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SINO BIOLOGICAL'S CENTER FOR BIOPROCESSING (C4B): US-BASED CRO SERVICES
In October 2023, Sino Biological, Inc. opened its Center for Bioprocessing (C4B)
in Houston, Texas, nestled within the Levit Green district near the Texas
Medical Center. Spanning 10,000 sq ft, the C4B boasts cutting-edge laboratories
equipped with state-of-the-art equipment, proprietary technology platforms, and
a world-class team.
Since its opening, the C4B has executed 200+ projects, garnering 4.5 out of 5
stars on customer satisfaction. Specializing in recombinant protein and antibody
production utilizing mammalian expression systems, the C4B ensures high purity
and minimal endotoxin levels of the finished products.
The C4B also offers comprehensive biomolecular interaction analysis services
based on bio-layer interferometry (BLI) technology. With the state-of-the-art
Octet® R8 system and extensive expertise in BLI and protein science, the C4B
ensures the rapid delivery of accurate results, adhering to project plans
tailored to meet your specific requirements.
Get a Quote
BIOPROCESSING PROJECTS AT C4B
• Recombinant Protein Production
• Biomolecular Interaction Analysis with BLI
• Recombinant Antibody Production
• Process Development and Optimization
If you have any questions about CRO services, please email
cro_us@sinobiologicalus.com or call 215-583-7898.
5 REASONS TO CHOOSE C4B
Sino Biological has built expertise in recombinant production for over 17 years,
and the C4B represents a considerable global expansion of its CRO service
capabilities.
One-stop antibody & protein CRO service provider Optimized expression platforms
ensure the highest chances of success
HEK293/CHO transient expression platform & stable cell line development platform
Extensive proficiency in manufacturing a wide range of antibody formats
IgGs, IgAs, IgMs, antibody fragments, bispecifics, and beyond. Customized
antibodies & proteins
delivered in as fast as 2 weeks 24 well plates to 25 L bioreactors for your
screening to production level protein needs State-of-the-art equipment &
minimal endotoxin during processing A world-class team of industrial
professionals & academic experts • Combined experience in recombinant culture
and purification • All projects led by PhD-level project managers
BIOPROCESSING CASE STUDIES
The C4B routinely employs various types of chromatography, to fulfil the
requirements of recombinant production. The following case studies illustrate
the purification results.
ONE-STEP PURIFICATION OF A C-TAGGED RECOMBINANT PROTEIN USING CAPTURESELECT™
C-TAG AFFINITY MATRIX
C-tag is a small size affinity tag with 4 amino acids (E-P-E-A) that can be
fused with protein constructs. It provides high affinity and selectivity for
protein purification while having limited effects on protein functionality.
Purity
SDS-PAGE: 95%
SEC-HPLC: 93%
Endotoxin < 0.1 EU/mg
ONE-STEP PROTEIN A PURIFICATION OF A RECOMBINANT IGG ANTIBODY
The C4B provides various scales from a few milliliter to 25 liter culture
volumes to produce high-quality recombinant antibodies. One, two, or three-step
(CH1, CEX, SEC, etc.) purification schemes are available to meet different
production requirements.
Purity
SDS-PAGE: 95%
SEC-HPLC: 96%
Endotoxin < 0.1 EU/mg
STATE-OF-THE-ART EQUIPMENT
Kuhner incubator shakers
Cytiva ReadyToProcess WAVE 25 rocker
Agilent 1290 Infinity II LC System
ÄKTA pure™ chromatography systems
Octet® R8, 8-channel protein analysis system
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WHY CHOOSE C4B?
ABOUT C4B
BLI SERVICES OFFERED AT C4B
FEATURED RECOMBINANT PRODUCTION SERVICES
* Recombinant Antibody Production Services
* High-throughput Antibody Production Service
* Large-scale Antibody Manufacturing Services
* Bispecific Antibody Production Service
* Antibody Fragment Production Service
* Chimeric Antibody Production Service
* Recombinant Protein Expression Services
* Mammalian Transient Protein Expression Service
* CHO Stable Cell Line Development for Protein/Antibody Production
* Stable Cell Line Development for Assays
More CRO Services
SOLUTIONS
* Multispecific Antibody Development Solutions
* Solutions for In Vitro Efficacy Evaluation
* Solutions for CAR-T Therapy
* Solutions for CAR-NK Therapy
* Influenza Vaccine Development and Production Solutions
* SARS-CoV-2 Variants Research Solutions
More
TECHNICAL RESOURCES
* Recombinant Antibody Technology: Its Criticality to Past and Future
Biopharmaceutical Success
* In Focus: Next-generation Antibody Therapeutics
* Innovations in Baculovirus-Insect Cell Expression Systems
* Custom Antibody Development and Manufacturing: Taking a Customer-Focused
Approach
* Sino Biological: Advancing Life Science Research with Optimized Recombinant
Technology
* Antibody–Drug Conjugates: A Breakthrough in the Targeted Therapy Era
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