www.rxlist.com Open in urlscan Pro
104.18.32.6  Public Scan

Form analysis
0 forms found in the DOM

Text Content

 * Drugs & Vitamins
   
   * Drugs A-Z
   * Generic Drugs A-Z
   * Drugs by Classification
   * Drugs Comparison (Drug Vs. Drug)
   * Vitamins & Supplements
   * Drug Interaction Checker
   * Pill Identifier
 * Tools & Resources
   
   * Medical Dictionary
   * Slideshows
   * Images
   * Quizzes
     
 * Privacy & Other Trust Info
   
   * Privacy Policy
   * About Us
   * Contact Us
   * Terms of Use
   * Advertising Policy


Search




PROPINE

 * Generic Name: dipivefrin
 * Brand Name: Propine
 * Drug Class: Antiglaucoma, Miotics

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 7/26/2022

home drugs a-z list propine (dipivefrin) drug


DRUG SUMMARY

WHAT IS PROPINE?

Propine (dipivefrin HCI ophthalmic solution) works by regulating the flow of
fluid within the eye to maintain a normal pressure and is used to treat
open-angle glaucoma or ocular hypertension (high pressure inside the eye).
Propine is available in generic form.

WHAT ARE SIDE EFFECTS OF PROPINE?

Common side effects of Propine include:


 * burning/stinging/irritation/itching of the eyes
 * redness of the eye or eyelid
 * eye pain
 * blurred vision
 * headache, and
 * increased sensitivity to light

WHAT ARE THE POSSIBLE SIDE EFFECTS OF PROPINE?

Propine may cause serious side effects including:

 * hives,
 * difficulty breathing,
 * swelling of your face, lips, tongue, or throat,
 * rash, and
 * severe dizziness

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side
effects:

 * Serious eye symptoms such as sudden vision loss, blurred vision, tunnel
   vision, eye pain or swelling, or seeing halos around lights;
 * Serious heart symptoms such as fast, irregular, or pounding heartbeats;
   fluttering in your chest; shortness of breath; and sudden dizziness,
   lightheartedness, or passing out;
 * Severe headache, confusion, slurred speech, arm or leg weakness, trouble
   walking, loss of coordination, feeling unsteady, very stiff muscles, high
   fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur.
Check with your physician for additional information about side effects.

DOSAGE FOR PROPINE

The usual dosage of Propine is one drop in the eye(s) every 12 hours.

WHAT DRUGS, SUBSTANCES, OR SUPPLEMENTS INTERACT WITH PROPINE?

Other drugs may interact with Propine ophthalmic. Avoid using any eye
medications your doctor has not prescribed. Tell your doctor all medications and
supplements you use.

PROPINE DURING PREGNANCY OR BREASTFEEDING

Propine should be used only when prescribed during pregnancy. It is unknown if
this drug passes into breast milk. Consult your doctor before breastfeeding.

ADDITIONAL INFORMATION

Our Propine (dipivefrin HCI ophthalmic solution) Side Effects Drug Center
provides a comprehensive view of available drug information on the potential
side effects when taking this medication.


FDA DRUG INFORMATION

 * Drug Description
 * Indications
 * Dosage
 * Side Effects & Drug Interactions
 * Warnings & Precautions
 * Overdose & Contraindications
 * Clinical Pharmacology
 * Medication Guide


DESCRIPTION FOR PROPINE

PROPINE® contains dipivefrin hydrochloride in a sterile, isotonic solution.
Dipivefrin HCI is a white, crystalline powder, freely soluble in water.

Empirical Formula:

C19-H29O5N•HCI







Chemical Name: (±) -3,4-Dihydroxy-α-[(methyl-amino) methyl] benzyl-alcohol
3,4-dipivalate hydrochloride.

Contains: Active: dipivefrin HCI 0.1%

Preservative: benzalkonium chloride; Inactives: edetate disodium; sodium
chloride; hydrochloric acid to adjust pH; and purified water.




