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Select  Phenotype Database BXDPhenotypeDB BXHPhenotypeDB CXBPhenotypeDB
AXB/BXAPhenotypeDB FemaleAgingColonyDB More...     

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    Neurogenetics Online   Complex Trait
Consortium   Genenetwork   Mouse Brain Library   iScope Project
  Neurocartographer   CITG Memphis   IBANGS   Contact Us



 

 Welcome   to Neurogenetics Online




Welcome to Nervenet.org and The Informatics Center for Mouse Neurogenetics. This
server hosts the Mouse Brain Library, an expanding collection of high-resolution
histological images, atlases, MRIs, and databases on brain structure of more
than 120 different lines of mice. Nervenet also includes several useful genetics
and gene mapping databases to download (SNP databases, Map Manager databases,
and the Portable Dictionary of the Mouse Genome). The publications section
includes revised, expanded, and annotated papers, tutorials, and reviews on
neurogenetics, gene mapping, complex trait analysis, stereology, and the control
of neuron number.

To submit to the database of your choice use the links listed in the scroll-down
menu at the top or use the [Database Main Page.]





  Annotated List of Papers Reviews Grants and Abstracts [ HTML & PDF Format ]



 

Elissa Chesler Reviewer Response [Mapping comparision plot, heritability
expression and compare colocalization] New March, 2005 GenomeMixer: a complex
genetic cross simulator [pdf] November, 2004 Seeing the Unseen: Microarray-Based
Gene Expression Profiling in Vision October, 2004 A new set of BXD recombinant
inbred lines from advanced intercross populations in mice [pdf] April, 2004
Genetic Correlates of Gene Expression in Recombinant Inbred Strains: A
Relational Model System to Explore Neurobehavioral Phenotypes December, 2003
Image Registration Using Threefold Orthogonal Wavelet December, 2003 A Guide to
Building Image-Centric Databases December, 2003 Subicular Dendritic Arborization
in Alzheimer�s Disease Correlates with Neurofibrillary Tangle Density December,
2003 Elastic 3-D Alignment of Rat Brain Histological Images December, 2003
Design and Implementation of Software for Assembly and Browsing of 3D Brain
Atlases December, 2003 Informatics Center for Mouse Genomics The Dissection of
Complex Traits of the Nervous System December, 2003 Developmental and Genetic
Control of Cell Number in Retina Aug 29, 2003 Providing access to slide and
tissue banks March 2003 Everyday bioinformatics for neuroscientists:
From maps to microarrays Nov 02, 2002 Bioinformatics 2002: A Neuroscientist's
Guide to Tools and Techniques for Mining and Refining Massive Data Sets 2002
Surface Alignment of an Elastic Body Using a Multi-Resolution Wavelet
Representation December, 2003

    More...


Brief Contents Overview

Short Course Tutorial in Quantitative Neurogenetics

Efficient methods to quantify cells in thick or thin sections, particularly
direct three-dimensional counting and several adaptations of the disector make
it easier to obtain unbiased estimate of neuroanatomical traits. As a practical
matter, the most important advance in quantitative techniques has been the rapid
hybridization of microscopes, video systems, fast microcomputers, and powerful
application programs such as NIH Image. [More]

Developmental and Genetic Control of Cell Number in Retina This review is
divided into sections that consider developmental, genetic, and functional
factors that modulate types and numbers of cells in the vertebrate retina from
these two complementary viewpoints.. [View Paper] Providing access to slide and
tissue banks This paper describes highly effective bioinformatic and software
solutions developed over the past three years in the laboratories of the
Informatics Center for Neurogenetics. [More..]

A Collaborative Cross for High-Precision Complex Trait Analysis. CTC Workgroup
Report

This Report explains our reasoning and provides an outline of the methods and
costs associated with making the Collaborative Cross. [Read Review]




  The iScope Project


iScope What can I do with the iScope system?

Internet microscopy from the University of Tennessee in Memphis

Control a research-grade light microscope: By downloading our free control
software (available for Windows, Linux and Mac OS X support), you can control
one of our microscopes in real time from your desktop computer and explore a
wealth of mouse brain tissue.. [Help]



  The WebQTL Project


The WebQTL Project What is WebQTL?

The WebQTL Project

WebQTL is an unique World Wide Web service that makes it possible for
neurogeneticists to rapidly identify and map genes and quantitative trait loci
(QTL), particularly those related to brain structure and behavior. WebQTL allows
rapid QTL mapping of CNS traits for major recombinant inbred (RI) sets, for
shared intercrosses and backcrosses, and particularly for a very large advanced
intercross population (the G10). (Please see http://www.webqtl.org for further
information)




  The Complex Trait Consortium


CTC Review CTC Publications and Presentations

www.complextrait.org

Quantitative genetics and QTL mapping have undergone a revolution in the last
decade. Progress in the next decade promises to be even more rapid, and
prospects for exploring the complex interplay between gene variants, disease,
and the environment will be radically improved. [CTC Publications]





  Neuroinformatics The Human Brain Project

Funding - The MBL and iScope projects are supported as part of the Informatics
Center for Mouse Neurogenetics, a Human Brain Project/Neuroinformatics program
funded jointly by the National Institute of Mental Health, National Institute on
Drug Abuse, and the National Science Foundation (P20-MH 62009). More



 
News & Updates
 


 
Genetic Regulatory Networks of the Developing Cerebellum

GenomeMixer 0.54c is a cross-platform application that allows you to simulate
complex multi-generational breeding schemes.

Watch Gumbo 2.3 Movie Tutorial

Gumbo v2.7 and Aria 3-D v1.5 is also available

Watch WebQTL Demo



 



 
MBL
 


 
The MBL Process This manual explains the process of embedding brain tissue in
12% celloidin, cutting the tissue with a microtome, staining and coverslipping
the brain sections, the images of which are then posted on the internet for
research purposes.

Browse the library

Brain Atlases 8/2/02 Horizontal A/J Atlas. This is a high resolution
(2.6µ/pixel) atlas in 8-bit color.



 



 
Databases
 


 
Databases and tables of mouse brain data.
Phenome Databases
Genomic Databases  



 
Downloads
 


 
Genome Mixer 0.54c
Microarray data submissions to ArrayExpress.    
Gumbo v2.7
Control a research-grade light microscope.    
Aria 3D v1.5
(Automated Remote Image Analysis) for viewing focus-through movies and
stereology.



 


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