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HEALTH PREDISPOSITIONS*LEARN ABOUT CONSIDERATIONS AND LIMITATIONS FOR HEALTH
PREDISPOSITIONS REPORTS, CARRIER STATUS REPORTS AND GENETIC HEALTH RISKS

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Phone Slide 0: Health Predispositions*Learn about Considerations and Limitations
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Learn how your DNA influences your facial features, taste, smell and other
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Health Predisposition reports*Learn about Considerations and Limitations for
Health Predispositions Reports, Carrier Status Reports and Genetic Health Risks
Learn how your genetics can influence your chances of developing certain health
conditions.



Carrier Status reports*Learn about Considerations and Limitations for Health
Predispositions Reports, Carrier Status Reports and Genetic Health Risks
If you are starting a family, find out if you are a carrier for certain
inherited conditions.



Wellness reports
Learn how your genes play a role in your well-being and lifestyle choices.



Family Health History Tree
Easily input, track and download your family health history to share with your
healthcare provider.



Pharmacogenetics reports**Learn about Considerations and Limitations for
Pharmacogenetics Reports
Discover how your DNA may impact how your body processes certain medications
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*23andMe health predisposition reports include both reports that meet FDA
requirements for genetic health risks and reports which are based on 23andMe
research and have not been reviewed by the FDA. The test uses qualitative
genotyping to detect select clinically relevant variants in the genomic DNA of
adults from saliva for the purpose of reporting and interpreting genetic health
risks. It is not intended to diagnose any disease. Your ethnicity may affect the
relevance of each report and how your genetic health risk results are
interpreted. Each genetic health risk report describes if a person has variants
associated with a higher risk of developing a disease, but does not describe a
person’s overall risk of developing the disease. The test is not intended to
tell you anything about your current state of health, or to be used to make
medical decisions, including whether or not you should take a medication, how
much of a medication you should take, or determine any treatment. Our carrier
status reports can be used to determine carrier status, but cannot determine if
you have two copies of any genetic variant. These carrier reports are not
intended to tell you anything about your risk for developing a disease in the
future, the health of your fetus, or your newborn child's risk of developing a
particular disease later in life. For certain conditions, we provide a single
report that includes information on both carrier status and genetic health risk.
Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for
BRCA1/BRCA2 (Selected Variants) is indicated for reporting of the 185delAG and
5382insC variants in the BRCA1 gene and the 6174delT variant in the BRCA2 gene.
The report describes if a woman is at increased risk of developing breast and
ovarian cancer, and if a man is at increased risk of developing breast cancer or
may be at increased risk of developing prostate cancer. The three variants
included in this report are most common in people of Ashkenazi Jewish descent
and do not represent the majority of BRCA1/BRCA2 variants in the general
population. This report does not include variants in other genes linked to
hereditary cancers and the absence of variants included in this report does not
rule out the presence of other genetic variants that may impact cancer risk. The
PGS test is not a substitute for visits to a healthcare professional for
recommended screenings or appropriate follow-up. Results should be confirmed in
a clinical setting before taking any medical action. For important information
and limitations regarding each genetic health risk and carrier status report,
visit 23andme.com/test-info/

**23andMe PGS Pharmacogenetics reports: The 23andMe test uses qualitative
genotyping to detect 3 variants in the CYP2C19 gene, 2 variants in the DPYD gene
and 1 variant in the SLCO1B1 gene in the genomic DNA of adults from saliva for
the purpose of reporting and interpreting information about the processing of
certain therapeutics to inform discussions with a healthcare professional. It
does not describe if a person will or will not respond to a particular
therapeutic and does not describe the association between detected variants and
any specific therapeutic. Our CYP2C19 Pharmacogenetics report provides certain
information about variants associated with metabolism of some therapeutics and
provides interpretive drug information regarding the potential effect of
citalopram and clopidogrel therapy. Results for SLCO1B1 and DPYD and certain
CYP2C19 results should be confirmed by an independent genetic test prescribed by
your own healthcare provider before taking any medical action. Warning: Test
information should not be used to start, stop, or change any course of treatment
and does not test for all possible variants that may affect metabolism or
protein function. The PGS test is not a substitute for visits to a healthcare
professional. Making changes to your current regimen can lead to harmful side
effects or reduced intended benefits of your medication, therefore consult with
your healthcare professional before taking any medical action. For important
information and limitations regarding Pharmacogenetics reports, visit
23andme.com/test-info/pharmacogenetics/


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