USES FOR PROPINE

PROPINE® (dipivefrin HCI ophthalmic solution, USP) is indicated as initial
therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Patients responding inadequately to other antiglaucoma therapy may respond to
addition of PROPINE® (dipivefrin) .

In controlled and open-label studies of glaucoma, PROPINE® (dipivefrin)
ophthalmic solution demonstrated a statistically significant intraocular
pressure-lowering effect. Patients using PROPINE® (dipivefrin) twice daily in
studies with mean durations of 76-146 days experienced mean pressure reductions
ranging from 20-24%.

Therapeutic response to PROPINE® (dipivefrin) ophthalmic solution twice daily is
somewhat less than 2% epinephrine twice daily. Controlled studies showed
statistically significant differences in lowering of intraocular pressure
between PROPINE® (dipivefrin) and 2% epinephrine. In controlled studies in
patients with a history of epinephrine intolerance, only 3% of patients treated
with PROPINE® (dipivefrin) ophthalmic solution exhibited intolerance, while 55%
of those treated with epinephrine again developed intolerance.

Therapeutic response to PROPINE® (dipivefrin) twice daily therapy is comparable
to 2% pilocarpine 4 times daily. In controlled clinical studies comparing
PROPINE® (dipivefrin) ophthalmic solution and 2% pilocarpine, there were no
statistically significant differences in the maintenance of IOP levels for the
two medications. PROPINE® (dipivefrin) does not produce miosis or accommodative
spasm which cholinergic agents are known to produce. Night blindness often
associated with miotic agents is not present with PROPINE® (dipivefrin) therapy.
Patients with cataracts avoid the inability to see around lenticular opacities
caused by constricted pupil.


DOSAGE FOR PROPINE

INITIAL GLAUCOMA THERAPY

The usual dosage of PROPINE® (dipivefrin) is one drop in the eye(s) every 12
hours.

REPLACEMENT WITH PROPINE® (DIPIVEFRIN) OPHTHALMIC SOLUTION

When patients are being transferred to PROPINE® (dipivefrin) from antiglaucoma
agents other than epinephrine, on the first day continue the previous medication
and add one drop of PROPINE® (dipivefrin) ophthalmic solution in each eye every
12 hours. On the following day, discontinue the previously used antiglaucoma
agent and continue with PROPINE® (dipivefrin) .

In transferring patients from conventional epinephrine therapy to PROPINE®
(dipivefrin) ophthalmic solution, simply discontinue the epinephrine medication
and institute the PROPINE® (dipivefrin) regimen.

ADDITION OF PROPINE® (DIPIVEFRIN) OPHTHALMIC SOLUTION

When patients on other antiglaucoma agents require additional therapy, add one
drop of PROPINE® (dipivefrin) every 12 hours.

CONCOMITANT THERAPY

For difficult to control patients, the addition of PROPINE® (dipivefrin)
ophthalmic solution to other agents such as pilocarpine, carbachol,
echothiophate iodide or acetazolamide has been shown to be effective.

Note: Not for injection.


HOW SUPPLIED

PROPINE® (dipivefrin HCI ophthalmic solution, USP) 0.1%, is supplied sterile in
plastic dropper bottles as follows: 5 mL - 0023-9208-05; 10 mL - 0023-9208-10;
15 mL - 0023-9208-15.

Note: Store in tight, light-resistant containers.

Allergan, Inc. Irvine, CA 92612, U.S.A. Revised December 2000. FDA Rev date:
4/12/2002




SIDE EFFECTS FOR PROPINE

CARDIOVASCULAR EFFECTS

Tachycardia, arrhythmias and hypertension have been reported with ocular
administration of epinephrine.

