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Advertisement * * news * careers * commentary * Journals * * * Log in * Become A Member science science advances science immunology science robotics science signaling science translational medicine science partner journals Quick Search anywhere Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Searching: Anywhere AnywhereScienceScience AdvancesScience ImmunologyScience RoboticsScience SignalingScience Translational Medicine Advanced Search Search TRENDING TERMS: * cancer * climate * artificial intelligence * postdoc * aging Log In Become A Member Quick Search anywhere Enter Search Term science.org * news * careers * commentary * Journals * science * science advances * science immunology * science robotics * science signaling * science translational medicine * science partner journals * Custom publishing * newsletters * collections * videos * podcasts * blogs * visualizations * prizes and awards * authors & reviewers * librarians * advertisers * about * help * * * * * * * Terms of Service * Privacy Policy * Accessibility * News * Careers * Commentary * Journals GET OUR E-ALERTS Science Translational Medicine27 March 2024 COMPARING VACCINES FOR MPOX VIRUS * Catherine Jacob-Dolan * Darren Ty * et al. MVA and multivalent Ad35-based vaccines induced robust protection against Mpox challenge in nonhuman primates, whereas ACAM200 induced near complete protection. Science Advances27 Mar 2024 HEART-ON-A-CHIP MODELS COVID INFLAMMATION By * Rick Xing Ze Lu * Naimeh Rafatian * et al. Science Robotics27 Mar 2024 HUMAN-ROBOT SOCIAL SYNCHRONY By * Rachael E. Jack Science Signaling26 Mar 2024 TAKING THE STING OUT OF LIPID BUILDUP By * Rui Wang * Hongyang Sun * et al. Science Immunology22 Mar 2024 NAIVE B CELLS INVADE AUTOREACTIVE GERMINAL CENTERS By * Theo van den Broek * Kristine Oleinika * et al. Careers 21 Mar 2024 I felt alone as a Black Ph.D. student. A simple gift reminded me of my community By * Alexis N. Peña LATEST NEWS 27 Mar 2024 ‘I need your urine!’ Unusual experiment tests whether human pee can help save forests 27 Mar 2024 Black hole at center of Milky Way may be blasting out a jet 26 Mar. 2024 Bird flu discovered in U.S. dairy cows is ‘disturbing’ 26 Mar 2024 Startups aim to curb climate change by pulling carbon dioxide from the ocean—not the air 26 Mar 2024 Scientists with East Asian and African names get short shrift in news coverage 26 Mar 2024 Genetically engineered marmosets promise insight into early stages of Parkinson’s Such speculative views of [artificial general intelligence] … differ from views held by people who study biological intelligence, especially human cognition. * Expert Voices * 22 Mar 2024 * Melanie Mitchell ADVERTISEMENT ADVERTISEMENT FIRST RELEASE Science Immunology26 Mar 2024 THE PALMITOYLATION OF GASDERMIN D DIRECTS ITS MEMBRANE TRANSLOCATION AND PORE FORMATION DURING PYROPTOSIS Science14 Mar 2024 SISTER CHROMATID COHESION ESTABLISHMENT DURING DNA REPLICATION TERMINATION Science14 Mar 2024 ANTIBACTERIAL ACTIVITY OF NONANTIBIOTICS IS ORTHOGONAL TO STANDARD ANTIBIOTICS Science7 Mar 2024 MECHANISM FOR FEATURE LEARNING IN NEURAL NETWORKS AND BACKPROPAGATION-FREE MACHINE LEARNING MODELS Science7 Mar 2024 GENERALIZED BIOMOLECULAR MODELING AND DESIGN WITH ROSETTAFOLD ALL-ATOM Science29 Feb 2024 VOCAL LEARNING-ASSOCIATED CONVERGENT EVOLUTION IN MAMMALIAN PROTEINS AND REGULATORY ELEMENTS Science Immunology8 Feb 2024 ZEB2 DRIVES THE FORMATION OF CD11C + ATYPICAL B CELLS TO SUSTAIN GERMINAL