overviewplus icon
     * Vaccine IT Overview
   * Data Reporting Requirementsplus icon
     * Supporting Jurisdictions in Enrolling Healthcare Providers
   * Vaccine Administration Management System (VAMS) plus icon
     * Getting Started in VAMS
     * General Public User
     * Resources for Jurisdictions, Clinics, and Organizations
     * VAMS Program Information
   * Vaccines.gov Reportingplus icon
     * Vaccines.gov FAQs
     * Vaccines.gov Factsheet
     * Factsheet for Jurisdictions
   * VTrckS
 * Vaccinate with Confidenceplus icon
   * What Is Vaccine Confidence?
   * Vaccine Confidence Strategies
   * Rapid Community Assessment Guide
   * COVID-19 Vaccine Confidence Data
   * 12 COVID-19 Vaccination Strategies for Your Community
   * How to Engage the Arts to Build COVID-19 Vaccine Confidence
   * Strategies for Reaching People with Limited Access to COVID-19 Vaccines


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