LOCAL EFFECTS

The most frequent side effects reported with PROPINE® (dipivefrin) alone were
injection in 6.5% of patients and burning and stinging in 6%. Follicular
conjunctivitis, eye pain, mydriasis, blurry vision, eye pruritus, headache and
allergic reaction to PROPINE® (dipivefrin) ophthalmic solution have been
reported. Epinephrine therapy can lead to adrenochrome deposits in the
conjunctiva and cornea.


DRUG INTERACTIONS FOR PROPINE

No information provided.


WARNINGS FOR PROPINE

No information provided.


PRECAUTIONS FOR PROPINE

APHAKIC PATIENTS

Macular edema has been shown to occur in up to 30% of aphakic patients treated
with epinephrine. Discontinuation of epinephrine generally results in reversal
of the maculopathy.

PREGNANCY

PREGNANCY CATEGORY B

Reproduction studies have been performed in rats and rabbits at daily oral doses
up to 10 mg/kg body weight (5 mg/kg in teratogenicity studies), and have
revealed no evidence of impaired fertility or harm to the fetus due to
dipivefrin HCI. There are, however, no adequate and well-controlled studies in
pregnant women. Because animal reproduction studies are not always predictive of
human response, this drug should be used during pregnancy only if clearly
needed.

NURSING MOTHERS

It is not known whether this drug is excreted in human milk. Because many drugs
are excreted in human milk, caution should be exercised when PROPINE®
(dipivefrin) ophthalmic solution is administered to a nursing woman.

PEDIATRIC USE

Safety and effectiveness in pediatric patients have not been established.

ANIMAL STUDIES

Rabbit studies indicated a dose-related incidence of meibomian gland retention
cysts following topical administration of both dipivefrin hydrochloride and
epinephrine.


OVERDOSE INFORMATION FOR PROPINE

No information provided.


CONTRAINDICATIONS FOR PROPINE

PROPINE® (dipivefrin) should not be used in patients with narrow angles since
any dilation of the pupil may predispose the patient to an attack of
angle-closure glaucoma. This product is contraindicated in patients who are
hypersensitive to any of its components.


CLINICAL PHARMACOLOGY FOR PROPINE

PROPINE® (dipivefrin HCI ophthalmic solution, USP) is a member of a class of
drugs known as prodrugs. Prodrugs are usually not active in themselves and
require biotransformation to the parent compound before therapeutic activity is
seen. These modifications are undertaken to enhance absorption, decrease side
effects and enhance stability and comfort, thus making the parent compound a
more useful drug. Enhanced absorption makes the prodrug a more efficient
delivery system for the parent drug because less drug will be needed to produce
the desired therapeutic response.

PROPINE® (dipivefrin) ophthalmic solution is a prodrug of epinephrine formed by
the diesterification of epinephrine and pivalic acid. The addition of pivaloyl
groups to the epinephrine molecule enhances its lipophilic character and as a
consequence, its penetration into the anterior chamber.

PROPINE® (dipivefrin) is converted to epinephrine inside the human eye by enzyme
hydrolysis. The liberated epinephrine, an adrenergic agonist, appears to exert
its action by decreasing aqueous production and by enhancing outflow facility.
The PROPINE® (dipivefrin) prodrug delivery system is a more efficient way of
delivering the therapeutic effects of epinephrine, with fewer side effects than
are associated with conventional epinephrine therapy.

The onset of action with one drop of PROPINE® (dipivefrin) occurs about 30
minutes after treatment, with maximum effect seen at about one hour.

Using a prodrug means that less drug is needed for therapeutic effect since
absorption is enhanced with the prodrug. PROPINE® ophthalmic solution at 0.1%
dipivefrin was judged less irritating than a 1% solution of epinephrine
hydrochloride or bitartrate. In addition, only 8 of 455 patients (1.8%) treated
with PROPINE® (dipivefrin) reported discomfort due to photophobia, glare or
light sensitivity.


PATIENT INFORMATION FOR PROPINE

No information provided. Please refer to the PRECAUTIONS section.


