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WELCOME TO A NEW ERA IN MITOCHONDRIAL THERAPEUTICS


We are leading the way for a new era of life-changing medicines for patients and
families affected by mitochondrial disease. By understanding and targeting the
underlying causes, we are ushering in a new treatment paradigm that addresses
the drivers of mitochondrial disease, and not just singular symptoms.

Learn About Our Approach

1 in 5K

people has a
genetic mitochondrial
disease

1K-10K

Each cell on average contains 1,000-10,000 copies of mitochondrial DNA

>50

diseases are
associated with dysfunctional mitochondria

1 in 5K

people has a
genetic mitochondrial
disease

1K-10K

Each cell on average contains 1,000-10,000 copies of mitochondrial DNA

>50

diseases are
associated with dysfunctional mitochondria

1 in 5K

people has a
genetic mitochondrial
disease





A VAST OPPORTUNITY FOR THERAPEUTIC INNOVATION


Mitochondrial disease results from cells not being able to make the energy
required for organs to function properly and leads to a variety of
life-altering, and often life-threatening, syndromes. Deficiency in
mitochondrial DNA (mtDNA) is a common cause of mitochondrial disease, and
Pretzel is designing a portfolio of programs to upregulate mtDNA to improve
survival, function and quality of life.

Learn About Our Impact
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