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Skip to navigation Skip to main content Menu Close Search... Submit * Prostate Cancer * ED * CKD * UrologyOpen Submenu * Urology Back * Urology News * Conference Coverage * Benign Prostatic Hyperplasia (BPH) * Bladder Cancer * Erectile Dysfunction * Hypogonadism * Kidney Cancer * Kidney Stones * Men’s Health * Overactive Bladder (OAB) * Premature Ejaculation * Prostate Cancer * Reproductive Medicine * Upper Tract Urothelial Carcinoma * Urinary Incontinence * Urinary Tract Infections (UTI) * NephrologyOpen Submenu * Nephrology Back * Nephrology * Conference Coverage * Acute Kidney Injury * Anemia * Contrast Nephropathy * Cardiovascular Disease (CVD) * Chronic Kidney Disease (CKD) * Diabetes * Diabetic Nephropathy * End-Stage Renal Disease * Hemodialysis * Hyperkalemia * Hyperphosphatemia * Hypertension * Hyperuricemia * Lupus Nephritis * Nutrition * Peritoneal Dialysis * Secondary Hyperparathyroidism * Transplantation * My PracticeOpen Submenu * My Practice Back * Commentary * Drug Information Database * Ethical Issues in Medicine * General Medicine * HIPAA Compliance * Legal Issues in Medicine * Practice Management * Product Guide * Web ExclusivesOpen Submenu * Web Exclusives Back * Expert Perspectives * Cartoons * Clinical Quiz * Drugs in the Pipeline * Medical Calculators * Medical Charts * Multimedia * Polls * Prostate Cancer Management Across America * Conferences * Resources Toggle Search Menu * Headlines * Jobs * Commentary * Poll * Drugs * CME Login Register * Submit * * * Home » News » Nephrology » Hyperkalemia Publish Date August 31, 2021 KIDNEY FAILURE RISK UP SUBSTANTIALLY WITH HYPERKALEMIA Natasha Persaud * Share on Facebook * Share on Twitter * Share on LinkedIn * Share on Reddit * Print * Share by Email Kidney failure risk was 17-fold higher among adults with than without hyperkalemia who had a baseline estimated glomerular filtration rate of 60 mL/min/1.73 m2 or greater. Credit: Getty Images Hyperkalemia is associated with poor long-term health outcomes, particularly kidney failure, independent of established risk factors, a new study finds. “Clinicians should note that even minor episodes of hyperkalaemia are prognostically relevant, important to communicate, and worthy of consideration in the planning of ongoing care, monitoring and expectations for future health,” Simon Sawhney, MBChB, BScMedSci, PhD, and colleagues from Aberdeen Centre for Health Data Sciences, University of Aberdeen in Grampian, UK, concluded in an article published in the American Journal of Kidney Diseases. Based on data from 302,630 adults in Grampian, UK, during 2012-2014, the annual population incidence of hyperkalemia (defined as serum potassium 5.5 mmol/L or greater) was 0.96 episodes per 100 person-years. The hyperkalemia incidence rate doubled for each 10-year increase in age from age 40 years. Results showed that 66.4% of episodes occurred in the community, 18.1% at hospital admission, and 15.6% during initial hospitalization. Today’s top picks on the Haymarket Medical Network Glucose-Lowering Therapy Delayed for Newly Diagnosed T2DM PatientsHaymarket MediaJuly 19, 2021 Free Fatty Acids Associated With Rapid Decline in Glomerular Filtration Rates in Type 1 DiabetesLauren BiscaldiAugust 2, 2021 Korsuva Approved for Chronic Kidney Disease-Associated PruritusBrian Park, PharmDAugust 25, 2021 -------------------------------------------------------------------------------- Continue Reading Adults with hyperkalemia had a 20- and 17-fold higher likelihood of concurrent acute kidney injury (AKI) and stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate less than 30 mL/min/1.73 m2), respectively, compared with those without hyperkalemia. They also had a 5-, 4-, and 4-fold higher likelihood of heart failure, diabetes, and peripheral arterial disease, respectively. Hyperkalemia occurrence was associated with poor health outcomes over 5 years of follow-up. Kidney failure risk was 17- and 2-fold higher among adults with than without hyperkalemia who had a baseline eGFR of 60 or greater and less than 30 mL/min/1.73 m2, respectively. The risk for major adverse cardiac events (MACE; defined as fatal or non-fatal myocardial infarction, heart failure or stroke) was 1.8- and 1.4-fold higher with hyperkalemia at the respective levels of kidney function. All-cause mortality risk was 2.3- and 1.5-fold higher, respectively. Having both hyperkalemia and AKI was associated with higher cumulative risks for MACE and death than having either condition alone. “An increase in kidney failure after hyperkalemia among those with preserved baseline kidney function is particularly notable and implies a mechanism of reduced kidney reserve may be contributing to the poorer outcomes,” Dr Sawhney’s team wrote. “Thus, ‘mild’ hyperkalemia is a novel predictor of lasting poor health outcomes that is independent of conventional kidney excretory function metrics.” They added that hyperkalemia “should not be considered solely an acute or transient problem, but a red flag indicator of diminished kidney reserve, and of lasting future health risk.” Reference Mclean A, Nath M, Sawhney S. Population epidemiology of hyperkalemia: cardiac and kidney long-term health outcomes. Am J Kidney Dis. Published online August 19, 2021. doi:10.1053/j.ajkd.2021.07.008 TOPICS: Acute Kidney Injury Cardiovascular Disease Chronic Kidney Disease End-Stage Renal Disease Epidemiology Heart Failure Hyperkalemia Myocardial Infarction Renal Replacement Therapy Stroke * GET RENAL UROLOGY ADVISOR IN YOUR INBOX Sign up to get the latest renal and urology news in your inbox. *Select a CountryAfghanistanAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBoliviaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo (DRC)Cook IslandsCosta RicaCroatiaCubaCyprusCzech RepublicCôte D'IvoireDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFiji IslandsFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsraelItalyJamaicaJapanJordanKazakhstanKenyaKiribatiKoreaKuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacaoMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNetherlands AntillesNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorth KoreaNorthern Mariana IslandsNorwayOmanPakistanPalauPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarReunionRomaniaRussiaRwandaSaint HelenaSaint Kitts and NevisSaint LuciaSaint MartinSaint Pierre and MiquelonSaint Vincent and The GrenadinesSan MarinoSao Tome & PrincipeSaudi ArabiaSenegalSerbia and MontenegroSerbia-MontenegroSeychellesSierra LeoneSingaporeSlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVatican CityVenezuelaViet NamVirgin IslandsVirgin Islands, BritishWallis and FutunaWestern SamoaYemenZambiaZimbabwe Today’s Update Renal & Urology News eTOC I would like to receive relevant information via email from Renal and Urology News / Haymarket Medical Network. 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