FROM

EYE HEALTH RESOURCES

 * Supplements for Vision and Healthy Eyes
 * 12 Devices That Can Help Your Low Vision
 * Wet AMD Treatments

FEATURED CENTERS

 * What Are the Best PsA Treatments for You?
 * Understanding Biologics
 * 10 Things People With Depression Wish You Knew


REPORT PROBLEMS TO THE FOOD AND DRUG ADMINISTRATION

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit the website or call 1-800-FDA-1088.FDA MedWatch
Close modal
You are about to visit a website outside of medicinenet. Please familiarize
yourself with this other website's Privacy Policy as it differs from ours.
continue

Pill Identifier Tool Quick, Easy, Pill Identification

Drug Interaction Tool Check Potential Drug Interactions

Pharmacy Locator Tool Including 24 Hour, Pharmacies


 * 
 * 

DRUG CATEGORIES

 * Drugs & Medications
 * Pill Identification Tool
 * Vitamins, Herbs, & Dietary Supplements
 * Dictionary

RXLIST

 * About Us
 * Consumer Contact RxList
 * Terms of Use
 * Privacy Policy
 * Sponsor Policy

Your Privacy Choices

Copyright © 2024 by RxList Inc. An Internet Brands company. RxList does not
provide medical advice, diagnosis or treatment. See additional information.





YOUR CHOICE ON COOKIES

We and our 57 partners store and/or access information on a device, such as
unique IDs in cookies to process personal data. You may accept or manage your
choices by clicking below, including your right to object where legitimate
interest is used, or at any time in the privacy policy page. These choices will
be signaled to our partners and will not affect browsing data.


WE AND OUR PARTNERS PROCESS DATA TO PROVIDE:

Use precise geolocation data. Actively scan device characteristics for
identification. Store and/or access information on a device. Personalised
advertising and content, advertising and content measurement, audience research
and services development. See our List of Partners

Accept Essential Accept All
Customize Choices




ABOUT YOUR PRIVACY

We process your data to deliver content or advertisements and measure the
delivery of such content or advertisements to extract insights about our
website. We share this information with our partners on the basis of consent and
legitimate interest. You may exercise your right to consent or object to a
legitimate interest, based on a specific purpose below or at a partner level in
the link under each purpose. These choices will be signaled to our vendors
participating in the Transparency and Consent Framework.
Allow All


MANAGE CONSENT PREFERENCES

STRICTLY NECESSARY COOKIES

Always Active

These cookies are necessary for the website to function and cannot be switched
off in our systems. They are usually only set in response to actions made by you
which amount to a request for services, such as setting your privacy
preferences, logging in or filling in forms. You can set your browser to block
or alert you about these cookies, but some parts of the site will not then work.
These cookies do not store any personally identifiable information.

TARGETING COOKIES

Targeting Cookies

These cookies may be set through our site by our advertising partners. They may
be used by those companies to build a profile of your interests and show you
relevant adverts on other sites. They do not store directly personal
information, but are based on uniquely identifying your browser and internet
device. If you do not allow these cookies, you will experience less targeted
advertising.

PERFORMANCE COOKIES

Performance Cookies

These cookies allow us to count visits and traffic sources so we can measure and
improve the performance of our site. They help us to know which pages are the
most and least popular and see how visitors move around the site. All
information these cookies collect is aggregated and therefore anonymous. If you
do not allow these cookies we will not know when you have visited our site, and
will not be able to monitor its performance.

FUNCTIONAL COOKIES

Functional Cookies

These cookies enable the website to provide enhanced functionality and
personalisation. They may be set by us or by third party providers whose
services we have added to our pages. If you do not allow these cookies then some
or all of these services may not function properly.

STORE AND/OR ACCESS INFORMATION ON A DEVICE 51 PARTNERS CAN USE THIS PURPOSE

Store and/or access information on a device

Cookies, device or similar online identifiers (e.g. login-based identifiers,
randomly assigned identifiers, network based identifiers) together with other
information (e.g. browser type and information, language, screen size, supported
technologies etc.) can be stored or read on your device to recognise it each
time it connects to an app or to a website, for one or several of the purposes
presented here.

