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ACIP Update

In June 2023, the Advisory Committee on Immunization Practices (ACIP) voted on
pneumococcal recommendations that are now official and have been adopted by the
CDC. They have been published in MMWR. See how Prevnar 20® is the only PCV
option you need for the treatment of IPD in babies and children.1* Click here
for more details.

*Children who have received Prevnar 20® and who have certain underlying medical
conditions do not require a dose of PPSV23.1
Discover Expanded Serotype Coverage
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Built on the legacy of Prevnar® (PCV7) and Prevnar 13® See HowLoading
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To stock Prevnar 20®, call 1-800-666-7248 or click below to order on Pfizer
Prime.

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CDC=Centers for Disease Control and Prevention; IPD=invasive pneumococcal
disease; MMWR=Morbidity and Mortality Weekly Report; PCV=pneumococcal conjugate
vaccine; PPSV23=23-valent pneumococcal polysaccharide
vaccine.References:Advisory Committee on Immunization Practices (ACIP). ACIP
recommendations. Meeting recommendations: June 2023—pneumococcal vaccines.
Centers for Disease Control and Prevention. Last reviewed August 4, 2023.
Accessed August 18, 2023.
https://www.cdc.gov/vaccines/acip/recommendations.html.Prevnar 20® (Pneumococcal
20-valent Conjugate Vaccine) Prescribing Information, Wyeth Pharmaceuticals LLC,
2023.Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197
Protein]) Prescribing Information, Wyeth Pharmaceuticals LLC, 2019.Vaxneuvance™
(Pneumococcal 15-valent Conjugate Vaccine) Prescribing Information, Merck Sharp
& Dohme Corp., 2023. Gierke R. Current epidemiology of pneumococcal disease and
pneumococcal vaccine coverage among children, United States. Centers for Disease
Control and Prevention. February 24, 2022. Accessed August 18, 2023.
https://stacks.cdc.gov/view/cdc/114840.
Manufactured by Wyeth Pharmaceuticals Inc.
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INDICATIONS 
 * Prevnar 20® is a vaccine indicated for active immunization for the prevention
   of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5,
   6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F
   in individuals 6 weeks of age and older
 * Both Prevnar 20® and Prevnar 13® are vaccines indicated for active
   immunization for the prevention of otitis media caused by S. pneumoniae
   serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5
   years of age
 * Prevnar 13® is a vaccine indicated for active immunization for the prevention
   of invasive disease caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F,
   9V, 14, 18C, 19A, 19F, and 23F in individuals 6 weeks through 17 years of age

Prevnar 13® Limitations of Use: Prevnar 13® will only help protect against S.
pneumoniae serotypes in the vaccine.
Important Safety Information
 * Do not administer Prevnar 20® or Prevnar 13® to individuals with a severe
   allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or
   Prevnar 13® or to diphtheria toxoid
 * Safety and immunogenicity data on Prevnar 20® are not available for
   individuals in immunocompromised groups, and vaccination should be considered
   on an individual basis. Based on experience with pneumococcal vaccines,
   individuals with altered immunocompetence may have reduced immune responses
   to Prevnar 20®
 * Immunocompromised individuals or individuals with impaired immune
   responsiveness due to the use of immunosuppressive therapy may have reduced
   antibody response to Prevnar 13®
 * Apnea following intramuscular vaccination has been observed in some infants
   born prematurely. Vaccination of premature infants should be based on the
   infant’s medical status and the potential benefits and risks
 * For Prevnar 20®, in individuals 2, 4, 6, and 12 through 15 months of age
   vaccinated with a 4-dose schedule, the most commonly reported solicited
   adverse reactions (>10%) were irritability, pain at the injection site,
   drowsiness, decreased appetite, injection site redness, injection site
   swelling, and fever
 * For Prevnar 20®, in individuals 15 months through 17 years of age vaccinated
   with a single dose, the most commonly reported solicited adverse reactions
   (>10%) were irritability, pain at the injection site, drowsiness, fatigue and
   muscle pain, decreased appetite, injection site swelling, injection site
   redness, headache, and fever
 * For Prevnar 13®, in individuals 6 weeks through 17 years of age, the most
   commonly reported serious adverse events were bronchiolitis (0.9%),
   gastroenteritis (0.9%), and pneumonia (0.9%)
 * For Prevnar 13®, in individuals 6 weeks through 17 years of age, the most
   common side effects were irritability, decreased appetite, decreased or
   increased sleep, fever, and injection site tenderness, redness, or swelling
 * In individuals 6 years through 17 years of age, Prevnar 13® is administered
   as a single dose

Patients should always ask their healthcare providers for medical advice about
adverse events. You are encouraged to report negative side effects of vaccines
to the US Food and Drug Administration (FDA) and the Centers for Disease Control
and Prevention (CDC). Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20® full Prescribing Information.

Please click for Prevnar 13® full Prescribing Information.Indications
 * Prevnar 20® is a vaccine indicated for active immunization for the prevention
   of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5,
   6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F
   in individuals 6 weeks of age and older
 * Both Prevnar 20® and Prevnar 13® are vaccines indicated for active
   immunization for the prevention of otitis media caused by S. pneumoniae
   serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5
   years of age
 * Prevnar 13® is a vaccine indicated for active immunization for the prevention
   of invasive disease caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F,
   9V, 14, 18C, 19A, 19F, and 23F in individuals 6 weeks through 17 years of age

Prevnar 13® Limitations of Use: Prevnar 13® will only help protect against S.
pneumoniae serotypes in the vaccine.


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