CENTERS THAT CONTROL PERSISTENT INFECTION Science Immunology8 Feb 2024 AGE-ASSOCIATED CD4+ T CELLS WITH B CELL-PROMOTING FUNCTIONS ARE REGULATED BY ZEB2 IN AUTOIMMUNITY More First Release Papers Fewer First Release Papers SCIENCE * Volume 383 * Issue 6689 * March 2024 View Cover COVER Tropical Heliconius butterflies display a diversity of warning patterns that they also use during mate choice. Researchers have now linked behavioral preferences for the red colors of Heliconius melpomene (shown here) to a specific gene, which has been shared with other species with similar colors through hybridization. See pages 1290 and 1368. Photo: Carolin Bleese Research ArticleBy * Ashley E. Larsen * Frederik Noack * et al. SPILLOVER EFFECTS OF ORGANIC AGRICULTURE ON PESTICIDE USE ON NEARBY FIELDS Research ArticleBy * S. Ephraim Neumann * Junpyo Kwon * et al. THE PROPENSITY FOR COVALENT ORGANIC FRAMEWORKS TO TEMPLATE POLYMER ENTANGLEMENT Research ArticleBy * Kenan A. J. Bozhüyük * Leonard Präve * et al. EVOLUTION-INSPIRED ENGINEERING OF NONRIBOSOMAL PEPTIDE SYNTHETASES Research ArticleBy * Rawan Almallahi * James Wortman * et al. OVERCOMING LIMITATIONS IN PROPANE DEHYDROGENATION BY CODESIGNING CATALYST-MEMBRANE SYSTEMS View Table of Contents SCIENCE ADVANCES * Volume 10 * Issue 13 * March 2024 View Cover ONLINE COVER A flooded river after heavy rains. Estimating river flood risks under climate change is challenging due to the myriad of flood-generating variables. These flood drivers can include atmospheric processes, temperature changes, and ground conditions. The interaction of these drivers determines the timing, location, and severity of river floods. Jiang et al. used explainable machine learning techniques to quantify the compounding effects of flood drivers in catchments across the globe. Analyzing the variables that contribute to flooding can improve understanding of flood extremes and advance predictive capabilities for future flood risks. Credit: SimpleImages/Getty Research ArticleBy * Shun Hu * Liding Zhang * et al. SENSITIVE DETECTION OF MULTIPLE BLOOD BIOMARKERS VIA IMMUNOMAGNETIC EXOSOMAL PCR FOR THE DIAGNOSIS OF ALZHEIMER’S DISEASE Research ArticleBy * Syed Arif Abdul Rehman * Chiara Cazzaniga * et al. DISCOVERY AND CHARACTERIZATION OF NONCANONICAL E2-CONJUGATING ENZYMES Research ArticleBy * Seung-Chul Choi * Yuk Pheel Park * et al. LUPUS SUSCEPTIBILITY GENE PBX1 CONTROLS THE DEVELOPMENT, STABILITY, AND FUNCTION OF REGULATORY T CELLS VIA RTKN2 EXPRESSION Research ArticleBy * Collin B. Merrill * Iris Titos * et al. ITERATIVE ASSAY FOR TRANSPOSASE-ACCESSIBLE CHROMATIN BY SEQUENCING TO ISOLATE FUNCTIONALLY RELEVANT NEURONAL SUBTYPES View Table of Contents SCIENCE IMMUNOLOGY * Volume 9 * Issue 93 * March 2024 View Cover ONLINE COVER A Neuroimmune Circuit Drives Chronic UTI Pain. Recurrent urinary tract infections (rUTIs) can cause urinary frequency and chronic pelvic pain, even after the original bacterial infection has resolved. Hayes et al. detected the sprouting of nociceptive (pain-sensing) sensory neurons in bladder biopsies from rUTI patients. When they recapitulated this phenomenon in a murine rUTI model, they found that bladder nerve sprouting was triggered in mice by the release of nerve growth factor (NGF) from bladder-resident mast cells and recruited monocytes during the infection. Inhibition of chronic mast cell activation, however, could curb NGF release and nerve sprouting to limit pelvic pain. This month’s cover illustration depicts mast cells (purple) releasing NGF (blue vesicles) to promote the sprouting of nerves (yellow and orange). Credit: N. Burgess/Science Immunology Research ArticleBy * Yinshui Chang * Luisa Bach * et al. TGF-Β SPECIFIES TFH VERSUS TH17 CELL FATES IN MURINE CD4+ T CELLS THROUGH C-MAF Research ArticleBy * Elliot A. Philips * Jia Liu * et al. TRANSMEMBRANE DOMAIN–DRIVEN PD-1 DIMERS MEDIATE T CELL INHIBITION ReviewBy * Karen O. Dixon * Gonzalo Fernandez Lahore * et al. BEYOND T CELL EXHAUSTION: TIM-3 REGULATION OF MYELOID CELLS Research ArticleBy * Abani Kanta Naik * Danielle J. Dauphars * et al. RORΓT UP-REGULATES RAG GENE EXPRESSION IN DP THYMOCYTES TO EXPAND THE TCRA REPERTOIRE View Table of Contents SCIENCE ROBOTICS * Volume 9 * Issue 88 * March 2024 View Cover ONLINE COVER Snake-Like Robot—A Robot for Autonomous Navigation and Exploration of Icy Terrain. Vaquero et al. report on a snake-like robot, Exobiology Extant Life Surveyor (EELS), that was developed to autonomously explore icy moons such as Enceladus. EELS has a perception head containing sensors and cameras for detection of its surroundings, as well as screw-like segments that generate forward and backward motion horizontally on icy surfaces and vertically within ice vents. The robot was capable of autonomous motion planning and risk awareness. This month’s cover is an image of EELS being tested on Athabasca Glacier in Alberta, Canada. Credit: Courtesy of NASA/JPL-Caltech Research ArticleBy * T. S. Vaquero * G. Daddi * et al. EELS: AUTONOMOUS SNAKE-LIKE ROBOT WITH TASK AND MOTION PLANNING CAPABILITIES FOR ICE WORLD EXPLORATION Research ArticleBy * Yuhang Hu * Boyuan Chen * et al. HUMAN-ROBOT FACIAL COEXPRESSION Research ArticleBy * Chong Hong * Yingdan Wu * et al. WIRELESS FLOW-POWERED MINIATURE ROBOT CAPABLE OF TRAVERSING TUBULAR STRUCTURES Research ArticleBy * David Hoeller * Nikita Rudin * et al. ANYMAL PARKOUR: LEARNING AGILE NAVIGATION FOR QUADRUPEDAL ROBOTS View Table of Contents SCIENCE SIGNALING * Volume 17 * Issue 829 * March 2024 View Cover ONLINE COVER This week, Wang et al. show that glucocerebrosidase deficiency in mice causes lipid-dependent microglial activation and the loss of cortical neurons that can be prevented by inhibiting STING signaling. This may be one way in which Gaucher disease increases the risk for Parkinson’s disease—and one strategy for reducing that risk. The image is a colored scanning electron micrograph of a microglial cell. Image: Steve Gschmeissner/Science Source Research ArticleBy * Rui Wang * Hongyang Sun * et al. GLUCOSYLCERAMIDE ACCUMULATION IN MICROGLIA TRIGGERS STING-DEPENDENT NEUROINFLAMMATION AND NEURODEGENERATION IN MICE Editors' ChoiceBy * Leslie K. Ferrarelli BIASING MICROGLIA TO HELP, NOT HURT View Table of Contents SCIENCE TRANSLATIONAL MEDICINE * Volume 16 * Issue 740 * March 2024 View Cover ONLINE COVER A Head-to-Head Vaccine Comparison. The cover image shows an electron micrograph of Mpox virus. The global outbreak of Mpox in 2022–2023 highlighted the need for effective and safe vaccines against poxviruses. To add to the vaccine toolbox for these viruses, Jacob-Dolan et al. tested two adenovirus 35-based subunit vaccines in nonhuman primates, benchmarking against the approved ACAM2000 and JYNNEOS vaccines. The authors found that all four vaccines protected against intravenous challenge with a contemporary Mpox strain and that elicitation of humoral immunity was associated with this protection. These data not only demonstrate the efficacy of the ACAM2000 and