List of IAB Vendors‎ | View Illustrations 

PERSONALISED ADVERTISING AND CONTENT, ADVERTISING AND CONTENT MEASUREMENT,
AUDIENCE RESEARCH AND SERVICES DEVELOPMENT 56 PARTNERS CAN USE THIS PURPOSE

Personalised advertising and content, advertising and content measurement,
audience research and services development

 * USE LIMITED DATA TO SELECT ADVERTISING 46 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Advertising presented to you on this service can be based on limited data,
   such as the website or app you are using, your non-precise location, your
   device type or which content you are (or have been) interacting with (for
   example, to limit the number of times an ad is presented to you).
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

 * CREATE PROFILES FOR PERSONALISED ADVERTISING 39 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Information about your activity on this service (such as forms you submit,
   content you look at) can be stored and combined with other information about
   you (for example, information from your previous activity on this service and
   other websites or apps) or similar users. This is then used to build or
   improve a profile about you (that might include possible interests and
   personal aspects). Your profile can be used (also later) to present
   advertising that appears more relevant based on your possible interests by
   this and other entities.
   
   View Illustrations 

 * USE PROFILES TO SELECT PERSONALISED ADVERTISING 39 PARTNERS CAN USE THIS
   PURPOSE
   
   Switch Label
   
   Advertising presented to you on this service can be based on your advertising
   profiles, which can reflect your activity on this service or other websites
   or apps (like the forms you submit, content you look at), possible interests
   and personal aspects.
   
   View Illustrations 

 * CREATE PROFILES TO PERSONALISE CONTENT 13 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Information about your activity on this service (for instance, forms you
   submit, non-advertising content you look at) can be stored and combined with
   other information about you (such as your previous activity on this service
   or other websites or apps) or similar users. This is then used to build or
   improve a profile about you (which might for example include possible
   interests and personal aspects). Your profile can be used (also later) to
   present content that appears more relevant based on your possible interests,
   such as by adapting the order in which content is shown to you, so that it is
   even easier for you to find content that matches your interests.
   
   View Illustrations 

 * USE PROFILES TO SELECT PERSONALISED CONTENT 11 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Content presented to you on this service can be based on your content
   personalisation profiles, which can reflect your activity on this or other
   services (for instance, the forms you submit, content you look at), possible
   interests and personal aspects. This can for example be used to adapt the
   order in which content is shown to you, so that it is even easier for you to
   find (non-advertising) content that matches your interests.
   
   View Illustrations 

 * MEASURE ADVERTISING PERFORMANCE 52 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Information regarding which advertising is presented to you and how you
   interact with it can be used to determine how well an advert has worked for
   you or other users and whether the goals of the advertising were reached. For
   instance, whether you saw an ad, whether you clicked on it, whether it led
   you to buy a product or visit a website, etc. This is very helpful to
   understand the relevance of advertising campaigns.
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

 * MEASURE CONTENT PERFORMANCE 16 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Information regarding which content is presented to you and how you interact
   with it can be used to determine whether the (non-advertising) content e.g.
   reached its intended audience and matched your interests. For instance,
   whether you read an article, watch a video, listen to a podcast or look at a
   product description, how long you spent on this service and the web pages you
   visit etc. This is very helpful to understand the relevance of
   (non-advertising) content that is shown to you.
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

 * UNDERSTAND AUDIENCES THROUGH STATISTICS OR COMBINATIONS OF DATA FROM
   DIFFERENT SOURCES 33 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Reports can be generated based on the combination of data sets (like user
   profiles, statistics, market research, analytics data) regarding your
   interactions and those of other users with advertising or (non-advertising)
   content to identify common characteristics (for instance, to determine which
   target audiences are more receptive to an ad campaign or to certain
   contents).
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

 * DEVELOP AND IMPROVE SERVICES 48 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Information about your activity on this service, such as your interaction
   with ads or content, can be very helpful to improve products and services and
   to build new products and services based on user interactions, the type of
   audience, etc. This specific purpose does not include the development or
   improvement of user profiles and identifiers.
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

 * USE LIMITED DATA TO SELECT CONTENT 6 PARTNERS CAN USE THIS PURPOSE
   
   Switch Label
   
   Content presented to you on this service can be based on limited data, such
   as the website or app you are using, your non-precise location, your device
   type, or which content you are (or have been) interacting with (for example,
   to limit the number of times a video or an article is presented to you).
   
   View Illustrations 
   Object to Legitimate Interests Remove Objection

List of IAB Vendors‎

USE PRECISE GEOLOCATION DATA 15 PARTNERS CAN USE THIS PURPOSE

Use precise geolocation data

With your acceptance, your precise location (within a radius of less than 500
metres) may be used in support of the purposes explained in this notice.

List of IAB Vendors‎

ACTIVELY SCAN DEVICE CHARACTERISTICS FOR IDENTIFICATION 3 PARTNERS CAN USE THIS
PURPOSE

Actively scan device characteristics for identification

With your acceptance, certain characteristics specific to your device might be
requested and used to distinguish it from other devices (such as the installed
fonts or plugins, the resolution of your screen) in support of the purposes
explained in this notice.

List of IAB Vendors‎

ENSURE SECURITY, PREVENT AND DETECT FRAUD, AND FIX ERRORS 48 PARTNERS CAN USE
THIS PURPOSE

Always Active

Your data can be used to monitor for and prevent unusual and possibly fraudulent
activity (for example, regarding advertising, ad clicks by bots), and ensure
systems and processes work properly and securely. It can also be used to correct
any problems you, the publisher or the advertiser may encounter in the delivery
of content and ads and in your interaction with them.

List of IAB Vendors‎ | View Illustrations 

DELIVER AND PRESENT ADVERTISING AND CONTENT 41 PARTNERS CAN USE THIS PURPOSE

Always Active

Certain information (like an IP address or device capabilities) is used to
ensure the technical compatibility of the content or advertising, and to
facilitate the transmission of the content or ad to your device.

List of IAB Vendors‎ | View Illustrations 

MATCH AND COMBINE DATA FROM OTHER DATA SOURCES 40 PARTNERS CAN USE THIS PURPOSE

Always Active

Information about your activity on this service may be matched and combined with
other information relating to you and originating from various sources (for
instance your activity on a separate online service, your use of a loyalty card
in-store, or your answers to a survey), in support of the purposes explained in
this notice.

List of IAB Vendors‎

LINK DIFFERENT DEVICES 35 PARTNERS CAN USE THIS PURPOSE

Always Active

In support of the purposes explained in this notice, your device might be
considered as likely linked to other devices that belong to you or your
household (for instance because you are logged in to the same service on both
your phone and your computer, or because you may use the same Internet
connection on both devices).

List of IAB Vendors‎

IDENTIFY DEVICES BASED ON INFORMATION TRANSMITTED AUTOMATICALLY 36 PARTNERS CAN
USE THIS PURPOSE

Always Active

Your device might be distinguished from other devices based on information it
automatically sends when accessing the Internet (for instance, the IP address of
your Internet connection or the type of browser you are using) in support of the
purposes exposed in this notice.

List of IAB Vendors‎
Back Button


COOKIE LIST



Search Icon
Filter Icon

Clear
checkbox label label
Apply Cancel
Consent Leg.Interest
checkbox label label
checkbox label label
checkbox label label

Confirm My Choices
Close modal
You are about to visit a website outside of medicinenet. Please familiarize
yourself with this other website's Privacy Policy as it differs from ours.
continue