JYNNEOS vaccines but also suggest that subunit vaccines, like the two tested here, merit further development and clinical evaluation. Credit: National Institutes of Health/Science Source Research ArticleBy * Minrui Liang * Nicholas Dickel * et al. ATTENUATION OF FIBROBLAST ACTIVATION AND FIBROSIS BY ADROPIN IN SYSTEMIC SCLEROSIS Research ArticleBy * Catharina C. Gross * Andreas Schulte-Mecklenbeck * et al. MULTIPLE SCLEROSIS ENDOPHENOTYPES IDENTIFIED BY HIGH-DIMENSIONAL BLOOD SIGNATURES ARE ASSOCIATED WITH DISTINCT DISEASE TRAJECTORIES Research ArticleBy * Catherine Jacob-Dolan * Darren Ty * et al. COMPARISON OF THE IMMUNOGENICITY AND PROTECTIVE EFFICACY OF ACAM2000, MVA, AND VECTORED SUBUNIT VACCINES FOR MPOX IN RHESUS MACAQUES Research ArticleBy * Patrick J. Gleeson * Nicolas Benech * et al. THE GUT MICROBIOTA POSTTRANSLATIONALLY MODIFIES IGA1 IN AUTOIMMUNE GLOMERULONEPHRITIS View Table of Contents Skip slideshow CUSTOM PUBLISHING SPONSORED webinar It's personal: Organoids leading the charge in precision medicine By * Jackie Oberst, Ph.D. * , et al. SPONSORED Sponsored Feature Organoids: Today’s research tool, tomorrow’s organ transplant solution SPONSORED webinar Transforming team science: How is Cancer Grand Challenges addressing cancer’s toughest problems? By * Erika Gebel Berg, Ph.D. * , et al. SPONSORED Sponsored Feature Celebrating the immigrant scientist: Meet the 2024 Vilcek Foundation Prize winners SPONSORED webinar Compressing the next 250 years of chemistry research into the next 25 By * Erika Gebel Berg, Ph.D. * , et al. View More ADVERTISEMENT CAREERS 26 Mar 2024By * Katie Langin Scientists with East Asian and African names get short shrift in news coverage 25 Mar 2024By * Katie Langin Fewer U.S. scientists are pursuing postdoc positions, new data show 21 Mar 2024By * Alexis N. Peña I felt alone as a Black Ph.D. student. A simple gift reminded me of my community 14 Mar 2024By * Rodrigo Pérez Ortega Men psychology researchers can’t seem to remember their women colleagues 14 Mar 2024By * Jeffrey McDonnell How I lost and found my scientific creativity 13 Mar 2024By * Robin Donovan Signs of change for ASL in STEM View More NEWS FEATURES 21 Mar 2024By * Meredith Wadman Can new drugs stop a deadly set of brain-eating diseases? One treatment that would knock out prion proteins before they go bad is facing its first big test 14 Mar 2024By * Sara Reardon Are your earliest childhood memories still lurking in your mind—or gone forever? Studies of “infantile amnesia” find that memory works differently in the developing brain 7 Mar 2024By * Cathleen O’Grady ‘Failure at every level’: How science sleuths exposed massive ethics violations at a famed French institute A group of agitators has spent years pushing for action against Didier Raoult and his collaborators. Now they’re wondering whether anyone will be fully held to account 29 Feb 2024By * Dan Charles ‘A tough experience.’ Why would a scientist serve as an expert witness? Sharing their expertise in court carries risks and rewards, researchers say 22 Feb 2024By * Leslie Roberts A deadly viral illness is exploding in West Africa. Researchers are scrambling to figure out why Lassa fever, a rodent-borne disease long neglected by research, is killing thousands every year View More COMMENTARY Science Advances27 Mar 2024By * Eliot B. Blatt * Ralph J. DeBerardinis GLUTAMINE ANTAGONISTS MAY KEAP LUNG CANCER IN CHECK Science Robotics27 Mar 2024By * Rachael E. 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